IN2014DN10758A - - Google Patents

Info

Publication number
IN2014DN10758A
IN2014DN10758A IN10758DEN2014A IN2014DN10758A IN 2014DN10758 A IN2014DN10758 A IN 2014DN10758A IN 10758DEN2014 A IN10758DEN2014 A IN 10758DEN2014A IN 2014DN10758 A IN2014DN10758 A IN 2014DN10758A
Authority
IN
India
Prior art keywords
group
alkyl group
epoxyketone
substituent
producing
Prior art date
Application number
Inventor
Yukihiro Nishino
Kazuya Wakui
Shota Murase
Yoshifumi Sakai
Original Assignee
Nissan Chemical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd filed Critical Nissan Chemical Ind Ltd
Publication of IN2014DN10758A publication Critical patent/IN2014DN10758A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/19—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic hydroperoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

A novel method for producing a stereoselective epoxyketone compound is provided. A method for producing an epoxyketone compound represented by the formula (1) as represented by the following scheme whereby it is possible to obtain an epoxyketone derivative in good yield and at high selectivity and to provide an industrially useful production method and an intermediate thereof. wherein R is a hydrogen atom a linear branched or cyclic alkyl group an aromatic group which may have a substituent or a heterocyclic group which may have a substituent and R is a protective group for an amino group. R is a hydrogen atom or a C alkyl group and R s may be the same or different provided that at least one R is a C alkyl group.
IN10758DEN2014 2012-06-29 2013-06-27 IN2014DN10758A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2012146821 2012-06-29
US201261735196P 2012-12-10 2012-12-10
JP2013026801 2013-02-14
US201361789996P 2013-03-15 2013-03-15
PCT/JP2013/068308 WO2014003203A2 (en) 2012-06-29 2013-06-27 Method for producing stereoselective epoxyketone compound

Publications (1)

Publication Number Publication Date
IN2014DN10758A true IN2014DN10758A (en) 2015-09-04

Family

ID=49783967

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10758DEN2014 IN2014DN10758A (en) 2012-06-29 2013-06-27

Country Status (6)

Country Link
US (1) US9187442B2 (en)
EP (1) EP2867202B1 (en)
JP (1) JP6176259B2 (en)
CN (1) CN104411682B (en)
IN (1) IN2014DN10758A (en)
WO (1) WO2014003203A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104230857A (en) * 2014-08-19 2014-12-24 上海皓元生物医药科技有限公司 Preparation method of intermediate compounds of carfilzomib and intermediate compounds
WO2016185450A1 (en) 2015-05-21 2016-11-24 Laurus Labs Private Limited An improved processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof
CN105017181B (en) * 2015-07-02 2017-10-10 南京师范大学 The preparation method of Carfilzomib key intermediate and its derivative
CN105622458A (en) * 2015-12-22 2016-06-01 中国药科大学 Preparation method of (S)-4-amino-2-methyl-5-phenyl-1-cyclopenten-3-ketone
BR112018077390A2 (en) 2016-06-29 2019-04-09 Kezar Life Sciences crystalline salts of immunoproteasome inhibitor epoxicentone peptide
CN109641860B (en) 2016-06-29 2024-05-28 科智生命科学公司 Process for preparing peptide epoxyketone immune proteasome inhibitors and precursors thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8088741B2 (en) * 2004-05-10 2012-01-03 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
WO2005111009A2 (en) 2004-05-10 2005-11-24 Proteolix, Inc. Synthesis of amino acid keto-epoxides
JP2007538081A (en) * 2004-05-17 2007-12-27 プロテオリックス， インコーポレイテッド Synthesis of amino acid ketoepoxides.
US20070232838A1 (en) 2004-06-24 2007-10-04 Yoshiharu Iwabuchi Alcohol Oxidation Catalyst and Method of Synthesizing the Same
SI2041158T1 (en) 2006-06-19 2013-09-30 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
JP4803074B2 (en) 2007-03-06 2011-10-26 日産化学工業株式会社 Alcohol oxidation catalyst and synthesis method thereof
US8013189B2 (en) * 2007-09-21 2011-09-06 Basf Se Accelerated amide and ester reductions with amine boranes and additives
US8367617B2 (en) * 2007-10-04 2013-02-05 Onyx Therapeutics, Inc. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
US7902376B2 (en) * 2008-01-23 2011-03-08 Merck Sharp & Dohme Corp. Process for preparing chiral dipeptidyl peptidase-IV inhibitor intermediates
WO2009145323A1 (en) 2008-05-30 2009-12-03 日産化学工業株式会社 Method for oxidizing alcohol by using polycyclic compound

Also Published As

Publication number Publication date
WO2014003203A2 (en) 2014-01-03
US9187442B2 (en) 2015-11-17
US20150126755A1 (en) 2015-05-07
CN104411682B (en) 2016-11-16
JP6176259B2 (en) 2017-08-09
WO2014003203A3 (en) 2014-03-20
EP2867202A2 (en) 2015-05-06
EP2867202B1 (en) 2017-08-09
JP2015526384A (en) 2015-09-10
CN104411682A (en) 2015-03-11

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