CN104398901A - Medicine capable of nourishing yin to clear away heat and treating bronchitis and asthma, and preparation method of medicine - Google Patents

Medicine capable of nourishing yin to clear away heat and treating bronchitis and asthma, and preparation method of medicine Download PDF

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CN104398901A
CN104398901A CN201410765554.0A CN201410765554A CN104398901A CN 104398901 A CN104398901 A CN 104398901A CN 201410765554 A CN201410765554 A CN 201410765554A CN 104398901 A CN104398901 A CN 104398901A
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asthma
radix
medicine
pericarpium citri
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陈思
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/835—Aquilaria
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a medicine capable of nourishing yin to clear away heat and treating bronchitis and asthma. The medicine is characterized in that the medicine is prepared from the drug substances in parts by weight: 9-15 parts of pericarpium citri reticulatae, 5-10 parts of radix peucedani, 8-12 parts of radish, 10-15 parts of liquorice, 5-9 parts of oyster rhoeo, 4-9 parts of white mustard seeds, 8-13 parts of kingfisher, 5-9 parts of henbane leaves, 6-9 parts of floating wheat, 8-14 parts of Chinese eaglewood and 9-16 parts of fructus momordicae. The medicine has the excellent effects that the medicine is prepared from natural herb materials which have effects of nourishing yin, clearing away heat, clearing away the lung-heat, reducing phlegm, and relieving cough and asthma and are selected from motherland medicine treasure based on Chinese medicine knowledge of bronchitis, asthma pathogenesis; the selected raw materials of the medicine are traditional Chinese medicine materials, are free of toxic or side effects, and can effectively treat exogenous and endogenous bronchitis and asthma.

Description

Bronchitis merges asthma replenishing YIN and removing heat medicament and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of bronchitis and merge asthma replenishing YIN and removing heat medicament and preparation method thereof.
Background technology
Bronchitis refers to the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Bronchitis main cause is that the repeated infection of virus and antibacterial defines bronchial chronic nonspecific inflammation.When under mercury dropped, respiratory tract small blood vessel spasm ischemia, defense function, degradation is beneficial to pathogenic.Asthma participates in chronic airway inflammation illness by various kinds of cell (as eosinophilic granulocyte, mastocyte, T lymphocyte, neutrophilic granulocyte, human airway epithelial cells etc.) and cellular component.This chronic inflammatory disease causes the generation of airway hyperreactivity, the reversible airflow limitation that usual appearance is extensively changeable, and causing the symptoms such as the panting of recurrent exerbation, out of breath, uncomfortable in chest or cough, be everlasting night and (or) outbreak in morning, most of patients can spontaneous remissions or alleviate through treatment.Bronchitis merges the chief complaint that asthma is harm humans life, patient may cause because of asthma recurrent exerbation of panting, there is serious phenomenon out of breath uncomfortable in chest, even can develop into emphysema or pulmonary heart disease gradually, have a strong impact on the orthobiosis of patient, the great misery brought.
Bronchitis and asthma belong to the category of Chinese medicine " cough ", " phlegm retention ", " the syndrome of dyspnea ".The discussion of Huangdi's Internal Classics to cough is quite detailed.As " Plain Questions declares a section " is said: " five kinds of diseases caused by disorders of ZANG-QI ... disorder of the lung giving rise to cough ", " conjunction of fur person lung also, fur is first by pathogen, and pathogen is to close also from it ", as " Plain Questions coughs an opinion section " day: " vital organs of the human body all make us coughing, and non-only lung also ".Modern doctor thinks, the stage of attack of tracheitis or asthma or catabasis are all the cards of simulataneous insufficiency and excessive, deficiency in origin and excess in superficiality.Luo Fengping thinks that its pathogenesis mostly is insufficiency of lung-QI, phlegm retention volt lung, and the lung network stasis of blood is stagnant, feels the heresy of phlegm-damp, wind heat, wind and cold again, causes impaired depurative descending of lung QI, water-damp not being transformed, wet consor expectorant, stops up choke road, and mental disorder is fought knot, abnormal rising of lung-QI, the card work of cough with asthma.Otherwise the deficiency of vital energy is unable reduces phlegm, the existence of phlegm-damp is again increase the weight of the key factor that expectoration breathes heavily.So, differential diagnosis in tcm should be taked to treat.
Publication number CN 101450157 A(application number 200710150540.8) Chinese invention patent disclose a kind of pharmaceutical composition for the treatment of chronic bronchitis and asthma, be made up of following active ingredients: ambroxol hydrochloride 5-20mg, Corm Eleocharitis 100-30g, Radix Astragali 10-20g, Radix Codonopsis 10-50g, Sedum spectabile Boreau 20-50g, Radix Glycyrrhizae 6-20g.Publication number CN 101234167 A(application number 200810049294.1) Chinese invention patent disclose a kind of Chinese medicine for the treatment of bronchial asthma, chronic bronchitis, by Herba Epimedii 140-160g, Radix Panacis Quinquefolii 85-95g, Gecko 40-50g, Pheretima 110-130g, Bulbus Fritillariae Cirrhosae 85-95g, Herba Ephedrae 18-22g, Semen Armeniacae Amarum 85-95g, Radix Glycyrrhizae 20-25g, Rhizoma Anemarrhenae 45-55g, Folium Perillae 45-55g, Folium Mori 45-55g makes.Publication number CN 1907388 A(application number 200610051176.5) Chinese invention patent disclose a kind of Chinese medicine for the treatment of bronchitis and bronchial asthma, it is made up of following crude drug: Herba Ephedrae 6-8, Semen Armeniacae Amarum 10-15, Gypsum Fibrosum 18-25, Bulbus Fritillariae Uninbracteatae 5-10, Bombyx Batryticatus 10-15, Radix Glycyrrhizae 6-8, Rhizoma Belamcandae 8-10, Radix Platycodonis 6-8, Fructus Perillae 10-15.
Merge the treatment of asthma at present about bronchitis, Western medicine uses antibiotic usually, cures the symptoms, not the disease, and large to the side effect of human body, relapse rate is high.The duration of drug effect is short.Reusability easily produces drug resistance again, the lighter's impairing the spleen and stomach, and severe one causes lesions of liver and kidney, has endless trouble.Mechanotherapy, hormone therapy, western medicine, takes into account inside and outside being all difficult to accomplish, can only eliminate surface symptoms, can not reach the effect of not only taking stopgap measures but also effecting a permanent cure.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that one is prepared simply, taking convenience, portable bronchitis merge asthma replenishing YIN and removing heat medicament and preparation method thereof.This curative effect of medicine is definite and have no side effect.
Technical scheme of the present invention is:
Bronchitis merges asthma replenishing YIN and removing heat medicament, it is characterized in that, is prepared from by following bulk drugs, be weight portion: Pericarpium Citri Reticulatae 9-15; Radix Peucedani 5-10; Radix Raphani 8-12; Radix Glycyrrhizae 10-15; Flos Rhoeo discolorae 5-9; Semen Sinapis Albae 4-9; Alcedo atthis bengalensis 8-13; Folium Hyoscyami 5-9; Fructus Tritici Levis 6-9; Lignum Aquilariae Resinatum 8-14; Fructus Momordicae 9-16.
In preferred scheme, Pericarpium Citri Reticulatae 11-13; Radix Peucedani 7-8; Radix Raphani 9-11; Radix Glycyrrhizae 12-13; Flos Rhoeo discolorae 6-8; Semen Sinapis Albae 5-8; Alcedo atthis bengalensis 10-11; Folium Hyoscyami 6-8; Fructus Tritici Levis 7-8; Lignum Aquilariae Resinatum 10-12; Fructus Momordicae 12-13.
Be more preferably, Pericarpium Citri Reticulatae 12; Radix Peucedani 7.5; Radix Raphani 10; Radix Glycyrrhizae 12.5; Flos Rhoeo discolorae 7; Semen Sinapis Albae 6.5; Alcedo atthis bengalensis 10.5; Folium Hyoscyami 7; Fructus Tritici Levis 7.5; Lignum Aquilariae Resinatum 11; Fructus Momordicae 12.5.
Bronchitis merges asthma replenishing YIN and removing heat medicament, and the preparation method of described decoction is:
(1) Pericarpium Citri Reticulatae is cleaned, shredding, and then get humus flava usta and put stir-fry pine in pot, pour Pericarpium Citri Reticulatae silk into, frying to surface with moderate heat is coke yellow degree of being, take out, sieve removes soil, cools; Get clean Fructus Tritici Levis, put in pot, add with slow fire and propagandize hotly to brown color, taking-up cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 20-30 minute, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Alcedo atthis bengalensis is cleaned, and removes intestinal, stripping and slicing, for subsequent use;
(3) by the Alcedo atthis bengalensis after process in step (2) and Radix Raphani, Radix Peucedani, Radix Glycyrrhizae, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae are placed in medicinal cupping, the clear water adding 8-10 times amount soaks, then Pericarpium Citri Reticulatae and Fructus Tritici Levis that step (1) processed and the Semen Sinapis Albae that step (2) processes and Folium Hyoscyami is added, intense fire boils, then slow fire boiling 2 times, first time decocts 40-60 minute (preferably first time decocts 50 minutes), second time decocts 25-45 minute (preferably second time decocts 35 minutes), period constantly adds clear water, clear water is kept not have medical material 3-5cm, filter, merge twice decocting liquid,
(4) gained decocting liquid is concentrated into 1/3 of original volume in 80 DEG C of heating, stops, cooling, sterilizing, fill, to obtain final product.
Above-mentioned bronchitis merges the preparation method of asthma replenishing YIN and removing heat decoction, and preferred scheme is, dries 2-5 hour (dry 3-4 hour in preferred 120 DEG C of baking ovens, dry 3.5 hours in the 120 DEG C of baking ovens be more preferably) in step (2) in 120 DEG C of baking ovens.
Above-mentioned bronchitis merges the preparation method of asthma replenishing YIN and removing heat decoction, and preferred scheme is, in step (3), clear water soak time is 1-3 hour (preferred clear water soak time is 1.5-2.5 hour, and the clear water soak time be more preferably is 2 hours).
The preparation method of described pill is:
(1) Pericarpium Citri Reticulatae is cleaned, shredding, and then get humus flava usta and put stir-fry pine in pot, pour Pericarpium Citri Reticulatae silk into, frying to surface with moderate heat is coke yellow degree of being, take out, sieve removes soil, cools, grinds to form powder; Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 20-30 minute, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use;
(2) Radix Peucedani section, puts in pot, and it is yellow for spending that slow fire fries extremely surface, and taking-up cools, and pulverizes; Front English white is mixed homogeneously with step (1) gained tangerine peel powder, Semen Sinapis Albae powder and Black Henbane, sieves, obtain mixing fine powders for subsequent use;
(3) Alcedo atthis bengalensis is cleaned, and removes intestinal, stripping and slicing, together be placed in medicinal cupping with Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, decoct with water 2 times, each 2-3 hour, collecting decoction filters, and filtrate is condensed into relative density 1.05-1.15(60 DEG C), obtain thick paste, be placed into room temperature, adding ethanol makes ethanol content reach 75%, places 12-20 hour (preferably placing 16 hours), filters, distilling under reduced pressure is extremely without alcohol taste, and vacuum drying gets dry extract;
(4) by broken for above-mentioned dried cream powder, then stir with step (2) gained mixing fine powders, with water pill, make pill, to obtain final product.
Above-mentioned bronchitis merges the preparation method of asthma replenishing YIN and removing heat pill, and preferred scheme is, the middle 40-80 mesh sieve excessively of step (2) (preferred 50-70 mesh sieve excessively, mistake 60 mesh sieve be more preferably).
The preparation method of described granule is:
(1) get Pericarpium Citri Reticulatae salt adding, Sucus Zingberis, vinegar soak 15-35 minute, enter pot and steam to time savory, cease fire, stewing 10-20 hour, until color turn black after dry; Refined honey is added boiled water dilution, add Radix Peucedani sheet and mix thoroughly, braised through, be then placed in pot, slow fire is fried to time tack-free, takes out, cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 25-35 minute, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Semen Sinapis Albae powder and Black Henbane mixing, cross 40-60 mesh sieve (preferred mistake 50 mesh sieve), obtain mixing fine powders;
(3) Alcedo atthis bengalensis is cleaned, remove intestinal, stripping and slicing, together medicinal cupping is placed in Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, add the Pericarpium Citri Reticulatae and Radix Peucedani that processed in step (1) simultaneously, the clear water adding 10 times of weight in medicinal cupping decocts twice, first time decocts 1-2 hour (preferably first time decocts 1.5 hours), second time decocts 45-60 minute (preferably second time decocts 55 minutes), merge twice decoction liquor, decoction liquor drying under reduced pressure is obtained the extractum that density is about 1.25g/mL;
(4) in above-mentioned extractum, step (2) gained mixing fine powders is added; stirring makes mix homogeneously; then using 80% ethanol of 10% low-substituted hydroxypropyl cellulose as adhesive, with extract powder: Bidismutose: starch quality is placed in granulator than the ratio for 10:3:2 and stirs, and obtains granule.
The preparation method of described tablet is:
(1) get Pericarpium Citri Reticulatae salt adding, Sucus Zingberis, vinegar soak 15-35 minute, enter pot and steam to time savory, cease fire, stewing 10-20 hour (preferably stewing 15 hours), until color turn black after dry; Refined honey is added boiled water dilution, add Radix Peucedani sheet and mix thoroughly, braised through, be then placed in pot, slow fire is fried to time tack-free, takes out, cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 30 minutes, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Semen Sinapis Albae powder and Black Henbane mixing, cross 60 mesh sieve sieves, obtain mixing fine powders;
(3) Alcedo atthis bengalensis is cleaned, remove intestinal, stripping and slicing, together be placed in medicinal cupping with Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, add the Pericarpium Citri Reticulatae and Radix Peucedani that processed in step (1) simultaneously, the clear water adding 10 times of weight in medicinal cupping decocts twice, first time decocts 1-2 hour, second time decocts 45-60 minute, merges twice decoction liquor, decoction liquor drying under reduced pressure is obtained the extractum that density is about 1.25g/mL;
(4) by above-mentioned extractum in 80 DEG C of oven dry, be ground into powder, with gained mixing fine powders in step (2), stir, mix homogeneously, add corn starch, dextrin and Icing Sugar (extract powder: corn starch: dextrin: the mass ratio of Icing Sugar is 10:7:1:1) and make tablet according to the processing method of tablet, to obtain final product.
Drug prescription science provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,the present invention is based on the pathogenetic understanding of motherland's medical science to bronchitis, asthma, filter out from motherland's medical treasure-house replenishing YIN and removing heat, removing heat from the lung and dissipating phlegm, relieving cough and asthma natural drug prescription form;
2,this prescription selected materials is all Chinese medicine material, without any side effects, effectively can treat exogenous and endogenous bronchitis merging asthma;
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Raphani: base is former: be fresh of Cruciferae Radix Raphani platymiscium Radix Raphani.Composition: root contains glycoside glucosinolate, glucose raphanin, raphanusin.Phenolic acids: P-coumaric acid, caffeic acid, ferulic acid, phenylpyruvic acid, gentisic acid etc.The property of medicine: acrid, sweet, cool; Ripe person is sweet, flat.Return spleen, stomach, lung, large intestine channel.Function cures mainly: help digestion, and the therapeutic method to keep the adverse QI flowing downwards is reduced phlegm, hemostasis.Cure mainly dyspepsia, food stagnation distension, acid regurgitation, regurgitation of food from the stomach, tells food, and hemorrhoidal hamorrhage is had loose bowels, dysentery, constipation, phlegm-heat cough, discomfort in the throat, hemoptysis, and spit blood, epistaxis, has blood in stool, and quenches one's thirst, and drenches worm.Outer treatment skin ulcer abscess, damage congestive edema, scalds and chilblain.
Folium Hyoscyami: base is former: be the blade of plant of Solanaceae hyoscyami, gather after the Beginning of summer, dry.Chemical analysis: Folium Hyoscyami containing ash 20%, total alkaloids 0.045% ~ 0.14, wherein mainly hyoscyamine, scopolamine and atropine; Another containing a kind of bitter glycoside name hyospicrin.Function cures mainly: analgesia, spasmolytic.Treat for stomachache, toothache, cough and asthma caused by tracheitis.
Fructus Tritici Levis: base is former: be shrivelled frivolous Semen Tritici aestivi, water washes in a pan the person of floating.Character: dry caryopsis is Long Circle, is about 2 ~ 6 millimeters, diameter about 1.5 ~ 2.5 millimeters.Surface light yellowish brown or yellow, slightly wrinkle, there are darker longitudinal furrow in outside of belly central authorities, and back side base portion has unconspicuous embryo 1 piece, and there is yellow pubescence on top.Matter is hard, and the extremely flat person of minority, quality is softer.Section white or fallow.Minority is with grain husk and bran.Gas without, lightly seasoned.Even with grain, frivolous, surperficial glossy person is good.Nature and flavor: Gan Xian are cool.Function cures mainly: control hectic fever due to YIN-deficiency consumptive fever, only spontaneous sweating.
Lignum Aquilariae Resinatum: base is former: be the timber containing resin of Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum or Lignum Aquilariae Resinatum.Chemical analysis: the acetone extract (40 ~ 50%) of Lignum Aquilariae Resinatum distills after saponification, obtains volatile oil 13%, in containing benzylacetone, to methoxybenzyl benzylacetone etc., have 3-phenylpropionic acid in residue, to methoxyl group 3-phenylpropionic acid etc.The Lignum Aquilariae Resinatum of fungal infection is containing agarospirol, linalool, dihydroagarofuran, 4-Hydroxydihydroagarofuran, 3,4-dihydroxy dihydroagarofurans, Nor-Ketoagarofuran; The sulfur-bearing do not infected, selinane, linalool etc.Nature and flavor: arduous, temperature.Gui Jing: enter kidney, spleen, stomach warp.Function cures mainly: sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI.Control QI rising in reverse order to pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.
Fructus Momordicae: base is former: be the fruit of cucurbitaceous plant Fructus Momordicae.Chemical analysis: containing volume glucose etc.Nature and flavor: 1. " south of the Five Ridges gather medicinal herbs record ": " sweet in the mouth." return through " Guangxi Chinese medicinal herbal ": " enter lung, spleen two warp." function cures mainly: lung heat clearing intestine moistening.Cure mainly pertussis, phlegm-fire cough, the dry constipation of blood.
Semen Sinapis Albae: base is former: be the seed of crucifer Caulis et Folium Sinapis albee.Chemical analysis: Semen Sinapis Albae is containing Sinapine glucosinalbate., sinapic acid choline ester., myrosase, fat, protein and phlegmatic temperament.Sinapine glucosinalbate. is hydrolyzed through myrosase, produces P-hydroxybonzyl isothiocyanale (white mustard oil), sinapine bisulfate and glucose.Sinapine bisulfate can generate sinapic acid and choline through basic hydrolysis.Nature and flavor: pungent, temperature.Gui Jing: enter lung, stomach warp.Function cures mainly: promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.Control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Radix Glycyrrhizae: base is former: this product is drying report and the rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Nature and flavor: sweet are flat.Gui Jing: GUIXIN.Lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Peucedani: base is former: be the root of samphire Peucedanum praeruptorum DUNN or RADIX PEUCEDANI.Chemical analysis: RADIX PEUCEDANI root feeds Coumarins containing furan: Radix Peucedani glycoside about 1.61%.Also containing spongosterol, mannitol, volatile oil.The main constituent of volatile oil is estragole and limonene.Xanthotoxin is containing praeruptorin A, B prime, C prime, D prime.Pharmacological action: the method for collecting tracheal mucus secretion with anesthetized cat proves oral RADIX PEUCEDANI decoct 1 g/kg, can show the secretion increasing respiratory mucus, therefore tool phlegm-dispelling functions.Nature and flavor: toil are cool.Gui Jing: enter lung, spleen channel.Function cures mainly: dispelling wind-heat, the therapeutic method to keep the adverse QI flowing downwards, expectorant.Control headache due to pathogenic wind-heat, expectorant heat syndrome cough is breathed heavily, vomiting, and chest and diaphragm is full vexed.
Flos Rhoeo discolorae: base is former: be the inflorescence with bract of the purple Rohdea japonica Roth of Commelianaceae plant.Character: dry inflorescence, all like boat shape or folding fan-shaped, height about 2 centimetres, grows crosswise 5 ~ 6 centimetres.Feeble QI is fragrant, lightly seasoned.Chemical composition: flower is containing flavonoid glycoside, organic acid.Nature and flavor: sweet are cool.Function: removing heat from the lung and dissipating phlegm, removing heat from blood, dysentery relieving, cures mainly lung-heat type cough, and spit blood, epistaxis, dysentery, has blood in stool.
Pericarpium Citri Reticulatae: base is former: be the dry mature skin of rutaceae orange and variety thereof.Nature and flavor: bitter in the mouth, pungent, warm in nature.Gui Jing: return lung, spleen channel.Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Cure mainly: for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Alcedo atthis bengalensis: base is former: be meat and the bone of Alcedinidae Alcedo animal kingfisher.The property of medicine: supplement to the Herbal: " salty, flat, nontoxic." function cures mainly: 1. supplement to the Herbal: " and main fishbone and fishbone can not go out in entering, patient, burn to make black, are end, decoction being taken at a draught it.Boil extracting juice drink also good." 2. " Luchuan book on Chinese herbal medicine ": " Zhichuan.Control year asthma of a specified duration.”
embodiment 1bronchitis merges asthma replenishing YIN and removing heat medicament, is prepared from, is weight portion (350g/ part): Pericarpium Citri Reticulatae 9 parts by following bulk drugs; Radix Peucedani 5 parts; Radix Raphani 8 parts; 10 parts, Radix Glycyrrhizae; Flos Rhoeo discolorae 5 parts; Semen Sinapis Albae 4 parts; Alcedo atthis bengalensis 8 parts; Folium Hyoscyami 5 parts; Fructus Tritici Levis 6 parts; Lignum Aquilariae Resinatum 8 parts; Fructus Momordicae 9 parts.
The preparation method that above-mentioned bronchitis merges asthma replenishing YIN and removing heat decoction is:
(1) Pericarpium Citri Reticulatae is cleaned, shredding, and then get humus flava usta and put stir-fry pine in pot, pour Pericarpium Citri Reticulatae silk into, frying to surface with moderate heat is coke yellow degree of being, take out, sieve removes soil, cools; Get clean Fructus Tritici Levis, put in pot, add with slow fire and propagandize hotly to brown color, taking-up cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 20 minutes, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries 2 hours, have fragrant peppery gas to surface in buff, take out, cool, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Alcedo atthis bengalensis is cleaned, and removes intestinal, stripping and slicing, for subsequent use;
(3) Alcedo atthis bengalensis after process in step (2) and Radix Raphani, Radix Peucedani, Radix Glycyrrhizae, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae are placed in medicinal cupping, the clear water adding 8 times amount soaks 1 hour, then add Pericarpium Citri Reticulatae and Fructus Tritici Levis that step (1) processed and the Semen Sinapis Albae that step (2) processes and Folium Hyoscyami, intense fire boils, then slow fire boiling 2 times, first time decocts 40 minutes, second time decocts 25 minutes, and period constantly adds clear water, keeps clear water not have medical material 3-5cm, filter, merge twice decocting liquid;
(4) gained decocting liquid is concentrated into 1/3 of original volume in 80 DEG C of heating, stops, cooling, sterilizing, fill, to obtain final product.
The instructions of taking of decoction of the present invention is: twice daily, each 200-300mL, 7 days courses for the treatment of.
Model case: XXX, man, 62 years old, people from Zhangqiu.Patient's readme: check out to suffer from tracheitis, asthma at the beginning of 2011 3 months, when season alternation, disease is shown effect.Finally develop into and often show effect throughout the year, during outbreak, cough is violent, and asthma sound is thick and heavy, throughout the year by the maintenance that has Western medicine, coughs after taking medicine, pants and alleviate, but recur again soon.Patient is because of ailing and Western medicine torment throughout the year, and lean body mass, One's eyesight is restrained, immunity degradation, minor illness is continuous.Under the advice of layman, carry out here trial treatment by Chinese herbs.
Take the present embodiment gained bronchitis and merge asthma replenishing YIN and removing heat decoction, after taking two courses for the treatment of, patient pants alleviations, and cough and expectoration alleviates, and continues to take two courses for the treatment of, and patient airway is scorching, asthma disappears, patient's recovery from illness.Patient did not take other drug so far again, and tracheitis, asthma do not recur again.
embodiment 2bronchitis merges asthma replenishing YIN and removing heat medicament, is prepared from, is weight portion (150g/ part): Pericarpium Citri Reticulatae 15 parts by following bulk drugs; Radix Peucedani 10 parts; Radix Raphani 12 parts; 15 parts, Radix Glycyrrhizae; Flos Rhoeo discolorae 9 parts; Semen Sinapis Albae 9; Alcedo atthis bengalensis 13 parts; Folium Hyoscyami 9 parts; Fructus Tritici Levis 9 parts; Lignum Aquilariae Resinatum 14 parts; Fructus Momordicae 16 parts.
The preparation method that above-mentioned bronchitis merges asthma replenishing YIN and removing heat pill is:
(1) Pericarpium Citri Reticulatae is cleaned, shredding, and then get humus flava usta and put stir-fry pine in pot, pour Pericarpium Citri Reticulatae silk into, frying to surface with moderate heat is coke yellow degree of being, take out, sieve removes soil, cools, grinds to form powder; Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 25 minutes, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use;
(2) Radix Peucedani section, puts in pot, and it is yellow for spending that slow fire fries extremely surface, and taking-up cools, and pulverizes; Front English white is mixed homogeneously with step (1) gained tangerine peel powder, Semen Sinapis Albae powder and Black Henbane, crosses 60 mesh sieves, obtain mixing fine powders for subsequent use;
(3) Alcedo atthis bengalensis is cleaned, and removes intestinal, stripping and slicing, together be placed in medicinal cupping with Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, decoct with water 2 times, each 2.5 hours, collecting decoction filters, and filtrate is condensed into relative density 1.05-1.15(60 DEG C), obtain thick paste, be placed into room temperature, adding ethanol makes ethanol content reach 75%, places 16 hours, filters, distilling under reduced pressure is extremely without alcohol taste, and vacuum drying gets dry extract;
(4) by broken for above-mentioned dried cream powder, then stir with step (2) gained mixing fine powders, with water pill, make pill, to obtain final product.
The instructions of taking of pill of the present invention is: every day three times, each 6-10 ball, 7 days courses for the treatment of.
Model case: XXX, female, 17 years old, student.Patient is a high school student, and learning pressure is large at ordinary times, depression, and body constitution is poor, and one enters the winter, and just cough is constantly, coughs the sticky expectorant of white, time have amount of expectoration to increase, sputum retrogradation or in yellow, not easily expectoration.Check: patient's soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, flushed cheeks night sweat, tinnitus is dizzy, red tongue with a little fluid, yellowish or reddish urine, thready and rapid pulse.Belong to liver-kidney yin deficiency bronchitis.
Take the present embodiment gained bronchitis and merge asthma replenishing YIN and removing heat pill, every day three times, each 6-10 ball, 7 days courses for the treatment of.After the course for the treatment of of medication, patient's dysphoria with smothery sensation symptom is eliminated, and cough, expectoration obviously alleviates, other transference cures.Continue a course for the treatment of of medication, patient's self-induction is fully recovered, and does not occur any discomfort when patient takes, so far without recurring.
embodiment 3bronchitis merges asthma replenishing YIN and removing heat medicament, is prepared from, is weight portion (300g/ part): Pericarpium Citri Reticulatae 11 parts by following bulk drugs; Radix Peucedani 7 parts; Radix Raphani 9 parts; 12 parts, Radix Glycyrrhizae; Flos Rhoeo discolorae 6 parts; Semen Sinapis Albae 5 parts; Alcedo atthis bengalensis 10 parts; Folium Hyoscyami 6 parts; Fructus Tritici Levis 7 parts; Lignum Aquilariae Resinatum 10 parts; Fructus Momordicae 12 parts.
The preparation method that above-mentioned bronchitis merges asthma replenishing YIN and removing heat granule is:
(1) get Pericarpium Citri Reticulatae salt adding, Sucus Zingberis, vinegar soak 25 minutes, enter pot and steam to time savory, cease fire, stewing 15 hours, until color turn black after dry; Refined honey is added boiled water dilution, add Radix Peucedani sheet and mix thoroughly, braised through, be then placed in pot, slow fire is fried to time tack-free, takes out, cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 30 minutes, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Semen Sinapis Albae powder and Black Henbane mixing, cross 50 mesh sieves, obtain mixing fine powders;
(3) Alcedo atthis bengalensis is cleaned, remove intestinal, stripping and slicing, together be placed in medicinal cupping with Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, add the Pericarpium Citri Reticulatae and Radix Peucedani that processed in step (1) simultaneously, the clear water adding 10 times of weight in medicinal cupping decocts twice, first time decocts 1.5 hours, second time decocts 55 minutes, merges twice decoction liquor, decoction liquor drying under reduced pressure is obtained the extractum that density is about 1.25g/mL;
(4) in above-mentioned extractum, step (2) gained mixing fine powders is added; stirring makes mix homogeneously; then using 80% ethanol of 10% low-substituted hydroxypropyl cellulose as adhesive, with extract powder: Bidismutose: starch quality is placed in granulator than the ratio for 10:3:2 and stirs, and obtains granule.
The instructions of taking of granule of the present invention is: every day three times, each 2-3 bag (can take the circumstances into consideration plus-minus according to the state of an illness), warm boiled water, 7 days courses for the treatment of.
Model case: XXX, female, 47 years old, peasant.Patient's readme: in December, 2010 does not go out because of cough with asthma, chronic cough, and trunnion has foreign body sensation and goes local hospital inspection.Result is diagnosed as asthma.With symptoms such as nasal obstruction, sneeze, ophthalmic pruritus, during outbreak, in the short time, there is severe dyspnea, hypoxemia in each premorbid.The state of an illness is generally shown effect at night or morning and increases the weight of.Once took western medicine, but effect is undesirable, introduces through relative, carry out here diagnosis and treatment.Check: patient's symptoms of asthma is obvious, and with vexed insomnia, fever in the afternoon, dry mouth and tougue, the few tongue of red tongue, the insufficiency of heart-YIN of thready and rapid pulse, hyperactivity of heart-fire symptom.
Take the present embodiment gained bronchitis and merge asthma replenishing YIN and removing heat granule, every day three times, each 3 bags, more than patient allly after treating a course for the treatment of to alleviate, continue to take two the course for the treatment of patient vexedly to remove, sleep peace, spirit can, patient's self-induction fully recover, so far without recur.
embodiment 4bronchitis merges asthma replenishing YIN and removing heat medicament, is prepared from, is weight portion (200g/ part): Pericarpium Citri Reticulatae 13 parts by following bulk drugs; Radix Peucedani 8 parts; Radix Raphani 11 parts; 13 parts, Radix Glycyrrhizae; Flos Rhoeo discolorae 8 parts; Semen Sinapis Albae 8; Alcedo atthis bengalensis 11 parts; Folium Hyoscyami 8 parts; Fructus Tritici Levis 8 parts; Lignum Aquilariae Resinatum 12 parts; Fructus Momordicae 13 parts.
The preparation method that above-mentioned bronchitis merges asthma replenishing YIN and removing heat tablet is:
(1) get Pericarpium Citri Reticulatae salt adding, Sucus Zingberis, vinegar soak 25 minutes, enter pot and steam to time savory, cease fire, stewing 15 hours, until color turn black after dry; Refined honey is added boiled water dilution, add Radix Peucedani sheet and mix thoroughly, braised through, be then placed in pot, slow fire is fried to time tack-free, takes out, cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 30 minutes, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Semen Sinapis Albae powder and Black Henbane mixing, cross 60 mesh sieves, obtain mixing fine powders;
(3) Alcedo atthis bengalensis is cleaned, remove intestinal, stripping and slicing, together be placed in medicinal cupping with Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, add the Pericarpium Citri Reticulatae and Radix Peucedani that processed in step (1) simultaneously, the clear water adding 10 times of weight in medicinal cupping decocts twice, first time decocts 1.5 hours, second time decocts 53 minutes, merges twice decoction liquor, decoction liquor drying under reduced pressure is obtained the extractum that density is about 1.25g/mL;
(4) by above-mentioned extractum in 80 DEG C of oven dry, be ground into powder, with gained mixing fine powders in step (2), stir, mix homogeneously, add corn starch, dextrin and Icing Sugar (extract powder: corn starch: dextrin: the mass ratio of Icing Sugar is 10:7:1:1) and make tablet according to the processing method of tablet, to obtain final product.
The instructions of taking of Tablets is: every day three times, each 4-6 sheet, 7 days courses for the treatment of.
Model case: XXX, man, 29 years old, company clerk.Patient's readme: in JIUYUE, 2010, discontinuity is coughed, expectoration one week, and period, night sweat, chest pain, take JIZHI TANGJIANG treatment, the state of an illness was alleviated to some extent, but Relapse rate, bad during fashion, Long-term taking medicine, does not prolongedly heal with heating.Carry out here diagnosis and treatment after being introduced, check and find that the two lung marking of patient is normal, cough band blood, fever in the afternoon, flushed cheeks, the few tongue of red tongue, dry mouth and throat, thready and rapid pulse, belongs to lung-heat yin-deficiency type bronchitis.
Take the present embodiment gained bronchitis and merge asthma replenishing YIN and removing heat tablet, after taking two courses for the treatment of, patient coughs, and expectoration alleviates, and the amount of receiving increases, and spirit can.Continue to take a course for the treatment of, patient is without cough, and chest pain, the heart are tired to disappear.Patient's self-induction is fully recovered.Follow up a case by regular visits to so far without recurrence.
embodiment 5bronchitis merges asthma replenishing YIN and removing heat medicament, is prepared from, is weight portion (250g/ part): Pericarpium Citri Reticulatae 12 parts by following bulk drugs; Radix Peucedani 7.5 parts; Radix Raphani 10 parts; 12.5 parts, Radix Glycyrrhizae; Flos Rhoeo discolorae 7 parts; Semen Sinapis Albae 6.5 parts; Alcedo atthis bengalensis 10.5 parts; Folium Hyoscyami 7 parts; Fructus Tritici Levis 7.5 parts; Lignum Aquilariae Resinatum 11 parts; Fructus Momordicae 12.5 parts.
The preparation method that above-mentioned bronchitis merges asthma replenishing YIN and removing heat decoction is:
(1) Pericarpium Citri Reticulatae is cleaned, shredding, and then get humus flava usta and put stir-fry pine in pot, pour Pericarpium Citri Reticulatae silk into, frying to surface with moderate heat is coke yellow degree of being, take out, sieve removes soil, cools; Get clean Fructus Tritici Levis, put in pot, add with slow fire and propagandize hotly to brown color, taking-up cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 25 minutes, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries 3.5 hours, have fragrant peppery gas to surface in buff, take out, cool, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Alcedo atthis bengalensis is cleaned, and removes intestinal, stripping and slicing, for subsequent use;
(3) Alcedo atthis bengalensis after process in step (2) and Radix Raphani, Radix Peucedani, Radix Glycyrrhizae, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae are placed in medicinal cupping, the clear water adding 9 times amount soaks 2 hours, then add Pericarpium Citri Reticulatae and Fructus Tritici Levis that step (1) processed and the Semen Sinapis Albae that step (2) processes and Folium Hyoscyami, intense fire boils, then slow fire boiling 2 times, first time decocts 50 minutes, second time decocts 35 minutes, and period constantly adds clear water, keeps clear water not have medical material 5cm, filter, merge twice decocting liquid;
(4) gained decocting liquid is concentrated into 1/3 of original volume in 80 DEG C of heating, stops, cooling, sterilizing, fill, to obtain final product.
The instructions of taking of decoction of the present invention is: twice daily, each 200-300mL, 7 days courses for the treatment of.
test example 1embodiment 5 gained bronchitis merges the clinical practice of asthma replenishing YIN and removing heat decoction:
1, data and method
1.1 physical data
In May ,-2012 in October, 2009, screen 327 routine patients in 5 hospitals, wherein male 185 example, women 142 example, age 23-70 year, 43.5 ± 2.5 years old mean age.
1.2 selection standard
Patient all meets bronchitis and merges asthma, and with the symptom of fever due to yin deficiency.Get rid of and suffer from the disease such as hypertension or peptic ulcer, and do not use glucocorticoid or antibiotic at least two weeks.
1.3 Therapeutic Method
All patients are divided into two groups at random, experimental group and matched group, and experimental group takes embodiment 5 products obtained therefrom, and instructions of taking is: twice daily, each 200-300mL, 7 days courses for the treatment of.Matched group takes other medicine (as JIZHI TANGJIANG, breathing heavily the conventional medication such as Yiganning capsule, Gelomyrtol Forte of coughing).Observe three courses for the treatment of of treatment altogether.
1.4 efficacy assessment standard
Cure: take three courses for the treatment of of this product, pulmonary is dry, moist rales disappears, bronchus wheezing sound disappears, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: pulmonary is dry, moist rales disappears, and bronchus wheezing sound disappears, and malaise symptoms alleviates or partial disappearance, energy and muscle power strengthen; Effective: bronchus wheezing sound disappears, and malaise symptoms is eased.Invalid: symptom is unchanged or increase the weight of.
1.5 therapeutic outcome
Result is as shown in table 1.
Table 1: take embodiment 5 product 23-70 year patient treatment outcome
Therapeutic effect: cure 146 examples (81.1%), effective 23 examples (12.8%), effective 9 examples (5%), invalid 2 examples (1.1%), total effective rate 98.9%.Successful is better than matched group.
Scientific formulation of the present invention is reasonable, and wherein Radix Raphani cures mainly phlegm-heat cough, discomfort in the throat; Semen Sinapis Albae promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain, to phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain determined curative effect; Flos Rhoeo discolorae removing heat from the lung and dissipating phlegm, cures mainly lung-heat type cough; Alcedo atthis bengalensis is to year asthma Be very effective of a specified duration; Fructus Momordicae lung heat clearing intestine moistening; Lignum Aquilariae Resinatum sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI; Fructus Tritici Levis controls hectic fever due to YIN-deficiency consumptive fever, only spontaneous sweating; Folium Hyoscyami has analgesia, effect of spasmolytic.Full side's compatibility is precise and appropriate, and curative effect is obvious.All medicines also have the effect of replenishing YIN and removing heat while being used in relieving cough and asthma.Take three courses for the treatment of in experimental group, effective percentage can reach 98.9%, and matched group is only 78.9%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. bronchitis merges asthma replenishing YIN and removing heat medicament, it is characterized in that, is prepared from by following bulk drugs, be weight portion: Pericarpium Citri Reticulatae 9-15; Radix Peucedani 5-10; Radix Raphani 8-12; Radix Glycyrrhizae 10-15; Flos Rhoeo discolorae 5-9; Semen Sinapis Albae 4-9; Alcedo atthis bengalensis 8-13; Folium Hyoscyami 5-9; Fructus Tritici Levis 6-9; Lignum Aquilariae Resinatum 8-14; Fructus Momordicae 9-16.
2. bronchitis as claimed in claim 1 merges asthma replenishing YIN and removing heat medicament, it is characterized in that, is prepared from by following bulk drugs, be weight portion: Pericarpium Citri Reticulatae 11-13; Radix Peucedani 7-8; Radix Raphani 9-11; Radix Glycyrrhizae 12-13; Flos Rhoeo discolorae 6-8; Semen Sinapis Albae 5-8; Alcedo atthis bengalensis 10-11; Folium Hyoscyami 6-8; Fructus Tritici Levis 7-8; Lignum Aquilariae Resinatum 10-12; Fructus Momordicae 12-13.
3. bronchitis as claimed in claim 1 merges asthma replenishing YIN and removing heat medicament, it is characterized in that, is prepared from by following bulk drugs, be weight portion: Pericarpium Citri Reticulatae 12; Radix Peucedani 7.5; Radix Raphani 10; Radix Glycyrrhizae 12.5; Flos Rhoeo discolorae 7; Semen Sinapis Albae 6.5; Alcedo atthis bengalensis 10.5; Folium Hyoscyami 7; Fructus Tritici Levis 7.5; Lignum Aquilariae Resinatum 11; Fructus Momordicae 12.5.
4. the bronchitis as described in as arbitrary in claim 1-3 merges asthma replenishing YIN and removing heat medicament, and it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) Pericarpium Citri Reticulatae is cleaned, shredding, and then get humus flava usta and put stir-fry pine in pot, pour Pericarpium Citri Reticulatae silk into, frying to surface with moderate heat is coke yellow degree of being, take out, sieve removes soil, cools; Get clean Fructus Tritici Levis, put in pot, add with slow fire and propagandize hotly to brown color, taking-up cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 20-30 minute, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Alcedo atthis bengalensis is cleaned, and removes intestinal, stripping and slicing, for subsequent use;
(3) by the Alcedo atthis bengalensis after process in step (2) and Radix Raphani, Radix Peucedani, Radix Glycyrrhizae, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae are placed in medicinal cupping, the clear water adding 8-10 times amount soaks, then Pericarpium Citri Reticulatae and Fructus Tritici Levis that step (1) processed and the Semen Sinapis Albae that step (2) processes and Folium Hyoscyami is added, intense fire boils, then slow fire boiling 2 times, first time decocts 40-60 minute (preferably first time decocts 50 minutes), second time decocts 25-45 minute (preferably second time decocts 35 minutes), period constantly adds clear water, clear water is kept not have medical material 3-5cm, filter, merge twice decocting liquid,
(4) gained decocting liquid is concentrated into 1/3 of original volume in 80 DEG C of heating, stops, cooling, sterilizing, fill, to obtain final product.
5. the preparation method of decoction as claimed in claim 4, is characterized in that, dries 2-5 hour (dry 3-4 hour in preferred 120 DEG C of baking ovens, dry 3.5 hours in the 120 DEG C of baking ovens be more preferably) in step (2) in 120 DEG C of baking ovens.
6. the preparation method of decoction as claimed in claim 4, is characterized in that, in step (3), clear water soak time is 1-3 hour (preferred clear water soak time is 1.5-2.5 hour, and the clear water soak time be more preferably is 2 hours).
7. the bronchitis as described in as arbitrary in claim 1-3 merges asthma replenishing YIN and removing heat medicament, and it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) Pericarpium Citri Reticulatae is cleaned, shredding, and then get humus flava usta and put stir-fry pine in pot, pour Pericarpium Citri Reticulatae silk into, frying to surface with moderate heat is coke yellow degree of being, take out, sieve removes soil, cools, grinds to form powder; Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 20-30 minute, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use;
(2) Radix Peucedani section, puts in pot, and it is yellow for spending that slow fire fries extremely surface, and taking-up cools, and pulverizes; Front English white is mixed homogeneously with step (1) gained tangerine peel powder, Semen Sinapis Albae powder and Black Henbane, sieves, obtain mixing fine powders for subsequent use;
(3) Alcedo atthis bengalensis is cleaned, and removes intestinal, stripping and slicing, together be placed in medicinal cupping with Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, decoct with water 2 times, each 2-3 hour, collecting decoction filters, and filtrate is condensed into relative density 1.05-1.15(60 DEG C), obtain thick paste, be placed into room temperature, adding ethanol makes ethanol content reach 75%, places 12-20 hour (preferably placing 16 hours), filters, distilling under reduced pressure is extremely without alcohol taste, and vacuum drying gets dry extract;
(4) by broken for above-mentioned dried cream powder, then stir with step (2) gained mixing fine powders, with water pill, make pill, to obtain final product.
8. the preparation method of pill as claimed in claim 7, is characterized in that, crosses 40-80 mesh sieve (preferred cross 50-70 mesh sieve, mistake 60 mesh sieve be more preferably) in step (2).
9. the bronchitis as described in as arbitrary in claim 1-3 merges asthma replenishing YIN and removing heat medicament, and it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Pericarpium Citri Reticulatae salt adding, Sucus Zingberis, vinegar soak 15-35 minute, enter pot and steam to time savory, cease fire, stewing 10-20 hour, until color turn black after dry; Refined honey is added boiled water dilution, add Radix Peucedani sheet and mix thoroughly, braised through, be then placed in pot, slow fire is fried to time tack-free, takes out, cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 25-35 minute, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Semen Sinapis Albae powder and Black Henbane mixing, cross 40-60 mesh sieve (preferred mistake 50 mesh sieve), obtain mixing fine powders;
(3) Alcedo atthis bengalensis is cleaned, remove intestinal, stripping and slicing, together medicinal cupping is placed in Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, add the Pericarpium Citri Reticulatae and Radix Peucedani that processed in step (1) simultaneously, the clear water adding 10 times of weight in medicinal cupping decocts twice, first time decocts 1-2 hour (preferably first time decocts 1.5 hours), second time decocts 45-60 minute (preferably second time decocts 55 minutes), merge twice decoction liquor, decoction liquor drying under reduced pressure is obtained the extractum that density is about 1.25g/mL;
(4) in above-mentioned extractum, step (2) gained mixing fine powders is added; stirring makes mix homogeneously; then using 80% ethanol of 10% low-substituted hydroxypropyl cellulose as adhesive, with extract powder: Bidismutose: starch quality is placed in granulator than the ratio for 10:3:2 and stirs, and obtains granule.
10. the bronchitis as described in as arbitrary in claim 1-3 merges asthma replenishing YIN and removing heat medicament, and it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Pericarpium Citri Reticulatae salt adding, Sucus Zingberis, vinegar soak 15-35 minute, enter pot and steam to time savory, cease fire, stewing 10-20 hour (preferably stewing 15 hours), until color turn black after dry; Refined honey is added boiled water dilution, add Radix Peucedani sheet and mix thoroughly, braised through, be then placed in pot, slow fire is fried to time tack-free, takes out, cools;
(2) Semen Sinapis Albae is cleaned, and be placed in aqua methnae and soak 30 minutes, pull out, filtration is anhydrated, and is then placed in 120 DEG C of baking ovens and dries, and has fragrant peppery gas to surface in buff, takes out, cools, smash to pieces; Folium Hyoscyami is dried, and grinds into powder for subsequent use; Semen Sinapis Albae powder and Black Henbane mixing, cross 60 mesh sieves, obtain mixing fine powders;
(3) Alcedo atthis bengalensis is cleaned, remove intestinal, stripping and slicing, together be placed in medicinal cupping with Radix Raphani, Radix Glycyrrhizae, Fructus Tritici Levis, Flos Rhoeo discolorae, Lignum Aquilariae Resinatum and Fructus Momordicae, add the Pericarpium Citri Reticulatae and Radix Peucedani that processed in step (1) simultaneously, the clear water adding 10 times of weight in medicinal cupping decocts twice, first time decocts 1-2 hour, second time decocts 45-60 minute, merges twice decoction liquor, decoction liquor drying under reduced pressure is obtained the extractum that density is about 1.25g/mL;
(4) by above-mentioned extractum in 80 DEG C of oven dry, be ground into powder, with gained mixing fine powders in step (2), stir, mix homogeneously, add corn starch, dextrin and Icing Sugar (extract powder: corn starch: dextrin: the mass ratio of Icing Sugar is 10:7:1:1) and make tablet according to the processing method of tablet, to obtain final product.
CN201410765554.0A 2014-12-15 2014-12-15 Medicine capable of nourishing yin to clear away heat and treating bronchitis and asthma, and preparation method of medicine Pending CN104398901A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1136956A (en) * 1996-03-03 1996-12-04 李英新 Compound pill of trachitis
CN103920106A (en) * 2014-01-17 2014-07-16 赵庆军 Traditional Chinese medicinal composition for treating bronchitis and bronchial asthma
CN103977314A (en) * 2014-05-20 2014-08-13 李果 Medicinal composition for treating respiratory diseases as well as preparation method and application of medicinal composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1136956A (en) * 1996-03-03 1996-12-04 李英新 Compound pill of trachitis
CN103920106A (en) * 2014-01-17 2014-07-16 赵庆军 Traditional Chinese medicinal composition for treating bronchitis and bronchial asthma
CN103977314A (en) * 2014-05-20 2014-08-13 李果 Medicinal composition for treating respiratory diseases as well as preparation method and application of medicinal composition

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