CN104398773A - Medicine for eliminating damages of tannins to liver, and its application in putrid skin disease treatment - Google Patents

Medicine for eliminating damages of tannins to liver, and its application in putrid skin disease treatment Download PDF

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Publication number
CN104398773A
CN104398773A CN201410616383.5A CN201410616383A CN104398773A CN 104398773 A CN104398773 A CN 104398773A CN 201410616383 A CN201410616383 A CN 201410616383A CN 104398773 A CN104398773 A CN 104398773A
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parts
radix
medicine
herba
fructus
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占水秀
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medicine for eliminating damages of tannins to liver. The medicine comprises Chinese gall, Medicine Terminalia Fruit, garlic, licorice root, honeysuckle flower, wild chrysanthemum flower, rheum officinale, Cortex Fraxini, Herba Houttuyniae, hawthorn fruit, Rhizoma Coptidis, Radix Scutellariae, Amur Corktree Bark, isatis root, Rhizoma Alismatis, Chinese angelica, dried orange peel, Radix Asparagi, Weeping Forsythia, Artemisia carvifolia, dark plum, pangolin, fortune paulownia flower, Cayratia japonica, Solanum lyratum Thunb, Ligusticum wallichii and Panax Notoginseng. The medicine for eliminating damages of tannins to liver can be used for treating turtle putrid skin disease, and Chinese gall and Medicine Terminalia Fruit are decocted in an ethanol solution to reduce the extraction rate of tannins. The above traditional Chinese medicinal prescription can be used for the putrid skin disease, and has a substantial curative effect and no side effects. Garlic and other heavy taste materials are used, and are reasonably combined with other medicines in order to realize taste removal and curative effect remaining purposes. Iron trichloride reacts with hydrolysable tannins to generate precipitates. The medicine can be combined with western antibiotics, and sodium bicarbonate and other components can be added to further improve the curative effect.

Description

Eliminate medicine that tannin injure liver and treating the application in skin fester disease
Technical field
The present invention relates to a kind of medicine eliminated tannin and liver is injured, the invention still further relates to its application in skin fester disease, the medicine for the treatment of skin fester disease in addition.
Background technology
Galla Chinensis, Fructus Chebulae etc. may be used for treating rotten-skin diseases of trionyx sinensis, but there is very major part to be hydrolysis-type tannin in main chemical compositions tannin wherein, the liver of hydrolysis-type tannin to Trionyx sinensis Wiegmann has very strong, should not take orally, described in " being cautious use of Chinese medicine Galla Chinensis control trionyx disease ".Although external application injury is few, in actual production, for eliminating skin fester disease as early as possible, prevent herd infection, dosage is comparatively large, and Trionyx sinensis Wiegmann liver is fragile simultaneously, immunity is low, and external application tannin is still very important to Trionyx sinensis Wiegmann injury.Be necessary to eliminate tannin to the injury of liver." controlling experiment of greenhouse Trionyx sinensis Wiegmann beancurd sheet, shothole disease complication " and " pathogen separation of Trionyx sinensis (Wiegmann) beancurd sheet, furuncle, complication pathogenic bacterium and Susceptibility Test Analysis " discloses the fundamental symptoms, etiology and pathology etc. of skin fester disease, and it can treat the foundation of skin fester disease as prior art.200910227132.7 relate to a kind of medicine for the treatment of Trionyx sinensis Wiegmann white point and beancurd sheet, comprise oxytetracycline, ciprofloxacin etc.Long-time use antibiotic easily makes Trionyx sinensis Wiegmann produce resistance.201010182385.X relates to a kind of method for the treatment of rotten-skin diseases of trionyx sinensis, and it carries out successively according to the following steps: taken out by the Trionyx sinensis Wiegmann suffering from skin fester disease, carry out lumbar injection with penicillin to it, and the dosage of injection is by per kilogram of body weight 15-20 ten thousand unit.Injectable drug uses inconvenience, and reasonable scheme is sprinkled in pond by medicine, and medicine does not affect the Trionyx sinensis Wiegmann existence in pond simultaneously.201110262972.4 formula relating to a kind of prevention and therapy Trionyx sinensis Wiegmann skin fester disease, each to Rhizoma Coptidis, Radix Glycyrrhizae, Flos Lonicerae and Rhubarb 2g mixing is added in 1kg Trionyx sinensis Wiegmann feedstuff by it.The offer limited effectiveness of single medicine, as " trionyx disease diagnosis and comprehensive diseases prevention " (Zhang Jian) illustrates that the DeGrain of single medicine preferably concentrates the advantage of multi-medicament, rapid and lasting treatment rotten-skin diseases of trionyx sinensis.But prior art does not disclose the therapeutic scheme of some concrete compound preparations.
Summary of the invention
The present invention proposes a kind of medicine eliminated tannin and injure liver, which reduces tannin, reduces the injury to Trionyx sinensis Wiegmann liver.
For solving the problems of the technologies described above, the present invention constructs following technical proposals:
A kind of medicine eliminated tannin and liver is injured, it is characterized in that, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 30 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Chuanxiong 9 parts, Radix Notoginseng 9 parts.
A kind of medicine eliminated tannin and liver is injured, it is characterized in that, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 20 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 18 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Chuanxiong 9 parts, Radix Notoginseng 9 parts.
A kind of medicine eliminated tannin and liver is injured, it is characterized in that, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 30 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Rhizoma Chuanxiong 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Radix Notoginseng 9 parts.
Reasonable compatibility Chinese medicine, the content of Galla Chinensis and Fructus Chebulae can ensure good therapeutic effect, reduces the injury to liver simultaneously.Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Radix Notoginseng etc. can play the effect of hepatoprotective.
Eliminate the medicine that tannin injures liver, it is treating the application in rotten-skin diseases of trionyx sinensis.
Be used for the treatment of a prescription for rotten-skin diseases of trionyx sinensis, it is the medicine that aforementioned elimination tannin injures liver.
Be used for the treatment of a preparation method for the prescription of rotten-skin diseases of trionyx sinensis, it is characterized in that, comprise the following steps:
Mixing Galla Chinensis, Fructus Chebulae, the mass fraction adding 5 times of quality is 80% alcoholic solution, heats 30min, filter to get filtrate at 40 DEG C;
Extracting liquorice, Cortex Fraxini, Herba Houttuyniae, Radix Isatidis, Rhizoma Alismatis, Radix Angelicae Sinensis, Radix Asparagi, Fructus Forsythiae, Herba Artemisiae Annuae, Fructus Mume, Squama Manis, Flos Paulowniae, Herba Cayatiae Japonicae, Herba Solani Lyrati, Rhizoma Chuanxiong, Radix Notoginseng, pulverize, add the water of twice quality, be warming up to 50 DEG C, multistage microwave amplifier under power 400W, frequency 2450MHZ, extraction time 20min, filters, obtains filtrate;
Pericarpium Citri Reticulatae and Fructus Crataegi are pulverized, add the water of 2 times of quality, decoct 2h, extracting juice, Bulbus Allii is pulverized, and adds in medicine juice, obtains Bulbus Allii mixed liquor;
By Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri mixing, in 80 DEG C of water-baths, be the alcoholic solution reflux, extract, filtrate 2 times of 70% by the volume fraction of 10 times amount, each 2h, merging extracted twice liquid;
Mix each filtrate, Bulbus Allii mixed liquor and extracting solution, slow fire boiling, until yield rate is 1g/ml, namely make described prescription.
A kind of spray agent being used for the treatment of rotten-skin diseases of trionyx sinensis, it is characterized in that, according to the mass fraction, consist of the following composition: Chinese herbal medicine 100 parts, sodium bicarbonate 8 ~ 10 parts, acetic acid 8 ~ 10 parts, phosphoric acid 8 ~ 10 parts, norfloxacin 1 ~ 5 part, vitamin C 4 parts, oxytetracycline 1 ~ 5 part, ferric chloride 1 ~ 3 part.
Be used for the treatment of a preparation method for the spray agent of rotten-skin diseases of trionyx sinensis, it is characterized in that, comprise the following steps:
Prepare prescription, after adding sodium bicarbonate, norfloxacin, ferric chloride, be warming up to 60 DEG C, keep 2min, near room temperature, add acetic acid, phosphoric acid, vitamin C and oxytetracycline, after mix homogeneously, namely make described spray agent.
Eliminate tannin to may be used for treating rotten-skin diseases of trionyx sinensis to the medicine that liver injures, Galla Chinensis, Fructus Chebulae adopt alcoholic solution to decoct, and reduce tannin extraction ratio.Prescription of the present invention may be used for treating skin fester disease, evident in efficacy, has no side effect.Although employ the highly seasoned materials such as Bulbus Allii, reasonable compatibility other drug, reaches the object de-tasting and do not go curative effect.Ferric chloride can generate with hydrolysis-type tannin and precipitate.Especially itself and western medicine antibiotics are share, add the compositions such as sodium bicarbonate simultaneously, curative effect can be improved further.
Detailed description of the invention
Describe in detail the present invention below, unaccomplished matter is see the routine techniques knowledge of pharmacopeia 2010 or aquaculture field.
Embodiment one
Eliminate the medicine that tannin injures liver, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 30 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Chuanxiong 9 parts, Radix Notoginseng 9 parts.
This medicine is used for the treatment of rotten-skin diseases of trionyx sinensis, and preparation method is as follows:
Mixing Galla Chinensis, Fructus Chebulae, the mass fraction adding 5 times of quality is 80% alcoholic solution, heats 30min, filter to get filtrate at 40 DEG C; Extracting liquorice, Cortex Fraxini, Herba Houttuyniae, Radix Isatidis, Rhizoma Alismatis, Radix Angelicae Sinensis, Radix Asparagi, Fructus Forsythiae, Herba Artemisiae Annuae, Fructus Mume, Squama Manis, Flos Paulowniae, Herba Cayatiae Japonicae, Herba Solani Lyrati, Rhizoma Chuanxiong, Radix Notoginseng, pulverize, add the water of twice quality, be warming up to 50 DEG C, multistage microwave amplifier under power 400W, frequency 2450MHZ, extraction time 20min, filters, obtains filtrate; Pericarpium Citri Reticulatae and Fructus Crataegi are pulverized, add the water of 2 times of quality, 2h at a simmer, extracting juice, Bulbus Allii is pulverized, and adds in medicine juice, obtains Bulbus Allii mixed liquor; By Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri mixing, in 80 DEG C of water-baths, be the alcoholic solution reflux, extract, filtrate 2 times of 70% by the volume fraction of 10 times amount, each 2h, merging extracted twice liquid; Mix each filtrate, Bulbus Allii mixed liquor and extracting solution, slow fire boiling, until yield rate is 1g/ml, namely make described prescription.
Yield rate 1g/ml refers to the fried 1ml prescription (water preparation) of 1g raw material.Slow fire adopts medical science routine to understand, and refers to and refers to that fire when decocting medicinal herbs is little and slow, generally must not in 1min boiled 1L water.
Embodiment two
Eliminate the medicine that tannin injures liver, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 30 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Rhizoma Chuanxiong 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Radix Notoginseng 9 parts.
Embodiment three
Eliminate the medicine that tannin injures liver, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 20 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 18 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Chuanxiong 9 parts, Radix Notoginseng 9 parts.
Embodiment four
Be used for the treatment of the spray agent of rotten-skin diseases of trionyx sinensis, according to the mass fraction, consist of the following composition: Chinese herbal medicine 100 parts, sodium bicarbonate 8 ~ 10 parts, acetic acid 8 ~ 10 parts, phosphoric acid 8 ~ 10 parts, norfloxacin 1 ~ 5 part, vitamin C 4 parts, oxytetracycline 1 ~ 5 part, ferric chloride 1 ~ 3 part.
The preparation method of spray agent, comprises the following steps: prepare prescription, after adding sodium bicarbonate, norfloxacin, ferric chloride, be warming up to 60 DEG C, keep 2min, near room temperature, add acetic acid, phosphoric acid, vitamin C and oxytetracycline, after mix homogeneously, namely make described spray agent.
Experiment one
Test method:
1, plant is divided into the test tank of equal-volume (50cm × 50cm × 40cm), is labeled as 30 groups according to Chinese medicine ingredients.Often group adopts same water source (tap water after lake water or aeration), without being communicated with between group.Water temperature 20 to 28 DEG C, pH=6-8.
2, get Trionyx sinensis Wiegmann 600 tail at random in ill plant, be placed in test tank by 20 tails/component.Every day throws in bait by the 3-4% of Trionyx sinensis Wiegmann body weight, and 8: 00,13: 00,16: 00 respectively throw something and feed once.Every day puts half water from bottom, injects water source to 60 ± 10cm simultaneously.
3, daily check, takes out dead or is about to dead Trionyx sinensis Wiegmann, in order to avoid cross infection, affecting result of the test.
Experimental Comparison:
Different Chinese herbal medicine decoctions is thrown according to group name.According to reality survival number, delimit the effect of the monomer in treating skin fester disease of each Chinese medicine ingredients as following table: it is better that "+" represents curative effect more.
Through test, the present invention chooses some drugs, simultaneously proportion optimizing.Bulbus Allii plays therapeutic effect, and Flos Chrysanthemi Indici, Flos Lonicerae, Fructus Crataegi, Pericarpium Citri Reticulatae etc. de-taste.In addition, Radix Glycyrrhizae, Radix Notoginseng and Rhizoma Chuanxiong can reduce Trionyx sinensis Wiegmann hepatic lesions, improve hepatocyte and repair speed.
Test two
Test material and environment: test Trionyx sinensis Wiegmann derives from breeding soft-shell turtle field, Nanchang City, Jiangxi Province, and the gross area is about 980m 2, total Trionyx sinensis Wiegmann number about 30000, there is skin fester disease in this plant, Trionyx sinensis Wiegmann is sporadicly dead.Trionyx sinensis Wiegmann test site is located at Duchang County, Jiangxi Province, is less than 10km apart from poyang lake water, and environment is suitable for Trionyx sinensis Wiegmann existence.Between test period February to April, cultivation 30d.
Test method:
1, plant is divided into six groups of test tanks of equal-volume (300cm × 300cm × 80cm), be labeled as A experimental group, B experimental group, C experimental group, D test group, A matched group, B matched group (matched group is common reference group, mentions in other experiments simultaneously) respectively.Often group adopts same water source (tap water after lake water or aeration), without being communicated with between group.Water temperature 20 to 28 DEG C, pH=6-8.
2, get Trionyx sinensis Wiegmann 600 tail at random in ill plant, be placed in six groups of test tanks by 100 tails/component.Every day throws in bait by the 3-4% of Trionyx sinensis Wiegmann body weight, and 8: 00,13: 00,16: 00 respectively throw something and feed once.Every day puts half water from bottom, injects water source to 60 ± 10cm simultaneously.
3, daily check, takes out dead or is about to dead Trionyx sinensis Wiegmann, in order to avoid cross infection, affecting result of the test.
Experimental Comparison:
In A experimental group, B experimental group, C experimental group, spray the prescription of embodiment one to three while throwing in bait respectively, dose concentration 50ml/m 3.Experimental group D throws in the spray agent of embodiment four, dose concentration 50ml/m 3.Control group A throws in antibiotic (oxytetracycline) 15g/m 3.Matched group B does not throw in medicine.
Along with the passing of culturing time, in test tank, dead Trionyx sinensis Wiegmann mantissa is as following table:
Liver injury causes dead, generally shows 20 to 5.As can be seen from experimental result, experimental group later death quantity is few, and tend to be steady (sporadic deaths is inevitable), so tannin reduces liver injury.Skin fester disease has infectiousness, although timing is changed water and taken out by dead Trionyx sinensis Wiegmann, antibacterial can remain, breed in water, and morbidity is not easily discovered early stage.Along with the prolongation of time, only change water, do not carry out Drug therapy, the dead quantity of Trionyx sinensis Wiegmann is increasing, the whole association culturing area of crisis.Be used alone antibiotic, early stage is good to bacteriostatic ability, but the later stage is weak.Medicine of the present invention can play certain inhibition early stage, and the later stage can play therapeutical effect, eliminates the threat of skin fester disease completely.If a small amount of Western medicine of compatibility simultaneously, curative effect is more remarkable.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (8)

1. the medicine eliminated tannin and liver is injured, it is characterized in that, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 30 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Chuanxiong 9 parts, Radix Notoginseng 9 parts.
2. the medicine eliminated tannin and liver is injured, it is characterized in that, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 20 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 18 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Chuanxiong 9 parts, Radix Notoginseng 9 parts.
3. the medicine eliminated tannin and liver is injured, it is characterized in that, according to the mass fraction, consist of the following composition: Galla Chinensis 30 parts, Fructus Chebulae 30 parts, 30 parts, Bulbus Allii, 30 parts, Radix Glycyrrhizae, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Radix Et Rhizoma Rhei 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Fructus Crataegi 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Rhizoma Chuanxiong 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Radix Notoginseng 9 parts.
4. eliminate the medicine that tannin injures liver, it is characterized in that being made up of the medicine described in claims 1 to 3, it is treating the application in rotten-skin diseases of trionyx sinensis.
5. be used for the treatment of a prescription for rotten-skin diseases of trionyx sinensis, it is characterized in that, the medicine that the elimination tannin for claims 1 to 3 injures liver.
6. be used for the treatment of a preparation method for the prescription of rotten-skin diseases of trionyx sinensis, it is characterized in that, comprise the following steps:
Mixing Galla Chinensis, Fructus Chebulae, the mass fraction adding 5 times of quality is 80% alcoholic solution, heats 30min, filter to get filtrate at 40 DEG C;
Extracting liquorice, Cortex Fraxini, Herba Houttuyniae, Radix Isatidis, Rhizoma Alismatis, Radix Angelicae Sinensis, Radix Asparagi, Fructus Forsythiae, Herba Artemisiae Annuae, Fructus Mume, Squama Manis, Flos Paulowniae, Herba Cayatiae Japonicae, Herba Solani Lyrati, Rhizoma Chuanxiong, Radix Notoginseng, pulverize, add the water of twice quality, be warming up to 50 DEG C, multistage microwave amplifier under power 400W, frequency 2450MHZ, extraction time 20min, filters, obtains filtrate;
Pericarpium Citri Reticulatae and Fructus Crataegi are pulverized, add the water of 2 times of quality, decoct 2h, extracting juice, Bulbus Allii is pulverized, and adds in medicine juice, obtains Bulbus Allii mixed liquor;
By Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri mixing, in 80 DEG C of water-baths, be the alcoholic solution reflux, extract, filtrate 2 times of 70% by the volume fraction of 10 times amount, each 2h, merging extracted twice liquid;
Mix each filtrate, Bulbus Allii mixed liquor and extracting solution, slow fire boiling, until yield rate is 1g/ml, namely make described prescription.
7. one kind is used for the treatment of the spray agent of rotten-skin diseases of trionyx sinensis, it is characterized in that, according to the mass fraction, consist of the following composition: Chinese herbal medicine 100 parts, sodium bicarbonate 8 ~ 10 parts, acetic acid 8 ~ 10 parts, phosphoric acid 8 ~ 10 parts, norfloxacin 1 ~ 5 part, vitamin C 4 parts, oxytetracycline 1 ~ 5 part, ferric chloride 1 ~ 3 part.
8. be used for the treatment of a preparation method for the spray agent of rotten-skin diseases of trionyx sinensis, it is characterized in that, comprise the following steps:
Prepare prescription, after adding sodium bicarbonate, norfloxacin, ferric chloride, be warming up to 60 DEG C, keep 2min, near room temperature, add acetic acid, phosphoric acid, vitamin C and oxytetracycline, after mix homogeneously, namely make described spray agent.
CN201410616383.5A 2014-11-06 2014-11-06 Medicine for eliminating damages of tannins to liver, and its application in putrid skin disease treatment Pending CN104398773A (en)

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Application publication date: 20150311