CN104383350B - A kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth and preparation method thereof - Google Patents
A kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth and preparation method thereof, it is joined using good fortune, rattletop, radix bupleuri, green tea, honeysuckle, lophatherum gracile, the dried rhizome of rehmannia, chrysanthemum, peppermint and radix glycyrrhizae is prescription medicinal material, after medicinal material extract, concentration drying will be mixed with starch, microcrystalline cellulose, particle is mixed and made into citric acid, Macrogol 6000, lactose again, sodium acid carbonate compression molding is eventually adding.The characteristics of multiple target effects such as gained Chinese medicine compound prescription effervescent tablet for rinsing mouth is dried using medicinal material wind-dispelling heat-dissipating, inducing diaphoresis, anti-inflammation, reach evacuation oral cavity wind-heat, let out damp and hot more ulcer pain, fresh breath, the purpose for safeguarding oral health, and its be convenient for carrying, it is easy to use, with wide market potential.
Description
Technical field
Present invention relates particularly to a kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth and preparation method thereof.
Background technology
With the continuous improvement of living standards of the people, the continuous improvement of quality of life, animal food is in menu routine
Ratio be continuously increased, solar eclipse greasy and surfeit flavour；Busy life and work rhythm, bring anxiety and physical and psychological pressure plus
Greatly, to give birth in yang pathogens, taste volt fire, flaring up of heart fire, fire excess from yin deficiency, water retention due to hypofunction of the spleen, spleen kidney deficiency are weak etc., so as to cause dispute
The illness such as ulcer, swelling and aching of gum, periodontitis, acute toothache, bitter taste dry, halitosis peculiar smell, catarrh.Though these are not ailing tight
Weight, but the influence for life, mood and work is very big, as the saying goes " toothache is not disease, and pain, which is got up, has wanted life ".The traditional Chinese medical science thinks
The main method of solution is damp and hot, clearing heat and cooling blood, the beneficial Yin and promoting production of body liquid for evacuating spleen soil, draws hot descending, reaches removing toxic substances, analgesic, detumescence
Effect.
It is understood that how there's no such thing as a totally safe medicine, quickly eliminate ailing and do not increase body carrying external source medication amount, be beneficial to
Physical and mental health, focus surface direct drug injection is undoubtedly an effectively and rapidly channel, and gargle is a good medication choosing
Select mode.Market gargle style, species are on the increase in recent years, are broadly divided into health and the major class of therapeutic type two.Health
Gargle is mainly to maintain oral cleaning, prevention mouth disease, and its main component is oral cleansing lotion；Therapeutic type gargle is pin
To some common diseases of oral cavity, some complementary therapeutic actions can be played, but wherein occupied with bactericide, essence and alcoholic content
It is many, a variety of side effects such as change, mucous membrane of mouth and taste bud damage, tooth and the mucous membrane discoloration of oral microorganism flora are easily caused,
So market in urgent need has the rinse product of natural green drug ingedient, few side effects.The natural traditional Chinese medicine compound of Mutiple Targets is gargled
Liquid can be very good to meet this market demand, and the Mutiple Targets such as it dries using Chinese medicine wind-dispelling heat-dissipating, inducing diaphoresis, anti-inflammation are made
With the characteristics of, release ailing, easily and effectively, but such gargle is also rare in the market.Present invention application traditional Chinese medical science pharmacology
By, in selection medication practice for oral disease have the good fortune ginseng of significant curative effect, rattletop, radix bupleuri, green tea, honeysuckle, lophatherum gracile,
This 10 sections of medicinal materials of the dried rhizome of rehmannia, chrysanthemum, peppermint, radix glycyrrhizae, with the meridian distribution of property and flavor of different medicinal materials, integrate for common mouth disease and transport
Prescription is carried out with the property of medicine, to reach the purpose of Mutiple Targets prevention, health care, treatment.Again because in the market gargle more than with liquid
Based on dress, big bottle liquid is carried inconvenience more, and the present invention uses preparation technique there is provided a kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth,
Make it easy to carry, collect and use, easily and effectively, with wide market potential.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth and preparation method thereof, it can evacuate oral cavity wind
Heat, fresh breath, safeguard oral health, and be convenient for carrying, it is easy to use, with wide market potential.
To achieve the above object, the present invention is adopted the following technical scheme that：
A kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth, its prescription medicinal material be good fortune ginseng, rattletop, radix bupleuri, green tea, honeysuckle, lophatherum gracile,
The dried rhizome of rehmannia, chrysanthemum, peppermint and radix glycyrrhizae.
By weight, the consumption of each medicinal material is：Good fortune joins 12 parts, 8 parts of rattletop, 8 parts of radix bupleuri, 11 parts of green tea, honeysuckle 11
Part, 9 parts of lophatherum gracile, 12 parts of the dried rhizome of rehmannia, 12 parts of chrysanthemum, 7 parts of peppermint, 10 parts of radix glycyrrhizae.
The preparation method of the Chinese medicine compound prescription effervescent tablet for rinsing mouth comprises the following steps：
1）Good fortune is joined, rattletop, radix bupleuri, green tea, honeysuckle, lophatherum gracile, the dried rhizome of rehmannia, chrysanthemum, peppermint and radix glycyrrhizae are chopped into respectively
Length 1-2 cm, according to solid-liquid ratio 1 after mixing:10, which add water-bath at the alcohol that mass fraction is 75%, 60 DEG C, extracts 3 times, merges
3 filtrates, concentration, to the 1/5-1/6 that medicinal extract volume is former filtrate volume；
2）By step 1）Gained medicinal extract and starch, microcrystalline cellulose by volume 1:1.5:After 0.7 mixing, 15 are dried in 60 DEG C
H, is crushed after cooling, crosses 30-40 mesh sieves；
3）By step 2）Gained mixed powder is mixed evenly to prepare particle with citric acid, Macrogol 6000, lactose；
4）By step 3）Gained particle is mixed with sodium acid carbonate, in 20-25 DEG C of temperature, humidity 30%-35% condition lower sheetings,
Aluminum-plastic packaged finished product.
Citric acid used, sodium acid carbonate are crushed respectively, cross 20-30 mesh sieves；Macrogol 6000 used is crushed, and crosses 160 mesh
Sieve.
Weight percent sum is 85-89% containing mixed powder, citric acid 1.1-1.6% in 100% meter, gained effervescent tablet, is gathered
Ethylene glycol 6000 3-5%, lactose 5-8%, sodium acid carbonate 1.4-1.9%.
Good fortune is joined（Angelicamorii Hayata）Umbelliferae angelica, pungent, micro-sweet, hardship；It is warm-natured, with middle benefit gas QI invigorating
The effect of, cure mainly insufficiency of the spleen.Acute toothache is treated, decoct soup, which is gargled, to be stood more.
Honeysuckle is sweet, cold in nature, with clearing heat and detoxicating effect, its fragrance thoroughly up to again can eliminating evil, can dispelling wind-heat, also
Kind removing summer-heat blood poison.
Radix bupleuri bitter, pungent, cold nature, Return liver, gallbladder channel, with soothing liver-gallbladder, thin gas solution is strongly fragrant, dissipate effect of fire.
Rattletop is sweet, pungent, cold nature, return lung, spleen, large intestine, stomach, with yang invigorating, deliver promoting eruption, it is clearing heat and detoxicating it
Effect, can detoxify pain, and happen suddenly pyogenic infections, and stomach energy toothache, dispute sore, noma swells and ache.Larynx numbness decoct soup, heat gargles pharynx.
Lophatherum gracile is sweet, light, cold in nature；The thoughts of returning home, lung, stomach, bladder warp, can clear away heart-fire, diuresis, agitation of dispelling, for swelling and aching of gum,
Stomatitis etc. has good curative effect.
The dried rhizome of rehmannia is sweet, cold in nature, the thoughts of returning home, liver and kidney channel.The effect of with clearing heat and cooling blood, beneficial Yin and promoting production of body liquid.The blood-head of cool internal heat,
The damp and hot of spleen soil is rushed down, only the nosebleed heat in nose, except the dysphoria with smothery sensation of five hearts.
Chrysanthemum sweet-bitter flavor, cold nature, main scattered wind is clearing heat and detoxicating.
Peppermint is pungent, cool in nature, enters lung channel, Liver Channel.The effect of with dispelling wind and heat from the body, head clearing, cure mainly anemopyretic cold, head
Bitterly, abscess of throat.
Radix glycyrrhizae is sweet, mild-natured, return 12 warps.There are removing toxic substances, eliminating the phlegm, analgesic, spasmolysis, the effect of invigorating the spleen and benefiting qi cures mainly throat
Swell and ache, pain subcutaneous ulcer sore.
The Tea Polyphenols that green tea contains has stronger killing action to the pathogenic bacteria in oral cavity, and catechin has antibacterial, deodorization
Effect, can suppress the bacterial reproduction in oral cavity, remove the foreign odor in oral cavity.
Therefore, scientific composition of the present invention, is joined, radix glycyrrhizae is invigorated the spleen and benefited qi with good fortune, and the dried rhizome of rehmannia lets out the damp and hot of spleen, chrysanthemum, honeysuckle, bavin
Recklessly, peppermint and rattletop dispelling wind and heat from the body, coordinate radix glycyrrhizae clearing heat and cooling blood, removing summer-heat blood poison, beneficial Yin and promoting production of body liquid, and lophatherum gracile clears away heart-fire diuresis, ignites
It is descending, green tea antibacterial and deodouring, obtained Chinese medicine compound prescription effervescent tablet for rinsing mouth is dried using each medicinal material wind-dispelling heat-dissipating, inducing diaphoresis, antibacterial
The action character of the Mutiple Targets such as anti-inflammatory, reaches evacuation oral cavity wind-heat, lets out damp and hot more ulcer pain, fresh breath, safeguards oral health
Effect, and be convenient for carrying, it is easy to use, with wide market potential.
Embodiment
In order that content of the present invention easily facilitates understanding, with reference to embodiment to of the present invention
Technical scheme is described further, but the present invention is not limited only to this.
Embodiment 1
A kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth, its preparation method comprises the following steps：
1）Good fortune is joined into 1.2 kg, the kg of rattletop 0.8, the kg of radix bupleuri 0.8, the kg of green tea 1.1, the kg of honeysuckle 1.1, lophatherum gracile
0.9 kg, the kg of the dried rhizome of rehmannia 1.2, the kg of chrysanthemum 1.2, the kg of peppermint 0.7, the kg of radix glycyrrhizae 1.0 are chopped into the cm of length 1, pressed after mixing respectively
Take care of liquor ratio 1:10, which add water-bath at the alcohol that mass fraction is 75%, 60 DEG C, extracts 3 times, merges 3 filtrates, concentration, to medicinal extract
Volume is the 1/5 of former filtrate volume；
2）By step 1）Gained medicinal extract and starch, microcrystalline cellulose by volume 1:1.5:After 0.7 mixing, 15 are dried in 60 DEG C
H, is crushed after cooling, crosses 30 mesh sieves；
3）Citric acid, sodium acid carbonate are crushed respectively, 20 mesh sieves are crossed；Macrogol 6000 is crushed, and crosses 160 mesh sieves
4）By step 2）Gained mixed powder is mixed with the g of citric acid 565, the kg of Macrogol 6000 1.5, the kg of lactose 3.0
After particle is made；
5）By step 4）Gained particle is mixed with the g of sodium acid carbonate 565, in 20 DEG C of temperature, the condition lower sheeting of humidity 30%, aluminium
Modeling packaging finished product.
Embodiment 2
A kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth, its preparation method comprises the following steps：
1）Good fortune is joined into 1.2 kg, the kg of rattletop 0.8, the kg of radix bupleuri 0.8, the kg of green tea 1.1, the kg of honeysuckle 1.1, lophatherum gracile
0.9 kg, the kg of the dried rhizome of rehmannia 1.2, the kg of chrysanthemum 1.2, the kg of peppermint 0.7, the kg of radix glycyrrhizae 1.0 is chopped into the cm of length 1.5 respectively, after mixing
According to solid-liquid ratio 1:10 add the alcohol that mass fractions are 75%, and water-bath is extracted 3 times at 60 DEG C, merge 3 filtrates, concentration, to soaking
Paste volume is the 1/6 of former filtrate volume；
2）By step 1）Gained medicinal extract and starch, microcrystalline cellulose by volume 1:1.5:After 0.7 mixing, 15 are dried in 60 DEG C
H, is crushed after cooling, crosses 30 mesh sieves；
3）Citric acid, sodium acid carbonate are crushed respectively, 30 mesh sieves are crossed；Macrogol 6000 is crushed, and crosses 160 mesh sieves
4）By step 2）Gained mixed powder is mixed with the g of citric acid 419, the kg of Macrogol 6000 1.9, the kg of lactose 3.0
After particle is made；
5）By step 4）Gained particle is mixed with the g of sodium acid carbonate 724, in 22 DEG C of temperature, the condition lower sheeting of humidity 34%, aluminium
Modeling packaging finished product.
Embodiment 3
A kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth, its preparation method comprises the following steps：
1）Good fortune is joined into 1.2 kg, the kg of rattletop 0.8, the kg of radix bupleuri 0.8, the kg of green tea 1.1, the kg of honeysuckle 1.1, lophatherum gracile
0.9 kg, the kg of the dried rhizome of rehmannia 1.2, the kg of chrysanthemum 1.2, the kg of peppermint 0.7, the kg of radix glycyrrhizae 1.0 are chopped into the cm of length 2, pressed after mixing respectively
Take care of liquor ratio 1:10, which add water-bath at the alcohol that mass fraction is 75%, 60 DEG C, extracts 3 times, merges 3 filtrates, concentration, to medicinal extract
Volume is the 1/6 of former filtrate volume；
2）By step 1）Gained medicinal extract and starch, microcrystalline cellulose by volume 1:1.5:After 0.7 mixing, 15 are dried in 60 DEG C
H, is crushed after cooling, crosses 40 mesh sieves；
3）Citric acid, sodium acid carbonate are crushed respectively, 30 mesh sieves are crossed；Macrogol 6000 is crushed, and crosses 160 mesh sieves
4）By step 2）Gained mixed powder is mixed with the g of citric acid 575, the kg of Macrogol 6000 1.1, the kg of lactose 1.8
After particle is made；
5）By step 4）Gained particle is mixed with the g of sodium acid carbonate 503, in 25 DEG C of temperature, the condition lower sheeting of humidity 35%, aluminium
Modeling packaging finished product.
Randomly choose out-patient of the tens place with oral diseases such as the repeated ulcer in serious oral cavity, gingivitis, implications
Tried out.In use, by obtained Chinese medicine compound prescription effervescent tablet for rinsing mouth take it is a piece of be put into water, 3 ~ 5 min are become as one glass
The all good gargle of taste, effect.After being tried out through tens place patient, feel that anti-inflammatory, radiating are unsting, wound healing works well, implication
Pure and fresh, administration time is short, evident in efficacy, easy to carry, without bottled water volume of gargling is big, loading amount is heavy, it is scarce to carry inconvenience etc.
Fall into, and temperature, cold water all can be used, it is economic, practical, effective, quite welcome by patient, therefore, with wide market potential.
The foregoing is only presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification, should all belong to the covering scope of the present invention.
Claims (4)
1. a kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth, it is characterised in that：The prescription medicinal material of the Chinese medicine compound prescription effervescent tablet for rinsing mouth is good fortune
Ginseng, rattletop, radix bupleuri, green tea, honeysuckle, lophatherum gracile, the dried rhizome of rehmannia, chrysanthemum, peppermint and radix glycyrrhizae；
By weight, the consumption of each medicinal material is：12 parts of good fortune ginseng, 8 parts of rattletop, 8 parts of radix bupleuri, 11 parts of green tea, 11 parts of honeysuckle are light
9 parts of the leaf of bamboo, 12 parts of the dried rhizome of rehmannia, 12 parts of chrysanthemum, 7 parts of peppermint, 10 parts of radix glycyrrhizae.
2. Chinese medicine compound prescription effervescent tablet for rinsing mouth according to claim 1, it is characterised in that：Its preparation method comprises the following steps：
1）Good fortune is joined, rattletop, radix bupleuri, green tea, honeysuckle, lophatherum gracile, the dried rhizome of rehmannia, chrysanthemum, peppermint and radix glycyrrhizae are chopped into length respectively
1-2 cm, according to solid-liquid ratio 1 after mixing:10, which add water-bath at the alcohol that mass fraction is 75%, 60 DEG C, extracts 3 times, merges 3 times
Filtrate, concentration, to the 1/5-1/6 that medicinal extract volume is former filtrate volume；
2）By step 1）Gained medicinal extract and starch, microcrystalline cellulose by volume 1:1.5:After 0.7 mixing, 15h is dried in 60 DEG C, it is cold
But crush afterwards, cross 30-40 mesh sieves；
3）By step 2）Gained mixed powder is mixed evenly to prepare particle with citric acid, Macrogol 6000, lactose；
4）By step 3）Gained particle is mixed with sodium acid carbonate, in 20-25 DEG C of temperature, humidity 30%-35% condition lower sheetings, plastic-aluminum
Pack finished product.
3. Chinese medicine compound prescription effervescent tablet for rinsing mouth according to claim 2, it is characterised in that：Citric acid used, sodium acid carbonate difference
Crush, cross 20-30 mesh sieves；Macrogol 6000 used is crushed, and crosses 160 mesh sieves.
4. Chinese medicine compound prescription effervescent tablet for rinsing mouth according to claim 2, it is characterised in that：Weight percent sum is 100%
85-89% containing mixed powder, citric acid 1.1-1.6%, Macrogol 6000 3-5%, lactose 5-8%, carbonic acid in meter, gained effervescent tablet
Hydrogen sodium 1.4-1.9%.
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| CN201410754244.9A CN104383350B (en) | 2014-12-11 | 2014-12-11 | A kind of Chinese medicine compound prescription effervescent tablet for rinsing mouth and preparation method thereof |
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| CN104383350B true CN104383350B (en) | 2017-08-08 |
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|---|---|---|---|---|
| CN105982821A (en) * | 2015-06-14 | 2016-10-05 | 胡雅群 | Portable solid herbal mouthwash effervescent tablets and preparation method thereof |
| CN107648494A (en) * | 2017-10-30 | 2018-02-02 | 黄旋平 | One kind treats gingivitis and canker sore Chinese medical collutory and preparation method thereof |
| CN108815001B (en) * | 2018-07-02 | 2021-11-30 | 博凯药业有限公司 | Mouthwash effervescent tablet and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166171A (en) * | 2010-11-29 | 2011-08-31 | 吴克 | Effervescent tablet for rinsing mouth and preparation process thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166171A (en) * | 2010-11-29 | 2011-08-31 | 吴克 | Effervescent tablet for rinsing mouth and preparation process thereof |
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| CN104383350A (en) | 2015-03-04 |
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