CN104382869A - Orally disintegrating tablet with functions of oral cavity paralysis and taste masking and preparation method of orally disintegrating tablet - Google Patents
Orally disintegrating tablet with functions of oral cavity paralysis and taste masking and preparation method of orally disintegrating tablet Download PDFInfo
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- CN104382869A CN104382869A CN201410572552.XA CN201410572552A CN104382869A CN 104382869 A CN104382869 A CN 104382869A CN 201410572552 A CN201410572552 A CN 201410572552A CN 104382869 A CN104382869 A CN 104382869A
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Abstract
The invention relates to the technical field of medicine and discloses an orally disintegrating tablet with functions of oral cavity paralysis and taste masking and a preparation method of the orally disintegrating tablet. The orally disintegrating tablet with the functions of oral cavity paralysis and taste masking comprises the following raw materials in percentage by weight: 40-80 percent of a medicine core, 10-50 percent of an auxiliary material absorbed with a taste masking agent, 5-30 percent of a disintegrating agent, 0-2 percent of a lubricating agent and 0-0.5 percent of an essence, wherein the taste masking agent is a water decoction formed by one or a combination of more of chili, black pepper and Sichuan pepper. The orally disintegrating tablet tastes good, has a spicy fragrance, and has a good taste masking effect; the taste masking effect on roxithromycin, norfloxacin and amoxicillin is extremely good by virtue of verification at present; by adding sesame oil and the essence, the stink of the amoxicillin can be well masked.
Description
Technical field
The present invention relates to medical art, refer more particularly to and a kind ofly benumb oral cavity disintegration tablet of oral cavity taste masking and preparation method thereof.
Background technology
Along with improving constantly of people's living standard, the requirement of people to drug quality is more and more higher, and " good medicine tastes bitter " no longer becomes fashion, and people wish to obtain the good and product of taking convenience of good drug efficacy, mouthfeel, improve the quality of living, meet body and mind demand.Especially pediatric drugs, taste is easy to children's and accepts, and greatly can improve the compliance of medication.Therefore, effectively cover adverse drug taste, improve the quality of products, more and more pay attention to by pharmacy circle personage.Taste masking technology covers the original disagreeable taste of principal agent by preparation means exactly, especially bitterness.
Existing oral taste masking preparation, generally realized by interpolation correctives, sugar coating or film-coat, but this several technology taste masking time is relatively short, taste masking effect is poor, expensive, affect other sense of taste, especially, for the old man having dysphagia and child, after medicine time in mouth is slightly long, be easy to feel bitter.
Summary of the invention
The object of the present invention is to provide and a kind ofly benumb oral cavity disintegration tablet of oral cavity taste masking and preparation method thereof, features good taste, spicy fragrance, taste masking is effective, as the taste-masking material of medicine-food two-purpose, and safety non-toxic, super quality and competitive price.
For achieving the above object, the present invention is by the following technical solutions:
Benumb an oral cavity disintegration tablet for oral cavity taste masking, comprise the raw material of following percentage by weight: drug core 40%-80%, inhale the adjuvant 10%-50% having odor mask, disintegrating agent 5%-30%, lubricant 0-2%, essence 0-0.5%; Described drug core comprises the raw material of following weight portion: antibacterials 1 part, coating material 0.5-20 parts; Described suction has the adjuvant of odor mask to comprise the raw material of following weight portion: water suction adjuvant 1 part, odor mask 1-2 parts, and described odor mask is one or more water decoctions combined of Fructus Capsici, Fructus Piperis, Pericarpium Zanthoxyli.
Preferably, described water suction adjuvant is cellulose material or starch based material.
Preferably, described antibacterials are the wherein one of erythromycin series medicine, quinolones, penicillin medicine; Described coating material be acrylic resin, gelatin, arabic gum, alginate, cyclodextrin wherein one or more.
Preferably, described disintegrating agent be cross linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose, gas-producing disintegrant, carboxymethyl starch sodium, dried starch, gellan gum wherein one or more.
Preferably, described lubricant is magnesium stearate, and described essence is Oleum Sesami essence.
The invention also discloses a kind of preparation method of benumbing the oral cavity disintegration tablet of oral cavity taste masking, comprise following sequential steps:
(1) make drug core: by weight, after antibacterials 1 part, coating material 0.5 ~ 20 part of mix homogeneously, pulverous drug core is made in dissolving, enclose, oven dry, excessively 60 mesh sieves;
(2) adjuvant having odor mask is inhaled in preparation: by weight, the 1 part of absorption of water suction adjuvant is had the odor mask 1-2 parts of paralysis oral cavity effect, dries;
(3) tabletting: by weight percentage, by drug core 40-80%, inhale the adjuvant 10-50% having odor mask, disintegrating agent 5-30%, lubricant 0-2%, essence 0.01-0.5% mix homogeneously, is pressed into tablet.
Preferably, described odor mask is one or more water decoctions combined of Fructus Capsici, Fructus Piperis, Pericarpium Zanthoxyli; Described water suction adjuvant is cellulose material or starch based material.
Preferably, described antibacterials are the wherein one of erythromycin series medicine, quinolones, penicillin medicine; Described coating material be acrylic resin, gelatin, arabic gum, alginate, cyclodextrin wherein one or more.
Preferably, described disintegrating agent be cross linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose, gas-producing disintegrant, carboxymethyl starch sodium, dried starch, gellan gum wherein one or more.
Preferably, described lubricant is magnesium stearate, and described essence is Oleum Sesami essence.
Oral cavity disintegration tablet tablet quality of the present invention is 0.2-1g.
The present invention compared with prior art, has the following advantages: oral cavity disintegration tablet features good taste of the present invention, spicy fragrance, and taste masking is effective, at present through verifying Roxithromycin, and norfloxacin, amoxicillin has fabulous taste masking effect; By adding Oleum sesami essence, also having the bad smell of amoxicillin and fabulous covering effect; As the taste-masking material of medicine-food two-purpose, safety non-toxic, super quality and competitive price; Be temporary paralysis bitterness taste bud to oral cavity, do not affect other sense of taste, oral cavity disintegration tablet Orally disintegrating of the present invention, be beneficial to and swallow.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme of the present invention is further described in detail.
Benumb an oral cavity disintegration tablet for oral cavity taste masking, comprise the raw material of following percentage by weight: drug core 40%-80%, inhale the adjuvant 10%-50% having odor mask, disintegrating agent 5%-30%, lubricant 0-2%, essence 0-0.5%; Described drug core comprises the raw material of following weight portion: antibacterials 1 part, coating material 0.5-20 parts; Described suction has the adjuvant of odor mask to comprise the raw material of following weight portion: water suction adjuvant 1 part, odor mask 1-2 parts, and described odor mask is one or more water decoctions combined of Fructus Capsici, Fructus Piperis, Pericarpium Zanthoxyli.Wherein, antibacterials are the wherein one of erythromycin series medicine, quinolones, penicillin medicine.Coating material be acrylic resin, gelatin, arabic gum, alginate, cyclodextrin wherein one or more.Disintegrating agent be cross linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose, gas-producing disintegrant, carboxymethyl starch sodium, dried starch, gellan gum wherein one or more.Lubricant is magnesium stearate.Essence is Oleum Sesami essence.
Embodiment one:
Benumb an oral cavity disintegration tablet for oral cavity taste masking, comprise the raw material of following percentage by weight: drug core 55%, inhale the adjuvant 30% having odor mask, cross linked polyvinyl pyrrolidone 7%, low-substituted hydroxypropyl cellulose 6%, magnesium stearate 1.5%, Oleum sesami essence 0.5%; Odor mask is the water decoction of Fructus Capsici.
A kind of preparation method of benumbing the oral cavity disintegration tablet of oral cavity taste masking of the present embodiment, comprises following sequential steps:
(1) make drug core: by weight, by Roxithromycin 1 part, acrylic resin 10 parts, after cyclodextrin 10 parts of mix homogeneously, pulverous drug core is made in dissolving, enclose, oven dry, excessively 60 mesh sieves;
(2) adjuvant having odor mask is inhaled in preparation: by weight, cellulose 1 part of absorption is had the odor mask 2 parts of paralysis oral cavity effect, dries;
(3) tabletting: by weight percentage, by drug core 55%, inhales the adjuvant 30% having odor mask, cross linked polyvinyl pyrrolidone 7%, low-substituted hydroxypropyl cellulose 6%, magnesium stearate 1.5%, Oleum sesami essence 0.5% mix homogeneously, is pressed into tablet, and tablet quality is 1g.
Embodiment two:
Benumb an oral cavity disintegration tablet for oral cavity taste masking, comprise the raw material of following percentage by weight: drug core 80%, inhale the adjuvant 10% having odor mask, gas-producing disintegrant 2%, carboxymethyl starch sodium 5.5%, magnesium stearate 2%, Oleum sesami essence 0.5%; Odor mask is the water decoction of Fructus Piperis, Pericarpium Zanthoxyli combination.
A kind of preparation method of benumbing the oral cavity disintegration tablet of oral cavity taste masking of the present embodiment, comprises following sequential steps:
(1) make drug core: by weight, after norfloxacin 1 part, alginate 0.5 part of mix homogeneously, pulverous drug core is made in dissolving, enclose, oven dry, excessively 60 mesh sieves;
(2) adjuvant having odor mask is inhaled in preparation: by weight, by starch 1 part, dries;
(3) tabletting: by weight percentage, by drug core 80%, inhales the adjuvant 10% having odor mask, gas-producing disintegrant 2%, carboxymethyl starch sodium 5.5%, magnesium stearate 2%, Oleum sesami essence 0.5% mix homogeneously, is pressed into tablet, and tablet quality is 0.5g.
Embodiment three:
Benumb an oral cavity disintegration tablet for oral cavity taste masking, comprise the raw material of following percentage by weight: drug core 40%, inhale the adjuvant 40% having odor mask, dried starch 10%, gellan gum 10%; Odor mask is the water decoction of Fructus Capsici, Pericarpium Zanthoxyli combination.
A kind of preparation method of benumbing the oral cavity disintegration tablet of oral cavity taste masking of the present embodiment, comprises following sequential steps:
(1) make drug core: by weight, after 1 part, amoxicillin, 10 parts, gelatin, arabic gum 10 parts of mix homogeneously, pulverous drug core is made in dissolving, enclose, oven dry, excessively 60 mesh sieves;
(2) adjuvant having odor mask is inhaled in preparation: by weight, by Xanthan gum 0.5 part, and galactomannan 0.5 part of absorption has the odor mask 1.5 parts of paralysis oral cavity effect, dries;
(3) tabletting: by weight percentage, by drug core 40%, inhale the adjuvant 40% having odor mask, dried starch 10%, gellan gum 10% mix homogeneously, is pressed into tablet, and tablet quality is 0.8g.
Embodiment four:
Benumb an oral cavity disintegration tablet for oral cavity taste masking, comprise the raw material of following percentage by weight: drug core 70%, inhale the adjuvant 23% having odor mask, low-substituted hydroxypropyl cellulose 5%, magnesium stearate 1.8%, Oleum sesami essence 0.2%; Odor mask is the water decoction of Fructus Capsici, Fructus Piperis combination.
A kind of preparation method of benumbing the oral cavity disintegration tablet of oral cavity taste masking of the present embodiment, comprises following sequential steps:
(1) make drug core: by weight, after norfloxacin 1 part, acrylic resin 7.5 parts, alginate 7.5 parts of mix homogeneously, pulverous drug core is made in dissolving, enclose, oven dry, excessively 60 mesh sieves;
(2) adjuvant having odor mask is inhaled in preparation: by weight, Xanthan gum 1 part of absorption is had the odor mask 1.8 parts of paralysis oral cavity effect, dries;
(3) tabletting: by weight percentage, by drug core 70%, inhales the adjuvant 23% having odor mask, low-substituted hydroxypropyl cellulose 5%, magnesium stearate 1.8%, Oleum sesami essence 0.2%; Odor mask is the water decoction mix homogeneously of Fructus Capsici, Fructus Piperis combination, and be pressed into tablet, tablet quality is 0.2g.
Embodiment five:
Benumb an oral cavity disintegration tablet for oral cavity taste masking, comprise the raw material of following percentage by weight: drug core 45%, inhale the adjuvant 18% having odor mask, gas-producing disintegrant 15%, carboxymethyl starch sodium 15%, magnesium stearate 1.6%, Oleum sesami essence 0.4%; Odor mask is the water decoction of Pericarpium Zanthoxyli.
A kind of preparation method of benumbing the oral cavity disintegration tablet of oral cavity taste masking of the present embodiment, comprises following sequential steps:
(1) make drug core: by weight, after 1 part, amoxicillin, acrylic resin 5 parts, 5 parts, gelatin, arabic gum 5 parts, alginate 5 parts of mix homogeneously, pulverous drug core is made in dissolving, enclose, oven dry, excessively 60 mesh sieves;
(2) adjuvant having odor mask is inhaled in preparation: by weight, by cellulose 0.5 part, starch 0.5 part, absorbs the odor mask 2 parts with the effect of paralysis oral cavity, dries;
(3) tabletting: by weight percentage, by drug core 45%, inhales the adjuvant 18% having odor mask, gas-producing disintegrant 15%, carboxymethyl starch sodium 15%, magnesium stearate 1.6%, Oleum sesami essence 0.4% mix homogeneously, is pressed into tablet, and tablet quality is 0.4g.
It should be noted last that, above detailed description of the invention is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from the spirit and scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (10)
1. benumb an oral cavity disintegration tablet for oral cavity taste masking, it is characterized in that, comprise the raw material of following percentage by weight: drug core 40%-80%, inhale the adjuvant 10%-50% having odor mask, disintegrating agent 5%-30%, lubricant 0-2%, essence 0-0.5%; Described drug core comprises the raw material of following weight portion: antibacterials 1 part, coating material 0.5-20 parts; Described suction has the adjuvant of odor mask to comprise the raw material of following weight portion: water suction adjuvant 1 part, odor mask 1-2 parts, and described odor mask is one or more water decoctions combined of Fructus Capsici, Fructus Piperis, Pericarpium Zanthoxyli.
2. the oral cavity disintegration tablet of paralysis oral cavity taste masking according to claim 1, is characterized in that, described water suction adjuvant is cellulose material or starch based material.
3. the oral cavity disintegration tablet of paralysis oral cavity taste masking according to claim 1, is characterized in that, described antibacterials are the wherein one of erythromycin series medicine, quinolones, penicillin medicine; Described coating material be acrylic resin, gelatin, arabic gum, alginate, cyclodextrin wherein one or more.
4. the oral cavity disintegration tablet of paralysis oral cavity taste masking according to claim 1, it is characterized in that, described disintegrating agent be cross linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose, gas-producing disintegrant, carboxymethyl starch sodium, dried starch, gellan gum wherein one or more.
5. the oral cavity disintegration tablet of paralysis oral cavity taste masking according to claim 1, is characterized in that, described lubricant is magnesium stearate, and described essence is Oleum Sesami essence.
6. a preparation method for the oral cavity disintegration tablet of the paralysis oral cavity taste masking that one of claim 1 to 5 is described, is characterized in that, comprise following sequential steps:
(1) make drug core: by weight, after medicine 1 part, coating material 0.5 ~ 20 part of mix homogeneously, pulverous drug core is made in dissolving, enclose, oven dry, excessively 60 mesh sieves;
(2) adjuvant having odor mask is inhaled in preparation: by weight, the 1 part of absorption of water suction adjuvant is had the odor mask 1-2 parts of paralysis oral cavity effect, dries;
(3) tabletting: by weight percentage, by drug core 40-80%, inhale the adjuvant 15-50% having odor mask, disintegrating agent 5-30%, lubricant 0.5-2%, essence 0.01-0.5% mix homogeneously, is pressed into tablet.
7. the preparation method of the oral cavity disintegration tablet of paralysis oral cavity taste masking according to claim 6, is characterized in that, described odor mask is one or more water decoctions combined of Fructus Capsici, Fructus Piperis, Pericarpium Zanthoxyli; Described water suction adjuvant is cellulose material or starch based material.
8. the preparation method of the oral cavity disintegration tablet of paralysis oral cavity taste masking according to claim 6, is characterized in that, described antibacterials are the wherein one of erythromycin series medicine, quinolones, penicillin medicine; Described coating material be acrylic resin, gelatin, arabic gum, alginate, cyclodextrin wherein one or more.
9. the preparation method of the oral cavity disintegration tablet of paralysis oral cavity taste masking according to claim 6, it is characterized in that, described disintegrating agent be cross linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose, gas-producing disintegrant, carboxymethyl starch sodium, dried starch, gellan gum wherein one or more.
10. the preparation method of the oral cavity disintegration tablet of paralysis oral cavity taste masking according to claim 6, is characterized in that, described lubricant is magnesium stearate, and described essence is Oleum Sesami essence.
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| CN201410572552.XA CN104382869B (en) | 2014-10-23 | 2014-10-23 | A kind of oral cavity disintegration tablet benumbing oral cavity taste masking and preparation method thereof |
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Cited By (4)
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| CN105168242A (en) * | 2015-08-24 | 2015-12-23 | 孟维宇 | Oral preparation for treating bacterial intestinal diseases, preparation method and applications thereof |
| CN112220037A (en) * | 2020-08-27 | 2021-01-15 | 吕志明 | A health food containing pine tree extract and its preparation method |
| CN112494450A (en) * | 2020-12-12 | 2021-03-16 | 海南海神同洲制药有限公司 | Special orally disintegrating tablet coating structure for chemical medicine and preparation method thereof |
| CN113476417A (en) * | 2021-08-12 | 2021-10-08 | 郑州味千生物技术有限公司 | Taste-masking outer layer of orally disintegrating tablet and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105168242A (en) * | 2015-08-24 | 2015-12-23 | 孟维宇 | Oral preparation for treating bacterial intestinal diseases, preparation method and applications thereof |
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| CN113476417A (en) * | 2021-08-12 | 2021-10-08 | 郑州味千生物技术有限公司 | Taste-masking outer layer of orally disintegrating tablet and preparation method thereof |
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