CN104378976B - 人源化il-7啮齿动物 - Google Patents

人源化il-7啮齿动物 Download PDF

Info

Publication number
CN104378976B
CN104378976B CN201380031333.4A CN201380031333A CN104378976B CN 104378976 B CN104378976 B CN 104378976B CN 201380031333 A CN201380031333 A CN 201380031333A CN 104378976 B CN104378976 B CN 104378976B
Authority
CN
China
Prior art keywords
hil
rodent
humanization
mouse
exon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380031333.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN104378976A (zh
Inventor
A·J·莫菲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CN104378976A publication Critical patent/CN104378976A/zh
Application granted granted Critical
Publication of CN104378976B publication Critical patent/CN104378976B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Catching Or Destruction (AREA)
CN201380031333.4A 2012-06-18 2013-06-14 人源化il-7啮齿动物 Expired - Fee Related CN104378976B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261660976P 2012-06-18 2012-06-18
US61/660,976 2012-06-18
US201261740074P 2012-12-20 2012-12-20
US61/740,074 2012-12-20
US13/795,765 2013-03-12
US13/795,765 US8962913B2 (en) 2012-06-18 2013-03-12 Humanized IL-7 rodents
PCT/US2013/045788 WO2013192030A1 (en) 2012-06-18 2013-06-14 Humanized il-7 rodents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610168011.XA Division CN105779467A (zh) 2012-06-18 2013-06-14 人源化il-7 啮齿动物

Publications (2)

Publication Number Publication Date
CN104378976A CN104378976A (zh) 2015-02-25
CN104378976B true CN104378976B (zh) 2016-03-23

Family

ID=49757275

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380031333.4A Expired - Fee Related CN104378976B (zh) 2012-06-18 2013-06-14 人源化il-7啮齿动物
CN201610168011.XA Pending CN105779467A (zh) 2012-06-18 2013-06-14 人源化il-7 啮齿动物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610168011.XA Pending CN105779467A (zh) 2012-06-18 2013-06-14 人源化il-7 啮齿动物

Country Status (27)

Country Link
US (7) US8962913B2 (enExample)
EP (2) EP2861063A1 (enExample)
JP (1) JP6174134B2 (enExample)
KR (1) KR20150027752A (enExample)
CN (2) CN104378976B (enExample)
AU (1) AU2013277457B2 (enExample)
BR (1) BR112014029892A2 (enExample)
CA (1) CA2873134A1 (enExample)
CY (1) CY1119071T1 (enExample)
DK (1) DK2859793T3 (enExample)
ES (1) ES2626965T3 (enExample)
HK (1) HK1203761A1 (enExample)
HR (1) HRP20170974T1 (enExample)
HU (1) HUE034592T2 (enExample)
IL (3) IL235773B (enExample)
IN (1) IN2014DN10189A (enExample)
LT (1) LT2859793T (enExample)
MX (1) MX363540B (enExample)
NZ (1) NZ702943A (enExample)
PL (1) PL2859793T3 (enExample)
PT (1) PT2859793T (enExample)
RS (1) RS56039B1 (enExample)
RU (1) RU2654565C2 (enExample)
SG (3) SG10201609576YA (enExample)
SI (1) SI2859793T1 (enExample)
SM (1) SMT201700313T1 (enExample)
WO (1) WO2013192030A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3241435T3 (da) * 2009-07-08 2021-08-23 Kymab Ltd Dyremodeller og terapeutiske molekyler
AU2012311286B2 (en) 2011-09-19 2018-07-26 Kymab Limited Antibodies, variable domains and chains tailored for human use
CA2866363C (en) * 2012-03-05 2019-08-27 Samsung Electronics Co., Ltd. Harq-ack signal transmission in response to detection of control channel type in case of multiple control channel types
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
HRP20231121T1 (hr) 2013-09-23 2023-12-22 Regeneron Pharmaceuticals, Inc. Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale
WO2015049517A2 (en) 2013-10-01 2015-04-09 Kymab Limited Animal models and therapeutic molecules
JP6492095B2 (ja) 2013-10-15 2019-03-27 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｉｌ−１５動物
US20150143559A1 (en) 2013-11-19 2015-05-21 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized a proliferation-inducing ligand gene
MX2016014504A (es) 2014-05-05 2017-05-23 Regeneron Pharma Animales c5 y c3 humanizados.
NO2785538T3 (enExample) 2014-05-07 2018-08-04
BR112017010490A2 (pt) 2014-12-05 2018-04-03 Regeneron Pharma roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano.
ES2950399T3 (es) * 2015-04-13 2023-10-09 Regeneron Pharma Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos
WO2017136712A1 (en) 2016-02-04 2017-08-10 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered angptl8 gene
CN109068621B (zh) 2016-02-29 2021-07-20 再生元制药公司 具有人源化的tmprss基因的啮齿类动物
GB201710984D0 (en) 2017-07-07 2017-08-23 Kymab Ltd Cells, vertebrates, populations & methods
WO2019067875A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE
CA3098040A1 (en) 2018-07-16 2020-01-23 Regeneron Pharmaceuticals, Inc. Non-human animal models of ditra disease and uses thereof
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
JP7506686B2 (ja) 2019-04-04 2024-06-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化凝固因子１２遺伝子座を含む非ヒト動物
WO2020247452A1 (en) 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
CN113939595A (zh) 2019-06-07 2022-01-14 瑞泽恩制药公司 包括人源化白蛋白基因座的非人动物
US20220312749A1 (en) * 2019-08-09 2022-10-06 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
WO2021154791A1 (en) * 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
KR102316506B1 (ko) 2020-02-26 2021-10-22 차의과학대학교 산학협력단 동물 면역계의 인간화 활성을 촉진하는 방법
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
JP2024500153A (ja) * 2020-12-21 2024-01-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｔｓｌｐ遺伝子、ヒト化ｔｓｌｐ受容体遺伝子、及び／又はヒト化ｉｌ７ｒａ遺伝子を有する非ヒト動物
CN114835798B (zh) * 2021-05-28 2024-02-23 百奥赛图(北京)医药科技股份有限公司 Cd36基因人源化非人动物的构建方法及应用
US20230417899A1 (en) * 2022-06-27 2023-12-28 Oshkosh Corporation Position tracking for a lift device
AU2023338373A1 (en) * 2022-09-08 2025-04-03 The Jackson Laboratory Humanized immunodeficient mouse models
WO2025212991A1 (en) 2024-04-05 2025-10-09 Regeneron Pharmaceuticals, Inc. Rodent models of disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2434578A (en) * 2006-01-26 2007-08-01 Univ Basel Transgenic animals
CN101302517A (zh) * 2008-02-03 2008-11-12 中国科学院广州生物医药与健康研究院 人白细胞介素7在真核宿主中表达的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA887773B (en) * 1987-10-26 1989-07-26 Immunex Corp Interleukin-7
EP1209968A1 (en) 1999-08-31 2002-06-05 Genencor International, Inc. Transgenic mammal capable of facilitating production of donor-specific functional immunity
US7759541B2 (en) 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
EP4502152A3 (en) * 2009-10-06 2025-04-30 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
PT4233537T (pt) 2011-02-15 2025-09-08 Regeneron Pharma Ratinhos humanizados para m-csf e utilizações dos mesmos
SI2818478T1 (sl) 2011-10-28 2017-07-31 Regeneron Pharmaceuticals, Inc. Humanizirani il-6 in receptor il-6
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2434578A (en) * 2006-01-26 2007-08-01 Univ Basel Transgenic animals
CN101302517A (zh) * 2008-02-03 2008-11-12 中国科学院广州生物医药与健康研究院 人白细胞介素7在真核宿主中表达的方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias;Ana silva et al;《Microenvironment and immunology》;20110731;第71卷(第14期);第4780-4790页 *
Improving human hemato-lymphoidsystem;Tim Willinger et al;《Trends in Immunology》;20110731;第32卷(第7期);第321-327页 *
Lentiviral Vector Delivery of Human Interleukin-7 (hIL-7)to Human Immune System (HIS) Mice Expands T Lymphocyte Populations;Ryan M. O’Connell et al;《Plos one》;20100831;第5卷(第8期);第1-11页 *
白细胞介素-7的生物学特性及其在临床治疗中的作用和意义;丁鹏等;《中国医学前沿杂志》;20110820(第4期);第116-120页 *

Also Published As

Publication number Publication date
HK1203761A1 (en) 2015-11-06
US9232776B2 (en) 2016-01-12
US20190343093A1 (en) 2019-11-14
BR112014029892A2 (pt) 2017-07-25
IL260250B (en) 2019-08-29
SG10201609576YA (en) 2016-12-29
SI2859793T1 (sl) 2017-07-31
MX2014015679A (es) 2015-04-08
EP2859793B1 (en) 2017-04-05
RU2014148107A (ru) 2016-08-10
IN2014DN10189A (enExample) 2015-08-21
IL235773B (en) 2018-07-31
IL268674A (en) 2019-10-31
WO2013192030A1 (en) 2013-12-27
RU2654565C2 (ru) 2018-05-21
EP2861063A1 (en) 2015-04-22
US20170064932A1 (en) 2017-03-09
SG11201407370QA (en) 2014-12-30
US20180360007A1 (en) 2018-12-20
US9737059B2 (en) 2017-08-22
HUE034592T2 (en) 2018-02-28
US20150082469A1 (en) 2015-03-19
RS56039B1 (sr) 2017-09-29
CY1119071T1 (el) 2018-01-10
US9974291B2 (en) 2018-05-22
AU2013277457B2 (en) 2018-03-15
NZ702943A (en) 2017-07-28
EP2859793A1 (en) 2015-04-15
CA2873134A1 (en) 2013-12-27
LT2859793T (lt) 2017-07-10
US8962913B2 (en) 2015-02-24
MX363540B (es) 2019-03-27
PL2859793T3 (pl) 2017-09-29
HRP20170974T1 (hr) 2017-09-22
PT2859793T (pt) 2017-07-06
JP6174134B2 (ja) 2017-08-02
CN104378976A (zh) 2015-02-25
AU2013277457A1 (en) 2015-01-22
SG10201609569PA (en) 2016-12-29
CN105779467A (zh) 2016-07-20
SMT201700313T1 (it) 2017-07-18
KR20150027752A (ko) 2015-03-12
HK1203302A1 (en) 2015-10-30
ES2626965T3 (es) 2017-07-26
US10314298B2 (en) 2019-06-11
IL235773A0 (en) 2015-01-29
JP2015523863A (ja) 2015-08-20
US20160052986A1 (en) 2016-02-25
US20130340104A1 (en) 2013-12-19
US20170311581A1 (en) 2017-11-02
DK2859793T3 (en) 2017-06-19

Similar Documents

Publication Publication Date Title
US10314298B2 (en) Humanized IL-7 rodents
CN105744829B (zh) 人源化的il-15动物
CN107257624B (zh) 具有人源化分化簇274基因的非人动物
US11234421B2 (en) Genetically modified non-human animal with human or chimeric IL15
US20220015343A1 (en) Genetically modified non-human animal with human or chimeric genes
US11464876B2 (en) Genetically modified mouse comprising a chimeric TIGIT
US20230058049A1 (en) GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPa/CD47
US20250134079A1 (en) Genetically modified non-human animal with human or chimeric genes
WO2022247936A1 (en) Genetically modified non-human animal with human or chimeric cd36
US11564381B2 (en) Genetically modified non-human animal with human or chimeric LAG3
HK1203302B (en) Humanized il-7 rodents
KR20260025082A (ko) 벡터, 유전자 변형 세포, 및 그것을 포함하는 유전자 변형 비인간 동물
JP2004290038A (ja) エピレグリン遺伝子欠損動物およびその利用方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160323

Termination date: 20200614