CN104368029A - Preparation method of membrane for promoting epidermal cell wet and scar-free growth - Google Patents
Preparation method of membrane for promoting epidermal cell wet and scar-free growth Download PDFInfo
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- CN104368029A CN104368029A CN201310348671.2A CN201310348671A CN104368029A CN 104368029 A CN104368029 A CN 104368029A CN 201310348671 A CN201310348671 A CN 201310348671A CN 104368029 A CN104368029 A CN 104368029A
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- polyhexamethylene guanidine
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Abstract
The invention discloses a preparation method of a membrane for promoting the epidermal cell wet and scar-free growth, and relates to a preparation method of a repairing material for repairing damaged human epidermal tissues. The membrane is composed of the following components in percentage by weight: 1 to 30% of iodophor, 1 to 30% of ethanol, 1 to 30% of polyhexamethylene guanidine, 1 to 30% of chitin, and 1 to 30% of chitosan. The preparation method comprises the following steps: step one, heating medical hot-melt adhesive and CMC to a temperature around 130-150 DEG C; step two, waiting for the medical hot-melt adhesive and CMC to form membranes; step three, adding iodophor, ethanol, polyhexamethylene guanidine, chitin, chitosan, and pure water into the membranes during the cooling process after the formation of the membranes. Components that can disinfect the skin and promote the cell growth are adding into the hydrogel material, thus the wounded skin will not be infected or basically not infected, moreover, the growth speed of the tissue of the wounded part is very fast, the scars are reduced, and the skin tissue cell growth is further promoted.
Description
Technical field:
The present invention relates to the preparation method of a kind of repair materials after human cuticular tissue's breakage, be specifically related to a kind ofly promote the moist preparation method without crust growing film of epidermis cell.
Background technology:
Process after human cuticular tissue's breakage is the basic assignment of medical domain, and long history, method is various.More ancient and usual way promotes that incrustation (dryness) then makes its self-sow.The new technique just risen in recent years makes wound not form a scab (moist), there is the hope meeting people in the material that epiderm skin histiocyte grows under moist condition, this is hydrocolloid material, but it also has a huge defect to be easy to exactly infect.
Summary of the invention:
The object of this invention is to provide and promote the moist preparation method without crust growing film of epidermis cell, it adds the composition of skin degerming and the composition of Promote cell's growth in hydrocolloid material, make skin wound place not easy infection or substantially do not infect and make it grow fast, cicatrix is corresponding minimizing also, the function that can further promote skin tissue cell to grow.
In order to solve the problem existing for background technology, effective ingredient of the present invention in hydrocolloid processing in conjunction with time the composition of material and percentage by weight be respectively: povidone iodine 1-30%, ethanol 1-30%, polyhexamethylene guanidine 1-30%, chitin 1-30%, chitosan 1-30%.
Its preparation method is:
1, medical hot melt adhesive and CMC are controlled at about 130-150 degrees centigrade;
2, wait for that medical hot melt adhesive and CMC form film;
3, after medical hot melt adhesive and CMC form film, in temperature-fall period, povidone iodine, ethanol, polyhexamethylene guanidine, chitin, chitosan and pure water is added.
In manufacturing process of the present invention, because medical hot melt adhesive and CMC could form film at the temperature of about 130-150 degree Celsius, and medicine can lose efficacy in this temperature, so after medical hot melt adhesive and CMC form film in temperature-fall period, when selecting suitable and add medicine.
The present invention has following beneficial effect: in hydrocolloid material, add the composition of skin degerming and the composition of Promote cell's growth, make skin wound place not easy infection or substantially do not infect and make it grow fast, cicatrix is corresponding minimizing also, the function that can further promote skin tissue cell to grow.
Detailed description of the invention:
Detailed description of the invention one: composition and the percentage by weight of this detailed description of the invention are respectively: povidone iodine 0.5%-1%, ethanol 0.5%-1%, polyhexamethylene guanidine 0.5%-1%, chitin 0.5%-1%, chitosan 0.5%-1%.
Its preparation method is:
1, medical hot melt adhesive and CMC are controlled at about 130-150 degrees centigrade;
2, wait for that medical hot melt adhesive and CMC form film;
3, after medical hot melt adhesive and CMC form film, in temperature-fall period, povidone iodine, ethanol, polyhexamethylene guanidine, chitin, chitosan is added.
Detailed description of the invention two: this detailed description of the invention and detailed description of the invention one difference are that its composition and percentage by weight are respectively: povidone iodine 0.25%-5%, ethanol 0.25%-5%, polyhexamethylene guanidine 0.25%-5%, chitin 0.25%-5%, chitosan 0.25%-5%; Its preparation method even detailed description of the invention one is identical.
Detailed description of the invention three: this detailed description of the invention and detailed description of the invention one difference are that its composition and percentage by weight are respectively: povidone iodine 5%-10%, ethanol 5%-10%, polyhexamethylene guanidine 5%-10%, chitin 5%-10%, chitosan 5%-10%; Its preparation method even detailed description of the invention one is identical; Its preparation method even detailed description of the invention one is identical.
Detailed description of the invention four: this detailed description of the invention and detailed description of the invention one difference are that its composition and percentage by weight are respectively: povidone iodine 5%-10%, ethanol 5%-10%, polyhexamethylene guanidine 10%-20%, chitin 5%-10%, chitosan 15%-30%; Its preparation method even detailed description of the invention one is identical; Its preparation method even detailed description of the invention one is identical.
Detailed description of the invention five: this detailed description of the invention and detailed description of the invention one difference are that its composition and percentage by weight are respectively: povidone iodine 5%-10%, ethanol 5%-10%, polyhexamethylene guanidine 15%-30%, chitin 5%-10%, chitosan 5%-10%; Its preparation method even detailed description of the invention one is identical; Its preparation method even detailed description of the invention one is identical.
Claims (5)
1. promote the moist preparation method without crust growing film of epidermis cell, it is characterized in that its composition and percentage by weight are respectively: povidone iodine 1-30%, ethanol 1-30%, polyhexamethylene guanidine 1-30%, chitin 1-30%, chitosan 1-30%; Its preparation method is: 1, medical hot melt adhesive and CMC are controlled at about 130-150 degrees centigrade; 2, wait for that medical hot melt adhesive and CMC form film; 3, after medical hot melt adhesive and CMC form film, in temperature-fall period, povidone iodine, ethanol, polyhexamethylene guanidine, chitin and chitosan is added.
2. the moist preparation method without crust growing film of promotion epidermis cell according to claim 1, is characterized in that its composition and percentage by weight are respectively: povidone iodine 0.5%-1%, ethanol 0.5%-1%, polyhexamethylene guanidine 0.5%-1%, chitin 0.5%-1%, chitosan 0.5%-1%.
3. the moist preparation method without crust growing film of promotion epidermis cell according to claim 1, is characterized in that its composition and percentage by weight are respectively: povidone iodine 2.5%-5%, ethanol 2.5%-5%, polyhexamethylene guanidine 2.5%-5%, chitin 2.5%-5%, chitosan 2.5%-5%.
4. the moist preparation method without crust growing film of promotion epidermis cell according to claim 1, is characterized in that its composition and percentage by weight are respectively: povidone iodine 5%-10%, ethanol 5%-10%, polyhexamethylene guanidine 5%-10%, chitin 5%-10%, chitosan 5%-10%.
5. the moist preparation method without crust growing film of promotion epidermis cell according to claim 1, is characterized in that its composition and percentage by weight are respectively: povidone iodine 5%-10%, ethanol 5%-10%, polyhexamethylene guanidine 15%-30%, chitin 5%-10%, chitosan 15%-30%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310348671.2A CN104368029A (en) | 2013-08-13 | 2013-08-13 | Preparation method of membrane for promoting epidermal cell wet and scar-free growth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310348671.2A CN104368029A (en) | 2013-08-13 | 2013-08-13 | Preparation method of membrane for promoting epidermal cell wet and scar-free growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104368029A true CN104368029A (en) | 2015-02-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310348671.2A Pending CN104368029A (en) | 2013-08-13 | 2013-08-13 | Preparation method of membrane for promoting epidermal cell wet and scar-free growth |
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| CN (1) | CN104368029A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101027996A (en) * | 2006-02-27 | 2007-09-05 | 权力敏 | Chitin antibacterial liquid |
| RU2352584C1 (en) * | 2007-09-06 | 2009-04-20 | Общество с ограниченной ответственностью "Линтекс" | Method of obtaining of gel on basis of carboxymethyl cellulose |
| CN101697731A (en) * | 2007-12-18 | 2010-04-28 | 王春霞 | Compound chitin guanidine decontamination solution |
| CN101890180A (en) * | 2009-05-21 | 2010-11-24 | 吴立宇 | Wound dressing |
| WO2011117384A1 (en) * | 2010-03-26 | 2011-09-29 | B. Braun Melsungen Ag | Antimicrobial wound dressing |
| CN103014914A (en) * | 2011-09-26 | 2013-04-03 | 李永兴 | Method for preparing medical high-efficiency disinfected chitosan fibers by using disinfectant |
-
2013
- 2013-08-13 CN CN201310348671.2A patent/CN104368029A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101027996A (en) * | 2006-02-27 | 2007-09-05 | 权力敏 | Chitin antibacterial liquid |
| RU2352584C1 (en) * | 2007-09-06 | 2009-04-20 | Общество с ограниченной ответственностью "Линтекс" | Method of obtaining of gel on basis of carboxymethyl cellulose |
| CN101697731A (en) * | 2007-12-18 | 2010-04-28 | 王春霞 | Compound chitin guanidine decontamination solution |
| CN101890180A (en) * | 2009-05-21 | 2010-11-24 | 吴立宇 | Wound dressing |
| WO2011117384A1 (en) * | 2010-03-26 | 2011-09-29 | B. Braun Melsungen Ag | Antimicrobial wound dressing |
| CN103014914A (en) * | 2011-09-26 | 2013-04-03 | 李永兴 | Method for preparing medical high-efficiency disinfected chitosan fibers by using disinfectant |
Non-Patent Citations (2)
| Title |
|---|
| R. JAYAKUMAR等: ""Biomaterials based on chitin and chitosan in wound dressing applications"", 《BIOTECHNOLOGY ADVANCES》 * |
| 陈煜等: ""甲壳素和壳聚糖在伤口敷料中的应用"", 《高分子通报》 * |
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Application publication date: 20150225 |