CN104367774A - 一种用于治疗鸡大肠杆菌病的中药颗粒剂及其制备方法 - Google Patents
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Abstract
本发明公开了一种用于治疗鸡大肠杆菌病的中药颗粒剂及其制备方法,属于传统草药未确定结构的药物制剂领域。本发明的中药颗粒剂主要是由以下重量份的原料组成:金银花9~12份,贯众9~12份,鱼腥草8~10份,知母8~10份,马齿苋5~7份,栀子3~5份,甘草1~3份。将所述7味中药加水煎煮,将煎液滤过并浓缩成浸膏,烘干粉碎,再加入蔗糖,混匀,制成颗粒过10目筛,烘干,再过10目筛制得。本发明对鸡大肠杆菌病具有较好的防治效果,残留低、不易产生耐药性,且不影响动物性产品的食用安全性,有着广阔的发展前景。
Description
技术领域
本发明属于传统草药未确定结构的药物制剂,具体涉及一种用于治疗鸡大肠杆菌病的中药颗粒剂及其制备方法。
背景技术
鸡大肠杆菌病是由某些致病性大肠埃希菌引起的一种条件性疾病。在自然条件下, 该病可发生于各种年龄的鸡, 但多发生于雏鸡, 特别是3~6周龄的雏鸡最易患病。发病率一般在30%~69%之间, 死亡率为42%~75%, 有时高达100%。大肠杆菌病给养禽业造成严重的经济损失,在淘汰的肉鸡中有43%与大肠杆菌败血症有关。
发病雏鸡主要临床症状为精神沉郁,食欲下降或废绝,饮水量增加,羽毛松乱,张口呼吸,离群呆立或蹲伏地,闭目昏睡,腹泻,排绿色水样粪便,有的为未消化的饲料。严重者卧地不起,随后出现死亡。剖检可见肝脏充血,肿大易碎,肝浆膜增厚,有大量渗出物;脾脏肿大;心包发炎,心包腔中有大量纤维素性渗出物;气囊浑浊,有干酪样物质覆盖。镜检,可见散在的卵圆形、无芽孢、革兰氏染色阴性短杆菌。
长期以来人们习惯使用抗生素治疗该病。虽然抗生素的广泛使用对鸡大肠杆菌病的控制发挥了重要作用,但其持续使用或不当使用将导致鸡药物敏感性降低、细菌耐药性增加和药物残留,严重影响了养鸡业的可持续发展和动物性食品的安全。
发明内容
本发明就是为了解决抗生素易形成耐药性和药物残留的问题,所提供一种用于治疗鸡大肠杆菌病的中药颗粒剂及其制备方法。
本发明是按以下技术方案实现的。
一种用于治疗鸡大肠杆菌病的中药颗粒剂,主要由以下重量份的原料组成:
金银花 9~12份, 贯众 9~12份,
鱼腥草 8~10份, 知母 8~10份,
马齿苋 5~7份, 栀子 3~5份,
甘草 1~3份。
上述的一种用于治疗鸡大肠杆菌病的中药颗粒剂,7味中药优选重量份配比为:
金银花 12份, 贯众 12份,
鱼腥草 9份,
知母 7份,
马齿苋 6份,
栀子 4份,
甘草 2份。
所述一种用于治疗鸡大肠杆菌病的中药颗粒剂的制备方法,将金银花9~12份,贯众9~12份,鱼腥草8~10份,知母8~10份,马齿苋5~7份,栀子3~5份,甘草1~3份,所述7味中药按比例混合,加8-12倍量的水,煎煮2-3次,每次1.5-2小时,将煎液合并且滤过,浓缩至80℃相对密度为1.28的浸膏,60~70℃烘干粉碎,再按浸膏˸蔗糖(v:w)等于1˸5的比例加入蔗糖,混匀,制粒,过10目(2000μm±70μm)筛,60℃烘干,再过10目(2000μm±70μm)筛。
这样设计的本发明对鸡大肠杆菌病具有较好的防治效果,方中金银花清热解毒,疏散风热;贯众清热解毒,凉血止血;鱼腥草清热解毒,利尿通淋;知母清热泻火;马齿苋清热解毒,凉血止血,止痢;栀子清热利湿,凉血解毒;甘草补脾益气,清热解毒,调和诸药。诸药合用,共奏清热解毒,凉血止血,立湿止痢之功效。同时中草药及中药复方制剂具有药物残留低、不易产生耐药性等优点,且应用后不影响动物性产品的食用安全性,有着广阔的发展前景。
具体实施方式
下面结合实施例对本发明进行详细的说明。
一、实施例
实施例1:称取金银花90g,贯众90g,鱼腥草90g,知母80g,马齿苋60g,栀子30g,甘草10g,将7味中草药混合加入4500ml的水,煎煮2次,每次1.5小时,合并煎液,滤过,浓缩至80℃时相对密度1.28的浸膏,60~70℃烘干后粉碎,加入450g蔗糖,混匀,制成颗粒过10目(2000μm±70μm)筛,60℃烘干,再过10目(2000μm±70μm)筛。
实施例2:称取金银花110g,贯众100g,鱼腥草100g,知母90g,马齿苋50g,栀子40g,甘草30g,将7味中草药混合加入5200ml的水,煎煮2次,每次1.5小时,合并煎液,滤过,浓缩至80℃时相对密度1.28的浸膏,60~70℃烘干后粉碎,加入520g 蔗糖,混匀,制成颗粒过10目(2000μm±70μm)筛,60℃烘干,再过10目(2000μm±70μm)筛。
实施例3:称取金银花120g,贯众110g,鱼腥草90g,知母80g,马齿苋60g,栀子50g,甘草20g,将7味中草药混合加入5300ml的水,煎煮2次,每次1.5小时,合并煎液,滤过,浓缩至80℃时相对密度1.28的浸膏,60~70℃烘干后粉碎,加入530g 蔗糖,混匀,制成颗粒过10目(2000μm±70μm)筛,60℃烘干,再过10目(2000μm±70μm)筛。
实施例4:称取金银花120g,贯众120g,鱼腥草90g,知母70g,马齿苋60g,栀子40g,甘草20g,将7味中草药混合加入5200ml的水,煎煮2次,每次1.5小时,合并煎液,滤过,浓缩至80℃时相对密度1.28的浸膏,60~70℃烘干后粉碎,加入520g 蔗糖,混匀,制成颗粒过10目(2000μm±70μm)筛,60℃烘干,再过10目(2000μm±70μm)筛。
二、临床试验
给药方式:将本发明所述中药颗粒剂兑水,按50g加入15kg水,搅匀,混饮,连续用药5天。
天津养殖户饲养的5000羽425日龄蛋鸡精神沉郁,排绿色水样粪便,并出现死亡。经临床检查、剖检及病原菌的分离鉴定,确诊为大肠杆菌病。从发病鸡群中挑选300羽鸡,分成两组,每组150羽,其中一组按照上述给药方式使用本药物,连续使用5天,另一组作为对照组,对各组死亡率、治愈率进行比较(表1)。
试验结果表明,本药物对鸡大肠杆菌具有很好的防治作用,且该药物为纯中药制剂,毒性小,副作用小,符合畜产品无公害化生产的要求。
Claims (3)
1.一种用于治疗鸡大肠杆菌病的中药颗粒剂,其特征在于:主要是由以下重量份的原料组成:
金银花 9-12份, 贯众 9-12份,
鱼腥草 8-10份, 知母 8-10份,
马齿苋 5-7份, 栀子 3-5份,
甘草 1-3份。
2.根据权利要求1所述的一种用于治疗鸡大肠杆菌病的中药颗粒剂,其特征在于:主要是由以下重量份的原料组成:
金银花 12份, 贯众 12份,
鱼腥草 9份, 知母 7份,
马齿苋 6份, 栀子 4份,
甘草 2份。
3. 一种如权利要求1所述的用于治疗鸡大肠杆菌病的中药颗粒剂的制备方法,其特征在于:将金银花9-12份,贯众9-12份,鱼腥草8-10份,知母8-10份,马齿苋5-7份,栀子3-5份,甘草1-3份,以上7味中药按比例混合,加8-12倍量的水,煎煮2-3次,每次1.5-2小时,将煎液合并且滤过,浓缩至80℃相对密度为1.28的浸膏,烘干粉碎,再按浸膏˸蔗糖等于1˸5的比例加入蔗糖,混匀,制粒,过10目筛,烘干,再过10目筛。
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CN103372075A (zh) * | 2012-04-11 | 2013-10-30 | 广东省农业科学院畜牧研究所 | 一种抗鸡大肠杆菌病的中药超微粉组合物及其制备方法 |
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