CN104367684A - Medicine and method applied to treatment of acne - Google Patents

Medicine and method applied to treatment of acne Download PDF

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Publication number
CN104367684A
CN104367684A CN201410697500.5A CN201410697500A CN104367684A CN 104367684 A CN104367684 A CN 104367684A CN 201410697500 A CN201410697500 A CN 201410697500A CN 104367684 A CN104367684 A CN 104367684A
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parts
medicine
acne
glycerol
cortex phellodendri
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曹新胜
王翔
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GUZHEN COUNTY PEOPLE'S HOSPITAL
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GUZHEN COUNTY PEOPLE'S HOSPITAL
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
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Abstract

The invention discloses a medicine and a method applied to treatment of acne. The medicine applied to treatment of acne is prepared by taking white vinegar and glycerol as main raw materials and taking egg white, white gourd juice, honeysuckle, cortex phellodendri, raw radix astragali, radix paeoniae rubra and fructus kochiae as auxiliary medicines. The medicine applied to treatment of acne comprises the following components in parts by weight: 100-200 parts of white vinegar, 50-100 parts of glycerol, 5-10 parts of egg white, 15-30 parts of white gourd juice, 5-10 parts of honeysuckle, 2-5 parts of cortex phellodendri, 5-10 parts of raw radix astragali, 5-10 parts of radix paeoniae rubra and 6-10 parts of fructus kochiae. The medicine applied to treatment of acne has the effects of reducing sebum secretion of sebaceous gland, inhibiting growth of bacteria in hair follicle, relieving scytitis reaction and facilitating adsorption and abreaction of red and swollen tubers of the hair follicle part; the satisfactory curative effect is achieved in clinic.

Description

A kind of medicine of Acne treatment and method
Technical field
The present invention relates to medicine and the manufacture method for the treatment of by Chinese herbs acne, belong to field of Chinese herbal medicine technology, specifically a kind of medicine of Acne treatment and method.
Background technology
Acne is that the chronic inflammatory skin of a kind of hair follicle and sebaceous gland is sick, frequently-occurring disease is in adolescence, modern medicine study thinks that acne is under the condition of inherited genetic factors, and effect two the aspect factors increasing the microorganisms such as the corynebacterium acnes in (dihydrotestosterone especially in skin histology is increased) and follicular orifice due to androgen secretion cause.The traditional Chinese medical science thinks face nose and thoracic dorsal subordinate lung, causes the reason of acne to be hinder caused by the skin by wind and heat in the lung meridian; Or because of surfeit delicious food, greasy, maror, taste intrinsic heat, damp and hot interior life, fumigates and forms in face.The defects such as medically there is no effective Therapeutic Method to acne at present, mainly use the western medicines such as tetracycline, metronidazole, tretinoin, there is uncertain therapeutic efficacy cuts, and the course for the treatment of is long, large, the easy recurrence of side effect.
Summary of the invention
The Chinese medicinal porridge that the object of the present invention is to provide a kind for the treatment of to suffer from a deficiency of the kidney and manufacture method.
Object of the present invention can be achieved through the following technical solutions:
A kind of medicine of Acne treatment and method, the medicine of described a kind of Acne treatment with white vinegar, glycerol for main material, to be made for ancillary drug containing Ovum Gallus domesticus album, Fructus Benincasae juice, Flos Lonicerae, Cortex Phellodendri, Radix Astragali, Radix Paeoniae Rubra, the Fructus Kochiae, there is the component of following weight portion: white vinegar 100-200 part, glycerol 50-100 part, Ovum Gallus domesticus album 5-10 part, Fructus Benincasae juice 15-30 part, Flos Lonicerae 5-10 part, Cortex Phellodendri 2-5 part, Radix Astragali 5-10 part, Radix Paeoniae Rubra 5-10 part and Fructus Kochiae 6-10 part.
The medicine of described a kind of Acne treatment with white vinegar, glycerol for main material, to be made for ancillary drug containing Ovum Gallus domesticus album, Fructus Benincasae juice, Flos Lonicerae, Cortex Phellodendri, Radix Astragali, Radix Paeoniae Rubra, the Fructus Kochiae, there is the component of following weight portion: white vinegar 200 parts, glycerol 100 parts, Ovum Gallus domesticus album 10 parts, Fructus Benincasae juice 20 parts, Flos Lonicerae 10 parts, Cortex Phellodendri 3 parts, Radix Astragali 5 parts, Radix Paeoniae Rubra 5 parts and the Fructus Kochiae 6 parts.
The medicine of described a kind of Acne treatment and method, the method specifically comprises the following steps:
A, selected medical material: in components by weight percent, Fructus Benincasae juice 15-30 part, Flos Lonicerae 5-10 part, Cortex Phellodendri 2-5 part, Radix Astragali 5-10 part, Radix Paeoniae Rubra 5-10 part and Fructus Kochiae 6-10 part;
B, medicine decoct: medical material mixing step " a " selected adds the water of 20-40 times of medical material amount, soaks after 3-5 hour, and intense fire decocts boiling 30 minutes, then uses slow fire boiling 30-40 minute, filters to obtain decoction liquor, and it is for subsequent use that taking-up decoction liquor is contained in container;
C, medical material hybrid filtering: decoction liquor step " b " obtained adds the Ovum Gallus domesticus album 10 parts got ready and stirs, collect the water cooking liquid be stirred above and merge, filter, place precipitation 12 hours through the beautiful yarn of 50-60 order, obtained supernatant;
D, making patent medicine: the supernatant 50-80 part of getting step " c ", obtains main material glycerol 50-100 part simultaneously.White vinegar 100-200 part, by weight 1: 1: 2 mixing, obtained liquid medicine, every day is sprayed at acne spots three times, ten minutes afterwash.
Beneficial effect of the present invention: the present invention adopts the defects such as common pure Chinese medicine makes, and scientific and reasonable, expense is low, good effect, short treating period, easy to use, not easily recurs, customer service western medicine, and there is uncertain therapeutic efficacy and cut, the course for the treatment of is long, large, the easy recurrence of side effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
The medicine of Acne treatment and a method, the method specifically comprises the following steps:
A, selected medical material: in components by weight percent, Fructus Benincasae juice 15 parts, Flos Lonicerae 5 parts, Cortex Phellodendri 2 parts, Radix Astragali 5 parts, Radix Paeoniae Rubra 5 parts and the Fructus Kochiae 6 parts;
B, medicine decoct: medical material mixing step " a " selected adds the water of 30 times of medical material amounts, soaks after 3-5 hour, and intense fire decocts boiling 30 minutes, then uses slow fire boiling 35 minutes, filters to obtain decoction liquor, and it is for subsequent use that taking-up decoction liquor is contained in container;
C, medical material hybrid filtering: decoction liquor step " b " obtained adds the Ovum Gallus domesticus album 10 parts got ready and stirs, collect the water cooking liquid be stirred above and merge, filter, place precipitation 12 hours through the beautiful yarn of 50-60 order, obtained supernatant;
D, making patent medicine: the supernatant 50 parts getting step " c ", obtains main material glycerol 50 parts simultaneously.White vinegar 100 parts, by weight 1: 1: 2 mixing, obtained liquid medicine, every day is sprayed at acne spots three times, ten minutes afterwash.
Clinical experiment:
1. physical data
Selected 150 routine cases are the patient being diagnosed as acne at hospital outpatient, and the age is between 13 years old ~ 30 years old.20 examples within the course of disease 1 year, 1 ~ 2 year 49 example, 2 ~ 4 years 56 examples, more than 4 years 35 routine.Mostly once with Chinese and western drugs treatment, poor effect, or easily recur.
2. diagnostic criteria
Canonical reference Pill Sburv and international improvement acne staging, Zhao distinguish show " clinical dermatology " second edition.Acne vulgaris diagnostic criteria pubarche, falls ill, and is apt to occur in the flourishing position of face, upper breast and back sebaceous gland, symmetrical.Skin lesion is pityriasis rubra pimple, black acne, pustule, tuberosity, cyst and cicatrix, with seborrhea, in chronic process.
3. clinical weight classification
Slight: main skin lesion is blackhead, and be distributed to multiple, inflamed papules distributes.Total focus number 10 ~ 30.Lighter moderate: main skin lesion is acne, and has pimple and the potentiality pustule of moderate quatity, and total focus number 31 ~ 50, is confined to face.Heavier moderate: main skin lesion is dark in property inflammatory papules and pustule, and total focus number 50 ~ 100, tuberosity < 3, betides face, cervical region, chest and back.Severe: skin lesion to be that total focus number > 100, tuberosity/cyst > 3, easily forms cicatrix deeply at property inflammatory papules and pustule, betide above the waist.
4. Therapeutic Method
Morning, noon and afternoon every day respectively once, are sprayed at acne growth site, with warm water cleaning after ten minutes, adhere to 1-3 month.
In order to upper Regimen Chemotherapy 1-3 month, treatment 150 routine acne patients, cure rate 81.33%, effective percentage 96.66%, follow up a case by regular visits to and do not recur for 1 year, treatment situation sees the following form:
Calibration Number of cases Cure Effective Effectively Invalid Effective percentage
Slightly 44 40 4 0 0 100%
Lighter moderate 36 32 3 1 0 100%
Heavier moderate 40 33 5 2 2 95%
Severe 30 18 6 6 3 90%
Add up to 150 122 18 9 5 96.7%
Above-mentioned specific embodiment is only concrete case of the present invention; scope of patent protection of the present invention includes but not limited to above-mentioned specific embodiment; any meet claims of the present invention and any person of an ordinary skill in the technical field to its suitable change done or modification, all should fall into scope of patent protection of the present invention.

Claims (3)

1. the medicine of an Acne treatment and method, it is characterized in that, the medicine of described a kind of Acne treatment with white vinegar, glycerol for main material, to be made for ancillary drug containing Ovum Gallus domesticus album, Fructus Benincasae juice, Flos Lonicerae, Cortex Phellodendri, Radix Astragali, Radix Paeoniae Rubra, the Fructus Kochiae, there is the component of following weight portion: white vinegar 100-200 part, glycerol 50-100 part, Ovum Gallus domesticus album 5-10 part, Fructus Benincasae juice 15-30 part, Flos Lonicerae 5-10 part, Cortex Phellodendri 2-5 part, Radix Astragali 5-10 part, Radix Paeoniae Rubra 5-1 part and Fructus Kochiae 6-10 part.
2. the medicine of a kind of Acne treatment according to claim 1 and method, it is characterized in that, the medicine of described a kind of Acne treatment with white vinegar, glycerol for main material, to be made for ancillary drug containing Ovum Gallus domesticus album, Fructus Benincasae juice, Flos Lonicerae, Cortex Phellodendri, Radix Astragali, Radix Paeoniae Rubra, the Fructus Kochiae, there is the component of following weight portion: white vinegar 200 parts, glycerol 100 parts, Ovum Gallus domesticus album 10 parts, Fructus Benincasae juice 20 parts, Flos Lonicerae 10 parts, Cortex Phellodendri 3 parts, Radix Astragali 5 parts, Radix Paeoniae Rubra 5 parts and the Fructus Kochiae 6 parts.
3. the medicine of a kind of Acne treatment according to claim 1-2 any one and method, it is characterized in that, the method specifically comprises the following steps:
A, selected medical material: in components by weight percent, Fructus Benincasae juice 15-30 part, Flos Lonicerae 5-10 part, Cortex Phellodendri 2-5 part, Radix Astragali 5-10 part, Radix Paeoniae Rubra 5-10 part and Fructus Kochiae 6-10 part;
B, medicine decoct: medical material mixing step " a " selected adds the water of 20-40 times of medical material amount, soaks after 3-5 hour, and intense fire decocts boiling 30 minutes, then uses slow fire boiling 30-40 minute, filters to obtain decoction liquor, and it is for subsequent use that taking-up decoction liquor is contained in container;
C, medical material hybrid filtering: decoction liquor step " b " obtained adds the Ovum Gallus domesticus album 10 parts got ready and stirs, collect the water cooking liquid be stirred above and merge, filter, place precipitation 12 hours through the beautiful yarn of 50-60 order, obtained supernatant;
D, making patent medicine: the supernatant 50-80 part of getting step " c ", obtains main material glycerol 50-100 part simultaneously.White vinegar 100-200 part, by weight 1: 1: 2 mixing, obtained liquid medicine, every day is sprayed at acne spots three times, ten minutes afterwash.
CN201410697500.5A 2014-11-27 2014-11-27 Medicine and method applied to treatment of acne Pending CN104367684A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105055608A (en) * 2015-07-17 2015-11-18 柳培健 Medicine for treating acne
CN112972328A (en) * 2021-02-25 2021-06-18 云南贝泰妮生物科技集团股份有限公司 Phellodendron and liquorice acne-removing plant composition and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
何跃青主编: "《汉方祛斑美白秘笈》", 30 June 2012 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105055608A (en) * 2015-07-17 2015-11-18 柳培健 Medicine for treating acne
CN112972328A (en) * 2021-02-25 2021-06-18 云南贝泰妮生物科技集团股份有限公司 Phellodendron and liquorice acne-removing plant composition and application thereof

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