CN104352998A - 一种治疗重度失眠的中药组合物 - Google Patents

一种治疗重度失眠的中药组合物 Download PDF

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CN104352998A
CN104352998A CN201410746076.9A CN201410746076A CN104352998A CN 104352998 A CN104352998 A CN 104352998A CN 201410746076 A CN201410746076 A CN 201410746076A CN 104352998 A CN104352998 A CN 104352998A
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parts
grams
radix
rhizoma
chinese medicine
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杨其义
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Abstract

本发明公开了一种治疗重度失眠的中药组合物，由以下药材制备成：珍珠母、龙骨、牡蛎、酸枣仁、藿香、半夏、陈皮、竹茹、黄连、肉桂、白芍、生地、熟地、当归、硫黄菌、川芎、桃仁、红花、绿萼梅、杏仁、石菖蒲、郁金、白豆蔻、厚朴、远志、竹叶、通草、牛角藓、滑石、磁石、斑花杓兰、焦枣仁、百合、合欢皮、高粱、夜交藤、枸杞子、仙灵脾、柏子仁、石斛、白术、党参、黄芪、茯苓、丹参、山栀子、淡豆豉、天竺黄、知母、琥珀、桑椹子、徐长卿、黄芩、鸡子黄、黄连。临床实验证明，本发明能够安全有效的治疗重度失眠。

Description

一种治疗重度失眠的中药组合物
技术领域
本发明涉及一种中药领域，特别是一种治疗重度失眠的中药组合物。 
背景技术
失眠即睡眠失常。重度失眠情况则大多表现为彻夜不寐，而且其病程明显要比轻度失眠的病程长。表现为入睡困难，断断续续不连贯，而过早地醒来，醒后不能再继续睡，有睡眠不足，全身乏力。失眠是由于情志、饮食内伤，或病后及年迈，禀赋不足，心虚胆怯等病因，引起心神失养或心神不安，从而导致经常不能获得正常睡眠为特征的一类病症。主要表现为睡眠时间深度的不足、以及不能消除疲劳、恢复体力与精力，轻者入睡困难，或寐而不酣，时寐时醒，或醒后不能再寐，重则彻夜不寐。失眠是临床常见病症之一，虽不属于危重疾病，但妨碍人们正常生活、工作、学习和健康，并能加重或诱发心悸、胸痹、眩晕、头痛、中风病等病症。重度失眠，给病人带来长期的痛苦，甚至形成对安眠药物的依赖，而长期服用安眠药物又可引起医源性疾病。 
失眠在《内经》中称为“目不瞑”、“不得眠”、“不得卧”，并认为失眠原因主要有两种：一是其他病症影响，如咳嗽、呕吐、腹满等，使人不得安卧；二是气血阴阳失和，使人不能入寐。 
目前，用于治疗重度失眠的药物较多，多以西药类催眠镇静药和抗焦虑药为主，存在治疗效果较差、治疗时间长、副作用大等不足。 
发明内容
本发明要解决的问题是：提供一种治疗重度失眠的中药组合物，通过选择合适的药材及其配比，达到安全有效治愈重度失眠的目的。 
为了解决上述技术问题，本发明采用以下技术方案： 
一种治疗重度失眠的中药组合物，其特征在于，它是由以下重量份数配比的药材制备成：珍珠母20-30份、龙骨12-18份、牡蛎12-18份、酸枣仁12-18份、藿香8-12份、半夏8-10份、陈皮8-10份、竹茹8-12份、黄连8-10份、肉桂1-3份、白芍10-15份、生地10-15份、熟地12-18份、当归8-12份、硫黄菌10-15份、川芎8-12份、桃仁8-12份、红花8-12份、绿萼梅10-15份、杏仁10-15份、石菖蒲10-15份、郁金10-15份、白豆蔻6-9份、厚朴5-8份、远志6-10份、竹叶8-10份、通草8-12份、牛角藓10-15份、滑石12-18份、磁石22-28份、斑花杓兰10-15份、焦枣仁22-28份、百合12-18份、合欢皮12-18份、高粱10-15份、夜交藤10-15份、枸杞子12-18份、仙灵脾12-18份、柏子仁 12-18份、石斛10-15份、白术8-12份、党参10-15份、黄芪10-15份、茯苓10-15份、丹参12-18份、山栀子8-12份、淡豆豉8-12份、天竺黄3-6份、知母3-6份、琥珀(冲服)5-8份、桑椹子10-15份、徐长卿10-15份、黄芩10-15份、鸡子黄2-5枚、黄连2-5份。 
所述治疗重度失眠的中药组合物，其特征在于，它是由以下重量份数配比的药材制备成：珍珠母25份、龙骨15份、牡蛎15份、酸枣仁15份、藿香10份、半夏9份、陈皮9份、竹茹10份、黄连9份、肉桂2份、白芍12份、生地12份、熟地15份、当归10份、硫黄菌12份、川芎10份、桃仁10份、红花10份、绿萼梅12份、杏仁12份、石菖蒲12份、郁金12份、白豆蔻8份、厚朴6份、远志8份、竹叶10份、通草10份、牛角藓12份、滑石15份、磁石25份、斑花杓兰12份、焦枣仁25份、百合15份、合欢皮15份、高粱12份、夜交藤12份、枸杞子15份、仙灵脾15份、柏子仁15份、石斛12份、白术10份、党参12份、黄芪12份、茯苓12份、丹参15份、山栀子10份、淡豆豉10份、天竺黄5份、知母5份、琥珀(冲服)6份、桑椹子12份、徐长卿12份、黄芩12份、鸡子黄3枚、黄连3份。 
所述的治疗重度失眠的中药组合物的制备方法是：由所述中药组合物按常规方法制成汤剂、胶囊剂、散剂或颗粒剂。 
用法及用量：本发明的中药组合物以汤剂为主，每日1付，分2次服用，早、晚各服用1次，30天为1个疗程，一般3-6个疗程即可治愈；也可将其制成胶囊剂、散剂或颗粒剂。 
本发明与现有技术相比所具有的有益效果是：本发明是在传统中医理论和临床经验指导下，精选出各原料药及其配比，通过清热泻火、疏肝降逆，滋阴、理气解郁、清心宁神、调和肝脾、调理脏腑、扶正气、提高机体抗病能力、增强自身免疫功能全方位综合系统的治疗重度失眠；本发明具有疗效显著、见效快、无毒副作用、制备方法简单等优点，经临床验证，本发明治疗重度失眠有效率95％。 
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。 
具体实施例1 
1)、汤剂的制备方法：第一步称取琥珀6克，粉碎成琥珀粉，分成均匀的2份：第二步称取珍珠母25克、龙骨15克、牡蛎15克、酸枣仁15克、藿香10克、半夏9克、陈皮9克、竹茹10克、黄连9克、肉桂2克、白芍12克、生地12克、熟地15克、当归10克、硫黄菌12克、川芎10克、桃仁10克、红花10克、绿萼梅12克、杏仁12克、石菖蒲12克、郁金12克、白豆蔻8克、厚朴6克、远志8克、竹叶10克、通草10克、牛角藓12克、滑石15克、磁石25克、斑花杓兰12克、焦枣仁25克、百合15克、合欢 皮15克、高粱12克、夜交藤12克、枸杞子15克、仙灵脾15克、柏子仁15克、石斛12克、白术10克、党参12克、黄芪12克、茯苓12克、丹参15克、山栀子10克、淡豆豉10克、天竺黄5克、知母5克、桑椹子12克、徐长卿12克、黄芩12克、鸡子黄3枚、黄连3克。用传统的煎药方法，把药物放入药锅中加入适量的水浸泡1小时，用武火煮沸以后再用中火煮20-30分钟，把药汁倒出，再放适量的水用武火煮沸后中火煎煮15-20分，倒出药汁，2次药汁混合后分2份；第三步：用第二步中的药汁冲服第一步中的琥珀粉，早晚各一次服用。 
2)、胶囊剂的制备方法：第一步称取琥珀6克，粉碎成琥珀粉；第二步称取珍珠母25克、龙骨15克、牡蛎15克、酸枣仁15克、藿香10克、半夏9克、陈皮9克、竹茹10克、黄连9克、肉桂2克、白芍12克、生地12克、熟地15克、当归10克、硫黄菌12克、川芎10克、桃仁10克、红花10克、绿萼梅12克、杏仁12克、石菖蒲12克、郁金12克、白豆蔻8克、厚朴6克、远志8克、竹叶10克、通草10克、牛角藓12克、滑石15克、磁石25克、斑花杓兰12克、焦枣仁25克、百合15克、合欢皮15克、高粱12克、夜交藤12克、枸杞子15克、仙灵脾15克、柏子仁15克、石斛12克、白术10克、党参12克、黄芪12克、茯苓12克、丹参15克、山栀子10克、淡豆豉10克、天竺黄5克、知母5克、桑椹子12克、徐长卿12克、黄芩12克、鸡子黄3枚、黄连3克。把药物放入药锅中加10倍量水，煎煮1小时，过滤；滤渣加8倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥成中药粉；第三步：将第一步中的琥珀粉和第二步中的中药粉混合均匀，装入空胶囊中，即得符合正常成人一天用量的胶囊剂。 
用于治疗重度失眠。口服，每日分早晚两次服用。 
3)、散剂的制备方法：第一步称取琥珀6克，粉碎成琥珀粉；第二步称取珍珠母25克、龙骨15克、牡蛎15克、酸枣仁15克、藿香10克、半夏9克、陈皮9克、竹茹10克、黄连9克、肉桂2克、白芍12克、生地12克、熟地15克、当归10克、硫黄菌12克、川芎10克、桃仁10克、红花10克、绿萼梅12克、杏仁12克、石菖蒲12克、郁金12克、白豆蔻8克、厚朴6克、远志8克、竹叶10克、通草10克、牛角藓12克、滑石15克、磁石25克、斑花杓兰12克、焦枣仁25克、百合15克、合欢皮15克、高粱12克、夜交藤12克、枸杞子15克、仙灵脾15克、柏子仁15克、石斛12克、白术10克、党参12克、黄芪12克、茯苓12克、丹参15克、山栀子10克、淡豆豉10克、天竺黄5克、知母5克、桑椹子12克、徐长卿12克、黄芩12克、鸡子黄3枚、黄连3克。把药物放入药锅中加12倍量水，煎煮2小时，过滤；滤渣加10倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥中药粉；第三步：将第一步中的琥珀粉和第二步中的中药粉混合均匀，包装，即得符合正常成人一天用量的散剂。 
用于治疗重度失眠。口服，每日分早晚两次服用。 
4)、颗粒剂的制备方法：第一步称取琥珀6克，粉碎成琥珀粉；第二步称取珍珠母25克、龙骨15克、牡蛎15克、酸枣仁15克、藿香10克、半夏9克、陈皮9克、竹茹10克、黄连9克、肉桂2克、白芍12克、生地12克、熟地15克、当归10克、硫黄菌12克、川芎10克、桃仁10克、红花10克、绿萼梅12克、杏仁12克、石菖蒲12克、郁金12克、白豆蔻8克、厚朴6克、远志8克、竹叶10克、通草10克、牛角藓12克、滑石15克、磁石25克、斑花杓兰12克、焦枣仁25克、百合15克、合欢皮15克、高粱12克、夜交藤12克、枸杞子15克、仙灵脾15克、柏子仁15克、石斛12克、白术10克、党参12克、黄芪12克、茯苓12克、丹参15克、山栀子10克、淡豆豉10克、天竺黄5克、知母5克、桑椹子12克、徐长卿12克、黄芩12克、鸡子黄3枚、黄连3克。把药物放入药锅中加8倍量水，煎煮2小时，过滤；滤渣加6倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥中药粉；第三步：将第一步中的琥珀粉和第二步中的中药粉混合均匀，再加入适量的糊精和矫味剂，按照本领域常规工艺制粒，包装，即得符合正常成人一天用量的颗粒剂。 
用于治疗重度失眠。口服，每日分早晚两次服用。 
具体实施例2 
称取珍珠母20克、龙骨12克、牡蛎12克、酸枣仁12克、藿香8克、半夏8克、陈皮8克、竹茹8克、黄连8克、肉桂1克、白芍10克、生地10克、熟地12克、当归8克、硫黄菌10克、川芎8克、桃仁8克、红花8克、绿萼梅10克、杏仁10克、石菖蒲10克、郁金10克、白豆蔻6克、厚朴5克、远志6克、竹叶8克、通草8克、牛角藓10克、滑石12克、磁石22克、斑花杓兰10克、焦枣仁22克、百合12克、合欢皮12克、高粱10克、夜交藤10克、枸杞子12克、仙灵脾12克、柏子仁12克、石斛10克、白术8克、党参10克、黄芪10克、茯苓10克、丹参12克、山栀子8克、淡豆豉8克、天竺黄3克、知母3克、琥珀(冲服)5克、桑椹子10克、徐长卿10克、黄芩10克、鸡子黄2枚、黄连2克。 
按照实施例1的方法制备成汤剂、胶囊剂、散剂或颗粒剂。 
具体实施例3 
称取珍珠母30克、龙骨18克、牡蛎18克、酸枣仁18克、藿香12克、半夏10克、陈皮10克、竹茹12克、黄连10克、肉桂3克、白芍15克、生地15克、熟地18克、当归12克、硫黄菌15克、川芎12克、桃仁12克、红花12克、绿萼梅15克、杏仁15克、石菖蒲15克、郁金15克、白豆蔻9克、厚朴8克、远志10克、竹叶10克、通草12克、牛角藓15克、滑石18克、磁石28克、斑花杓兰15克、焦枣仁28克、百合18克、合欢 皮18克、高粱15克、夜交藤15克、枸杞子18克、仙灵脾18克、柏子仁18克、石斛15克、白术12克、党参15克、黄芪15克、茯苓15克、丹参18克、山栀子12克、淡豆豉12克、天竺黄6克、知母6克、琥珀(冲服)8克、桑椹子15克、徐长卿15克、黄芩15克、鸡子黄5枚、黄连5克。 
按照实施例1的方法制备成汤剂、胶囊剂、散剂或颗粒剂。 
实验例： 
1)临床资料：本发明共治疗重度失眠患者60例，其中男29例，女31例，年龄为38-65岁。 
2)治疗方法：本发明的中药组合物以汤剂为主，每日1付，分2次服用，早、晚各服用1次30天为1个疗程，一般3-6个疗程即可治愈；也可将其制成胶囊剂、散剂或颗粒剂。 
3)疗效评价标准： 
治愈：症状消失，实验室检查正常； 
好转：症状明显改善，实验室检查有改善； 
未愈：主症未改善，实验室检查未改善。 
4)治疗结果：本发明共治疗重度失眠患者60例，经过3-6个疗程的治疗，治愈51例，占85％，好转6例，占10％，未愈3例，占5％，有效率为95％。 
5)典型病例： 
1、宋某，男，39岁，患重度失眠多年，服用多种西药，疗效不佳，服用本发明的中药组合物3个疗程后好转，服用6个疗程治愈，随访至今未复发。 
2、范某某，女，42岁，患重度失眠3年，经多方治疗，不见效果，服用本发明的中药组合物2个疗程后好转，服用5个疗程治愈，3年未复发。 
3、张某，女，57岁，患重度失眠5年，经多方治疗无效，服用本发明的中药组合物2个疗程后好转，服用5个疗程治愈，加服一个疗程巩固，随访至今未复发。 
4、刘某，女，62岁，患重度失眠2年，一直服用西药，效果不好，服用本发明的中药组合物2个疗程后好转，服用5个疗程治愈，随访至今未复发。 
经过大量的临床医疗实践证明，本发明治疗重度失眠的中药组合物，属于纯中药制剂，对人体毒、副作用小，对治疗重度失眠具有可靠、安全、显著的治疗效果。 

Claims (3)

1.一种治疗重度失眠的中药组合物，其特征在于，它是由以下重量份数配比的药材制备成：珍珠母20-30份、龙骨12-18份、牡蛎12-18份、酸枣仁12-18份、藿香8-12份、半夏8-10份、陈皮8-10份、竹茹8-12份、黄连8-10份、肉桂1-3份、白芍10-15份、生地10-15份、熟地12-18份、当归8-12份、硫黄菌10-15份、川芎8-12份、桃仁8-12份、红花8-12份、绿萼梅10-15份、杏仁10-15份、石菖蒲10-15份、郁金10-15份、白豆蔻6-9份、厚朴5-8份、远志6-10份、竹叶8-10份、通草8-12份、牛角藓10-15份、滑石12-18份、磁石22-28份、斑花杓兰10-15份、焦枣仁22-28份、百合12-18份、合欢皮12-18份、高粱10-15份、夜交藤10-15份、枸杞子12-18份、仙灵脾12-18份、柏子仁12-18份、石斛10-15份、白术8-12份、党参10-15份、黄芪10-15份、茯苓10-15份、丹参12-18份、山栀子8-12份、淡豆豉8-12份、天竺黄3-6份、知母3-6份、琥珀(冲服)5-8份、桑椹子10-15份、徐长卿10-15份、黄芩10-15份、鸡子黄2-5枚、黄连2-5份。
2.根据权利要求1所述的治疗重度失眠的中药组合物，其特征在于，它是由以下重量份数配比的药材制备成：珍珠母25份、龙骨15份、牡蛎15份、酸枣仁15份、藿香10份、半夏9份、陈皮9份、竹茹10份、黄连9份、肉桂2份、白芍12份、生地12份、熟地15份、当归10份、硫黄菌12份、川芎10份、桃仁10份、红花10份、绿萼梅12份、杏仁12份、石菖蒲12份、郁金12份、白豆蔻8份、厚朴6份、远志8份、竹叶10份、通草10份、牛角藓12份、滑石15份、磁石25份、斑花杓兰12份、焦枣仁25份、百合15份、合欢皮15份、高粱12份、夜交藤12份、枸杞子15份、仙灵脾15份、柏子仁15份、石斛12份、白术10份、党参12份、黄芪12份、茯苓12份、丹参15份、山栀子10份、淡豆豉10份、天竺黄5份、知母5份、琥珀(冲服)6份、桑椹子12份、徐长卿12份、黄芩12份、鸡子黄3枚、黄连3份。
3.一种治疗重度失眠的中药组合物的制备方法，其特征在于，由权利要求1或2所述的治疗重度失眠的中药组合物按常规方法制成汤剂、胶囊剂、散剂或颗粒剂。
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