CN104435891A - 一种治疗顽固性失眠的中药组合物 - Google Patents

一种治疗顽固性失眠的中药组合物 Download PDF

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CN104435891A
CN104435891A CN201410742807.2A CN201410742807A CN104435891A CN 104435891 A CN104435891 A CN 104435891A CN 201410742807 A CN201410742807 A CN 201410742807A CN 104435891 A CN104435891 A CN 104435891A
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chinese medicine
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杨其义
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Abstract

本发明公开了一种治疗顽固性失眠的中药组合物，由以下药材制备成：当归、茯苓、龙骨、牡蛎、夜交藤、浮小麦、党参、桑白皮、珍珠母、玄参、丹参、麦冬、百合、琥珀、大枣、花生嫩叶、绿萼梅、薏苡仁、茯神、槭叶草、赤小豆、斑花杓兰、合欢皮、梅花参、艾叶、高粱、瓜子金、石菖蒲、牛角藓、元胡、酸枣仁、人参叶、生地、陈皮、青皮、桃仁、桔梗、远志、五味子、朱砂、赤芍、柴胡、木通、制半夏、苏子、香附、大腹皮、甘草。临床实验证明，本发明能够安全有效的治疗顽固性失眠。

Description

一种治疗顽固性失眠的中药组合物
技术领域
本发明涉及一种中药领域，特别是一种治疗顽固性失眠的中药组合物。 
背景技术
失眠即睡眠失常。顽固性失眠情况则大多表现为彻夜不寐，而且其病程明显要比轻度失眠的病程长。表现为入睡困难，断断续续不连贯，而过早地醒来，醒后不能再继续睡，有睡眠不足，全身乏力。失眠是由于情志、饮食内伤，或病后及年迈，禀赋不足，心虚胆怯等病因，引起心神失养或心神不安，从而导致经常不能获得正常睡眠为特征的一类病症。主要表现为睡眠时间深度的不足、以及不能消除疲劳、恢复体力与精力，轻者入睡困难，或寐而不酣，时寐时醒，或醒后不能再寐，重则彻夜不寐。失眠是临床常见病症之一，虽不属于危重疾病，但妨碍人们正常生活、工作、学习和健康，并能加重或诱发心悸、胸痹、眩晕、头痛、中风病等病症。顽固性失眠，给病人带来长期的痛苦，甚至形成对安眠药物的依赖，而长期服用安眠药物又可引起医源性疾病。 
失眠在《内经》中称为“目不瞑”、“不得眠”、“不得卧”，并认为失眠原因主要有两种：一是其他病症影响，如咳嗽、呕吐、腹满等，使人不得安卧；二是气血阴阳失和，使人不能入寐。 
目前，用于治疗顽固性失眠的药物较多，多以西药类催眠镇静药和抗焦虑药为主，存在治疗效果较差、治疗时间长、副作用大等不足。 
发明内容
本发明要解决的问题是：提供一种治疗顽固性失眠的中药组合物，通过选择合适的药材及其配比，达到安全有效治愈顽固性失眠的目的。 
为了解决上述技术问题，本发明采用以下技术方案： 
一种治疗顽固性失眠的中药组合物，其特征在于，它是由以下重量份数配比的药材制备成：当归12-18份、茯苓12-18份、龙骨18-22份、牡蛎18-22份、夜交藤18-22份、浮小麦25-35份、党参12-18份、桑白皮12-18份、珍珠母18-22份、玄参8-12份、丹参10-15份、麦冬10-15份、百合10-15份、琥珀(冲服)3-6份、大枣8-12份、花生嫩叶25-35份、绿萼梅10-15份、薏苡仁12-18份、茯神10-15份、槭叶草10-15份、赤小豆18-25份、斑花杓兰10-15份、合欢皮12-18份、梅花参10-15份、艾叶8-10份、高粱10-15份、瓜子金10-15份、石菖蒲10-15份、牛角藓10-15份、元胡8-10份、酸枣仁12-18份、人参叶10-15份、生地8-10份、陈皮12-18份、青皮10-15份、桃仁12-18份、桔梗8-12 份、远志8-12份、五味子8-12份、朱砂3-6份、赤芍12-18份、柴胡10-15份、木通10-15份、制半夏8-10份、苏子10-15份、香附15-20份、大腹皮10-15份、甘草8-12份。 
所述治疗顽固性失眠的中药组合物，其特征在于，它是由以下重量份数配比的药材制备成：当归15份、茯苓15份、龙骨20份、牡蛎20份、夜交藤20份、浮小麦30份、党参15份、桑白皮15份、珍珠母20份、玄参10份、丹参12份、麦冬12份、百合12份、琥珀(冲服)5份、大枣10份、花生嫩叶30份、绿萼梅12份、薏苡仁15份、茯神12份、槭叶草12份、赤小豆20份、斑花杓兰12份、合欢皮15份、梅花参12份、艾叶9份、高粱12份、瓜子金12份、石菖蒲12份、牛角藓12份、元胡9份、酸枣仁15份、人参叶12份、生地9份、陈皮15份、青皮12份、桃仁15份、桔梗10份、远志10份、五味子10份、朱砂5份、赤芍15份、柴胡12份、木通12份、制半夏9份、苏子12份、香附18份、大腹皮12份、甘草10份。 
所述的治疗顽固性失眠的中药组合物的制备方法是：由所述中药组合物按常规方法制成汤剂、胶囊剂、散剂或颗粒剂。 
用法及用量：本发明的中药组合物以汤剂为主，每日1付，分2次服用，早、晚各服用1次，30天为1个疗程，一般3-6个疗程即可治愈；也可将其制成胶囊剂、散剂或颗粒剂。 
本发明与现有技术相比所具有的有益效果是：本发明是在传统中医理论和临床经验指导下，精选出各原料药及其配比，通过清热泻火、疏肝降逆，滋阴、理气解郁、清心宁神、调和肝脾、调理脏腑、扶正气、提高机体抗病能力、增强自身免疫功能全方位综合系统的治疗顽固性失眠；本发明具有疗效显著、见效快、无毒副作用、制备方法简单等优点，经临床验证，本发明治疗顽固性失眠有效率95￥。 
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。 
具体实施例1 
1)、汤剂的制备方法：第一步称取琥珀5克，粉碎成琥珀粉，分成均匀的2份：第二步称取当归15克、茯苓15克、龙骨20克、牡蛎20克、夜交藤20克、浮小麦30克、党参15克、桑白皮15克、珍珠母20克、玄参10克、丹参12克、麦冬12克、百合12克、大枣10克、花生嫩叶30克、绿萼梅12克、薏苡仁15克、茯神12克、槭叶草12克、赤小豆20克、斑花杓兰12克、合欢皮15克、梅花参12克、艾叶9克、高粱12克、瓜子金12克、石菖蒲12克、牛角藓12克、元胡9克、酸枣仁15克、人参叶12克、生地9克、陈皮15克、青皮12克、桃仁15克、桔梗10克、远志10克、五味子10克、朱砂5克、赤芍15克、柴胡12克、木通12克、制半夏9克、苏子12克、香附18克、大腹皮12克、甘草10克。用传统的煎药方法，把药物放入药锅中加入适量的水浸泡1小时，用 武火煮沸以后再用中火煮20-30分钟，把药汁倒出，再放适量的水用武火煮沸后中火煎煮15-20分，倒出药汁，2次药汁混合后分2份；第三步：用第二步中的药汁冲服第一步中的琥珀粉，早晚各一次服用。 
2)、胶囊剂的制备方法：第一步称取琥珀5克，粉碎成琥珀粉；第二步称取当归15克、茯苓15克、龙骨20克、牡蛎20克、夜交藤20克、浮小麦30克、党参15克、桑白皮15克、珍珠母20克、玄参10克、丹参12克、麦冬12克、百合12克、大枣10克、花生嫩叶30克、绿萼梅12克、薏苡仁15克、茯神12克、槭叶草12克、赤小豆20克、斑花杓兰12克、合欢皮15克、梅花参12克、艾叶9克、高粱12克、瓜子金12克、石菖蒲12克、牛角藓12克、元胡9克、酸枣仁15克、人参叶12克、生地9克、陈皮15克、青皮12克、桃仁15克、桔梗10克、远志10克、五味子10克、朱砂5克、赤芍15克、柴胡12克、木通12克、制半夏9克、苏子12克、香附18克、大腹皮12克、甘草10克。把药物放入药锅中加10倍量水，煎煮1小时，过滤；滤渣加8倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥成中药粉；第三步：将第一步中的琥珀粉和第二步中的中药粉混合均匀，装入空胶囊中，即得符合正常成人一天用量的胶囊剂。 
用于治疗顽固性失眠。口服，每日分早晚两次服用。 
3)、散剂的制备方法：第一步称取琥珀5克，粉碎成琥珀粉；第二步称取当归15克、茯苓15克、龙骨20克、牡蛎20克、夜交藤20克、浮小麦30克、党参15克、桑白皮15克、珍珠母20克、玄参10克、丹参12克、麦冬12克、百合12克、大枣10克、花生嫩叶30克、绿萼梅12克、薏苡仁15克、茯神12克、槭叶草12克、赤小豆20克、斑花杓兰12克、合欢皮15克、梅花参12克、艾叶9克、高粱12克、瓜子金12克、石菖蒲12克、牛角藓12克、元胡9克、酸枣仁15克、人参叶12克、生地9克、陈皮15克、青皮12克、桃仁15克、桔梗10克、远志10克、五味子10克、朱砂5克、赤芍15克、柴胡12克、木通12克、制半夏9克、苏子12克、香附18克、大腹皮12克、甘草10克。把药物放入药锅中加12倍量水，煎煮2小时，过滤；滤渣加10倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥成中药粉；第三步：将第一步中的琥珀粉和第二步中的中药粉混合均匀，包装，即得符合正常成人一天用量的散剂。 
用于治疗顽固性失眠。口服，每日分早晚两次服用。 
4)、颗粒剂的制备方法：第一步称取琥珀5克，粉碎成琥珀粉；第二步称取当归15克、茯苓15克、龙骨20克、牡蛎20克、夜交藤20克、浮小麦30克、党参15克、桑白皮15克、珍珠母20克、玄参10克、丹参12克、麦冬12克、百合12克、大枣10克、花生嫩叶30克、绿萼梅12克、薏苡仁15克、茯神12克、槭叶草12克、赤小豆20克、斑花杓兰12克、合欢皮15克、梅花参12克、艾叶9克、高粱12克、瓜子金12克、石 菖蒲12克、牛角藓12克、元胡9克、酸枣仁15克、人参叶12克、生地9克、陈皮15克、青皮12克、桃仁15克、桔梗10克、远志10克、五味子10克、朱砂5克、赤芍15克、柴胡12克、木通12克、制半夏9克、苏子12克、香附18克、大腹皮12克、甘草10克。把药物放入药锅中加8倍量水，煎煮2小时，过滤；滤渣加6倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥成中药粉；第三步：将第一步中的琥珀粉和第二步中的中药粉混合均匀，再加入适量的糊精和矫味剂，按照本领域常规工艺制粒，包装，即得符合正常成人一天用量的颗粒剂。 
用于治疗顽固性失眠。口服，每日分早晚两次服用。 
具体实施例2 
称取当归12克、茯苓12克、龙骨18克、牡蛎18克、夜交藤18克、浮小麦25克、党参12克、桑白皮12克、珍珠母18克、玄参8克、丹参10克、麦冬10克、百合10克、琥珀(冲服)3克、大枣8克、花生嫩叶25克、绿萼梅10克、薏苡仁12克、茯神10克、槭叶草10克、赤小豆18克、斑花杓兰10克、合欢皮12克、梅花参10克、艾叶8克、高粱10克、瓜子金10克、石菖蒲10克、牛角藓10克、元胡8克、酸枣仁12克、人参叶10克、生地8克、陈皮12克、青皮10克、桃仁12克、桔梗8克、远志8克、五味子8克、朱砂3克、赤芍12克、柴胡10克、木通10克、制半夏8克、苏子10克、香附15克、大腹皮10克、甘草8克。 
按照实施例1的方法制备成汤剂、胶囊剂、散剂或颗粒剂。 
具体实施例3 
称取当归18克、茯苓18克、龙骨22克、牡蛎22克、夜交藤22克、浮小麦35克、党参18克、桑白皮18克、珍珠母22克、玄参12克、丹参15克、麦冬15克、百合15克、琥珀(冲服)6克、大枣12克、花生嫩叶35克、绿萼梅15克、薏苡仁18克、茯神15克、槭叶草15克、赤小豆25克、斑花杓兰15克、合欢皮18克、梅花参15克、艾叶10克、高粱15克、瓜子金15克、石菖蒲15克、牛角藓15克、元胡10克、酸枣仁18克、人参叶15克、生地10克、陈皮18克、青皮15克、桃仁18克、桔梗12克、远志12克、五味子12克、朱砂6克、赤芍18克、柴胡15克、木通15克、制半夏10克、苏子15克、香附20克、大腹皮15克、甘12克。 
按照实施例1的方法制备成汤剂、胶囊剂、散剂或颗粒剂。 
实验例： 
1)临床资料：本发明共治疗顽固性失眠患者40例，其中男19例，女21例，年龄为38-65岁。 
2)治疗方法：本发明的中药组合物以汤剂为主，每日1付，分2次服用，早、晚各服用1次30天为1个疗程，一般3-6个疗程即可治愈；也可将其制成胶囊剂、散剂或颗粒剂。 
3)疗效评价标准： 
治愈：症状消失，实验室检查正常； 
好转：症状明显改善，实验室检查有改善； 
未愈：主症未改善，实验室检查未改善。 
4)治疗结果：本发明共治疗顽固性失眠患者40例，经过3-6个疗程的治疗，治愈34例，占85￥，好转4例，占10￥，未愈2例，占5￥，有效率为95￥。 
5)典型病例： 
1、崔某，男，39岁，患顽固性失眠多年，服用多种西药，疗效不佳，服用本发明的中药组合物3个疗程后好转，服用6个疗程治愈，随访至今未复发。 
2、郝某某，女，42岁，患顽固性失眠3年，经多方治疗，不见效果，服用本发明的中药组合物2个疗程后好转，服用5个疗程治愈，3年未复发。 
3、焦某，女，57岁，患顽固性失眠5年，经多方治疗无效，服用本发明的中药组合物2个疗程后好转，服用5个疗程治愈，加服一个疗程巩固，随访至今未复发。 
4、邓某，女，62岁，患顽固性失眠2年，一直服用西药，效果不好，服用本发明的中药组合物2个疗程后好转，服用5个疗程治愈，随访至今未复发。 
经过大量的临床医疗实践证明，本发明治疗顽固性失眠的中药组合物，属于纯中药制剂，对人体毒、副作用小，对治疗顽固性失眠具有可靠、安全、显著的治疗效果。 

Claims (3)

1.一种治疗顽固性失眠的中药组合物，其特征在于，它是由以下重量份数配比的药材制备成：当归12-18份、茯苓12-18份、龙骨18-22份、牡蛎18-22份、夜交藤18-22份、浮小麦25-35份、党参12-18份、桑白皮12-18份、珍珠母18-22份、玄参8-12份、丹参10-15份、麦冬10-15份、百合10-15份、琥珀(冲服)3-6份、大枣8-12份、花生嫩叶25-35份、绿萼梅10-15份、薏苡仁12-18份、茯神10-15份、槭叶草10-15份、赤小豆18-25份、斑花杓兰10-15份、合欢皮12-18份、梅花参10-15份、艾叶8-10份、高粱10-15份、瓜子金10-15份、石菖蒲10-15份、牛角藓10-15份、元胡8-10份、酸枣仁12-18份、人参叶10-15份、生地8-10份、陈皮12-18份、青皮10-15份、桃仁12-18份、桔梗8-12份、远志8-12份、五味子8-12份、朱砂3-6份、赤芍12-18份、柴胡10-15份、木通10-15份、制半夏8-10份、苏子10-15份、香附15-20份、大腹皮10-15份、甘草8-12份。
2.根据权利要求1所述的治疗顽固性失眠的中药组合物，其特征在于，它是由以下重量份数配比的药材制备成：当归15份、茯苓15份、龙骨20份、牡蛎20份、夜交藤20份、浮小麦30份、党参15份、桑白皮15份、珍珠母20份、玄参10份、丹参12份、麦冬12份、百合12份、琥珀(冲服)5份、大枣10份、花生嫩叶30份、绿萼梅12份、薏苡仁15份、茯神12份、槭叶草12份、赤小豆20份、斑花杓兰12份、合欢皮15份、梅花参12份、艾叶9份、高粱12份、瓜子金12份、石菖蒲12份、牛角藓12份、元胡9份、酸枣仁15份、人参叶12份、生地9份、陈皮15份、青皮12份、桃仁15份、桔梗10份、远志10份、五味子10份、朱砂5份、赤芍15份、柴胡12份、木通12份、制半夏9份、苏子12份、香附18份、大腹皮12份、甘草10份。
3.一种治疗顽固性失眠的中药组合物的制备方法，其特征在于，由权利要求1或2所述的治疗顽固性失眠的中药组合物按常规方法制成汤剂、胶囊剂、散剂或颗粒剂。
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