CN104352541B - The bio-fermented liquid and preparation method of a kind of prevention Fatty Liver Disease - Google Patents
The bio-fermented liquid and preparation method of a kind of prevention Fatty Liver Disease Download PDFInfo
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- CN104352541B CN104352541B CN201410725249.9A CN201410725249A CN104352541B CN 104352541 B CN104352541 B CN 104352541B CN 201410725249 A CN201410725249 A CN 201410725249A CN 104352541 B CN104352541 B CN 104352541B
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- artemisia capillaris
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- brown sugar
- fatty liver
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention discloses a kind of bio-fermented liquid for preventing Fatty Liver Disease, by Artemisia capillaris 10% ~ 40%, brown sugar 15% ~ 45%, the percentage composition by weight of water 30% ~ 70% be fermented, filtering is made.Inventive formulation is reasonable; its bio-fermented liquid is used to protect liver; prevent the effect of Fatty Liver Disease; the composition for the classes of compounds that the bio-fermented liquid is generated by biofermentation; with a variety of effective active compositions, by improving internal system, enhance metabolism; various toxin are cleared up, liver is protected.The invention also discloses a kind of preparation method of the bio-fermented liquid of prevention Fatty Liver Disease.
Description
Technical field
The present invention relates to a kind of bio-fermented liquid of prevention Fatty Liver Disease and preparation method.
Background technology
Fatty liver, refers to due to the excessive lesion of fat accumulation in liver cell caused by a variety of causes.Fatty liver disease is just
The health of serious threat compatriots, as the second largest hepatopathy for being only second to virus hepatitis, has been acknowledged as disguised hepatic sclerosis
Common cause.Fatty liver is a kind of common clinical picture, rather than a kind of independent disease, has been increased in the incidence of disease of China
20%.The cause of disease that it forms disease is many, including drink beyond one's capacity, high caloric diet, obesity, medicine, chemical factor etc..Clinically
It is classified as alcoholic fatty liver (Alcoholic fatty liver disease, AFLD) and NASH
(non-alcoholic fatty liver disease, NAFLD).There is researcher to point out, fatty liver not people all the time
Thought, be a kind of benign morbid state, if do not paid attention to, it can develop into irreversible liver in a short time and damage
Wound.At present, the Patients with Fatty Liver of China is up to ten thousand people more than 8,000, and wherein AFLD ratio accounts for more than 23.0%.The factors such as alcohol
Caused hepatopathy and it is diseases related increasing sharply, due also to alcoholic hepatitis, liver fibrosis and hepatic sclerosis disease it is serious
Harmfulness and difficulty are curative so that AFLD study on prevention receives extensive attention.
But up to the present, Western medicine there is no lipotropic active drug, with the treatment of Chinese medicine long-time conditioning most
It is good.Such as vitamin B, C, E, urso, silymarin, and some fat-reducing medicaments etc..Although said medicine is a lot, greatly
Still need further to verify its curative effect and security more, therefore, can't abuse.And because AFLD pathogenesis is not yet complete
The full specific drug that effective targeted therapy means and preventing and treating are clearly not yet found currently for AFLD.Silymarin conduct
A kind of hepatic is applied to clinic, and it has preferable clinic for many liver diseases including AML
Effect.But due to its poorly water-soluble, oral rear bioavailability is low so that its application is limited, 2010HepatologyMagazine
The hepatopathy association of the U.S. delivered combines with American Society of Gastroenterology to point out in the AML Clinics and Practices guide formulated, water
Winged silibin does not either all produce compellent effect to acute or chronic alcoholic liver disease patient, only limits the use of in alcohol
The clinical test of property hepatopathy.And still it is in the experience accumulation stage for other preventing and treatings AFLD medicine.Therefore, AFLD medicines are resisted
The research and development of thing becomes particularly important.
The content of the invention
The invention aims to overcome the shortcomings of that above-mentioned prior art is present, and provide a kind of, formula is simple, method
It is easy, improve internal system, enhance metabolism, clear up toxin, protection liver, the bio-fermented liquid for preventing Fatty Liver Disease
And preparation method.
To achieve the above object, technical scheme is as follows：
It is a kind of prevent Fatty Liver Disease bio-fermented liquid, by following raw material percentage composition by weight it is fermented, filtering make
Into：
The water 30% ~ 70% of 10% ~ 40% brown sugar of Artemisia capillaris 15% ~ 45%.
Described biofermentation formula of liquid is preferred：
The water 60% ~ 68% of 12% ~ 17% brown sugar of Artemisia capillaris 20% ~ 25%.
Described biofermentation formula of liquid is preferred：
The water 46% ~ 58% of 17% ~ 24% brown sugar of Artemisia capillaris 25% ~ 30%.
Described biofermentation formula of liquid is preferred：
The water 35% ~ 46% of 24% ~ 32% brown sugar of Artemisia capillaris 30% ~ 38%.
Described biofermentation formula of liquid is preferred：
The water 30% of 32% brown sugar of Artemisia capillaris 38%.
Described Artemisia capillaris harvests the fresh Artemisia capillaris in May to October then from what Changbaishan area grew naturally
Stem and leaf.
A kind of preparation method of the bio-fermented liquid of prevention Fatty Liver Disease as described above, comprises the following steps：
A. the offer of raw material：Artemisia capillaris, brown sugar, water are got out, described Artemisia capillaris is naturally raw from Changbaishan area
The long stem and leaf that harvest the fresh Artemisia capillaris in May to October then；
B. batch mixing：
1. the fresh Artemisia capillaris stem and leaf of collection are eluted with water；
2. clean fresh Artemisia capillaris stem and leaf are often spread one layer by 100 L containers, and brown sugar is uniformly then sprinkling upon into mattress
On old wormwood artemisia raw material, intersect repeatedly this process until 4/5 height of container；
3. adds water regulation water content to submerge Artemisia capillaris；
4. is covered with clean mat, after in the above with weight pressure；
C. ferment：Select well-ventilated, the place irradiated without strong sunshine, at 23 ~ 28 DEG C, ferment 3 months；
D. filter：Filtering fermentating liquid.
In the selection for the treatment of liver disease drug, the small natural plants hepatic of some toxic side effects is selected to protect as far as possible
Liver, because the poisonous side effect of medicine of some treatment liver diseases is larger, causes the secondary injury to liver.The present invention in order to from
New liver protecting medicine is found in natural plants, filters out and has medicable medicinal plant Artemisia capillaris to liver and gall.Artemisia capillaris
(Artemisia capillaries) be composite family, sagebruss, Artemisia capillaris first recorded in《Sheng Nong's herbal classic》The tender seedling of Artemisia capillaris.
Ancient herbal medicine is such as《Sheng Nong's herbal classic》And《Compendium of Materia Medica》Deng record：Cure mainly rheumatism, fever and chills, perverse trend thermojunction, jaundice etc..《South Korea
Herbal illustrated handbook》Record：Artemisia capillaris treating acute and chronic hepatitis, hepatic sclerosis, liver cancer, cholecystitis, cholecystolithiasis；The skins such as eczema, rubella
Skin disease；Promote choleresis, the regeneration of liver cell, reduce fat, be depressured, norcholesterol；Clearing heat and detoxicating, diuresis；Antibacterial is made
With, tulase, anthrax-bacilus, staphylococcus aureus；All parts of the country are distributed, and have special fragrance, mildly bitter flavor.Artemisia capillaris has
Choleretic effect, protection liver cell and the regeneration for promoting liver cell, promote choleresis and Excretion, are constantly subjected to numerous people
Attention.
The present inventor has carried out the investigation and exploratory experiment of nearly 2 years to medicinal plant Artemisia capillaris, achieves some and enters
Exhibition.The fresh stem and leaf for the Artemisia capillaris that the bio-fermented liquid of the present invention is grown using Changbaishan area naturally, by with brown sugar and water
Mix in proportion, bio-fermented liquid is obtained by the fermentation of certain time, with the beneficial natural products of rich content
And the composition of the classes of compounds generated by biofermentation, containing many effective active compositions, so as to more preferable
Improve internal system, enhance metabolism, while various toxin can be cleared up, protect liver.Inventive formulation is simple, method
It is easy, it is easy to operate.The present invention utilizes the small Changbaishan area natural medicinal plant of toxic side effect and the effective of resource closely
Connect, reach liver-protective effect purpose, the demand of hepatopath can be met, the preparation of zymotic fluid can be reduced again
Cost, with obvious social economic value.Various hepatics and health products that the present invention is used with other, also with following
Advantage：(1) Artemisia capillaris that the raw material of this products is mainly grown using nature, likes because of it and is born near the riverbank of low altitude area
Sand ground, roadside and low hillside area are moistened, is easily adopted；(2) zymotechniques are simple, not high to place, temperature, equipment requirement,
Input cost is low.
The bio-fermented liquid of the present invention eats method：30 minutes before meals morning and evening is each once, two times a day, every time 80 mL.Suitably
Crowd：With chronic hepatitis, cholecystitis and fatty liver crowd, the especially crowd with alcoholic fatty liver.
The cellular activity data of the present invention（The research center analysis inspection of cytoactive experiment commission Yanbian University's pharmaceutical developments
Survey）：The Artemisia capillaris bio-fermented liquid effect Hep3B cell MTT testing results such as following tables of 48 hours of various concentrations：
Embodiment
It is a kind of prevent Fatty Liver Disease bio-fermented liquid, by following raw material percentage composition by weight it is fermented, filtering make
Into：
The water 30% ~ 70% of 10% ~ 40% brown sugar of Artemisia capillaris 15% ~ 45%.
One of described biofermentation formula of liquid preferred scheme：Artemisia capillaris 12% ~ 17%, brown sugar 20% ~ 25%, water 60% ~
68%。
The two of described biofermentation formula of liquid preferred scheme：Artemisia capillaris 17% ~ 24%, brown sugar 25% ~ 30%, water 46% ~
58%。
The three of described biofermentation formula of liquid preferred scheme：Artemisia capillaris 24% ~ 32%, brown sugar 30% ~ 38%, water 35% ~
46%。
The four of described biofermentation formula of liquid preferred scheme：Artemisia capillaris 32%, brown sugar 38%, water 30%.
A kind of preparation method of the bio-fermented liquid of above-mentioned prevention Fatty Liver Disease, comprises the following steps：
A. the offer of raw material：Artemisia capillaris, brown sugar, water are got out, described Artemisia capillaris is naturally raw from Changbaishan area
The long stem and leaf that harvest the fresh Artemisia capillaris in May to October then；
B. batch mixing：
1. the fresh Artemisia capillaris stem and leaf of collection are eluted with water；
2. clean fresh Artemisia capillaris stem and leaf are often spread one layer by 100 L containers, and container can select Plastic Drum right
Brown sugar is uniformly sprinkling upon on Artemisia capillaris raw material afterwards, intersects repeatedly this process until 4/5 height of container；
3. adds water regulation water content to submerge Artemisia capillaris；
4. is covered with clean mat, and mat can select what straw or reed were worked out, and weight pressure is then used in the above
On；
C. ferment：Select well-ventilated, the place irradiated without strong sunshine, at 23 ~ 28 DEG C, ferment 3 months, it is complete
Into fermentation process；
D. filter：With filtered through gauze zymotic fluid.
Claims (6)
1. it is a kind of prevent Fatty Liver Disease bio-fermented liquid, by following raw material percentage composition by weight it is fermented, filtering be made：
The water 30% ~ 70% of 10% ~ 40% brown sugar of Artemisia capillaris 15% ~ 45%,
It is made up of following preparation method, specifically includes the following steps：
A. the offer of raw material：Artemisia capillaris, brown sugar, water are got out, what described Artemisia capillaris grew naturally from Changbaishan area
Harvest the stem and leaf of the fresh Artemisia capillaris in May to October then；
B. batch mixing：
1. the fresh Artemisia capillaris stem and leaf of collection are eluted with water；
2. clean fresh Artemisia capillaris stem and leaf are often spread one layer by 100 L containers, and brown sugar is uniformly then sprinkling upon into Artemisia capillaris
On raw material, intersect repeatedly this process until 4/5 height of container；
3. adds water regulation water content to submerge Artemisia capillaris；
4. is covered with clean mat, after in the above with weight pressure；
C. ferment：Select well-ventilated, the place irradiated without strong sunshine, at 23 ~ 28 DEG C, ferment 3 months；
D. filter：Filtering fermentating liquid.
2. the bio-fermented liquid of a kind of prevention Fatty Liver Disease according to claim 1, it is characterized in that being pressed by following raw material
Weight percentage is fermented, filtering is made：
The water 60% ~ 68% of 12% ~ 17% brown sugar of Artemisia capillaris 20% ~ 25%.
3. the bio-fermented liquid of a kind of prevention Fatty Liver Disease according to claim 1, it is characterized in that being pressed by following raw material
Weight percentage is fermented, filtering is made：
The water 46% ~ 58% of 17% ~ 24% brown sugar of Artemisia capillaris 25% ~ 30%.
4. the bio-fermented liquid of a kind of prevention Fatty Liver Disease according to claim 1, it is characterized in that being pressed by following raw material
Weight percentage is fermented, filtering is made：
The water 35% ~ 46% of 24% ~ 32% brown sugar of Artemisia capillaris 30% ~ 38%.
5. the bio-fermented liquid of a kind of prevention Fatty Liver Disease according to claim 1, it is characterized in that being pressed by following raw material
Weight percentage is fermented, filtering is made：
The water 30% of 32% brown sugar of Artemisia capillaris 38%.
6. it is a kind of right want method ask 1 as described in a kind of prevention Fatty Liver Disease bio-fermented liquid preparation method, including under
Row step：
A. the offer of raw material：Artemisia capillaris, brown sugar, water are got out, what described Artemisia capillaris grew naturally from Changbaishan area
Harvest the stem and leaf of the fresh Artemisia capillaris in May to October then；
B. batch mixing：
1. the fresh Artemisia capillaris stem and leaf of collection are eluted with water；
2. clean fresh Artemisia capillaris stem and leaf are often spread one layer by 100 L containers, and brown sugar is uniformly then sprinkling upon into Artemisia capillaris
On raw material, intersect repeatedly this process until 4/5 height of container；
3. adds water regulation water content to submerge Artemisia capillaris；
4. is covered with clean mat, after in the above with weight pressure；
C. ferment：Select well-ventilated, the place irradiated without strong sunshine, at 23 ~ 28 DEG C, ferment 3 months；
D. filter：Filtering fermentating liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410725249.9A CN104352541B (en) | 2014-12-04 | 2014-12-04 | The bio-fermented liquid and preparation method of a kind of prevention Fatty Liver Disease |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410725249.9A CN104352541B (en) | 2014-12-04 | 2014-12-04 | The bio-fermented liquid and preparation method of a kind of prevention Fatty Liver Disease |
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| CN104352541A CN104352541A (en) | 2015-02-18 |
| CN104352541B true CN104352541B (en) | 2017-10-31 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615927A (en) * | 2003-11-14 | 2005-05-18 | 韩全文 | Oriental wormwood biological oral liquor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ553169A (en) * | 2004-07-28 | 2009-10-30 | Cargill Inc | Physiologically-active composition based on collagen and a phenylethanoid (acteoside and/or isoacteoside) |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615927A (en) * | 2003-11-14 | 2005-05-18 | 韩全文 | Oriental wormwood biological oral liquor |
Non-Patent Citations (1)
| Title |
|---|
| "藏茵陈微生物发酵转化的研究";王虹等;《安徽农业科学》;20111231;第39卷(第14期);第8326-8328页 * |
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| CN104352541A (en) | 2015-02-18 |
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Granted publication date: 20171031 Termination date: 20181204 |