CN1043509C - 抗氧剂羟基咔唑化合物的制药用途 - Google Patents
抗氧剂羟基咔唑化合物的制药用途 Download PDFInfo
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- CN1043509C CN1043509C CN93120407A CN93120407A CN1043509C CN 1043509 C CN1043509 C CN 1043509C CN 93120407 A CN93120407 A CN 93120407A CN 93120407 A CN93120407 A CN 93120407A CN 1043509 C CN1043509 C CN 1043509C
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- 238000011282 treatment Methods 0.000 title claims abstract description 9
- QBPAUIDFWFXLKB-UHFFFAOYSA-N 9h-carbazol-1-ol Chemical class N1C2=CC=CC=C2C2=C1C(O)=CC=C2 QBPAUIDFWFXLKB-UHFFFAOYSA-N 0.000 title abstract description 9
- 238000000034 method Methods 0.000 title abstract description 8
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 34
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 230000006378 damage Effects 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 16
- 239000001301 oxygen Substances 0.000 claims description 16
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 4
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- 125000003435 aroyl group Chemical group 0.000 claims description 4
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- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052794 bromium Inorganic materials 0.000 claims description 4
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
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- 239000011593 sulfur Substances 0.000 claims description 4
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- 241000790917 Dioxys <bee> Species 0.000 description 1
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- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 description 1
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
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- UHUSDOQQWJGJQS-UHFFFAOYSA-N glycerol 1,2-dioctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCC UHUSDOQQWJGJQS-UHFFFAOYSA-N 0.000 description 1
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- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
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- 230000010410 reperfusion Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Paper (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98391692A | 1992-12-01 | 1992-12-01 | |
| US983,916 | 1992-12-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1098909A CN1098909A (zh) | 1995-02-22 |
| CN1043509C true CN1043509C (zh) | 1999-06-02 |
Family
ID=25530177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93120407A Expired - Fee Related CN1043509C (zh) | 1992-12-01 | 1993-12-01 | 抗氧剂羟基咔唑化合物的制药用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5405863A (https=) |
| EP (1) | EP0671913A1 (https=) |
| JP (1) | JPH08503710A (https=) |
| KR (1) | KR950703949A (https=) |
| CN (1) | CN1043509C (https=) |
| AU (1) | AU675481B2 (https=) |
| CA (1) | CA2150694A1 (https=) |
| WO (1) | WO1994012177A1 (https=) |
| ZA (1) | ZA938896B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040680A1 (en) * | 1996-04-29 | 1997-11-06 | Smithkline Beecham Corporation | Antioxidant compound |
| CN1157188C (zh) | 1996-10-09 | 2004-07-14 | 泊灵格曼海姆药品公司 | 抑制应激活化蛋白激酶的方法 |
| JP4126345B2 (ja) * | 1997-03-06 | 2008-07-30 | 松森 昭 | ウイルス感染症の予防・治療剤 |
| US20020054911A1 (en) * | 2000-05-11 | 2002-05-09 | Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi | Novel oral dosage form for carvedilol |
| US6291506B1 (en) | 1998-08-04 | 2001-09-18 | Wisconsin Alumni Research Foundation | Method of reducing retinal ganglion cell degeneration |
| US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| EP1499310A4 (en) * | 2002-04-30 | 2005-12-07 | Sb Pharmco Inc | MONOCITRATE MONOHYDRATE OF CARVEDILOL |
| MXPA04012923A (es) * | 2002-06-27 | 2005-03-31 | Sb Pharmco Inc | Sales de fosfato de carvedilol y/o solvatos de las mismas, composiciones correspondientes y/o metodos de tratamiento. |
| JP2005533822A (ja) * | 2002-06-27 | 2005-11-10 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | 臭化水素酸カルベジロール |
| US20050020666A1 (en) * | 2003-07-25 | 2005-01-27 | Dabur Research Foundation | Cardioprotective agents |
| CA2547137A1 (en) * | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods |
| EP1686967A4 (en) * | 2003-11-25 | 2012-08-08 | Smithkline Beecham Cork Ltd | CARVEDILOL-FREE BASE, SALTS, WATER-FREE FORMS OR SOLVATES THEREOF, CORRESPONDING PHARMACEUTICAL COMPOSITIONS, CONTROLLED RELEASE FORMULAS AND TREATMENT OR DISPOSAL PROCEDURES |
| JP2007512372A (ja) * | 2003-11-25 | 2007-05-17 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール塩、対応する組成物、送達および／または治療方法 |
| US20090076116A1 (en) * | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched carvediolo |
| US10281374B2 (en) * | 2015-11-04 | 2019-05-07 | Diagnostic Biosystems | Method of pretreatment of biological samples for an analyte-staining assay method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4503607A (en) * | 1980-06-27 | 1985-03-12 | Fuji Machine Mfg. Co., Ltd. | Method for automatically mounting non-lead electronic components on printed-circuit boards |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1993
- 1993-09-28 US US08/128,327 patent/US5405863A/en not_active Expired - Lifetime
- 1993-11-29 ZA ZA938896A patent/ZA938896B/xx unknown
- 1993-12-01 CA CA002150694A patent/CA2150694A1/en not_active Abandoned
- 1993-12-01 WO PCT/US1993/011597 patent/WO1994012177A1/en not_active Ceased
- 1993-12-01 AU AU57322/94A patent/AU675481B2/en not_active Ceased
- 1993-12-01 CN CN93120407A patent/CN1043509C/zh not_active Expired - Fee Related
- 1993-12-01 JP JP6513450A patent/JPH08503710A/ja active Pending
- 1993-12-01 KR KR1019950702199A patent/KR950703949A/ko not_active Ceased
- 1993-12-01 EP EP94903350A patent/EP0671913A1/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4503607A (en) * | 1980-06-27 | 1985-03-12 | Fuji Machine Mfg. Co., Ltd. | Method for automatically mounting non-lead electronic components on printed-circuit boards |
Non-Patent Citations (1)
| Title |
|---|
| CA.VOL,111,NO.23,208919X 1989.12.4 HOEHER MARTIN ATAL EFFECTS OF CARVEDIOF ON LEFE VENTEICULAR FUNCTION AND A * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU675481B2 (en) | 1997-02-06 |
| CA2150694A1 (en) | 1994-06-09 |
| EP0671913A4 (https=) | 1995-10-25 |
| KR950703949A (ko) | 1995-11-17 |
| AU5732294A (en) | 1994-06-22 |
| JPH08503710A (ja) | 1996-04-23 |
| EP0671913A1 (en) | 1995-09-20 |
| ZA938896B (en) | 1994-08-01 |
| CN1098909A (zh) | 1995-02-22 |
| US5405863A (en) | 1995-04-11 |
| WO1994012177A1 (en) | 1994-06-09 |
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