CN104306893B - 一种用于脑外伤后半侧肢体失灵的中药制剂及其制备方法 - Google Patents
一种用于脑外伤后半侧肢体失灵的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于脑外伤后半侧肢体失灵的中药制剂,它是由伸筋草、川乌、草乌、透骨草、苏木、土鳖虫、花椒、红花、延胡索、姜黄、川芎、续断、杜仲、川牛膝、五灵脂、降香、花蕊石、马钱子、儿茶、骨碎补、刘寄奴、生甘草按照一定的重量配比制成,并将原料药水煎,外洗于患处,具有祛风除湿、舒筋活络、活血祛瘀的功效,治疗效果显著。
Description
技术领域
本发明涉及一种中药制剂,具体涉及一种用于脑外伤后半侧肢体失灵的中药制剂,本发明还涉及该中药制剂的制备方法。
背景技术
脑外伤后半侧肢体失灵脑外伤后常见的一种后遗症,是一种肢体失用的表现,失用是指不能完成指令性的有目的的和连续的动作,失用患者对完成目的性或连续复杂动作的记忆似乎已丧失。四肢没有相应器质性损害,但却不能完成有目的的运动。或者是脑部受伤以后损害到大脑皮层的运动中枢受损,脑部受伤后淤血、肿块等都会造成对大脑皮层的压迫或损害,这些都是造成肢体失灵的原因。肢体失灵属于中医的痹症范畴,所谓痹症指当人体基肌表经络遭受外邪侵袭后,使气血运行不畅而引起肌肉、屈伸不利、行动障碍、关节肿大、局部疼痛的病症。
目前西医西药方面会采用手术或者是促进神经代谢类药物,手术不仅具有一定风险,而且对患者的身体造成更近一步的损伤,往往收效甚微,中医治疗有很强的整体观念,从患者的全身特点加以考虑,而不只是局限于脑外伤本身,中医治疗能纠正机体的某些失调。去除疾病的复发因素。其次,中药对健康细胞的伤害比较小,一般不会因为治疗本身的原因对体力产生新的破坏,体力也会逐渐得到恢复,逐步增强免疫力。
发明内容
本发明的目的在于提供一种用于脑外伤后半侧肢体失灵的中药制剂,该中药制剂对于脑外伤后半侧肢体失灵具有疗效明显,价格低廉,无不良反应和副毒作用的特点。
发明人在多年的临床医疗实践中,根据该病症的发展规律,以及中药的配伍原则,并通过大量的临床验证,反复探索总结出一种用于脑外伤后半侧肢体失灵的中药制剂的新配方。本发明具有疗效明显,价格低廉,无不良反应和副毒作用的特点。
本发明中药物的作用:
其中:
伸筋草:为石松科石松属植物石松Lycopodium japonicum Thunb.的全草。性味:苦、辛、温。归肝经。功效:祛风除湿、舒筋活络。用于风寒湿痹,筋脉拘挛疼痈。外用治跌打扭伤肿痛。
川乌:为毛茛科植物乌头Aconitum carmichaeli Debx. 的干燥母根。性味:辛、苦,热;有大毒。归心、肝、肾、脾经。功效:祛风除湿,温经止痛。用于风寒湿痹,关节疼痛,心腹冷痛,寒疝作痛,麻醉止痛。
草乌:为毛茛科植物北乌头Aconitum kusnezoffii Reichb. 的干燥块根。性味:辛、苦,热;有大毒。归心、肝、肾、脾经。功效:祛风除湿,温经止痛。用于风寒湿痹,关节疼痛,心腹冷痛,寒疝作痛,麻醉止痛。
透骨草:为大戟科地构叶属植物地构叶Speranskia tuberculata (Bunge)Baill.、凤仙花科草本植物凤仙花Impatiens balsamina L.、紫葳科角蒿属植物角蒿Incarvillea sinensis Lam.、豆科野豌豆属植物山野豌豆Vicia amoena Fisch.的全草和杜鹃花科白珠树属植物滇白珠Gaultheria yunnanensis (Franch.)Rehd.的全株。性味:辛、苦,温。有小毒。归肝、肾经。功效:祛风除湿,解毒止痛。主风湿痹痛;筋骨挛缩;寒湿脚气;腰部扭伤;瘫痪;闭经;阴囊湿疹;疮疖肿毒。
苏木:为豆科植物苏木(Caesalpinia sappanL.)的干燥心材。性味甘、咸、辛,凉。归心;肝;胃;脾经。功效:活血祛瘀,消肿定痛。
土鳖虫:为鳖蠊科昆虫地鳖Eupolyphaga sinensis Walker或冀地鳖Stelephagaplancyi(Boleny)的雌虫全体。性味:寒,咸;有小毒。归肝经。功效:破瘀血,续筋骨,用于治疗跌打损伤,筋伤骨折,瘀肿疼痛。本品咸寒入血,主入肝经,性善走窜,能活血消肿止痛,续筋接骨疗伤,为伤科常用药,尤多用于骨折筋伤,瘀血肿痛。
花椒:为芸香科植物青椒(香椒、青花椒、山椒、狗椒)Zanthoxylum schinifoliumSieb. et Zucc.或花椒(蜀椒、川椒、红椒、红花椒、大红袍)Zantho xylum bungeanumMaxim.的干燥成熟果皮(花椒)及种子(椒目)入药。性味:辛,温。归脾、胃、肾经。功效:温中止痛,杀虫止痒。用于脘腹冷痛,呕吐泄泻,虫积腹痛,蛔虫症;外治湿疹瘙痒。
红花:为菊科植物红花Carthamus tinctorius L.的筒状花冠。性味:温,辛。归心、肝经。功效:活血通经、散瘀止痛。红花辛散温通,专入血分,能活血祛瘀,通经调脉,常与当归、川芎等合用。红花有扩张血管作用。红花黄色素可明显延长血浆复钙时间、凝血酶原时间和凝血时间。《本草衍义补遗》:红花,破留血,养血。多用则破血,少用则养血。
延胡索:为罂粟科植物延胡索Corydalis yanhusuo W. T. Wang 的干燥块茎。性味:辛、苦、温。归肝、脾经。功效:活血,利气,止痛。用于胸胁、脘腹疼痛,经闭痛经,产后瘀阻,跌扑肿痛。本品辛散温通,能行血中气滞,气中血滞,活血行气止痛,善治血瘀气滞所致的多种疼痛,其止痛作用优良。《本草求真》中记载:延胡索,不论是血是气,积而不散者,服此力能通达,以其性温,则于气血能行能畅,味辛则于气血能润能散,所以理一身上下诸痛。
姜黄:为姜科植物姜黄Curcuma longa L.的干燥根茎。性味:辛、苦,温。归脾、肝经。功效:破血行气,通经止痛。用于胸胁剌痛,闭经,癓瘕,风湿肩臂疼痛,跌扑肿痛。姜黄和郁金配合使用善治臂背痛。
川芎:为伞形科植物川芎Ligusticum chuanxiong Hort.的干燥根茎。性味:辛,温。归肝、胆、心经。功效:活血行气,祛风止痛。本品辛散温通,能上行巅顶,下达血海,外彻皮毛,旁通四肢,既能活血又能行气,昔人谓川芎为血中之气药,殆言其寓辛散、解郁、通达、止痛等功能。抗菌作用等体外试验:川芎对大肠、痢疾(宋内氏)、变形、绿脓、伤寒、副伤寒杆菌及霍乱弧菌等有抑制作用。川芎水浸剂(1:3)在试管内对某些致病性皮肤真菌也有抑制作用。
续断:为川续断科植物川续断Dipsacus asperoides C. Y. Cheng et T. M. Ai(或Dipsacus asper Wall)的干燥根。性味:苦、辛、微温。归肝、肾经。功效:补肝肾;强筋骨;调血脉;止崩漏。杜仲与续断均能补肝肾,强筋骨,用于治疗肝肾不足,筋骨不健及痹证日久,常相须为用,但是杜仲兼治肾阳不足之阳痿、小便频数等,而续断又能续折伤,用于跌打损伤、扭挫伤及骨折等。治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。本品甘温助阳,辛温散寒,用治肾阳不足,下元虚冷,阳痿不举,遗精滑泄,遗尿尿频等症,兼有补益肝肾,强健壮骨,通利血脉之功。
杜仲:为杜仲科植物杜仲(Eucommia ulmoides Oliver)的干燥树皮。性味:甘,温。归肝、肾、胃经。功效:补益肝肾、强筋壮骨、调理冲任、固经安胎。《本草纲目》:杜仲,古方只知滋肾,惟王好古言是肝经气分药,润肝燥,补肝虚,发昔人所未发也。盖肝主筋,肾主骨,肾充则骨强,肝充则筋健,屈伸利用,皆属于筋。
川牛膝:为苋科植物川牛膝Cyathula officinalis Kuan 的干燥根。性味:甘、微苦、平。归肝、肾经。功效:逐瘀通经,通利关节,利尿通淋。用于经闭症瘕,胞衣不下,关节痹痛,足痿筋挛,尿血血淋,跌扑损伤。
五灵脂:为鼯鼠科动物橙足鼯鼠Trogopterus Xanthipes Milne-Edwards或飞鼠科动物小飞鼠Pteromys volans L.的干燥粪便。性味:甘,温。入肝、脾经。功效:活血散瘀,炒炭止血。用于心腹淤血作痛,痛经,血瘀经闭,产后淤血腹痛;炒炭治崩漏下血;外用治跌打损伤,蛇、虫咬伤。
降香:为豆科植物降香檀 Dallbergia odarifera T.Chen 树干和根的干燥心材。性味辛,温。归肝、脾经。功效:行气活血,止痛,止血。
花蕊石:为变质岩类岩石蛇纹大理岩。性味:酸、涩,平。归肝经。功效:活血散瘀。治吐血、衄血、便血、崩漏,产妇血晕,死胎、胞衣不下,金疮出血。
马钱子:为马钱科植物马钱Strychnos nuxvomica L. 的干燥成熟种子。性味:苦,温;有大毒。归肝、脾经。功效:通络止痛,散结消肿。用于风湿顽痹,麻木瘫痪,跌扑损伤,痈疽肿痛;小儿麻痹后遗症,类风湿性关节痛。
儿茶:为豆科合欢属植物儿茶树Acacia catechu(L. f.) Willd.的去皮枝、干的干燥煎膏。性味:苦、涩,微寒。归肺经。功效:收湿生肌敛疮。用于溃疡不敛,湿疹,口疮,跌扑伤痛,外伤出血。
骨碎补:为水龙骨科植物槲蕨Drynaria fortunei (Kunze) J. Sm.的干燥根茎。全年均可采挖,除去泥沙,干燥,或再燎去茸毛(鳞片)。性味:苦,温。归肾、肝经。功效:补肾强骨,续伤止痛。用于肾虚腰痛,耳鸣耳聋,牙齿松动,跌扑闪挫,筋骨折伤;外治斑秃,白癜风。
刘寄奴:为菊科植物奇蒿(Herba Artemisiae Anomalae)的带花全草。性味:味辛;微苦;性温。归心;肝;脾经。功效:破瘀通经;止血消肿;消食化积。用于经闭,痛经;产后瘀滞腹痛;恶露不尽,症瘕;跌打损伤;金疮出血;风湿痹痛;便血;尿血;痈疮肿毒;烫伤;食积腹痛;泄泻痢疾。
生甘草:为豆科植物甘草 Glycyrrhiza uralensis Fisch.,胀果甘草Glycyrrhiza Inflata Bat.或光果甘草Glycyrrhiza Glabra L.的干燥根及根茎。炙甘草为甘草的蜜烘制加工品。性味甘,平。归心、肺、脾、胃经。功效:补脾和胃,益气复脉。《日华子本草》:安魂定魄。补五劳七伤,一切虚损、惊悸、烦闷、健忘。通九窍,利百脉,益精养气,壮筋骨,解冷热。
本发明的方解是:方中伸筋草、透骨草祛风除湿、舒筋活络,川乌、草乌祛风除湿、温经止痛,苏木活血祛瘀,消肿定痛,土鳖虫破瘀血、续筋骨,以上六味共为君药,一方面祛风除湿,消除痹痛,治疗筋脉拘挛疼痈,另一方面舒筋活络、活血祛瘀,疏通闭塞的经脉,是血液循环能力增强,给予病灶处以充足的营养物质,促进患者肢体的灵活性,缓解病痛。花椒温中止痛,杀虫止痒,红花助君药活血通经、散瘀止痛,延胡索活血利气,姜黄破血行气、通经止痛,川芎活血行气,祛风止痛,续断、杜仲补益肝肾、强筋壮骨,以上七味共为臣药,不仅可以助君药舒筋通络、活血祛瘀,还可以补益肝肾,肝主筋肾主骨,从整体上调理患者的身体,使患者筋骨得以荣养,肢体失灵现象自然消失。川牛膝逐瘀通经,通利关节,五灵脂活血散瘀,降香行气活血,花蕊石活血散瘀,马钱子通络止痛,儿茶收敛止血,骨碎补补肾强骨,续伤止痛,刘寄奴破瘀通经、止血消肿以上八味共为佐药,有均与君药、臣药祛风除湿、舒筋活络、活血祛瘀的药效增加,同时也不至于使药力过盛,对于刚刚受到脑部外伤的患者药力过盛会使身体一时承受不了,反而不利于患者的恢复,生甘草补脾和胃,调和诸药、引药归经,为使药。此方诸药合用,君臣协力,佐使共辅,具有祛风除湿、舒筋活络、活血祛瘀的功效,能够有效治疗脑外伤后半侧肢体失灵。
本发明药物原料用量是经发明人进行大量摸索总结得出的,各原料用量为在下述重量份范围都具有较好的疗效:伸筋草15-25份、川乌4-14份、草乌4-14份、透骨草15-25份、苏木7-17份、土鳖虫7-17份、花椒5-15份、红花5-15份、延胡索15-25份、姜黄15-25份、川芎10-20份、续断15-25份、杜仲15-25份、川牛膝13-23份、五灵脂7-17份、降香5-15份、花蕊石10-20份、马钱子4-14份、儿茶5-15份、骨碎补15-25份、刘寄奴19-29份、生甘草4-14份。
其中优选为:伸筋草20份、川乌9份、草乌9份、透骨草20份、苏木12份、土鳖虫12份、花椒10份、红花10份、延胡索20份、姜黄20份、川芎15份、续断20份、杜仲20份、川牛膝18份、五灵脂12份、降香10份、花蕊石15份、马钱子9份、儿茶10份、骨碎补20份、刘寄奴24份、生甘草9份。
一种用于脑外伤后半侧肢体失灵的中药制剂的制备方法如下:
步骤一:按本发明重量配比,称取花蕊石粉碎研磨至120目筛,然后将土鳖虫、五灵脂风干粉碎过120目筛,两组粉末混合均匀,备用;
步骤二:按本发明重量配比,称取川乌、草乌、花椒、姜黄、川芎、续断、杜仲、川牛膝、降香、儿茶、骨碎补放入砂锅中,加入8倍体积的水,先用武火将水煎开,然后转为文火,煎煮1小时,然后再加入2倍体积的水将伸筋草、透骨草、延胡索、马钱子、刘寄奴放入锅内煎煮0.5小时,最后加入红花、生甘草煎煮约10分钟,过滤,得滤液,备用;
步骤三:将步骤一中所得粉末混合于药汤中,趁热搅拌均匀,既得本发明所述外用制剂。
本发明使用方法:药汤热时可以适量熏蒸患处,待水温合适,用药水外洗肢体失灵的患处,注意不要烫伤。一天两次,20日为一个疗程。
本发明药物具有祛风除湿、舒筋活络、活血祛瘀的功效,且疗效明显,价格低廉,无不良反应和副毒作用,该中药制剂采用的方式治疗可以解除患者因脑外伤后半侧肢体失灵带来的生活上面的不便,减轻患者的病痛,据对临床160例患者观察统计,使用本发明药物一个疗程总有效率85%,两个疗程总有效率95%。
具体实施方式
实施例一、伸筋草15份、川乌4份、草乌4份、透骨草15份、苏木7份、土鳖虫7份、花椒5份、红花5份、延胡索15份、姜黄15份、川芎10份、续断15-份、杜仲15份、川牛膝13份、五灵脂7份、降香5份、花蕊石10份、马钱子4份、儿茶5份、骨碎补15份、刘寄奴19份、生甘草4份。
实施例二、伸筋草20份、川乌9份、草乌9份、透骨草20份、苏木12份、土鳖虫12份、花椒10份、红花10份、延胡索20份、姜黄20份、川芎15份、续断20份、杜仲20份、川牛膝18份、五灵脂12份、降香10份、花蕊石15份、马钱子9份、儿茶10份、骨碎补20份、刘寄奴24份、生甘草9份。
实施例三、伸筋草25份、川乌14份、草乌14份、透骨草25份、苏木17份、土鳖虫17份、花椒15份、红花15份、延胡索25份、姜黄25份、川芎20份、续断25份、杜仲25份、川牛膝23份、五灵脂17份、降香15份、花蕊石20份、马钱子14份、儿茶15份、骨碎补25份、刘寄奴29份、生甘草14份。
下面是患者使用本发明药物的临床统计资料:
一、一般资料
收治门诊患者160例,其中男性84例,女性76例,男女比例1.1:1,最大年龄70岁,最小年龄22岁,病程不等。患者年龄、性别、病程等各项基本资料基本相同。
二、治疗方法:
按照本发明药物实施例二,以及优选的制备方法,取一日剂量,所煎药汤份两次外洗患处,水热时可以适量熏蒸患处,待水温合适,用药水外洗患处,注意不要烫伤。一天两次,20日为一个疗程。
三、疗效评定标准:
1、治愈:临床症状消失,疼痛、不适现象消失,肢体关节活动便利;
2、好转:临床症状基本消失,疼痛得到缓解,有轻度的感觉异常,不影响肢体关节活动;
3、无效:临床症状、体征无改变。
四、治疗结果统计
其中:总有效率=治愈率+好转率
通过治疗结果的统计表明,本发明中药在治疗脑外伤后肢体失灵具有良好的临床效果,能有效提高治疗的治愈率,值得在临床应用上推广。
典型病例及疗效:
病例一、吴某,男,27岁,因在打架斗殴,损伤头部,住院进行积极的治疗,脱离生命危险,但是左侧肢体出现活动不灵的现象,经查体有痉挛性偏瘫步态,走路不稳,需要两个人看护,医院采用经过各种治疗方法,效果不佳,后患者采用实施例二中药治疗一个疗程后,患者自己有些动作可以自理,扶着东西可以慢慢行走,继续使用一个疗程,临床疼痛现在基本消失,自己可以单独进行走路练习,走路逐渐变稳,继续使用一个疗程后,患者肢体活动灵活,肢体未感觉有不适现象,随访半年未见复发,痊愈。
病例二、齐某,女,34岁,因车祸,头部受到撞击,致脑挫裂伤、颅内出血,医院进行手术抢救,伤者脱离生命危险,但是处于昏迷状态,膝跳反应微弱,患者清醒以后,肢体失灵,右侧肢体连最基本的动作都无法完成,采用各种治疗方式,效果甚微,后患者采用实施例二中药治疗一个疗程后,患者右侧身体可以做一些灵活的肢体动作,站立、走路时间不能过长,继续使用一个疗程,肢体活动灵活,未感觉有不适现象,随访半年未见复发,痊愈。
Claims (3)
1.一种用于脑外伤后半侧肢体失灵的中药制剂,其特征在于,该中药制剂是由以下重量份的药物制成:伸筋草15-25份、川乌4-14份、草乌4-14份、透骨草15-25份、苏木7-17份、土鳖虫7-17份、花椒5-15份、红花5-15份、延胡索15-25份、姜黄15-25份、川芎10-20份、续断15-25份、杜仲15-25份、川牛膝13-23份、五灵脂7-17份、降香5-15份、花蕊石10-20份、马钱子4-14份、儿茶5-15份、骨碎补15-25份、刘寄奴19-29份、生甘草4-14份。
2.根据权利要求1所述的用于脑外伤后半侧肢体失灵的中药制剂,其特征在于,由以下重量份的药物制成:伸筋草20份、川乌9份、草乌9份、透骨草20份、苏木12份、土鳖虫12份、花椒10份、红花10份、延胡索20份、姜黄20份、川芎15份、续断20份、杜仲20份、川牛膝18份、五灵脂12份、降香10份、花蕊石15份、马钱子9份、儿茶10份、骨碎补20份、刘寄奴24份、生甘草9份。
3.根据权利要求1或2所述的用于脑外伤后半侧肢体失灵的中药制剂,其特征在于:所述中药制剂为外用洗剂。
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