CN104306740A - Plaster for prosopalgia and preparing method thereof - Google Patents
Plaster for prosopalgia and preparing method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
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- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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Abstract
A plaster for prosopalgia and a preparing method thereof are disclosed. The plaster is prepared from following raw materials by weight: 13-18 parts of kaempfer dutchmanspipe root, 10-14 parts of aristolochia tuberose, 10-14 parts of aristolochia fordiana, 13-18 parts of toddalia asiatica, 15-22 parts of kusnezoff monkshood, 15-22 parts of gastrodia elata, 8-10 parts of Chinese holly leaf, 20-25 parts of snake oil, 20-25 parts of chitosan and 30-38 parts of vaseline. The method includes following steps of: a) mixing the kaempfer dutchmanspipe root, the aristolochia tuberose, the aristolochia fordiana, the toddalia asiatica, the kusnezoff monkshood, the gastrodia elata and the Chinese holly leaf according to a ratio, and smashing into powder having a size of more than 200 meshes; and b) melting the vaseline at 56-60 DEG C, adding the snake oil and the chitosan, heating to 65-67 DEG C until the snake oil and the chitosan are completely melted, adding the powder in the step a), stirring for 10 min, and cooling.
Description
Technical field
The invention belongs to medical art, be specially a kind of for prosopalgic plaster and preparation method thereof.
Background technology
Trigeminal neuralgia is clinical more common a kind of disease.Clinical signs be recurrent exerbation in facial nervi trigeminus distributed areas paroxysmal lightning sample, the sample that lancinates, ridicule sample, fire burns sample or tear having an intense pain of sample, be mostly one-sided generation, the middle age of frequently-occurring disease more than 4O year or old people, women is slightly more than male.Often with the muscle twitches of homonymy face, the neurapraxias such as numbness disappearance.This disease is belonged to headache, wind syndrome of head, prosopodynia category by Chinese medicine.Qi depression to blood stasis is its main pathogenesis.Still lack effective treatment means at present, the unsatisfactory curative effects such as clinical conventional Drug therapy, stereotactic radiotherapy and surgical intervention, treated effect is low, and relapse rate is high, and untoward reaction increases.
Nervi trigeminus is fifth cranial nerve, belongs to sensorimotor mixed nerve, is divided into optic nerve, maxillary nerve, nervus mandibularis three.Pathological changes often affects ramus maxillaris and ramus of mandible, and ramus maxillaris is the most often got involved, and ramus of mandible takes second place, and ramus ophthalmicus is rare.Trigeminal neuralgia is generally divided into constitutional and Secondary cases two kinds, and the primary trigeminal neuralgia cause of disease is understood at present not yet completely.The cause of disease of secondary trigeminal neuralgia is many to be caused due to cerebellopontine angle tumor, Roots of trigeminal nerve and semilunar ganglion tumor, vascular malformation, aneurysm, arachnoiditis etc.Current prosopalgic Drug therapy comprises carbamazepine, phenytoin, heavy dose of vitamin B group etc.Be wherein good with carbamazepine effect, but side effect is also more, some patients can not tolerate.
Carbamazepine is the prosopalgic common drug of clinical treatment, has the effect such as convulsion and neuralgia.Acupuncture and moxibustion therapy trigeminal neuralgia is proved actively effectively.Acupuncture point Hegu can effective promoting blood circulation and stopping pain.Too punching is the source points of Liver Channel, can discongest sun bright few positive two not smooth through meridians to women's head-ornaments face disease curative effect better acupuncture Touwei points such as headache, dizziness simultaneously.Pass, ditch, Baihui and Sishengcong four cave in acupuncture, the analgesic efficacy such as can reach refreshment and allay excitement.Cave, ShiShimonoseki is made up of jointly Various Tissues, is wherein distributed with the Sensory nerve fibre of trigeminal ganglion, and this cave of acupuncture can Shufeng Huoluo and tonneau mandibular joint, effectively eases pain.
Treatment by Chinese herbs has bupleurum powder for relieving liver-qi main component to be Pericarpium Citri Reticulatae, Radix Bupleuri, Rhizoma Chuanxiong, Radix Paeoniae and Radix Glycyrrhizae etc., has dispersing the stagnated live-QI to relieve the stagnation of QI, the effects such as promoting the circulation of QI to relieve pain.Decoction for removing blood stasis have invigorate blood circulation, the effect such as blood stasis dispelling and pain relieving, in side, the Radix Paeoniae Alba has effect of suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, and Rhizoma Chuanxiong has effect of blood-activating and qi-promoting and wind-expelling pain-stopping, Scolopendra energy dispersing pathogen accumulation and removing obstruction in the collateral to relieve pain.
Summary of the invention
The object of this invention is to provide a kind of for prosopalgic plaster and preparation method thereof.
Of the present invention for prosopalgic plaster; Be made up of the raw material of following parts by weight: Radix Aristolochiae Kaempferi 13 ~ 18 parts, raw 10 ~ 14 parts of back of the body Serpentis, Radix Aristolochiae Tagalae 10 ~ 14 parts, Radix Toddaliae Asiaticae 13 ~ 18 parts, Radix Aconiti Kusnezoffii 15 ~ 22 parts, 15 ~ 22 parts, Rhizoma Gastrodiae, Folium Mahoniae 8 ~ 10 parts, Adeps Serpentis 20 ~ 25 parts, chitosan 20 ~ 25 parts, 30 ~ 38 parts, vaseline.
As optimization, this is used for prosopalgic plaster, is made up of the raw material of following parts by weight: Radix Aristolochiae Kaempferi 15 parts, raw 13 parts of back of the body Serpentis, Radix Aristolochiae Tagalae 11 parts, Radix Toddaliae Asiaticae 15 parts, Radix Aconiti Kusnezoffii 18 parts, 18 parts, Rhizoma Gastrodiae, Folium Mahoniae 9 parts, Adeps Serpentis 23 parts, chitosan 24 parts, 36 parts, vaseline.
Prepare this method for prosopalgic plaster, comprise the following steps:
A, Radix Aristolochiae Kaempferi, back of the body Serpentis life, Radix Aristolochiae Tagalae, Radix Toddaliae Asiaticae, Radix Aconiti Kusnezoffii, Rhizoma Gastrodiae, Folium Mahoniae to be mixed according to described parts by weight, be ground into the powder of more than 200 orders;
B, the vaseline of described parts by weight to be melted at 56 DEG C ~ 60 DEG C, add the Adeps Serpentis of described parts by weight, chitosan, heat to 65 DEG C ~ 67 DEG C completely fusing, add the powder in step a, stir after 10 minutes, cool and get final product.
Cooled umbilica sticking plaster is inserted ring size 4cm in 9cm × 10cm() non-woven fabrics umbilica sticking plaster cloth pad internal ring in, dose 2.8 grams.
In this medicament composing prescription, Radix Aristolochiae Kaempferi heat-clearing and toxic substances removing, reducing swelling and alleviating pain; For enteritis, dysentery stomachache, gastric abscess, laryngopharynx swelling and pain, venom.The raw heat-clearing and toxic substances removing of back of the body Serpentis, suppressing the hyperactive liver to relieve the wind syndrome, cough-relieving, hemostasis, improving eyesight removing nebula.Radix Aristolochiae Tagalae dispels the wind, ease pain, subside a swelling, detoxify; Main rheumatic ostalgia, gastric abscess, stomachache, pharyngolaryngitis, traumatic injury, infantile convulsion, venom.Radix Toddaliae Asiaticae dispels the wind, pain relieving, dissipating blood stasis, hemostasis.Dispelling the wind and dampness pathogens pain, stomachache, traumatic injury, spit blood, epistaxis, sub-official is hemorrhage, and knife injury is hemorrhage, amenorrhea, dysmenorrhea, intercostal neuralgia, furuncle toxic swelling.Radix Aconiti Kusnezoffii searches wind prevailing over dampness, dispersing cold for relieving pain, opens expectorant, and detumescence, controls anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery, sore throat, carbuncle, furuncle, scrofula; Rhizoma Gastrodiae endogenous wind stopping, arresting convulsion; Control dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom.Folium Mahoniae clearind deficient heat, liver and kidney tonifying, wind-damp dispelling; Main hectic fever due to deficiency of YIN; Cough spitting of blood; Have a dizzy spell; Soreness of the waist and knees; Rheumatic arthralgia; Vitiligo.Adeps Serpentis is exactly " fat " of Serpentis is a kind of traditional pure natural skin care item, without any side effects and the untoward reaction to human body, it contains needed by human unsaturated fatty acid, linolenic acid, linoleic acid etc., there is endocrine regulation imbalance, loosening bowel to relieve constipation, skin maintenance, prevents skin aging, prevents angiosclerotic effect.Chitosan can be generated natural metabolite by the lysozyme degraded in organism, has feature that is nontoxic, that can be absorbed completely by organism, therefore has larger superiority with it as medicinal slow release agent.
The present invention treats prosopalgic medicine, reducing swelling and alleviating pain, except emaciation due to emotional upset is swollen, heat-clearing and toxic substances removing, dispelling wind and removing obstruction in the collateral treatment trigeminal neuralgia is given prominence to, its vaseline, chitosan, Serpentis oil composition, existing analgesia therapy effect, contribute to very much again the absorption of medicine, and safe and reliable.
Detailed description of the invention
The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.
Embodiment 1, a, get Radix Aristolochiae Kaempferi 15 grams, raw 13 grams of back of the body Serpentis, Radix Aristolochiae Tagalae 11 grams, Radix Toddaliae Asiaticae 15 grams, Radix Aconiti Kusnezoffii 18 grams, 18 grams, Rhizoma Gastrodiae, Folium Mahoniae 9 grams mixing, be ground into the powder of more than 200 orders;
B, get 36 grams, vaseline and melt at 56 DEG C ~ 60 DEG C, add Adeps Serpentis 23 grams, chitosan 24 grams, heat to 65 DEG C ~ 67 DEG C completely fusing, add the powder in step a, stir after 10 minutes, cool and get final product.
Cooled umbilica sticking plaster is inserted ring size 4cm in 9cm × 10cm() non-woven fabrics umbilica sticking plaster cloth pad internal ring in, dose 2.8 grams.
Embodiment 2, a, get Radix Aristolochiae Kaempferi 13 grams, raw 10 grams of back of the body Serpentis, Radix Aristolochiae Tagalae 10 grams, Radix Toddaliae Asiaticae 13 grams, Radix Aconiti Kusnezoffii 15 grams, 15 grams, Rhizoma Gastrodiae, Folium Mahoniae 8 grams mixing, be ground into the powder of more than 200 orders;
B, get 30 grams, vaseline and melt at 56 DEG C ~ 60 DEG C, add Adeps Serpentis 20 grams, chitosan 20 grams, heat to 65 DEG C ~ 67 DEG C completely fusing, add the powder in step a, stir after 10 minutes, cool and get final product.
Cooled umbilica sticking plaster is inserted ring size 4cm in 9cm × 10cm() non-woven fabrics umbilica sticking plaster cloth pad internal ring in, dose 2.8 grams.
Embodiment 3, a, get Radix Aristolochiae Kaempferi 18 grams, raw 14 grams of back of the body Serpentis, Radix Aristolochiae Tagalae 14 grams, Radix Toddaliae Asiaticae 18 grams, Radix Aconiti Kusnezoffii 22 grams, 22 grams, Rhizoma Gastrodiae, Folium Mahoniae 10 grams mixing, be ground into the powder of more than 200 orders;
B, get 38 grams, vaseline and melt at 56 DEG C ~ 60 DEG C, add Adeps Serpentis 25 grams, chitosan 25 grams, heat to 65 DEG C ~ 67 DEG C completely fusing, add the powder in step a, stir after 10 minutes, cool and get final product.
Cooled umbilica sticking plaster is inserted ring size 4cm in 9cm × 10cm() non-woven fabrics umbilica sticking plaster cloth pad internal ring in, dose 2.8 grams.
Pertinent clinical data is as follows:
Physical data: choosing the affected nerves of patients with trigeminal neuralgia 164 the meeting dependent diagnostic standard example that year May in May, 2013 to 2014, my institute accepted for medical treatment is object of study.Patient age scope is 28 ~ 65 years old, year mean age (49.8 ± 5.21).All patients are divided into four groups at random, often organize 41 routine patients.Each group of patient no significant difference (P>0.05) in sex, age, the course of disease etc., has comparability.
Therapeutic Method: matched group patient takes carbamazepine to treat.The method taked is the oral carbamazepine of patient.Suffer from each 0.1g, every day 2 times.
Treatment group totally three groups on the treatment basis of matched group, use plaster in embodiment 1,2,3, to paste 18 hours at every turn, once a day.Observe the curative effect after one month.
The standard of curative effect evaluation: the pain degree after taking VAS method (visual simulation ruler method) assess patient to treat.Effective: patient pain's degree is obviously alleviated, or complete incidence graph, VI decline >75%; Effective: patient pain's degree moderate is alleviated, VAS declines >=50%; Invalid: patient pain's degree is not eased, or it is comparatively light to alleviate degree, VAS decline <50%.Total effective rate=(effective number of cases+effectively number of cases)/total number of cases X100%.Efficacy result is in table 1.
Statistical analysis: adopt SPSS 18.0 statistics software processes, measurement data mean ± standard deviation (x ± s) represents, adopts t inspection; The comparison of enumeration data rate adopts x
2inspection.P<0.05 is that difference has statistical significance.
Claims (3)
1. one kind for prosopalgic plaster; It is characterized in that by the raw material of following parts by weight: Radix Aristolochiae Kaempferi 13 ~ 18 parts, raw 10 ~ 14 parts of back of the body Serpentis, Radix Aristolochiae Tagalae 10 ~ 14 parts, Radix Toddaliae Asiaticae 13 ~ 18 parts, Radix Aconiti Kusnezoffii 15 ~ 22 parts, 15 ~ 22 parts, Rhizoma Gastrodiae, Folium Mahoniae 8 ~ 10 parts, Adeps Serpentis 20 ~ 25 parts, chitosan 20 ~ 25 parts, 30 ~ 38 parts, vaseline.
2. plaster according to claim 1, is characterized in that being made up of the raw material of following parts by weight: Radix Aristolochiae Kaempferi 15 parts, raw 13 parts of back of the body Serpentis, Radix Aristolochiae Tagalae 11 parts, Radix Toddaliae Asiaticae 15 parts, Radix Aconiti Kusnezoffii 18 parts, 18 parts, Rhizoma Gastrodiae, Folium Mahoniae 9 parts, Adeps Serpentis 23 parts, chitosan 24 parts, 36 parts, vaseline.
3. prepare a method for plaster described in claim 1, it is characterized in that comprising the following steps:
A, Radix Aristolochiae Kaempferi, back of the body Serpentis life, Radix Aristolochiae Tagalae, Radix Toddaliae Asiaticae, Radix Aconiti Kusnezoffii, Rhizoma Gastrodiae, Folium Mahoniae to be mixed according to described parts by weight, be ground into the powder of more than 200 orders;
B, the vaseline of described weight fraction to be melted at 56 DEG C ~ 60 DEG C, add Adeps Serpentis part of described parts by weight, chitosan, heat to 65 DEG C ~ 67 DEG C completely fusing, add the powder in step a, stir after 10 minutes, cool and get final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410501809.2A CN104306740A (en) | 2014-09-27 | 2014-09-27 | Plaster for prosopalgia and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410501809.2A CN104306740A (en) | 2014-09-27 | 2014-09-27 | Plaster for prosopalgia and preparing method thereof |
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| CN104306740A true CN104306740A (en) | 2015-01-28 |
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| CN201410501809.2A Pending CN104306740A (en) | 2014-09-27 | 2014-09-27 | Plaster for prosopalgia and preparing method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770680A (en) * | 2016-05-19 | 2016-07-20 | 汪大庆 | Traditional Chinese medicine for treating prosopalgia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1923262A (en) * | 2006-04-10 | 2007-03-07 | 马辉 | Exterior-applied Chinese medicine for treating facial palsy |
-
2014
- 2014-09-27 CN CN201410501809.2A patent/CN104306740A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1923262A (en) * | 2006-04-10 | 2007-03-07 | 马辉 | Exterior-applied Chinese medicine for treating facial palsy |
Non-Patent Citations (5)
| Title |
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| 刘建平: "《当代内科名方验方大全》", 31 May 2011, 广东科技出版社 * |
| 孙怡等: "三叉神经痛的中医药治疗", 《实用中医内科杂志》 * |
| 杨仁甲: "乌头汤加味治疗三叉神经痛", 《四川中医》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770680A (en) * | 2016-05-19 | 2016-07-20 | 汪大庆 | Traditional Chinese medicine for treating prosopalgia |
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