CN104306562B - 一种治疗水泡型脚气的软膏及其制备方法 - Google Patents

一种治疗水泡型脚气的软膏及其制备方法 Download PDF

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CN104306562B
CN104306562B CN201410501810.5A CN201410501810A CN104306562B CN 104306562 B CN104306562 B CN 104306562B CN 201410501810 A CN201410501810 A CN 201410501810A CN 104306562 B CN104306562 B CN 104306562B
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宋益兴
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Abstract

一种治疗水泡型脚气的软膏及其制备方法。水泡型脚气常为急性发展期脚气，起病较急，夏重冬轻。原发损害以小水疱为主，成群或散发，壁厚，疱液清，常位于趾间、足心及足侧缘。水疱位于表皮角质层下，由于足跖部角质层较厚，水疱壁不易被穿破，周围皮肤无红晕。本发明治疗水泡型脚气的软膏；由以下重量份数的原料制成：白鲜皮3～5份、金钱草6～8份、牛至6～8份、没药8～10份、红藤8～10份、蔓荆子4～6份、白术4～6份、丁公藤3～5份、壳聚糖10～12份、凡士林70～80份、甘油40～50份。各成分药效协同作用，治疗水泡型脚气药效更突出。

Description

一种治疗水泡型脚气的软膏及其制备方法
技术领域
本发明属于中药外用软膏领域，具体为一种治疗水泡型脚气的软膏及其制备方法。
背景技术
水泡型脚气常为急性发展期脚气，起病较急，夏重冬轻。原发损害以小水疱为主，成群或散发，壁厚，疱液清，常位于趾间、足心及足侧缘。水疱位于表皮角质层下，由于足跖部角质层较厚，水疱壁不易被穿破，周围皮肤无红晕。如果不继发细菌感染，数天后疱液可自行吸收。水疱破裂后形成环状脱屑，皮损继续向四周扩大。皮损不断向四周扩展蔓延时，部分小水疱可融合成大水疱。
水泡型脚气比较顽固，复发性很强，想根治没有很有效方法。因为脚气这种病很特殊，由于穿鞋、脚底潮湿等原因导致细菌生存力很强。一般患脚气的人冬天不犯，夏天会复发。治疗方法包括中药清洗或者外用克霉唑乳膏等多种方式。
发明内容
本发明的目的是提供一种治疗效果好、无毒副作用的治疗水泡型脚气的软膏及其制备方法。
本发明治疗水泡型脚气的软膏；由以下重量份数的原料制成：白鲜皮 3～5份、金钱草6～8份、牛至6～8份、没药8～10份、红藤8～10份、蔓荆子4～6份、白术4～6份、丁公藤3～5份、壳聚糖10～12份、凡士林70～80份、甘油40～50份。
作为优选，该治疗水泡型脚气的软膏；由以下重量份数的原料制成：白鲜皮 4份、金钱草4份、牛至6份、没药10份、红藤8份、蔓荆子4份、白术5份、丁公藤4份、壳聚糖11份、凡士林75份、甘油40份。
制备该治疗水泡型脚气软膏的方法，包括以下步骤：
a、将所属重量分数的白鲜皮、金钱草、牛至、没药、红藤、蔓荆子、白术、丁公藤分别粉碎成200目以上的粉末，然后混合均匀；
b、将所述重量份数的凡士林加热到62℃～70℃；然后加入步骤a中药粉，搅拌均匀；
c、将所述重量份数的甘油、壳聚糖通过超声波搅拌机搅拌均匀；
d、将步骤c中混合物加入到步骤b中，快速搅拌均匀，冷却后即得。
该治疗水泡型脚气软膏组分中，白鲜皮清热燥湿；祛风止痒；解毒。金钱草有清热利尿、祛风止痛、止血生肌、消炎解毒、杀虫之功。牛至，具有清热解表、理气化湿倒尿消肿之功效。没药主治胸腹瘀痛、痛经、经闭、症瘕、跌打损伤、痈肿疮疡、肠痈、目赤肿痛。红藤清凉解毒中药，具有活血通络，败毒散瘀，祛风杀虫的作用。蔓荆子具有疏散风热、清利头目的功效。白术健脾益气，燥湿利水，止汗，安胎。丁公藤祛风胜湿，舒筋活络，消肿，止痛。壳聚糖(chitosan)又称脱乙酰甲壳素，是由自然界广泛存在的几丁质(chitin)经过脱乙酰作用得到的，化学名称为聚葡萄糖胺(1-4)-2-氨基-B-D葡萄糖。各成分药效协同作用，治疗水泡型脚气药效更突出。
有关临床资料如下：
一般资料：治疗组380例：男性288例，女性92例，年龄16～66岁，平均年龄38．3岁，病程5天～2年；对照组322例：男性243例，女性79例，年龄18—65岁，平均年龄37.2岁，病程1周～3年。两组患者情况基本一致，无显著差异(P>O.05)，具有可比性。
诊断标准：所有患者均符合《中医病证诊断疗效标准》中诊断标准，水疱型手足癣多发生在夏季，症状是趾间、足缘、足底出现米粒大小，深在性水疱，疏散或成群分布，庖壁较厚，内容清澈，不易破裂。数日后干燥脱屑，相互融合形成多房性水疱，撕去庖壁，可见蜂窝状基底及鲜红色糜烂面，剧烈瘙痒。
治疗方法：治疗组接受实施例1中软膏临床治疗，洗脚后涂到患处，每日两次，十天为一疗程,对照组接受克霉唑乳膏临床治疗，洗脚后涂到患处，每日两次，十天为一疗程,一个疗程后观察疗效。
疗效判定标准：痊愈: 皮损消退, 自觉症状消失, 抽查真菌镜检阴性。有效: 皮损消退40%以上, 自觉症状明显减轻。无效: 皮损消退小于40%, 自觉症状无明显好转, 真菌镜检阳性。
具体实施方式
下面给出的实施例拟对本发明作进一步说明，但不能理解为是对本发明保护范围的限制，本领域技术人员根据本发明内容对本发明的一些非本质的改进和调整，仍属于本发明的保护范围。
实施例1：
a、取白鲜皮 4克、金钱草4克、牛至6克、没药10克、红藤8克、蔓荆子4克、白术5克、丁公藤4克分别粉碎成200目以上的粉末，然后混合均匀；
b、取凡士林75克，加热到62℃～70℃；然后加入步骤a中药粉，搅拌均匀；
c、取甘油40克、壳聚糖11克采用超声波搅拌机，搅拌均匀；
d、将步骤c中混合物加入到步骤b中，在62℃～70℃下快速搅拌均匀，冷却后即得。
实施例2：
a、取白鲜皮3克、金钱草6克、牛至6克、没药8克、红藤8克、蔓荆子4克、白术4克、丁公藤3克分别粉碎成200目以上的粉末，然后混合均匀；
b、取凡士林70克，加热到62℃～70℃；然后加入步骤a中药粉，搅拌均匀；
c、取甘油40克、壳聚糖10克采用超声波搅拌机，搅拌均匀；
d、将步骤c中混合物加入到步骤b的混合物中，在62℃～70℃下快速搅拌均匀，冷却后即得。
实施例3：
a、取白鲜皮5克、金钱草8克、牛至8克、没药10克、红藤10克、蔓荆子6克、白术6克、丁公藤5克分别粉碎成200目以上的粉末，然后混合均匀；
b、取凡士林80克，加热到62℃～70℃；然后加入步骤a中药粉，搅拌均匀；
c、取甘油50克、壳聚糖12克采用超声波搅拌机，搅拌均匀；
d、将步骤c中混合物加入到步骤b的混合物中，在62℃～70℃下快速搅拌均匀，冷却后即得。

Claims (2)

1.一种治疗水泡型脚气的软膏，其特征在于由以下重量份数的原料：白鲜皮 3～5份、金钱草6～8份、牛至6～8份、没药8～10份、红藤8～10份、蔓荆子4～6份、白术4～6份、丁公藤3～5份、壳聚糖10～12份、凡士林70～80份、甘油40～50份；
通过以下步骤制成：
a、将所述重量份数的白鲜皮、金钱草、牛至、没药、红藤、蔓荆子、白术、丁公藤分别粉碎成200目以上的粉末，然后混合均匀；
b、将所述重量份数的凡士林加热到62℃～70℃；然后加入步骤a中药粉，搅拌均匀；
c、将所述重量份数的甘油、壳聚糖通过超声波搅拌机搅拌均匀；
d、将步骤c中混合物加入到步骤b中，快速搅拌均匀，冷却后即得。
2.根据权利要求1所述治疗水泡型脚气的软膏，其特征在于由以下重量份数的原料制成：白鲜皮 4份、金钱草4份、牛至6份、没药10份、红藤8份、蔓荆子4份、白术5份、丁公藤4份、壳聚糖11份、凡士林75份、甘油40。
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CN1425433A (zh) * 2002-12-20 2003-06-25 孙建滨 治疗脚汗脚臭脚气鞋垫
CN101439151A (zh) * 2008-12-22 2009-05-27 刘锋 治疗脚气的药物
CN102370842A (zh) * 2010-08-19 2012-03-14 王士轩 一种治疗青春痘、脚气、皮肤癣的药物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1425433A (zh) * 2002-12-20 2003-06-25 孙建滨 治疗脚汗脚臭脚气鞋垫
CN101439151A (zh) * 2008-12-22 2009-05-27 刘锋 治疗脚气的药物
CN102370842A (zh) * 2010-08-19 2012-03-14 王士轩 一种治疗青春痘、脚气、皮肤癣的药物

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