CN104305200A - Peruvian ginseng and worm chrysalis health-care product and preparation method thereof - Google Patents
Peruvian ginseng and worm chrysalis health-care product and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a peruvian ginseng and worm chrysalis health-care product and a preparation method thereof. The peruvian ginseng and worm chrysalis health-care product is prepared from the following raw materials in parts by mass: 20-80 parts of a silkworm chrysalis extract, 20-80 parts of a peruvian ginseng broken-spore powder, 5-20 parts of a peruvian ginseng extract and 2-10 parts of auxiliaries. The preparation method comprises the following steps: first making silkworm chrysalis powder and the peruvian ginseng broken-spore powder, then respectively obtaining the silkworm chrysalis extract and the peruvian ginseng extract through alcohol extraction and water extraction, fully mixing the obtained materials after proportioning according to requirements, adding an alcohol solution to pelletize, and tabletting after drying to obtain the peruvian ginseng and worm chrysalis health-care product. A peruvian ginseng and worm chrysalis multi-functional compound tablet is processed and produced through the interaction mechanism of two biotins. The obtained peruvian ginseng and worm chrysalis compound tablet has multiple functions of improving body immunity, improving male functions, delaying body ageing and the like.
Description
Technical field
The present invention relates to a kind of health products and preparation method thereof, be specifically related to a kind of agate coffee silkworm chrysalis health-care product and preparation method thereof, belong to biomedicine technical field.
Background technology
Agate coffee (Maca) original producton location is positioned at the Andes of height above sea level more than 4000 meters in the middle part of South America Peru, and before thousand, just became one of famous tonic thing source of local Inca.Ma Ka fruit section belongs to Cruciferae separate row Vegetable spp, is 1 year season or 2 years season herbaceous plant.Its growth requires very harsh, grows under needing the special environment conditions such as High aititude, day and night temperature are comparatively large, nothing fertilizer, anoxic.Agate coffee because having rational trophic structure proportioning, and makes it have high nutritive value, also containing abundant mineral matter and several amino acids isoreactivity secondary metabolites in agate coffee, makes agate coffee have fabulous food medicine effect and alimentary health-care function to acceptor.
In recent years, at home and abroad find in much research, the nutritional labeling contained in agate coffee can effectively increase takes crowd's muscle power, and raising property function, keeps a series of health care functions useful to human body such as the energy of abundance.2006, the report that agate coffee researcher Paul Gonzales (Gonzales) professor of Peru has delivered in the 9th international ethnopharmacology conference " pharmacology of Peru's acrophyta agate coffee and production and outlet ", causes the great interest of medicine and health products trade.Agate coffee was formally defined as national new resource food in 2011 by China.Show according to correlative study, main active in agate coffee is: agate coffee alkaloid (i.e. agate coffee alkene and macamide, these two kinds of active alkali compositions are named by American scientist Zheng B.L), agate coffee alkene and macamide can directly act on human body pituitary and hypothalamus, thus regulate human body endocrinal glands system, stimulate as body of gland nature secreting hormones such as thyroid gland, pancreas, ovaries, thus reach the hormonal object of balanced human.In addition, in agate coffee, alkaloid component can alleviate the problem such as estradiol and stosterone hyposecretion in human body effectively, therefore treats using agate coffee as a kind of exogenous hormones substitute and improve the hyperfunction problem of human body pituitary class body of gland and provide theories integration.Secondly, agate coffee alkene and macamide can promote that human body sexual desire and adjustment improve men and women's property function, also have the reputation of plant vigour at European & American Market agate coffee.In addition, in agate coffee imidazole alkaloid (Lepidiline) can to cancer cell copy and diffusion has inhibitory action.
The multiple natural active matter be rich in silkworm chrysalis body and pheromones support that silkworm moth sprouts wings, circle in the air, breed and the energy of embryonic development, has important nutritive value and health care.Wherein protein, linoleic acid fat and compound amino acid and other micronutrient levels enrich easily absorbed by the body, thus the mankind very early since just using silkworm chrysalis as edible insects.Silkworm chrysalis nourishing enriches, and degreasing pupa protein content reaches 71 ~ 89%, and is full price albumen, and its nutritive value can match in excellence or beauty with egg, milk.The traditional Chinese medical science is thought, the flat taste of silkworm chrysalis is sweet, have dispel the wind, invigorating the spleen, only quench one's thirst, tranquillizing the mind by relieving convulsion, benefit essence is supporing yang etc. effect.Prescriptions Worth Thousand Gold for Emergencies says that " beneficial vital essence, strong man Yang Dao, controls and let out essence for it.", Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is said, and " male former silkworm benefit vital essence, reinforcing yin essence road, joins tireless, also only smart.Establishing-Yang thing, stopping leak essence, hematuria, warming the kidney, control storm wind, metal-inflicted wound, pernio, sore due to scald and burn, scar of going out.Silkworm moth property is excessive, goes out cocoon and namely reaches agreement, and as withered, therefore reinforcing yin essence benefit essence uses it.”
Pharmacological research shows, silkworm chrysalis can play certain corrective action to body sugar, fat metabolism.Proper amount of edible silkworm chrysalis, has good adjuvant treatment efficacy to hypertension, high fat of blood, chronic hepatitis and malnutritive patient.In addition, containing a kind of broad immune material in silkworm chrysalis, special efficacy is had to cancer.It is reported, the states such as Japan have produced alpha-interferon from silkworm chrysalis, clinical in anticancer therapy.
Scientific research shows: containing abundant active material in silkworm chrysalis body, male sex hormone (male silkworm chrysalis), female hormone (female silkworm chrysalis) rich content, to enhancing body immunity and property functional effect remarkable.Silkworm chrysalis it contain the Multiple components such as abundant cromoci, vitamin B12, nicotinic acid, a ecdyson and B-ecdyson, wherein brain hormone has fabulous health-care effect to the elderly, taking a certain amount of brain hormone can Promote cell's growth, stimulate dermal cell division, control specific proteins synthesizes, and reaches the effect delayed senility.The salty temperature of female silkworm chrysalis nature and flavor, can benefiting qi and nourishing blood, regulates female incretion, has good anti-ageing regulating action.
Although have a large amount of agate coffee product and silkworm chrysalis product in the market, what all adopt is single agate coffee and single silkworm chrysalis product, its function singleness, DeGrain.In sum, above-mentioned each material all has obvious effect to health, and being necessary to research and develop a kind of agate coffee and silkworm chrysalis can interactional health food, improves body immunity, improvement function, delays senility, the effect such as skin-protecting face nursing to reach.
Summary of the invention
For solving the problem such as function singleness, DeGrain of existing agate coffee product and silkworm chrysalis product, the invention provides a kind of agate coffee silkworm chrysalis health-care product and preparation method thereof, combining with the interaction realizing raw material effect.
The present invention is realized by following technical proposal: a kind of agate coffee silkworm chrysalis health-care product, is characterized in that being made up of the raw material of following masses part:
Pupa bombycis extract 30 ~ 60 parts,
Agate coffee wall cell disruption powder 20 ~ 50 parts,
Maca extract 10 ~ 20 parts,
Auxiliary material 5 ~ 10 parts.
The granularity of described Pupa bombycis extract and Maca extract is 100 ~ 120 orders.
Described Pupa bombycis extract obtains through following method: be screened by silkworm chrysalis, then decontamination, is crushed to 100 ~ 120 orders and obtains dried silkworm chrysalis meal, by dried silkworm chrysalis meal: the weight ratio of ethanol=1:6 ~ 10, add the ethanol that volumetric concentration is 75 ~ 90%, carry out refluxing extraction 1 ~ 3 hour, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 6 ~ 10 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, through reduced pressure concentration, drying, pulverize to obtain Pupa bombycis extract.
Above-mentioned refluxing extraction is 60 ~ 90 DEG C in temperature, carries out refluxing extraction under the condition of vacuum≤0.1Mpa.Reduced pressure concentration carries out reduced pressure concentration under the condition of temperature≤90 DEG C, vacuum≤0.1Mpa.
Described agate coffee wall cell disruption powder is screened by agate coffee dry fruit, then remove coring and impurity, cleans, is crushed to 1000 ~ 1200 orders after low temperature drying, to reach the shell-broken effect of cell, obtain agate coffee wall cell disruption powder.
Described Maca extract obtains through following method: in 100 ~ 120 object pueraria root powders, by pueraria root powder: the weight ratio of ethanol=1:6 ~ 10, add the ethanol that volumetric concentration is 75 ~ 90%, carry out refluxing extraction 1 ~ 3 hour, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 6 ~ 10 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, through reduced pressure concentration, drying, pulverize to obtain Maca extract.
Above-mentioned refluxing extraction carries out refluxing extraction under the condition of temperature≤65 DEG C, vacuum≤0.1Mpa, and reduced pressure concentration carries out reduced pressure concentration under the condition of temperature≤65 DEG C, vacuum≤0.1Mpa.
Described auxiliary material is one in microcrystalline cellulose, xylitol or two kinds, and the proportioning of two kinds is arbitrary.
Another object of the present invention is to the preparation method that a kind of agate coffee silkworm chrysalis health-care product are provided, through following each step:
(1) get the raw materials ready by the component of following mass parts:
Pupa bombycis extract 30 ~ 60 parts,
Agate coffee wall cell disruption powder 20 ~ 50 parts,
Maca extract 10 ~ 20 parts,
Auxiliary material 5 ~ 10 parts;
(2) the standby raw material of step (1) institute is fully mixed, then the volumetric concentration adding raw material gross weight 1/3rd be 50% ethanol stir to mixed material, obtain wet feed;
(3) after the wet feed of step (2) being granulated routinely, carry out drying at≤65 DEG C to moisture content be the particle of 2 ~ 5%;
(4) by step (3) gained particle compression molding routinely, agate coffee silkworm chrysalis health-care product are namely obtained.
In described step (2), the moisture content of wet feed is 20 ~ 30%.
Described step (3) is 18 ~ 24 orders in the granularity of particle.
Described step (4) gained agate coffee silkworm chrysalis health-care product film coating powder carries out film coating and obtains agate coffee silkworm chrysalis health-care fine work in high-efficiency coating machine, controls the weightening finish of film coating powder 2 ~ 3%.
The interaction mechanism of agate coffee and silkworm chrysalis: this genus of agate coffee crucifer, is characterized in being rich in high unit nutrient and multiplely has bioactive secondary metabolite.And in silkworm chrysalis body, be rich in multiple natural active matter and pheromones, wherein protein, linoleic acid fat and compound amino acid and other micronutrient levels enrich easily absorbed by the body, silkworm chrysalis and agate coffee two kinds of biotins have separately strengthen body immunity and enhancing sexual function etc. multinomial effect.The two combines can reach single silkworm chrysalis or the inaccessiable effect of single agate coffee; The two has the complementation effect of helping each other.The mechanism of action of the two is different, but cooperatively interacts, complements each other, common enhancing Abwehrkraft des Koepers and enhancing sexual function.
On enhancing body immunity, delaying senility function, the topmost feature of silkworm chrysalis is exactly that its degreasing pupa protein content is up to Multiple components such as 71 ~ 89% and abundant cromoci, vitamin B12, nicotinic acid, a ecdyson and B-ecdysons, wherein brain hormone can Promote cell's growth, stimulate dermal cell division, control specific proteins synthesizes, reach the effect strengthening body immunity, delay senility, female silkworm chrysalis can benefiting qi and nourishing blood, regulate female incretion, have good anti-ageing regulating action.In conjunction with alkaloid distinctive in agate coffee (containing macamides, agate coffee alkene), effective inhibitory action is had to the degraded of peroxynitrite, DPPH, hydrogen peroxide and deoxygenated ribose, thus accelerate to remove interior free yl, protection human body cell is from the injury of oxidation; Secondly being rich in the selenium (4.1mg/100g) of a large amount in agate coffee, be nearly 4 times of Cordyceps sinensis, and selenium is mainly by glutathione peroxidase, removes the peroxide that metabolism produces in cytoplasm, makes the anti-aging effects effect of silkworm chrysalis more obvious.
Silkworm chrysalis is the antibody generation by promoting when thymus-dependent antigen (TD-Ag) stimulates, and improves the generation that the humoral immune reaction depending on the single-minded antigen of T improves human immunoglobulin.And agate coffee is the lymphocyte transformation significantly improving PHA induction, promotes that serum hemolysin generates, and increase the generation of antibody-producting cell, strengthen Abwehrkraft des Koepers.
Use at enhancing sexual function, the topmost feature of silkworm chrysalis is exactly accumulate rich in protein in silkworm chrysalis, aliphatic acid, amino acid, arginine (male silkworm chrysalis), stosterone (male silkworm chrysalis), estradiol (female silkworm chrysalis) and Zn, Fe, Ca, the various trace elements such as Se, in conjunction with the main active in agate coffee be: agate coffee alkaloid (i.e. agate coffee alkene and macamide), agate coffee alkene and macamide can directly act on human body pituitary and hypothalamus, thus regulate human body endocrinal glands system, stimulate as thyroid gland, pancreas, the body of gland nature secreting hormones such as ovary, thus reach the hormonal object of balanced human.In addition, in agate coffee, alkaloid component can alleviate the problem such as estradiol and stosterone hyposecretion in human body effectively, therefore treats using agate coffee as a kind of exogenous hormones substitute and improve the hyperfunction problem of human body pituitary class body of gland and provide theories integration.Secondly, enrich the various trace elements such as K, Fe, Ca, Mn, Zn, P contained by agate coffee alkene and macamide and agate coffee and can promote that human body sexual desire and adjustment improve men and women's property function, also have the reputation of plant vigour at European & American Market agate coffee.
The present invention be with rare living resources agate coffee and silkworm chrysalis for main production raw material, utilize its interaction mechanism processing to obtain the multi-functional composite sheet of agate coffee silkworm chrysalis.The scientific matching of raw material can be carried out, to increase required effect according to different efficacies demand.Gained agate coffee silkworm chrysalis composite sheet of the present invention has raising body immunity, improvement function, delays the multinomial effects such as the interior aging of body.
Detailed description of the invention
Here is that the present invention will be further described in conjunction with the present embodiment.
Embodiment 1
(1) silkworm chrysalis is screened, then decontamination, be crushed to 120 orders and obtain dried silkworm chrysalis meal, by dried silkworm chrysalis meal: the weight ratio of ethanol=1:7, add the ethanol that volumetric concentration is 80%, be 80 DEG C in temperature, carry out refluxing extraction 2 hours under the condition of vacuum 0.08Mpa, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 7 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, carry out through reduced pressure concentration under the condition of temperature 80 DEG C, vacuum 0.08Mpa, then drying, pulverize granularity is 120 object Pupa bombycis extracts;
(2) agate coffee dry fruit screened, then remove coring and impurity, clean, be crushed to 1000 orders after low temperature drying, to reach the shell-broken effect of cell, obtain agate coffee wall cell disruption powder;
(3) in 120 object pueraria root powders, by pueraria root powder: the weight ratio of ethanol=1:7, add the ethanol that volumetric concentration is 80%, under the condition of temperature 60 C, vacuum 0.08Mpa, carry out refluxing extraction 2 hours, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 7 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, through reduced pressure concentration under the condition of temperature 60 C, vacuum 0.08Mpa, then drying, pulverize granularity is 120 object Maca extract;
(4) by above-mentioned steps gained material, get the raw materials ready by the component of following mass parts:
Pupa bombycis extract 60 parts,
Agate coffee wall cell disruption powder 25 parts,
Maca extract 10 parts,
Auxiliary material 5 parts;
Wherein auxiliary material is microcrystalline cellulose and xylitol, and proportioning is arbitrary;
(5) the standby raw material of step (4) institute is fully mixed, then the volumetric concentration adding raw material gross weight 1/3rd be 50% ethanol stir to mixed material, obtain the wet feed that moisture content is 25%;
(6), after being granulated routinely by the wet feed of step (5), to carry out drying to moisture content at 60 DEG C be 3%, and granularity is 20 object particles;
(7) by step (6) gained particle compression molding routinely, agate coffee silkworm chrysalis health-care product are namely obtained.Gained agate coffee silkworm chrysalis health-care product film coating powder carries out film coating and obtains agate coffee silkworm chrysalis health-care fine work in high-efficiency coating machine, controls the weightening finish of film coating powder 3%.
Embodiment 2
(1) silkworm chrysalis is screened, then decontamination, be crushed to 110 orders and obtain dried silkworm chrysalis meal, by dried silkworm chrysalis meal: the weight ratio of ethanol=1:6, add the ethanol that volumetric concentration is 75%, be 70 DEG C in temperature, carry out refluxing extraction 3 hours under the condition of vacuum 0.1Mpa, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 6 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, carry out through reduced pressure concentration under the condition of temperature 70 C, vacuum 0.1Mpa, then drying, pulverize granularity is 110 object Pupa bombycis extracts;
(2) agate coffee dry fruit screened, then remove coring and impurity, clean, be crushed to 1200 orders after low temperature drying, to reach the shell-broken effect of cell, obtain agate coffee wall cell disruption powder;
(3) in 110 object pueraria root powders, by pueraria root powder: the weight ratio of ethanol=1:6, add the ethanol that volumetric concentration is 75%, under the condition of temperature 65 DEG C, vacuum 0.1Mpa, carry out refluxing extraction 3 hours, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 6 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, through reduced pressure concentration under the condition of temperature 65 DEG C, vacuum 0.1Mpa, then drying, pulverize granularity is 110 object Maca extract;
(4) by above-mentioned steps gained material, get the raw materials ready by the component of following mass parts:
Pupa bombycis extract 40 parts,
Agate coffee wall cell disruption powder 35 parts,
Maca extract 20 parts,
Microcrystalline cellulose 5 parts;
(5) the standby raw material of step (4) institute is fully mixed, then the volumetric concentration adding raw material gross weight 1/3rd be 50% ethanol stir to mixed material, obtain the wet feed that moisture content is 30%;
(6), after being granulated routinely by the wet feed of step (5), to carry out drying to moisture content at 65 DEG C be 4%, and granularity is 18 ~ 24 object particles;
(7) by step (6) gained particle compression molding routinely, agate coffee silkworm chrysalis health-care product are namely obtained.Gained agate coffee silkworm chrysalis health-care product film coating powder carries out film coating and obtains agate coffee silkworm chrysalis health-care fine work in high-efficiency coating machine, controls the weightening finish of film coating powder 2%.
Embodiment 3
(1) silkworm chrysalis is screened, then decontamination, be crushed to 100 orders and obtain dried silkworm chrysalis meal, by dried silkworm chrysalis meal: the weight ratio of ethanol=1:10, add the ethanol that volumetric concentration is 90%, be 60 DEG C in temperature, carry out refluxing extraction 1 hour under the condition of vacuum 0.05Mpa, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 10 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, carry out through reduced pressure concentration under the condition of temperature 60 C, vacuum 0.06Mpa, then drying, pulverize granularity is 100 object Pupa bombycis extracts;
(2) agate coffee dry fruit screened, then remove coring and impurity, clean, be crushed to 1100 orders after low temperature drying, to reach the shell-broken effect of cell, obtain agate coffee wall cell disruption powder;
(3) in 100 object pueraria root powders, by pueraria root powder: the weight ratio of ethanol=1:10, add the ethanol that volumetric concentration is 90%, under the condition of temperature 55 DEG C, vacuum 0.05Mpa, carry out refluxing extraction 1 hour, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 10 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, through reduced pressure concentration under the condition of temperature 45 C, vacuum 0.06Mpa, then drying, pulverize granularity is 100 object Maca extract;
(4) by above-mentioned steps gained material, get the raw materials ready by the component of following mass parts:
Pupa bombycis extract 30 parts,
Agate coffee wall cell disruption powder 50 parts,
Maca extract 10 parts,
Xylitol 10 parts;
(5) the standby raw material of step (4) institute is fully mixed, then the volumetric concentration adding raw material gross weight 1/3rd be 50% ethanol stir to mixed material, obtain the wet feed that moisture content is 20%;
(6), after being granulated routinely by the wet feed of step (5), to carry out drying to moisture content at 45 DEG C be 2%, and granularity is 18 object particles;
(7) by step (6) gained particle compression molding routinely, agate coffee silkworm chrysalis health-care product are namely obtained.Gained agate coffee silkworm chrysalis health-care product film coating powder carries out film coating and obtains agate coffee silkworm chrysalis health-care fine work in high-efficiency coating machine, controls the weightening finish of film coating powder 3%.
Embodiment 4
(1) silkworm chrysalis is screened, then decontamination, be crushed to 120 orders and obtain dried silkworm chrysalis meal, by dried silkworm chrysalis meal: the weight ratio of ethanol=1:8, add the ethanol that volumetric concentration is 80%, be 90 DEG C in temperature, carry out refluxing extraction 2 hours under the condition of vacuum≤0.1Mpa, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 8 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, carry out through reduced pressure concentration under the condition of temperature≤90 DEG C, vacuum≤0.1Mpa, then drying, pulverize granularity is 120 object Pupa bombycis extracts;
(2) agate coffee dry fruit screened, then remove coring and impurity, clean, be crushed to 1200 orders after low temperature drying, to reach the shell-broken effect of cell, obtain agate coffee wall cell disruption powder;
(3) in 120 object pueraria root powders, by pueraria root powder: the weight ratio of ethanol=1:8, add the ethanol that volumetric concentration is 80%, under the condition of temperature≤65 DEG C, vacuum≤0.1Mpa, carry out refluxing extraction 2 hours, filter, so repeat to extract totally three times, merge three alcohol filtrates, the water then adding 8 times of weight in residue carries out boiling extraction 1 hour, filters, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, through reduced pressure concentration under the condition of temperature≤65 DEG C, vacuum≤0.1Mpa, then drying, pulverize granularity is 120 object Maca extract;
(4) by above-mentioned steps gained material, get the raw materials ready by the component of following mass parts:
Pupa bombycis extract 55 parts,
Agate coffee wall cell disruption powder 20 parts,
Maca extract 15 parts,
Microcrystalline cellulose and xylitol 10 parts;
(5) the standby raw material of step (4) institute is fully mixed, then the volumetric concentration adding raw material gross weight 1/3rd be 50% ethanol stir to mixed material, obtain the wet feed that moisture content is 25%;
(6), after being granulated routinely by the wet feed of step (5), to carry out drying to moisture content at≤65 DEG C be 5%, and granularity is 24 object particles;
(7) by step (6) gained particle compression molding routinely, agate coffee silkworm chrysalis health-care product are namely obtained.Gained agate coffee silkworm chrysalis health-care product film coating powder carries out film coating and obtains agate coffee silkworm chrysalis health-care fine work in high-efficiency coating machine, controls the weightening finish of film coating powder 2%.
One, to embodiment gained silkworm chrysalis agate coffee health products, detect according to Chinese Pharmacopoeia tablet general rule regulation, result is as follows:
(1) tablet hardness average >=4.0Kg;
(2) friability≤0.8%;
(3) disintegration≤15 minute;
Two, Maca extract and agate coffee Pupa bombycis extract contrast experiment
Experiment purpose: agate coffee and silkworm chrysalis are to the synergy of develop immunitypty
Experimental subjects: control group---Maca extract
Checking group---agate coffee Pupa bombycis extract (i.e. embodiment 2 gained agate coffee silkworm chrysalis health-care product)
Experimental technique: Kunming mouse is divided into three groups, namely blank group, control group, checking group; Continuous gastric infusion (3g/ (kg.d)) 15 days, blank group is given and isopyknic physiological saline, and the half measuring each tested group by thiobarbituricacidα-(TBA) method causes effect dosage ED50.
The ED50 value of table 1 agate coffee Pupa bombycis extract, Maca extract develop immunitypty
Experimental result: the ability of agate coffee Pupa bombycis extract develop immunitypty is the strongest, is 2.03 times of control group (Maca extract).
In sum, in checking group, two kinds of biological raw material active ingredients can reach a kind of effective synergy, can reach 2.03 times of single creature element effect, have high application and popularization value under repercussion effect.
Three, above-described embodiment 1 gained agate coffee silkworm chrysalis health-care product are got, for following efficacy validation:
1, leaders
Immunity is poor, resistance weak person 50 example; Fatiguability, sexual deterioration person 50 example.Be divided into checking group and each 75 examples of control group at random, 25 examples that wherein immunity is poor, vulnerable, 25 examples of fatiguability, sexual deterioration.
2, instructions of taking
Checking group is oral, and each agate coffee silkworm chrysalis health-care product tablet 2 ~ 3g, 3 times on the one, serve on 21.
Control group, by daily routine life, refuses to obey health products.
3, result
Agate coffee silkworm chrysalis health-care product clinical verification effect provided by the invention: poor to immunity, vulnerable efficiently reach 85%, 95% is reached and control group phenomenon without any improvement to fatiguability, the efficient of sexual deterioration.
4, conclusion
Agate coffee silkworm chrysalis health-care product provided by the invention on the basis not destroying related nutritional composition, extract agate coffee, silkworm chrysalis liposoluble constituent and related nutritional composition by low temperature alcohol extracting technology, extract agate coffee, the water-soluble nutritional labeling of silkworm chrysalis by water extraction method, improve effect in the common facilitation in conjunction with agate coffee and silkworm chrysalis.The health products of scientific matching make the pueraria root powder abolishing cell membrane can be released into absorption of human body area and ensure human absorptivity, and add that Maca extract, Pupa bombycis extract synergy ensure that its remarkable efficacy, its effect is better than control group.
Through test, the agate coffee macro powder of higher proportion and Maca extract can ensure the absorption of agate coffee biologically active alkali in human body effectively, agate coffee alkene and macamide can directly act on the incretory system of human body, thus stimulate human body glandular secretion hormone, reply and regulate human body hormonal balance; Meanwhile, silkworm chrysalis can promote that people's internal antibody produces, and improves the generation of human immunoglobulin.Finally, the nutrition active ingredient being reached different ratio by the difference of proportional quantity is taken in, thus reaches for different-effect object.
And containing the various trace elements active material such as rich in protein, aliphatic acid, amino acid, arginine (male silkworm chrysalis), stosterone (male silkworm chrysalis), estradiol (female silkworm chrysalis) and Zn, Fe, Ca, Se in Pupa bombycis extract, to enhancing body immunity and property functional effect remarkable.And silkworm chrysalis it contain the Multiple components such as abundant cromoci, vitamin B12, nicotinic acid, a ecdyson and B-ecdyson, wherein brain hormone has fabulous health-care effect to the elderly, taking a certain amount of brain hormone can Promote cell's growth, stimulate dermal cell division, control specific proteins synthesizes, and reaches the effect delayed senility.The salty temperature of female silkworm chrysalis nature and flavor, can benefiting qi and nourishing blood, regulates female incretion, has good anti-ageing regulating action.Coordinating active alkaloid in agate coffee can regulate effect of human body endocrinal glands system, strengthening body immunity, in the prevention done of delaying senility etc., effect is more efficient than the absorption effect of single creature element.
In sum, agate coffee health products provided by the invention have raising body immunity, improve function of male, delay the multinomial effects such as the interior aging of body.
Claims (10)
1. agate coffee silkworm chrysalis health-care product, is characterized in that being made up of the raw material of following masses part:
Pupa bombycis extract 30 ~ 60 parts,
Agate coffee wall cell disruption powder 20 ~ 50 parts,
Maca extract 10 ~ 20 parts,
Auxiliary material 5 ~ 10 parts.
2. agate coffee silkworm chrysalis health-care product according to claim 1, it is characterized in that: described Pupa bombycis extract obtains through following method: be that silkworm chrysalis is screened, decontamination again, be crushed to 100 ~ 120 orders and obtain dried silkworm chrysalis meal, by dried silkworm chrysalis meal: the weight ratio of ethanol=1:6 ~ 10, add the ethanol that volumetric concentration is 75 ~ 90%, carry out refluxing extraction 1 ~ 3 hour, filter, so repeat to extract totally three times, merge three alcohol filtrates, then the water adding 6 ~ 10 times of weight in residue carries out boiling extraction 1 hour, filter, repeat to boil and extract secondary altogether, merge intermediate water filtrate, finally alcohol filtrate and filter liquor are merged, through reduced pressure concentration, drying, pulverize to obtain Pupa bombycis extract.
3. agate coffee silkworm chrysalis health-care product according to claim 1, is characterized in that: described agate coffee wall cell disruption powder is screened by agate coffee dry fruit, then remove coring and impurity, clean, be crushed to 1000 ~ 1200 orders after low temperature drying, obtain agate coffee wall cell disruption powder.
4. agate coffee silkworm chrysalis health-care product according to claim 1, it is characterized in that: described Maca extract obtains through following method: in 100 ~ 120 object pueraria root powders, by pueraria root powder: the weight ratio of ethanol=1:6 ~ 10, add the ethanol that volumetric concentration is 75 ~ 90%, carry out refluxing extraction 1 ~ 3 hour, filter, so repeat to extract totally three times, merge three alcohol filtrates, then the water adding 6 ~ 10 times of weight in residue carries out boiling extraction 1 hour, filter, repeat to boil and extract secondary altogether, merge intermediate water filtrate; Finally alcohol filtrate and filter liquor are merged, through reduced pressure concentration, drying, pulverize to obtain Maca extract.
5. agate coffee silkworm chrysalis health-care product according to claim 1, is characterized in that: described auxiliary material is one in microcrystalline cellulose, xylitol or two kinds, and the proportioning of two kinds is arbitrary.
6. agate coffee silkworm chrysalis health-care product according to claim 2, is characterized in that: described refluxing extraction is 60 ~ 90 DEG C in temperature, carries out refluxing extraction under the condition of vacuum≤0.1Mpa; Reduced pressure concentration carries out reduced pressure concentration under the condition of temperature≤90 DEG C, vacuum≤0.1Mpa.
7. agate coffee silkworm chrysalis health-care product according to claim 4, is characterized in that: above-mentioned refluxing extraction carries out refluxing extraction under the condition of temperature≤65 DEG C, vacuum≤0.1Mpa; Reduced pressure concentration carries out reduced pressure concentration under the condition of temperature≤65 DEG C, vacuum≤0.1Mpa.
8. a preparation method for agate coffee silkworm chrysalis health-care product, is characterized in that through following each step:
(1) get the raw materials ready by the component of following mass parts:
Pupa bombycis extract 30 ~ 60 parts,
Agate coffee wall cell disruption powder 20 ~ 50 parts,
Maca extract 10 ~ 20 parts,
Auxiliary material 5 ~ 10 parts;
(2) the standby raw material of step (1) institute is fully mixed, then the volumetric concentration adding raw material gross weight 1/3rd be 50% ethanol stir to mixed material, obtain wet feed;
(3) after the wet feed of step (2) being granulated routinely, carry out drying at≤65 DEG C to moisture content be the particle of 2 ~ 5%;
(4) by step (3) gained particle compression molding routinely, agate coffee silkworm chrysalis health-care product are namely obtained.
9. preparation method according to claim 8, is characterized in that: in described step (2), the moisture content of wet feed is 20 ~ 30%.
10. preparation method according to claim 8, is characterized in that: described step (3) is 18 ~ 24 orders in the granularity of particle.
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| CN110496214A (en) * | 2019-09-09 | 2019-11-26 | 北京姿美堂生物技术有限公司 | A kind of oyster peptide combinations and preparation method thereof improving male's sexual |
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