CN103463123A - Method for extracting effective constituents from maca - Google Patents
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Abstract
The invention provides a method for extracting effective constituents from maca. The method includes the following steps that fresh or dry maca roots are taken as raw materials, the maca roots are washed, impurities are removed, an ethyl alcohol-water solution is used as homogenate liquid, the maca roots are homogenized, crushed and extracted, so that a homogenate extracting solution is obtained, filtering is conducted, filtering residues are mixed with an extraction solvent, negative pressure cavitation solid-liquid mixing cyclone extraction is conducted to obtain the extracting solution, the extraction solutions are combined and concentrated, a concentrated solution and a low-level solvent are mixed, then negative pressure cavitation liquid-liquid extraction is conducted, an extracting liquor is obtained, an extract is obtained after concentration, ethyl alcohol is added for redissolving, and thus a solution 1 is obtained; the extracted maca filtering residues are extracted again through hot water, an extracting solution is obtained after filtering, and a solution 2 is obtained after concentration; the solution 1 and the solution 2 are combined and dried, and extractives of the effective constituents of the maca are obtained. The method for extracting the effective constituents from the maca has the advantages that the technological process is simple, the production cycle is short, the effective constituents can be efficiently extracted, products can maintain the original flavor of the maca, used equipment is conventional equipment, production cost is low, and industrial production is easy to achieve.
Description
Technical field
The invention belongs to natural product chemistry and field of plant extraction, specifically a kind of from Lepidinm meyenii Walp the method for effective component extracting.
background technology
Lepidinm meyenii Walp (Maca) genus Cruciferae (
cruciferae) separate row Vegetable spp (
lepidium meyeniiwalp.) plant is annual herb.Originating in the above mountain area, Andean of Peru height above sea level 3500m, is one of important foodstuffs source of local resident.In the edible process of thousands of years, it is found that it has building body, improves fertility, improves sexual function, the effect such as antidepressant and anti-anemia.
Modern pharmacology research discovery, the multiple compounds that the effect of Lepidinm meyenii Walp contains with it is relevant, as alkaloid scalable endocrine gland, balance hormone; Lepidinm meyenii Walp alkene and Lepidinm meyenii Walp amide have the effect that promotes sexual function; Benzyl mustard oil glycosides and benzyl isothiocyanic acid can be used as agent for increasing testosterone level, and can improve learning and memory and male's sexual function, have anticancer effect simultaneously; Maca polysaccharide has the inhibitory action of removing superoxide radical and hydroxyl radical free radical.
Lepidinm meyenii Walp is introduced a fine variety in China, implantation time is shorter, mainly is distributed in the Lijiang County In Yunnan Province Yulong Xueshan.The Lepidinm meyenii Walp health product of selling in the market, mainly with Lepidinm meyenii Walp root dry powder, be raw material greatly, because active constituent content is low, taking dose is large, health-care effect is not obvious, therefore, the application that contains the Lepidinm meyenii Walp extract of effective composition will be the inexorable trend of its health product exploitation, and the research of associated extraction technique is still in the starting stage, wherein, the patent that China Patent Publication No. is CN1166387C, CN102836196A and CN102579547A discloses the extractive technique of fat-soluble active ingredient, and CN102898534A discloses a kind of technology of extracting maca polysaccharide.Above method is incomplete to the extracts active ingredients of Lepidinm meyenii Walp.The comprehensive method of extracting of pair effective component in Maka is separately arranged: as CN102895281A adopts supercritical CO
2the method that extractive technique combines with water extraction.But supercritical CO
2in leaching process, need to add and carry agent, extracting pressure is larger, thereby makes equipment investment large, and operating cost is high; Patent CN102526161A discloses a kind of ultrasonic extracting method, has reduced to a certain extent production cost, but the method is not considered the passivation to myrosin etc.Myrosase glycosides-myrosin system is that Cruciferae is distinctive, and in Lepidinm meyenii Walp drying and pulverizing process, glucosinolate contacts with myrosin and can produce penetrating odor, destroys the local flavor of extract, reduces active component content simultaneously.Partial monopoly, for suppressing this enzymatic activity, adopts low temperature liquid nitrogen to grind, and the technology such as microwave treatment, increase operating procedure, also increased production cost simultaneously.
summary of the invention
Purpose of the present invention is exactly in order to address the above problem, provide a kind of from Lepidinm meyenii Walp the method for effective component extracting, the method can be utilized factory's conventional equipment, has realized the high efficiency extraction of effective ingredient in the Lepidinm meyenii Walp.
Technical scheme concrete steps of the present invention are as follows: a kind of from Lepidinm meyenii Walp the method for effective component extracting, it is characterized in that carrying out according to the following steps:
1), using the bright root of Lepidinm meyenii Walp or dry root as raw material, clean remove impurity, with extracting solution 60-95% ethanol by 1: 6-1: 10 kg: L mixes, carry out the homogenate liquid-solid extraction, homogenate extraction times 2 – 6 min, obtaining homogenate is filtered, filtering residue again with extracting solution 60-95% ethanol by 1: 6-1: 10 kg: L mixes, through negative pressure cavitation DL liquid-solid extraction extracting solution, pressure limit is 0.1-0.6 MPa, extract 1-3 time, each 10-30min, merge after all extracting solution and carry out decompressed concentrate and remove ethanol, obtain concentrated solution, the rudimentary property of concentrated solution and equal-volume solvent, the negative pressure cavitation liquid-liquid extraction, static, get the low polar solvent layer, concentrate to obtain extractum, add a small amount of dissolve with ethanol, obtain solution 1, one or more mixing that described rudimentary property solvent is petroleum ether, normal hexane and ethyl acetate,
2), the Lepidinm meyenii Walp solid residue in step 1 is added efficient circulation extract in concentrated unit and add the hot water of 60-79 ℃, solid-liquid ratio is 1: 10 kg of 1: 8 –: L, under the condition that is 80 ℃-extracting solution boiling temperature in temperature, be extracted into the effluent color thin out, extracting solution is concentrated, obtain solution 2;
3), the solution 2 that obtains with step 2 of solution 1 that step 1 is obtained mixes, and adopts vacuum drying, lyophilization or spray drying, obtains the effective component in Maka extract.
Described extract drying, adopt vacuum drying, lyophilization or spray drying.
The present invention compared with prior art has following advantage:
1. the method that the present invention pulverizes with homogenate is carried out the homogenate extraction to the bright root of Lepidinm meyenii Walp or dry root, and whole process is carried out in solution, no dust pollution, the loss rate of minimizing Lepidinm meyenii Walp raw material.In Lepidinm meyenii Walp wall breaking pulverization process, effective ingredient discharges and is dissolved into rapidly in solvent, improves extraction efficiency, and simultaneously, alcoholic solution is combined with myrosin rapidly, makes its deactivation, stops itself and glucosinolate effect, greatly guarantees the extraction of effective ingredient.
2. the present invention uses equipment to be mainly factory's conventional equipments such as vacuum pump, extraction pot, enrichment facility, without adding expensive device, reduces the production equipment cost.
3. technological process of the present invention is simple, with short production cycle, uses conventional equipment, and mass transfer rate is fast, and extraction ratio is high.
The specific embodiment
Several embodiments of the present invention are described below, but the present invention is not limited to these embodiment.
Embodiment 1:
1), the bright root (moisture content 60.1%) of getting Lijiang County In Yunnan Province product Lepidinm meyenii Walp is raw material 1000 g, clean remove impurity, add 95% ethanol (mass concentration at 1: 10 by solid-liquid ratio, as follows) extracting solution, carry out the homogenate liquid-solid extraction, the homogenate time is 6 min, filter, collect filtrate, filtering residue is poured in the negative pressure extraction tank, add 95% ethanol at 1: 8 by solid-liquid ratio simultaneously, deaeration, make extraction pot internal pressure 0.1 MPa, tank bottoms ventilation, carry out negative pressure cavitation DL liquid-solid extraction, extraction time 30 min, filter, obtain extract, extract 1 time, merge after all filtrate and carry out decompressed concentrate and remove ethanol, obtain concentrated solution, add the equal-volume ethyl acetate, the negative pressure cavitation liquid-solid extraction, static layering, get ethyl acetate layer, concentrate to obtain extractum, add a small amount of dissolve with ethanol, obtain solution 1.
2), pour the Lepidinm meyenii Walp solid residue in step 1 into efficient circulation and extract in concentrated unit, add the hot water of 79 ℃ at 1: 8 by solid-liquid ratio, be heated to 90 ℃, observe the effluent color and become when light yellow, stop extraction.Collect extracting solution, extracting solution is concentrated, obtain solution 2.
3), the solution 2 that obtains with step 2 of solution 1 that step 1 is obtained mixes, vacuum drying.Obtain effective component in Maka extract 94.60 g.
This extract component and proportion: alkaloid: 3.28%, Lepidinm meyenii Walp alkene content: 1.06%, the Lepidinm meyenii Walp amide content: 0.01%, polyoses content: 56.03%, glucosinolate content: 10.57%, sterols content: 0.19%, other: 28.86%.
Embodiment 2:
1), the dry root (moisture content 8.4%) of getting Lijiang County In Yunnan Province product Lepidinm meyenii Walp is raw material 600 g, clean remove impurity, add 60% ethanol extract at 1: 8 by solid-liquid ratio, carry out the homogenate liquid-solid extraction, the homogenate time is 2 min, filter, collect filtrate, filtering residue is poured in the negative pressure extraction tank, add 60% ethanol at 1: 10 by solid-liquid ratio simultaneously, deaeration, make extraction pot internal pressure 0.6 MPa, tank bottoms ventilation, carry out negative pressure cavitation DL liquid-solid extraction, extraction time 10 min, filter, obtain extract, the negative pressure cavitation step repeats 3 times, merge after all filtrate and carry out decompressed concentrate and remove ethanol, obtain concentrated solution, add the equal-volume normal hexane, the negative pressure cavitation liquid-solid extraction, static layering, get the normal hexane layer, concentrate to obtain extractum, add a small amount of dissolve with ethanol, obtain solution 1.
2), pour the Lepidinm meyenii Walp solid residue in step 1 into efficient circulation and extract in concentrated unit, add the hot water of 60 ℃ at 1: 10 by solid-liquid ratio, be heated to seethe with excitement, observe the effluent color and become when light yellow, stop extracting, collect extracting solution, extracting solution is concentrated, obtain solution 2.
3), the solution 2 that obtains with step 2 of solution 1 that step 1 is obtained mixes, spray drying.Obtain effective component in Maka extract 78.87 g.
This extract component and proportion: alkaloid: 3.81%, Lepidinm meyenii Walp alkene content: 0.69%, the Lepidinm meyenii Walp amide content: 0.03%, polyoses content:: 59.44%, glucosinolate content: 6.10%, sterols content: 0.23%, other: 29.70%.
Embodiment 3:
1), the bright root (moisture content 60.1%) of getting Lijiang County In Yunnan Province product Lepidinm meyenii Walp is raw material 1000 g, clean remove impurity, add 80% ethanol extract at 1: 6 by solid-liquid ratio, carry out the homogenate liquid-solid extraction, the homogenate time is 4 min, filter, collect filtrate, filtering residue is poured in the negative pressure extraction tank, add 80% ethanol at 1: 6 by solid-liquid ratio simultaneously, deaeration, make extraction pot internal pressure 0.3 MPa, tank bottoms ventilation, carry out negative pressure cavitation DL liquid-solid extraction, extraction time 20 min, filter, obtain extract, extract 2 times, merge after all filtrate and carry out decompressed concentrate and remove ethanol, obtain concentrated solution, add the equal-volume petroleum ether, the negative pressure cavitation liquid-solid extraction, static layering, get petroleum ether layer, concentrate to obtain extractum, add a small amount of dissolve with ethanol, obtain solution 1.
2), pour the Lepidinm meyenii Walp solid residue in step 1 into efficient circulation and extract in concentrated unit, add the hot water of 70 ℃ at 1: 9 by solid-liquid ratio, be heated to 80 ℃, observe the effluent color and become when light yellow, stop extraction.Collect extracting solution, extracting solution is concentrated, obtain solution 2.
3), the solution 2 that obtains with step 2 of solution 1 that step 1 is obtained mixes, lyophilization.Obtain effective component in Maka extract 95.03 g.
This extract component and proportion: alkaloid: 3.45%, Lepidinm meyenii Walp alkene content: 1.09%, the Lepidinm meyenii Walp amide content: 0.01%, polyoses content:: 55.78%, glucosinolate content: 11.57%, sterols content: 0.20%, other: 27.90%.
Claims (2)
1. the method for an effective component extracting from Lepidinm meyenii Walp is characterized in that carrying out according to the following steps:
1), using the bright root of Lepidinm meyenii Walp or dry root as raw material, clean remove impurity, with extracting solution 60-95% ethanol by 1: 6-1: 10 kg: L mixes, carry out the homogenate liquid-solid extraction, homogenate extraction times 2 – 6 min, obtaining homogenate is filtered, filtering residue again with extracting solution 60-95% ethanol by 1: 6-1: 10 kg: L mixes, through negative pressure cavitation DL liquid-solid extraction extracting solution, pressure limit is 0.1-0.6 MPa, extract 1-3 time, each 10-30min, merge after all extracting solution and carry out decompressed concentrate and remove ethanol, obtain concentrated solution, the rudimentary property of concentrated solution and equal-volume solvent, the negative pressure cavitation liquid-liquid extraction, static, get the low polar solvent layer, concentrate to obtain extractum, add a small amount of dissolve with ethanol, obtain solution 1, one or more mixing that described rudimentary property solvent is petroleum ether, normal hexane and ethyl acetate,
2), the Lepidinm meyenii Walp solid residue in step 1 is added efficient circulation extract in concentrated unit and add the hot water of 60-79 ℃, solid-liquid ratio is 1: 10 kg of 1: 8 –: L, under the condition that is 80 ℃-extracting solution boiling temperature in temperature, be extracted into the effluent color thin out, extracting solution is concentrated, obtain solution 2;
3), the solution 2 that obtains with step 2 of solution 1 that step 1 is obtained mixes, and adopts vacuum drying, lyophilization or spray drying, obtains the effective component in Maka extract.
According to claim 1 a kind of from Lepidinm meyenii Walp the method for effective component extracting, it is characterized in that described extract drying, adopt vacuum drying, lyophilization or spray drying.
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Cited By (15)
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| CN103980383A (en) * | 2014-06-05 | 2014-08-13 | 丽江百岁坊生物科技开发有限公司 | Preparation method of maca polysaccharide and mustard oil glycoside |
| CN104187679A (en) * | 2014-09-13 | 2014-12-10 | 昆明元正生物科技有限公司 | Haematococcus pluvialis maca health product and preparation method thereof |
| CN104207134A (en) * | 2014-10-11 | 2014-12-17 | 王衍彬 | Production method of maca extracts |
| CN104305200A (en) * | 2014-11-04 | 2015-01-28 | 昆明元正生物科技有限公司 | Peruvian ginseng and worm chrysalis health-care product and preparation method thereof |
| CN104523803A (en) * | 2015-01-14 | 2015-04-22 | 昆明博尚生物技术有限公司 | Preparation method of extract preserving natural flavor of maca |
| CN104621436A (en) * | 2014-10-10 | 2015-05-20 | 浙江玛卡人生生物工程研究所 | Maca extract sugar-removing technology |
| CN104904969A (en) * | 2015-05-12 | 2015-09-16 | 甘肃省轻工研究院 | Maca coffee |
| CN105360798A (en) * | 2015-01-29 | 2016-03-02 | 华中科技大学 | Maca formula capable of strengthening tolerance and explosive force and preparation method thereof |
| CN105795430A (en) * | 2016-03-30 | 2016-07-27 | 吉林工商学院 | Preparation method for agastache rugosus seasoning |
| CN105832801A (en) * | 2016-05-22 | 2016-08-10 | 深圳市先康达生物科技有限公司 | Extraction and separation method for macaenes and maca amides |
| CN105853781A (en) * | 2016-04-06 | 2016-08-17 | 苏州普罗达生物科技有限公司 | Maca composition and application thereof |
| CN106668115A (en) * | 2017-02-10 | 2017-05-17 | 烟台新时代健康产业有限公司 | Method for extracting active ingredients from maca |
| CN108272848A (en) * | 2018-04-18 | 2018-07-13 | 佛山市飞程信息技术有限公司 | A kind of extraction process of Maca extract |
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| CN103980383B (en) * | 2014-06-05 | 2016-04-20 | 丽江百岁坊生物科技开发有限公司 | The preparation method of a kind of maca polysaccharide and glucosinolate |
| CN103980383A (en) * | 2014-06-05 | 2014-08-13 | 丽江百岁坊生物科技开发有限公司 | Preparation method of maca polysaccharide and mustard oil glycoside |
| CN104187679A (en) * | 2014-09-13 | 2014-12-10 | 昆明元正生物科技有限公司 | Haematococcus pluvialis maca health product and preparation method thereof |
| CN104187679B (en) * | 2014-09-13 | 2016-01-13 | 昆明元正生物科技有限公司 | A kind of haematococcus pluvialis agate coffee health products and preparation method thereof |
| CN104621436A (en) * | 2014-10-10 | 2015-05-20 | 浙江玛卡人生生物工程研究所 | Maca extract sugar-removing technology |
| CN104621436B (en) * | 2014-10-10 | 2017-12-15 | 浙江玛卡人生生物工程研究所 | A kind of Maca extract removes sugared technique |
| CN104207134A (en) * | 2014-10-11 | 2014-12-17 | 王衍彬 | Production method of maca extracts |
| CN104305200A (en) * | 2014-11-04 | 2015-01-28 | 昆明元正生物科技有限公司 | Peruvian ginseng and worm chrysalis health-care product and preparation method thereof |
| CN104523803B (en) * | 2015-01-14 | 2018-06-19 | 云南良旺生物技术有限公司 | A kind of preparation method for retaining the natural flavour mountaineous extract of maca |
| CN104523803A (en) * | 2015-01-14 | 2015-04-22 | 昆明博尚生物技术有限公司 | Preparation method of extract preserving natural flavor of maca |
| CN105360798A (en) * | 2015-01-29 | 2016-03-02 | 华中科技大学 | Maca formula capable of strengthening tolerance and explosive force and preparation method thereof |
| CN104904969A (en) * | 2015-05-12 | 2015-09-16 | 甘肃省轻工研究院 | Maca coffee |
| CN104904969B (en) * | 2015-05-12 | 2018-07-31 | 甘肃省轻工研究院 | Agate card coffee |
| CN105795430B (en) * | 2016-03-30 | 2018-10-30 | 吉林工商学院 | A kind of preparation method of wrinkled giant hyssop flavouring |
| CN105795430A (en) * | 2016-03-30 | 2016-07-27 | 吉林工商学院 | Preparation method for agastache rugosus seasoning |
| CN105853781A (en) * | 2016-04-06 | 2016-08-17 | 苏州普罗达生物科技有限公司 | Maca composition and application thereof |
| CN105832801A (en) * | 2016-05-22 | 2016-08-10 | 深圳市先康达生物科技有限公司 | Extraction and separation method for macaenes and maca amides |
| CN105832801B (en) * | 2016-05-22 | 2020-02-04 | 尹梦珍 | Extraction and separation method of macaene and macamide |
| CN106668115A (en) * | 2017-02-10 | 2017-05-17 | 烟台新时代健康产业有限公司 | Method for extracting active ingredients from maca |
| CN108272848A (en) * | 2018-04-18 | 2018-07-13 | 佛山市飞程信息技术有限公司 | A kind of extraction process of Maca extract |
| CN112795442A (en) * | 2021-01-22 | 2021-05-14 | 云南紫啤啤酒有限责任公司 | Preparation method of plant polypeptide beer |
| CN114671755A (en) * | 2022-04-24 | 2022-06-28 | 陕西嘉禾生物科技股份有限公司 | Preparation method of high-content macaene |
| CN114671755B (en) * | 2022-04-24 | 2023-07-28 | 陕西嘉禾生物科技股份有限公司 | Preparation method of high-content maca alkene |
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