CN104304345A - Composite traditional Chinese medicinal sterilizing agent for dairy farm - Google Patents
Composite traditional Chinese medicinal sterilizing agent for dairy farm Download PDFInfo
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Abstract
The invention discloses a composite traditional Chinese medicinal sterilizing agent for a dairy farm which has no medicine residue and is environmentally friendly. The composite traditional Chinese medicinal sterilizing agent product is prepared by compounding traditional Chinese herbs such as gallnut, houttuynia cordata, coptis chinensis, scutellaria baicalensis, folium isatidis, herba andrographitis, radix isatidis, wild chrysanthemum flower, gingko, rhizoma acori graminei, magnolia officinalis, thyme, lysimachia christinae hance and the like in an ultrasonic auxiliary two-step extraction process. The composite traditional Chinese medicinal sterilizing agent has advantages the that the production process of ultrasonic auxiliary ethanol extraction of traditional Chinese herb and decoction is adopted in the preparation process of the composite traditional Chinese medicinal sterilizing agent, so that the aqueous soluble and alcohol soluble antibacterial active substances in the traditional Chinese herbs can be more adequately utilized; secondly, tween 80 and propanediol are added in the composite traditional Chinese medicinal sterilizing agent, so that the stability, adsorption property and viscosity of the sterilizing agent can be improved, and the effect of the composite traditional Chinese medicinal sterilizing agent can be further improved; thirdly, the product is environmentally friendly and safe, has no adverse effect on cow and has no problems such as medicine residue and drug resistance.
Description
Technical field
The present invention relates to a kind of dairy cow farm compound Chinese herb disinfectant, belong to plant's technical field of epidemic prevention.
Background technology
The milk cow production of economical and efficient is the important component part of modern agriculture.Abroad, generally compare the development paying attention to milk cattle cultivating and related industry, the development degree of milk industry is seen as the important symbol of the agricultural modernization especially flourishing level of livestock breeding, milk crop and occupancy volume per person have been regarded as one of leading indicator of national economy development degree and overall national strength power; The milk industry output value of current developed country generally accounts for about 1/3 of the livestock breeding gross output value, has become the pillar industry of developed country's agricultural.China milk industry development is more late, but the milk cow production of China presents sustainable growth situation always at present, and within 2013, China's cow population reaches 1,500 ten thousand, and dairy village large-scale development trend highlights.
Scale high-density breeding community is while raising milk cattle cultivating economic benefit; also for the propagation of epidemic disease provides favourable objective condition; easily cause the propagation of certain epidemic disease and popular; increase milk cattle cultivating risk; particularly easily causing pathogens from dairy cattle affected smastitis to be propagated, is the topmost approach of milk cattle infected mastitis.Therefore, dairy cow farm assanation directly affects economic benefit and the food security of dairy cow farm, is one of significant problem needing solution badly in milk cattle cultivating industry development;
Effective sterilization can cut off epidemic disease route of transmission, reaches the pathogenetic objects of epidemic disease such as prevention and corntrol mastitis.Although current commercially available disinfectant is of a great variety, all belong to chemosterilant, as 84 thimerosals, hydrogen peroxide etc.There is larger drawback in chemosterilant, one is that side effect is comparatively large, gently then affect cow producing milk quality, heavy then endanger milk cow health and life; Although two is that chemosterilant has suppression pathogenic bacteria effect preferably, but certain toxicity and excitant are existed to human body and animal body, time as higher in 84 thimerosal concentration, stronger stimulation damage is produced to humans and animals body mucous membrane, have a strong impact on the health of staff and milk cow; Three is that chemical disinfection liquid medicine is seriously residual, and the abuse of chemosterilant brings serious environmental pollution to milk cattle cultivating environment, constrains the sustainable health development of milk cow production.
Summary of the invention
Herein for existing chemosterilant exist side effect large, there is the drawbacks such as certain toxicity and excitant, environmental pollution be serious, the compound Chinese herb disinfectant of a kind of dairy cow farm drug residue free, environmental protection is provided, it is effectively stable that described disinfectant is used for dairy cow farm, meet or exceed the due effects of chemosterilant, energy effective guarantee milk cow health and milk safety, promote milk cow production sustainable development.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The invention provides a kind of dairy cow farm compound Chinese herb disinfectant, it is characterized in that being made up of the bulk drug of following mass ratio: gall nut 26 ~ 34 parts, cordate houttuynia 25 ~ 30 parts, the coptis 23 ~ 27 parts, the root of large-flowered skullcap 22 ~ 26 parts, folium isatidis 21 ~ 25 parts, Herba Andrographitis 20 ~ 22 parts, Radix Isatidis 20 ~ 25 parts, mother chrysanthemum 20 ~ 23 parts, ginkgo 18 ~ 22 parts, grass-leaved sweetflag 15 ~ 20 parts, the bark of official magnolia 12 ~ 16 parts, thyme 10 ~ 15 parts, line grass 8 ~ 12 parts, 5 ~ 10 parts, Radix Glycyrrhizae.
According to above-mentioned dairy cow farm compound Chinese herb disinfectant, the optimum bulk drug mass ratio of described disinfectant consists of: gall nut 30 parts, cordate houttuynia 28.5 parts, the coptis 25 parts, the root of large-flowered skullcap 24 parts, folium isatidis 23 parts, Herba Andrographitis 21 parts, Radix Isatidis 23 parts, mother chrysanthemum 21.5 parts, ginkgo 20 parts, grass-leaved sweetflag 18 parts, the bark of official magnolia 14 parts, thyme 12 parts, line grass 10 parts, 8 parts, Radix Glycyrrhizae.
The invention provides a kind of dairy farm compound Chinese herb disinfectant, it is characterized in that specifically comprising the following steps:
(1) preparation of compound Chinese herb: according to above-mentioned formula precise Chinese herbal medicine, be crushed to 40 ~ 60 orders, mix;
(2) ultrasonic assistant alcohol extract: 60% ethanol adding 5 ~ 10 times in compound Chinese herb pulvis, under ultrasonic assistant effect (ultrasonic power 200W), refluxing extraction 30 ~ 50min under 60 ~ 80 DEG C of conditions, extracts 3 times;
(3) reduced pressure concentration: the filtrate of extracting is merged, after refrigeration placement 24 ~ 30h, under 60 ~ 80 DEG C of conditions, the medicinal extract of reduced pressure concentration proportion 1.1 ~ 1.2 is for subsequent use;
(4) ultrasonic assistant decocting: add 3 ~ 5 times of water in the filter residue after alcohol extract, be heated to 85 ~ 95 DEG C, boiling 1 ~ 2h under ultrasonic assistant effect, is down to after normal temperature cooling leaves standstill 1 ~ 2h and filters, extract 3 times, merge decocting liquid;
(5) composite: ethanol extract, Tween 80, propane diols are mixed in the ratio of 1:1:3, add the decocting liquid after merging while stirring;
(6) precipitate: place precipitation, get supernatant and namely obtain disinfectant.
The pharmacological action of the various bulk drug of the present invention:
Gall nut, has another name called hundred worm storehouses, fermented Chinese gall herb and tea leaves, gall.Nature and flavor: taste is sour, puckery, cold in nature; Gui Jing: return lung, large intestine, kidney channel; Effect: astringe the lung, hidroschesis, puckery intestines, controlling nocturnal emission with astringent drugs, hemostasis, removing toxic substances; Cure mainly: chronic cough of deficiency lung, spontaneous sweating, protracted dysentery are rushed down for a long time, prolapse of the anus, seminal emission, gonorrhoea, various hemorrhage, carbuncle swell sore furuncle.Result of study shows that gall nut has good bacteriostasis, and in vitro test all has significantly antibacterial or bactericidal action to staphylococcus aureus, streptococcus, pneumococcus and typhoid fever, paratyphoid, dysentery, anthrax, diphtheria, Pseudomonas aeruginosa etc.100% decoction flat board burrows method, all has inhibitory action to Pseudomonas aeruginosa, shigella dysenteriae, proteus, Escherichia coli, typhoid bacillus, bacillus enteritidis, bacillus anthracis, diphtheria bacillus, staphylococcus aureus, beta streptococcus and pneumococcus;
Cordate houttuynia, has the effects such as clearing heat and detoxicating, removing pus and relieving carbuncle, inducing diuresis for treating strangurtia, cure mainly that heat drenches main lung carbuncle pyemesis, phlegm heat panting is coughed, larynx Oh, hot dysentery, carbuncle sore tumefacting virus, heat drenches.In vitro test proves, cordate houttuynia decoction all has inhibitory action in various degree to multiple gram-positive bacteria and negative bacteria such as staphylococcus aureus, staphylococcus albus, hemolytic streptococcus, Diplococcus pneumopniae, micrococcus catarrhalis, diphtheria bacillus, proteus, will he, Amur, Fu Shi and bacterium sonnei, bacillus enteritidis etc.Cordate houttuynia ether extract has obvious inhibitory action to tubercle bacillus in vitro.Extract a kind of grease obtained in cordate houttuynia, all have inhibitory action to various microorganism (especially to Molds and yeasts), have obvious inhibitory action to hemolytic streptococcus, staphylococcus aureus, Bacillus influenzae, micrococcus catarrhalis, pneumococcus; Also inhibitory action is had to Escherichia coli, shigella dysenteriae, typhoid bacillus;
The coptis, herbaceos perennial, belongs to Ranunculaceae Coptis.Function cures mainly: heat-clearing and damp-drying drug, purging intense heat and detonicating; Pharmacological action: have the pharmacologically actives such as antibacterial, antitumor and anti-arrhythmia, also has antibacterial, hypoglycemic, antitumor, protection stomach lining isoreactivity.In resisting pathogenic microbes, to the pathogenic bacteria such as staphylococcus aureus, hemolytic streptococcus, pneumococcus, diplococcus meningitidis, shigella dysenteriae, bacillus anthracis and the virus such as influenza virus, hepatitis B, there is good inhibitory action; In addition, external suppression Amoeba, Trichomonas vaginalis, trypanosome;
The root of large-flowered skullcap, has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swell the diseases such as furuncle sore.The clinical practice antibacterial effect of the root of large-flowered skullcap is better, inhibitory action is had to multiple gram positive bacteria, gram-negative bacteria, pathogenic dermatophyte, also can suppress influenza virus, hepatitis type B virus, and not develop immunity to drugs, be the optimal medicine simply of agricultural disease control;
Folium isatidis, function: clearing heat and detoxicating, cooling blood and hemostasis, ecchymose removing.Main fever caused by exogenous pathogenic factors heat contains polydipsia, abscess of throat, aphtha, jaundice, pyrotoxic dysentery, chordapsus, swollen ulcer drug, bleeding from five sense organs or subcutaneous tissue, blood pouring, traumatism and bleeding.Smalt decoction all has bactericidal action to multiple shigella dysenteriae in vitro, also has killing action to meningococcus; In addition, also killing action is had to Leptospira Bo Mengna group, Serogroup Icterohaemorrhagiae Walden type, nanukayami type;
Herba Andrographitis, another name Banlangen, snake chopping sword, eel grass etc.; Meridian distribution of property and flavor: bitter, cold in nature.The thoughts of returning home, lung, large intestine, urinary bladder channel; Effect: clearing heat and detoxicating, cool blood, detumescence, eliminating dampness; Cure mainly: cold, fever, abscess of throat, aphthae, pertussis labor is coughed, dysentery, and heat drenches puckery pain, and carbuncle swells sore, venomous snake bite;
Radix Isatidis, call indigo-blue, indigo root, manyflower glorybower root; Effect: heat-clearing, removing toxic substances, cool blood, relieve sore throat.Radix Isatidis has effect to various bacteria.Infusion is to hay bacillus, staphylococcus aureus, and sarcine, Escherichia coli, typhoid bacillus, paratyphoid A bacillus, dysentery (will Hayes, Fu Shi) bacillus, bacillus enteritidis etc. have inhibitory action; Acetone leachate also has similar effect, and to hemolytic streptococcus effectively (all using agar aperture flat band method);
Mother chrysanthemum, another name mountain chrysanthemum, Flos Chrysanthemi; Nature and flavor: cold nature, bitter, pungent; Effect: antipyretic, diaphoretic medicine, heat-clearing and detoxifying drug.Test shows that mother chrysanthemum has good resisting pathogenic microbes ability.The minimum inhibitory concentration of mother chrysanthemum water decoction to strong malicious M. tuberculosis mycobacterium is 2.5mg/ml, is 10mg/ml to the minimum inhibitory concentration of mycobacterium kansasii; Mother chrysanthemum or mother chrysanthemum branches and leaves 1:5 decoction have the effect suppressing shigella dysenteriae in vitro, and branches and leaves still have the effect suppressing typhoid bacillus.Mother chrysanthemum decoction also has inhibitory action to other various pathogens, and MIC, between 1:10-1:80, also has inhibitory action in various degree to various skin fungi during high concentration;
Ginkgo, property is put down, and sweet-bitter flavor is puckery, slightly poisonous; Enter lung, kidney channel; Have gas of astringing the lung, relieving asthma and cough, be only with turbid, reduce just, the effects such as disinfection, cure mainly asthma, phlegm is coughed, nocturnal emission, leukorrhea, gonorrhoea, baby diarrhea, malnutrition due to parasitic infestation, intestines wind dysentery, gonorrhoea, frequent urination, and the illness such as mange, dermatitis rhus, in vain knurl wind;
Grass-leaved sweetflag, nature and flavor: pungent, bitter, temperature; Gui Jing: the thoughts of returning home, stomach warp; Function cures mainly: dampness elimination is whetted the appetite, open-minded phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.Grass-leaved sweetflag anti-mycotic efficiency is remarkable, in vitro to trichophyton, Trichophyton concentricum, permitted blue achorion, Du's big belly microspore tinea bacterium difficult to understand, rust microspore tinea bacterium, ulotrichy microspore tinea bacterium, the dermatophytes such as tinea bacterium, epidermophyton rubrum, Kaufman-Wolf Epidermophyton, star-shaped nocardia criticized by groin table all good inhibitory action;
The bark of official magnolia, nature and flavor: bitter, pungent, warm in nature; Gui Jing: the spleen channel, stomach warp, large intestine channel; Function: promoting the circulation of qi disappears long-pending, eliminating dampness except full, relieving asthma; Cure mainly: stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiao, gastral cavity ruffian are vomited and diarrhoea, phlegm stops up the circulation of vital energy in the wrong direction, fullness sensation in chest is breathed with cough.The ether of the bark of official magnolia and methanolic extract to cariogenic bacteria streptococcus mutans (
streptococusmatuans) there is strong antibacterial action, its Antibacterial Constituents is defined as Magnolol and Honokiol.The first deduction of the bark of official magnolia divides magnocurarine and Cortex Magnoliae Officinalis volatile oil saturated aqueous solution to have certain bacteriostasis to staphylococcus aureus, sarcine and hay bacillus, and the bark of official magnolia also has antibacterial activity to Diplococcus pneumopniae and shigella dysenteriae;
Thyme, cure mainly expel pathogenic wind from the body surface, promoting qi circulation and relieving pain, cough-relieving, step-down, for flu, cough, headache, toothache, indigestion, acute gastroenteritis, high blood pressure;
Line grass, toil, cool; Enter liver, courage, kidney, bladder, lung channel; Effect is classified: damp-clearing drug; Effect: heat-clearing, diuresis, antibechic, detumescence, removing toxic substances;
Radix Glycyrrhizae, has another name called Glycyrrhiza Uralensis, belongs to pulse family, is a kind of help Chinese herbal medicine, cures mainly and invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
A kind of dairy cow farm compound Chinese herb disinfectant of the present invention, Product Green environmental protection, drug residue free, sterilization effect is reliable and stable, the pathogenic microorganism Candida albicans, Escherichia coli, streptococcus, salmonella, Shigella, sporidiole bacteria etc. that can effectively suppress dairy cow farm common, be conducive to ensureing the healthy and milk safety of milk cow and staff, be conducive to improving milk cattle cultivating environment, promote milk cow production sustainable health development, there is economic benefit and environmental benefit significantly.
The invention provides a kind of dairy cow farm compound Chinese herb disinfectant, it is advantageous that: one is the production technology that have employed " Chinese herbal medicine ultrasonic assistant alcohol extract+decocting ferment " in compound Chinese herb disinfectant preparation process, make use of the water-soluble and alcohol dissolubility Substance in Chinese herbal medicine more fully; Two is with the addition of Tween 80 and propane diols in compound Chinese herb disinfectant, improves the stability of disinfectant, adsorptivity and toughness, improves the effect of compound Chinese herb disinfectant further; Three is this Product Green safety, has no adverse effects, there is not the problem such as medicament residue and drug resistance to milk cow.
Compound Chinese herb disinfectant of the present invention and now conventional chemosterilant 84 thimerosal are carried out bacteriostatic test to common dairy cow farm encountered pathogenic microorganism: adopt drug sensitive test paper lysoplate assay, get Escherichia coli respectively, Candida albicans, streptococcus, salmonella, Shigella, sporidiole bacteria be seeded on corresponding plating medium, get the drug paper disk being soaked with compound Chinese herb disinfectant and 84 thimerosals again, be attached to flat board respectively to exist, take out cultivate 24h under 37 DEG C of conditions after, measure bacteriostatic diameter.
After multiple cow house uses compound Chinese herb disinfectant of the present invention respectively, achieve effect of preventing epidemic preferably, compare with 84 thimerosals, result is as follows:
Embodiment
embodiment 1:
A kind of dairy cow farm compound Chinese herb disinfectant, concrete preparation process is as follows:
(1) preparation of compound Chinese herb: according to gall nut 26 parts, cordate houttuynia 30 parts, the coptis 23 parts, the root of large-flowered skullcap 26 parts, folium isatidis 21 parts, Herba Andrographitis 22 parts, Radix Isatidis 20 parts, mother chrysanthemum 23 parts, ginkgo 18 parts, grass-leaved sweetflag 20 parts, the bark of official magnolia 12 parts, thyme 15 parts, line grass 8 parts, Radix Glycyrrhizae 10 parts of ratio precise Chinese herbal medicines, be crushed to 40 ~ 60 orders, mixed;
(2) ultrasonic assistant alcohol extract: 60% ethanol adding 5 ~ 10 times in compound Chinese herb pulvis, under ultrasonic assistant effect (ultrasonic power 200W), refluxing extraction 30 ~ 50min under 60 ~ 80 DEG C of conditions, extracts 3 times;
(3) reduced pressure concentration: the filtrate of extracting is merged, after refrigeration placement 24 ~ 30h, under 60 ~ 80 DEG C of conditions, the medicinal extract of reduced pressure concentration proportion 1.1 ~ 1.2 is for subsequent use;
(4) ultrasonic assistant decocting: add 3 ~ 5 times of water in the filter residue after alcohol extract, be heated to 85 ~ 95 DEG C, boiling 1 ~ 2h under ultrasonic assistant effect, is down to after normal temperature cooling leaves standstill 1 ~ 2h and filters, extract 3 times, merge decocting liquid;
(5) composite: ethanol extract, Tween 80, propane diols are mixed in the ratio of 1:1:3, add the decocting liquid after merging while stirring;
(6) precipitate: place precipitation, get supernatant and namely obtain disinfectant.
embodiment 2:
A kind of dairy cow farm compound Chinese herb disinfectant, concrete preparation process is as follows:
(1) preparation of compound Chinese herb: according to gall nut 34 parts, cordate houttuynia 25 parts, the coptis 27 parts, the root of large-flowered skullcap 22 parts, folium isatidis 25 parts, Herba Andrographitis 20 parts, Radix Isatidis 25 parts, mother chrysanthemum 20 parts, ginkgo 22 parts, grass-leaved sweetflag 15 parts, the bark of official magnolia 16 parts, thyme 10 parts, line grass 12 parts, Radix Glycyrrhizae 5 parts of ratio precise Chinese herbal medicines, be crushed to 40 ~ 60 orders, mixed;
(2) ultrasonic assistant alcohol extract: 60% ethanol adding 5 ~ 10 times in compound Chinese herb pulvis, under ultrasonic assistant effect (ultrasonic power 200W), refluxing extraction 30 ~ 50min under 60 ~ 80 DEG C of conditions, extracts 3 times;
(3) reduced pressure concentration: the filtrate of extracting is merged, after refrigeration placement 24 ~ 30h, under 60 ~ 80 DEG C of conditions, the medicinal extract of reduced pressure concentration proportion 1.1 ~ 1.2 is for subsequent use;
(4) ultrasonic assistant decocting: add 3 ~ 5 times of water in the filter residue after alcohol extract, be heated to 85 ~ 95 DEG C, boiling 1 ~ 2h under ultrasonic assistant effect, is down to after normal temperature cooling leaves standstill 1 ~ 2h and filters, extract 3 times, merge decocting liquid;
(5) composite: ethanol extract, Tween 80, propane diols are mixed in the ratio of 1:1:3, add the decocting liquid after merging while stirring;
(6) precipitate: place precipitation, get supernatant and namely obtain disinfectant.
embodiment 3:
A kind of dairy cow farm compound Chinese herb disinfectant, concrete preparation process is as follows:
(1) preparation of compound Chinese herb: according to gall nut 30 parts, cordate houttuynia 28.5 parts, the coptis 25 parts, the root of large-flowered skullcap 24 parts, folium isatidis 23 parts, Herba Andrographitis 21 parts, Radix Isatidis 23 parts, mother chrysanthemum 21.5 parts, ginkgo 20 parts, grass-leaved sweetflag 18 parts, the bark of official magnolia 14 parts, thyme 12 parts, line grass 10 parts, Radix Glycyrrhizae 8 parts of ratio precise Chinese herbal medicines, be crushed to 40 ~ 60 orders, mixed;
(2) ultrasonic assistant alcohol extract: 60% ethanol adding 5 ~ 10 times in compound Chinese herb pulvis, under ultrasonic assistant effect (ultrasonic power 200W), refluxing extraction 30 ~ 50min under 60 ~ 80 DEG C of conditions, extracts 3 times;
(3) reduced pressure concentration: the filtrate of extracting is merged, after refrigeration placement 24 ~ 30h, under 60 ~ 80 DEG C of conditions, the medicinal extract of reduced pressure concentration proportion 1.1 ~ 1.2 is for subsequent use;
(4) ultrasonic assistant decocting: add 3 ~ 5 times of water in the filter residue after alcohol extract, be heated to 85 ~ 95 DEG C, boiling 1 ~ 2h under ultrasonic assistant effect, is down to after normal temperature cooling leaves standstill 1 ~ 2h and filters, extract 3 times, merge decocting liquid;
(5) composite: ethanol extract, Tween 80, propane diols are mixed in the ratio of 1:1:3, add the decocting liquid after merging while stirring;
(6) precipitate: place precipitation, get supernatant and namely obtain disinfectant.
Above embodiment only for illustration of technical scheme of the present invention, but not is limited; Although be described in detail by invention with reference to previous embodiment, for the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or equivalent replacement has been carried out to wherein portion of techniques feature; And to these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.
Claims (1)
1. a dairy cow farm compound Chinese herb disinfectant, is characterized in that preparation technology specifically comprises the following steps:
(1) preparation of compound Chinese herb: in gall nut 26 ~ 34 parts, cordate houttuynia 25 ~ 30 parts, the coptis 23 ~ 27 parts, the root of large-flowered skullcap 22 ~ 26 parts, folium isatidis 21 ~ 25 parts, Herba Andrographitis 20 ~ 22 parts, Radix Isatidis 20 ~ 25 parts, mother chrysanthemum 20 ~ 23 parts, ginkgo 18 ~ 22 parts, grass-leaved sweetflag 15 ~ 20 parts, the bark of official magnolia 12 ~ 16 parts, thyme 10 ~ 15 parts, line grass 8 ~ 12 parts, Radix Glycyrrhizae 5 ~ 10 parts of ratio precise Chinese herbal medicines, be crushed to 40 ~ 60 orders, mixed;
(2) ultrasonic assistant alcohol extract: 60% ethanol adding 5 ~ 10 times in compound Chinese herb pulvis, under ultrasonic assistant effect (ultrasonic power 200W), refluxing extraction 30 ~ 50min under 60 ~ 80 DEG C of conditions, extracts 3 times;
(3) reduced pressure concentration: the filtrate of extracting is merged, after refrigeration placement 24 ~ 30h, under 60 ~ 80 DEG C of conditions, the medicinal extract of reduced pressure concentration proportion 1.1 ~ 1.2 is for subsequent use;
(4) ultrasonic assistant decocting: add 3 ~ 5 times of water in the filter residue after alcohol extract, be heated to 85 ~ 95 DEG C, boiling 1 ~ 2h under ultrasonic assistant effect, is down to after normal temperature cooling leaves standstill 1 ~ 2h and filters, extract 3 times, merge decocting liquid;
(5) composite: ethanol extract, Tween 80, propane diols are mixed in the ratio of 1:1:3, add the decocting liquid after merging while stirring;
(6) precipitate: place precipitation, get supernatant and namely obtain disinfectant.
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