CN104292289A - 半乳糖配体及其在肝靶向脂质体中的应用 - Google Patents
半乳糖配体及其在肝靶向脂质体中的应用 Download PDFInfo
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- CN104292289A CN104292289A CN201410327622.5A CN201410327622A CN104292289A CN 104292289 A CN104292289 A CN 104292289A CN 201410327622 A CN201410327622 A CN 201410327622A CN 104292289 A CN104292289 A CN 104292289A
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- Prior art keywords
- liposome
- lactosi
- semi
- liver targeting
- cholesterol
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
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- Wood Science & Technology (AREA)
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- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
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Abstract
Description
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN106589042A (zh) * | 2016-12-16 | 2017-04-26 | 嘉应学院医学院 | 肝癌靶向糖配体分子及其制备方法和载药系统 |
CN107614475A (zh) * | 2015-09-24 | 2018-01-19 | 欣耀生医股份有限公司 | 有效于治疗肝毒性及脂肪肝疾病的化合物及其用途 |
CN108420794A (zh) * | 2018-03-12 | 2018-08-21 | 中国药科大学 | 程序靶向的脂质体级联递送单一药物用于化药联合治疗 |
WO2020211317A1 (zh) * | 2019-04-17 | 2020-10-22 | 江南大学 | 一种检测人体可溶性去唾液酸糖蛋白受体的方法 |
CN112778389A (zh) * | 2019-12-31 | 2021-05-11 | 嘉应学院医学院 | 一种靶向配体分子及其制备方法和载药系统 |
CN115487306A (zh) * | 2022-11-18 | 2022-12-20 | 深圳市华元生物技术股份有限公司 | 一种药物递送载体及其制备方法、应用、糖尿病治疗药物 |
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2014
- 2014-07-10 CN CN201410327622.5A patent/CN104292289B/zh not_active Expired - Fee Related
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107614475A (zh) * | 2015-09-24 | 2018-01-19 | 欣耀生医股份有限公司 | 有效于治疗肝毒性及脂肪肝疾病的化合物及其用途 |
CN106589042A (zh) * | 2016-12-16 | 2017-04-26 | 嘉应学院医学院 | 肝癌靶向糖配体分子及其制备方法和载药系统 |
CN106589042B (zh) * | 2016-12-16 | 2019-07-26 | 嘉应学院医学院 | 肝癌靶向糖配体分子及其制备方法和载药系统 |
CN110396121A (zh) * | 2016-12-16 | 2019-11-01 | 嘉应学院医学院 | 肝癌靶向糖配体分子及其制备方法和载药系统 |
CN110396121B (zh) * | 2016-12-16 | 2020-10-16 | 嘉应学院医学院 | 肝癌靶向糖配体分子及其制备方法和载药系统 |
CN108420794A (zh) * | 2018-03-12 | 2018-08-21 | 中国药科大学 | 程序靶向的脂质体级联递送单一药物用于化药联合治疗 |
CN108420794B (zh) * | 2018-03-12 | 2020-07-28 | 中国药科大学 | 程序靶向的脂质体级联递送单一药物用于化药联合治疗 |
WO2020211317A1 (zh) * | 2019-04-17 | 2020-10-22 | 江南大学 | 一种检测人体可溶性去唾液酸糖蛋白受体的方法 |
CN112778389A (zh) * | 2019-12-31 | 2021-05-11 | 嘉应学院医学院 | 一种靶向配体分子及其制备方法和载药系统 |
CN115487306A (zh) * | 2022-11-18 | 2022-12-20 | 深圳市华元生物技术股份有限公司 | 一种药物递送载体及其制备方法、应用、糖尿病治疗药物 |
CN115487306B (zh) * | 2022-11-18 | 2023-03-17 | 深圳市华元生物技术股份有限公司 | 一种药物递送载体及其制备方法、应用、糖尿病治疗药物 |
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