CN104288588A - Preparation capable of invigorating splenic yang and circulation of blood for yang asthenia chill type rheumatic heart disease and preparation method of preparation - Google Patents

Abstract

The invention discloses a preparation capable of invigorating splenic yang and circulation of blood for a yang asthenia chill type rheumatic heart disease. The preparation is prepared from the following main raw materials in parts by weight: 20-40 parts of astragalus membranaceus, 10-15 parts of radix stephaniae tetrandrae, 6-12 parts of phragmites communis, 8-16 parts of lateral root of aconite; 10-15 parts of white atractylodes rhizome, 9-12 parts of rhizoma ligustici wallichii, 10-15 parts of haloragis micrantha, 9-15 parts of semen lepidii, 5-12 parts of capparis acutifolia, 8-14 parts of poria with hostwood, 6-9 parts of alisma, 12-18 parts of salvia miltiorrhiza, 6-13 parts of cassia twig, 5-10 parts of gardenia roasted with ginger, and 3-6 parts of notoginseng (powder). The preparation disclosed by the invention is based on discrimination and compatibility of the Chinese herbal materials, has the effects of promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pain by combination of the Chinese herbal materials, can effectively relieve dyspnea, chest distress and pain, palpitation, shortness of breath, lacking in strength and other discomfort symptoms, and has the characteristics of accurate curative effect, quick effect taking, high cure rate and the like.

Description

Aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation and preparation method

Technical field

The invention belongs to traditional Chinese medicine field, especially relate to a kind of aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation and preparation method.

Background technology

Rheumatic heart disease is called for short rheumatic heart disease, is common a kind of heart disease, refers to due to rheumatic fever activity, involves cardiac valve and the valve disorder that causes, and be the consequence that rheumatism pathological changes invades heart, in patient, women is more than male.Impaired valve is the most common with Bicuspid valve, also can get involved by several valve simultaneously, is called combined valvular lesion.Usually non-evident sympton of ill initial stage, stage shows as palpitation and short breath, weak, cough, lower limbs edema, coughs pink foam expectorant etc., until heart failure and dead.Have then show as arterial thrombosis and cerebral infarction and dead.Primary disease is mainly in winter-spring season, under cold, moist and crowded environment, the onset age many 5-15 year, recurrence is many after onset in 3-5.

Primary disease main manifestations is have one or several valvular stenosis and (or) incompetence, valvular stenosis in Bicuspid valve, Tricuspid valve, aortic valve: valve commissure adhesion, thickens, hardening, can not opening completely, and valve is young, hinders blood proper flow.Valvular insufficiency: chordae tendineae and papillary muscles hypertrophy, shortening, sclerosis, valve can not be completely closed, blood reflux.Narrow or incompetence usually exists simultaneously clinically, but normal based on one.Result shows according to the study: wherein simple mitral lesion 46.7%, and ratio is the highest, is then followed successively by Bicuspid valve and merges aortic valve, serious Aortic, Tricuspid valve and valve of pulmonary trunk.Pathological changes mainly valve edge and basilar part generation edema, ooze out, and it is whole to expand valve gradually to, even involve chordae tendineae and papillary muscles, make that the lobe leaf in valve commissure district merges, chordae tendineae merge with shorten and the fibrosis of lobe leaf, stiff, curling and calcification, thus cause the narrow or incompetence of valve orifice etc.Clinically according to disease progression degree, mainly contain following main manifestations: 1. cardiopalmus, tachypnea after movable, even occur dyspnea, night can not put down sleeping.2. just there is cough, cough with blood-flecked phlegm silk after light activity or fatigue, be easy to flu of suffering from cold.3. inappetence, that is a period of time has a meal bad, and gastrointestinal tract blood stasis may digest bad, occurs that belly is swollen.Hypourocrinia, edema of lower limbs, abdominal distention, ascites, liver, splenomegaly etc.4. most of patient occurs that two cheekbones and lip are aubergine, i.e. " mitral facies ".5. cardiopalmus is usually because caused by atrial fibrillation or arrhythmia, rapid atrial fibrillation causes the conscious discomfort of patient, even dyspnea or make it to increase the weight of.6. chest pain, the chest pain that simple valve disease causes generally uses nitroglycerin invalid.

Chinese medicine thinks that rheumatic heart disease belongs to more " palpitation with a distress feeling ", " the syndrome of dyspnea ", " edema ", the category such as " obstruction of heart-QI ".Its pathogenesis is mainly invaded in wind-cold damp pathogen, for a long time and heat-transformation or rheumatism pathogenic heat are directly violated, inside gives up in the heart, be cause blockage of the cardiac vessels, blood vessels are not smooth, blood mistake degree, the heart is become homeless foster, and the mind is uneasy for it, performance cardiopalmus, palpitation with a distress feeling, even yang-energy not cloth on the decline, be difficult warm gasification, and extremity cold of the limbs, complexion is white all of a sudden, cheekbone face is dark red, and words are livid purple.Water-damp not being transformed, inside attacks lung gold, then overflow outward skin extremity or under walk between intestinal, see edema, cough is breathed hard, and gastral cavity abdomen painful abdominal mass uncomfortable in chest is swollen, can not put down sleeping grade for card.

At present, the medicine for the treatment of rheumatic heart disease also has a lot, publication number CN 101919949 A (application number 201010245657.6) patent document discloses a kind of Chinese medicine composition for the treatment of rheumatic heart disease and preparation method thereof, the raw materials by weight wherein making effective ingredient consists of: Semen Strychni 18%-28%, Sanguis Draxonis 6%-12%, Rhizoma Cyperi 18%-28%, Olibanum 3%-5%, Myrrha 3%-5%, Cortex Cinnamomi 8%-10%, Pericarpium Citri Reticulatae 6%-10%, Rhizoma Chuanxiong 8%-12%, the percentage by weight sum of each raw material is 100%.Publication number CN 104107398 A (application number 201410371004.0) patent document discloses a kind of Chinese medicine composition for the treatment of rheumatic heart disease, be made up of the raw material of following weight: Semen Nelumbinis 3-8 gram, Fructus Gardeniae 3-8 gram, Rhizoma Polygonati Odorati 5-15 gram, Fructus Schisandrae Chinensis 5-15 gram, Radix Stephaniae Tetrandrae 5-15 gram, Fructus Aurantii Immaturus 5-15 gram, Radix Ophiopogonis 5-15 gram, Ramulus Cinnamomi 5-15 gram, Radix Bupleuri 5-15 gram, Cortex Acanthopancis 5-15 gram, Radix Paeoniae Rubra 5-15 gram, Radix Angelicae Sinensis 5-15 gram, Radix Curcumae 10-20 gram, Semen Plantaginis 10-20 gram, Radix Codonopsis 10-20 gram, Radix Salviae Miltiorrhizae 10-20 gram, Radix Rehmanniae 10-20 gram, Radix Stephaniae Tetrandrae 10-20 gram, Gypsum Fibrosum 10-20 gram, Radix Gentianae Macrophyllae 10-20 gram, Radix Polygoni Multiflori 15-25 gram, Herba Taxilli 15-25 gram, Radix Astragali 15-25 gram, Radix Glycyrrhizae 3-8 gram.Publication number CN 103585251 A(application number 201310562074.X) patent document discloses a kind of Novel Chinese patent medicine being used for the treatment of rheumatic heart disease, be made up of the raw material of following parts by weight: Radix Hemsleyae Macrospermae 25-35 part, Radix Dichroae 5-10 part, Cornu Cervi Pantotrichum 12-18 part, Radix Phytolaccae 20-25 part, Radix Dipsaci 10-16 part, beniol 8-15 part, freshwater mussel flower 5-12 part and Arsenicum sablimatum 5-17 part.

The prior art comprising above-mentioned patent documentation has achieved certain effect in treatment rheumatic heart disease, but yet there is a lot of weak point.At present, the treatment of rheumatic heart disease is main mainly with operating substitution artificial valve, surgery cost is huge on the one hand, more crucially replace the safety that a valve can not ensure other several valves, after often changing valve 3-5, other valves may can recur again, so operation thoroughly can not cure rheumatic heart disease.And the curative effect of medicine in the market bad, result is unsatisfactory.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide a kind of aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, adopt Chinese crude drug comparatively common in the localities as raw material, the drug effect of each crude drug complements each other, there is effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, effectively alleviate dyspnea, feeling of oppression and pain in the chest, palpitation and short breath, the malaise symptoms such as weak, therapeutic effect is good, and the slight illness alleviated on the health of patient torments.Another object of the present invention is to provide the preparation method of above-mentioned aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 20-40 part; Radix Stephaniae Tetrandrae 10-15 part; Rhizoma Phragmitis 6-12 part; Radix Aconiti Lateralis Preparata 8-16 part; Rhizoma Atractylodis Macrocephalae 10-15 part; Rhizoma Chuanxiong 9-12 part; Herba Haloragidis Micranthae 10-15 part; Semen Lepidii (Semen Descurainiae) 9-15 part; Radix Capparis Membranaceae 5-12 part; Poria cum Radix Pini 8-14 part; Rhizoma Alismatis 6-9 part; Radix Salviae Miltiorrhizae 12-18 part; Ramulus Cinnamomi 6-13 part; (Rhizoma Zingiberis Recens) Fructus Gardeniae 5-10 part; Radix Notoginseng 3-6 part (punching).

Aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 25-35 part; Radix Stephaniae Tetrandrae 11-14 part; Rhizoma Phragmitis 8-10 part; Radix Aconiti Lateralis Preparata 10-14 part; Rhizoma Atractylodis Macrocephalae 11-14 part; Rhizoma Chuanxiong 10-11 part; Herba Haloragidis Micranthae 11-14 part; Semen Lepidii (Semen Descurainiae) 11-13 part; Radix Capparis Membranaceae 7-10 part; Poria cum Radix Pini 10-12 part; Rhizoma Alismatis 7-8 part; Radix Salviae Miltiorrhizae 14-16 part; Ramulus Cinnamomi 8-11 part; (Rhizoma Zingiberis Recens) Fructus Gardeniae 6-9 part; Radix Notoginseng 4-5 part (punching).

Aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: the Radix Astragali 30 parts; Radix Stephaniae Tetrandrae 12 parts; Rhizoma Phragmitis 9 parts; Radix Aconiti Lateralis Preparata 12 parts; The Rhizoma Atractylodis Macrocephalae 13 parts; Rhizoma Chuanxiong 10.5 parts; Herba Haloragidis Micranthae 13 parts; Semen Lepidii (Semen Descurainiae) 12 parts; Radix Capparis Membranaceae 8 parts; Poria cum Radix Pini 11 parts; Rhizoma Alismatis 7.5 parts; Radix Salviae Miltiorrhizae 15 parts; Ramulus Cinnamomi 9 parts; (Rhizoma Zingiberis Recens) Fructus Gardeniae 8 parts; Radix Notoginseng 4.5 parts (punching).

Present invention also offers the preparation method above-mentioned aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation being made pharmaceutically acceptable decoction, thick paste agent, concentrated pill and granule.

The preparation method of described aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation decoction, step is as follows:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 600-800 mesh sieve (preferred 650-750 mesh sieve, is more preferably 700 mesh sieves);

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water and soaks 1-2 days, be placed in pot, slow fire infusion 5-15 minute (preferred 8-12 minute, be more preferably 10 minutes), taking-up is dried in the air cool, mashes, be placed in glass container, with the preferred 33o-37o of 30o-40o(, be more preferably 35o) rice wine moistening 3-7 days (preferred 4-6 days is more preferably 5 days);

(3) respectively with the preferred 88%-92% of 85%-95%(, be more preferably 90%) and the preferred 53%-57% of 50%-60%(, be more preferably 55%) ethanol by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux, each 2 hours, filter, filtrate merges, reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue to decoct 20-40 minute (preferred 25-35 minute is more preferably 30 minutes);

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferred 13-17 minute is more preferably 15 minutes), sterile packaged.

According to preparation method recited above, preferred scheme is: the consumption of step (5) sodium benzoate is the 0.1%-0.3%(preferably 0.2% of concentrated solution quality), correctives uses sucrose, and consumption is the 6%-8%(preferably 7% of concentrated solution quality).

Instructions of taking: each 10ml, every day 2 times, 5 days courses for the treatment of.

The preparation method of described aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation thick paste agent, step is as follows:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 600-800 mesh sieve (preferred 650-750 mesh sieve, is more preferably 700 mesh sieves);

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water and soaks 1-2 days, be placed in pot, slow fire infusion 5-15 minute (preferred 8-12 minute, be more preferably 10 minutes), taking-up is dried in the air cool, mashes, be placed in glass container, with the preferred 33o-37o of 30o-40o(, be more preferably 35o) rice wine moistening 3-7 days (preferred 4-6 days is more preferably 5 days);

(3) respectively with the preferred 88%-92% of 85%-95%(, be more preferably 90%) and the preferred 53%-57% of 50%-60%(, be more preferably 55%) ethanol by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux, each 2 hours, filter, filtrate merges, reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue to decoct 20-40 minute (preferred 25-35 minute is more preferably 30 minutes);

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into the preferred 1.25-1.35 of relative density 1.20-1.40(, be more preferably 1.30), add sucrose, mix homogeneously, sterile packaged.

Instructions of taking: each 6g, takes with after warm water dilution thick paste, every day 2 times, 5 days courses for the treatment of.

The preparation method of described aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation concentrated pill, step is as follows:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 600-800 mesh sieve (preferred 650-750 mesh sieve, is more preferably 700 mesh sieves);

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water and soaks 1-2 days, be placed in pot, slow fire infusion 5-15 minute (preferred 8-12 minute, be more preferably 10 minutes), taking-up is dried in the air cool, mashes, be placed in glass container, with the preferred 33o-37o of 30o-40o(, be more preferably 35o) rice wine moistening 3-7 days (preferred 4-6 days is more preferably 5 days);

(3) respectively with the preferred 88%-92% of 85%-95%(, be more preferably 90%) and the preferred 53%-57% of 50%-60%(, be more preferably 55%) ethanol by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux, each 2 hours, filter, filtrate merges, reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue to decoct 20-40 minute (preferred 25-35 minute is more preferably 30 minutes);

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into the preferred 1.25-1.35 of relative density 1.20-1.40(, be more preferably 1.30), add sucrose, mix homogeneously, makes concentrated pill by standard pharmaceutically, sterile packaged.

Using method: each 6-10 ball, with warm water delivery service, every day 2 times, 5 days courses for the treatment of.

The preparation method of described aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule, step is as follows:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 600-800 mesh sieve (preferred 650-750 mesh sieve, is more preferably 700 mesh sieves);

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water and soaks 1-2 days, be placed in pot, slow fire infusion 5-15 minute (preferred 8-12 minute, be more preferably 10 minutes), taking-up is dried in the air cool, mashes, be placed in glass container, with the preferred 33o-37o of 30o-40o(, be more preferably 35o) rice wine moistening 3-7 days (preferred 4-6 days is more preferably 5 days);

(3) respectively with the preferred 88%-92% of 85%-95%(, be more preferably 90%) and the preferred 53%-57% of 50%-60%(, be more preferably 55%) ethanol by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux, each 2 hours, filter, filtrate merges, reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue to decoct 20-40 minute (preferred 25-35 minute is more preferably 30 minutes);

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into the preferred 1.25-1.35 of relative density 1.20-1.40(, be more preferably 1.30), add sucrose and dextrin, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.

According to preparation method recited above, preferred scheme is: the amount ratio of step (5) sucrose and dextrin is 1:1, and the 5%-7%(being concentrated solution quality preferably 6%).

Instructions of taking: each 5g, takes after melting, every day 2 times, 5 days courses for the treatment of by warm water.

The pharmacological effect of each crude drug is respectively:

The Radix Astragali: sweet in the mouth, warm in nature.Return lung, spleen channel.For the dry root of leguminous plant Radix Astagali or Radix Astragali.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.

Radix Stephaniae Tetrandrae: the large hardship of taste.Gas is trembled with fear.Return bladder, spleen, kidney channel.For the dry root of menispermaceous plants Radix stephaniae tetrandrae or aristolochiaceae plant Radix Aristolochiae Fangchi, containing multiple alkaloid, be mainly sinomenine, demethyl sinomenine.There is inducing diuresis to remove edema, effect of wind-expelling pain-stopping.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia, vascular hypertension.

Rhizoma Phragmitis: sweet in the mouth, cold in nature.Attach to the lung and stomach meridians.For the fresh of grass phragmites communis or dry rhizome.There is clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, effect of diuresis.For calentura excessive thirst, gastric heat is vomitted the sound of vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.

Radix Aconiti Lateralis Preparata: acrid in the mouth, sweet, extremely hot in nature.GUIXIN, kidney, spleen channel.For the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx..There is recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, by effect of wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.For the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, have loose bowels just clear, frequent fetal movement.

Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.For the dry rhizome of samphire Rhizoma Chuanxiong.There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Herba Haloragidis Micranthae: bitter in the mouth, sweet, cool in nature.Return lung, large intestine, urinary bladder channel.For the herb of Haloragaceae plant Herba Haloragidis Micranthae.There is relieving cough and asthma, clearing away heat-damp and promoting diuresis, effect of regulating menstruation and activating blood.For cough, asthma, dysentery, dysuria, menoxenia, traumatic injury, pyretic stranguria, constipation, falls and damages fracture, furuncle, acute mastitis, scalds, venom.

Semen Lepidii (Semen Descurainiae): acrid in the mouth, hardship, property Great Cold.Return lung, urinary bladder channel.For the dry mature seed of crucifer Lepidium sativum L. or descurainia sophia (l.) webb ex prantl.There is dirty lung relieving asthma, effect of line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria, pulmonary heart disease edema.

Radix Capparis Membranaceae: bitter in the mouth, puckery, property is put down.Capparidaceae Chinese lime platymiscium Radix Capparis Membranaceae, is used as medicine with root and leaf.There is promoting blood circulation to remove blood stasis, effect of relieving spasm to stop pain.Root: for rheumatic arthritis, muscles and bones is not relaxed, laryngopharynx swelling and pain, toothache, stomachache (particularly spasmic pain), amenorrhea; Furuncle toxic swelling is controlled in external, traumatic injury.Leaf: traumatic injury is controlled in external.

Poria cum Radix Pini: nature and flavor are sweet, light flat.GUIXIN, spleen channel.For Polyporaceae crouches the sclerotium of hole platymiscium Poria, original kind is rudimentary plant, is the fungus colonized on pinaster.Medicinal effects is dry sclerotia body.There is the functions such as eliminating dampness by diuresis, spleen invigorating, mind calming.For phlegm retention, edema, dysuria, have loose bowels, cardiopalmus, dizzy.

Rhizoma Alismatis: sweet in the mouth, cold in nature.Return kidney, urinary bladder channel.For the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.There is diuresis, effect of clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.GUIXIN, Liver Channel.For the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.For the dry twig of canella Cortex Cinnamomi.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, effect of the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

(Rhizoma Zingiberis Recens) Fructus Gardeniae: bitter in the mouth, cold in nature.GUIXIN, lung, tri-jiao channel.For the processed goods of Fructus Gardeniae, Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.There is pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.

Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature.Return liver, stomach warp.For the dry root and rhizome of panax araliaceae plant.There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.

Aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation of the present invention, meet the theory of the traditional Chinese medical science about treatment rheumatic heart disease, the basis that traditional differential diagnosis in tcm treats develops in conjunction with clinical practice, adopt pure Chinese medicine unique formula to refine to form, all medicines are harmonious and have effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, effectively alleviate dyspnea, feeling of oppression and pain in the chest, palpitation and short breath, the malaise symptoms such as weak, treatment rheumatic heart disease instant effect, cure rate are high, safe ready, to have no side effect.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, takes off and states primary raw material and be prepared from (getting 30g for every part): the Radix Astragali 20 parts; Radix Stephaniae Tetrandrae 10 parts; Rhizoma Phragmitis 6 parts; Radix Aconiti Lateralis Preparata 8 parts; The Rhizoma Atractylodis Macrocephalae 10 parts; Rhizoma Chuanxiong 9 parts; Herba Haloragidis Micranthae 10 parts; Semen Lepidii (Semen Descurainiae) 9 parts; Radix Capparis Membranaceae 5 parts; Poria cum Radix Pini 8 parts; Rhizoma Alismatis 6 parts; Radix Salviae Miltiorrhizae 12 parts; Ramulus Cinnamomi 6 parts; (Rhizoma Zingiberis Recens) Fructus Gardeniae 5 parts; Radix Notoginseng 3 parts (punching).

The preparation method of above-mentioned aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation decoction, step is as follows:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 700 mesh sieves;

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water to soak 2 days, is placed in pot, slow fire infusion 10 minutes, take out and dry in the air cool, mash, be placed in glass container, with the rice wine moistening 5 days of 35o;

(3) use the ethanol of 90% and 55% by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux respectively, each 2 hours, filter, filtrate merges, and reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 40 minutes, add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue decoction 30 minutes;

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilizes 15 minutes, sterile packaged.

Instructions of taking: each 10ml, every day 2 times, 5 days courses for the treatment of.

model case onexue XX, female, 58 years old, peasant, Zibo City of Shandong Province from Gaoqing County.Suffer from the rheumatic heart disease several years, the obvious inducement of more than 10 Nian Qianwu occurs cardiopalmus, breathes hard, interruptions uncomfortable in chest show effect relevant with fatigue, to county hospital diagnosis and treatment, be diagnosed as " rheumatic heart disease, mitral stenosis ".Giving heart tonifying and diuretic disease amelioration, all can there is shortness of breath and palpitation during each outbreak, have a dizzy spell in Relapse rate outbreak afterwards, the situation of exacerbation of symptoms after movable.Recent fever and cough, cardiopalmus dyspnea with rapid and short breath can not be put down sleeping, face lip cyanosis, dyspnea, sweating, and body swells, and electrocardiogram prompting paroxysm performance atrial fibrillation, uncomfortable in chest suddenly during rest, feeling suffocated, it is sleeping to put down, and occurs that right side limbs are unfavorable simultaneously.Then occur that god knows confused puzzled, face lip and finger tip cyanosis, two base of lung moist rales, apex can hear 3 grades of two phase noises, heart rate 128 beats/min, arrhythmia, lower limb pitting edema.Red tongue, yellow and greasy fur, the right stringy and rapid pulse of arteries and veins, a left side is counted accurately not whole.

After taking 2 courses for the treatment of of embodiment 1 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation decoction, heat is moved back, and dyspnea with rapid and short breath is calmed down, and night can sleep peacefully, and appetite takes a turn for the better, and pulse condition is still weak.After continuing to take 1 course for the treatment of of embodiment 1 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation decoction, cardiopalmus, breathing hard obviously alleviates, and diet, sleep are normal, but still fatigue and weak.The dry few Tianjin of red tongue, deficient pulse is soft not whole.After taking again 1 course for the treatment of, transference cure, body feels strong, refreshed.Mrs's Xue self-induction is fully recovered, and enjoins it to continue to take 1-2 the course for the treatment of and consolidates, in case recurrence.Later stage follows up a case by regular visits to and learns and do not recur.

embodiment 2aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, takes off and states primary raw material and be prepared from (getting 15g for every part): the Radix Astragali 25 parts; Radix Stephaniae Tetrandrae 11 parts; Rhizoma Phragmitis 8 parts; Radix Aconiti Lateralis Preparata 10 parts; The Rhizoma Atractylodis Macrocephalae 11 parts; Rhizoma Chuanxiong 10 parts; Herba Haloragidis Micranthae 11 parts; Semen Lepidii (Semen Descurainiae) 11 parts; Radix Capparis Membranaceae 7 parts; Poria cum Radix Pini 10 parts; Rhizoma Alismatis 7 parts; Radix Salviae Miltiorrhizae 14 parts; Ramulus Cinnamomi 8 parts; (Rhizoma Zingiberis Recens) Fructus Gardeniae 6 parts; Radix Notoginseng 4 parts (punching).

The preparation method of above-mentioned aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation thick paste agent, step is as follows:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 700 mesh sieves;

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water to soak 2 days, is placed in pot, slow fire infusion 10 minutes, take out and dry in the air cool, mash, be placed in glass container, with the rice wine moistening 5 days of 35o;

(3) use the ethanol of 90% and 55% by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux respectively, each 2 hours, filter, filtrate merges, and reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 40 minutes, add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue decoction 30 minutes;

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into relative density 1.30, add sucrose, mix homogeneously, sterile packaged.

Instructions of taking: each 6g, takes with after warm water dilution thick paste, every day 2 times, 5 days courses for the treatment of.

model case twosoviet Union XX, man, 62 years old, retired worker, people from Lanshan District, Linyi.Uncomfortable in chest, cardiopalmus after patient's appearance activity 33 years old that year, at hospital admission, ultrasound cardiogram is diagnosed as rheumatic heart disease, mitral stenosis, and at that time and non-operation theratment, after taking one section of medicine, symptom took a turn for the better, but time have outbreak.Before 5 or six years, once operationally prominent sense shortness of breath and palpitation, uncomfortable in chest, has a rest and slightly alleviates about half an hour.Later conscious muscle power day by day declines, and namely activity is felt and breathed hard uncomfortable in chest a little, and suppress awake during night, be once diagnosed as " arrhythmia " in locality, curative effect of taking medicine is bad.There is again cough afterwards, coughed the sticky expectorant of white, breathed hard obviously, face and two edema of lower limbs, chest distress and palpitation symptoms exacerbation of symptoms, accompanied weak, tachypnea, night breathe heavily suppress, edema of pair of lower extremities.Look into ultrasound cardiogram in hospital and show cardiac insufficiency, oral drugs half wheat harvesting period, symptom loses improvement.

Recognized that the curative effect of aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation of the present invention was fine afterwards, so take the agent of embodiment 2 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation thick paste, after 1 course for the treatment of, symptom is clearly better, and shortness of breath and palpitation, the symptom such as uncomfortable in chest obviously alleviate.Continue to take uncomfortable in chest, shortness of breath and palpitation after 2 courses for the treatment of, dizzyly weakly wait transference cure, electrocardiogram display is normal.For preventing again showing effect, Mr. Su adheres to and has taken the embodiment 2 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation thick paste agent of 1 course for the treatment of.Learn in 1 year so far in the following up a case by regular visits to of later stage and do not recur again.

embodiment 3aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, takes off and states primary raw material and be prepared from (getting 20g for every part): the Radix Astragali 25 parts; Radix Stephaniae Tetrandrae 14 parts; Rhizoma Phragmitis 10 parts; Radix Aconiti Lateralis Preparata 14 parts; The Rhizoma Atractylodis Macrocephalae 14 parts; Rhizoma Chuanxiong 11 parts; Herba Haloragidis Micranthae 14 parts; Semen Lepidii (Semen Descurainiae) 13 parts; Radix Capparis Membranaceae 10 parts; Poria cum Radix Pini 12 parts; Rhizoma Alismatis 8 parts; Radix Salviae Miltiorrhizae 16 parts; Ramulus Cinnamomi 11 parts; (Rhizoma Zingiberis Recens) Fructus Gardeniae 9 parts; Radix Notoginseng 5 parts (punching).

The preparation method of above-mentioned aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation concentrated pill, step is as follows:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 700 mesh sieves;

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water to soak 2 days, is placed in pot, slow fire infusion 10 minutes, take out and dry in the air cool, mash, be placed in glass container, with the rice wine moistening 5 days of 35o;

(3) use the ethanol of 90% and 55% by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux respectively, each 2 hours, filter, filtrate merges, and reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 40 minutes, add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue decoction 30 minutes;

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into relative density 1.30, add sucrose, mix homogeneously, make concentrated pill by standard pharmaceutically, sterile packaged.

Using method: each 8 balls, with warm water delivery service, every day 2 times, 5 days courses for the treatment of.

model case threekorea Spro XX, female, 44 years old, peasant, gave birth to a pair sons and daughters, Accessories during Binzhou, Shandong Province from Wudi County.Suffer from rheumatic heart disease existing more than 5 years, period is uncomfortable in chest, tachypnea repeatedly, abdominal distention.Initial owing to there is uncomfortable in chest, tachypnea after fatigue, rest can be alleviated, not symptom aggravation in a few days, symptom repeatedly, then to hospital therapy, be diagnosed as " rheumatic heart disease, mitral stenosis ", the operative treatment of hospital's suggestion at that time, but Mrs Han refuses, and carry out relief of symptoms, but symptom increases the weight of year by year by Long-term taking medicine, effect is undesirable, the trend that the state of an illness makes further progress.

After taking 2 courses for the treatment of of embodiment 3 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation pill, nervous, stifling, the weak symptom such as to breathe hard are clearly better, and edema disappears.After continuing to take 2 courses for the treatment of of embodiment 3 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation pill, the state of an illness is eased completely, clinical symptom disappearance, and occur without malaise symptoms after gentle activity, Mrs Han can normally work down.Mrs's Han also self-induction recovery from illness.Follow up a case by regular visits to so far, have no recurrence.

embodiment 4aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, takes off and states primary raw material and be prepared from (getting 10g for every part): the Radix Astragali 30 parts; Radix Stephaniae Tetrandrae 12 parts; Rhizoma Phragmitis 9 parts; Radix Aconiti Lateralis Preparata 12 parts; The Rhizoma Atractylodis Macrocephalae 13 parts; Rhizoma Chuanxiong 10.5 parts; Herba Haloragidis Micranthae 13 parts; Semen Lepidii (Semen Descurainiae) 12 parts; Radix Capparis Membranaceae 8 parts; Poria cum Radix Pini 11 parts; Rhizoma Alismatis 7.5 parts; Radix Salviae Miltiorrhizae 15 parts; Ramulus Cinnamomi 9 parts; (Rhizoma Zingiberis Recens) Fructus Gardeniae 8 parts; Radix Notoginseng 4.5 parts (punching).

The preparation method of above-mentioned aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule, step is as follows:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 700 mesh sieves;

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water to soak 2 days, is placed in pot, slow fire infusion 10 minutes, take out and dry in the air cool, mash, be placed in glass container, with the rice wine moistening 5 days of 35o;

(3) use the ethanol of 90% and 55% by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux respectively, each 2 hours, filter, filtrate merges, and reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 40 minutes, add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue decoction 30 minutes;

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into relative density 1.30, add sucrose and dextrin, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.

Instructions of taking: each 5g, takes after melting, every day 2 times, 5 days courses for the treatment of by warm water.

test example:for the examination of curative effect of embodiment 4 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule, we have done toxicity test and clinical trial, and concrete condition is as follows:

toxicity test: acute toxicity test: select SPF level kunming mice, Mouse feeder is in square transparent mouse cage, and the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.The feeding room to mice, cage tool, drinking bottle etc. is needed to carry out disinfection before raising.Before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, ensure female not producing, without pregnant.Gastric perfusion needle is used to carry out gavage to mice: to be melted by embodiment 4 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule warm water, gastric perfusion needle is inserted by animal bicker, general depth of needle 2.5-3cm, every mouse stomach injection 0.3ml medicinal liquid, the reaction of close observation mice after administration, observe 15 days, experimental animal does not find poisoning manifestations, without dead, dissect obviously not abnormal, judge that aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation of the present invention is to the nontoxic level in the true border of Mouse Acute Toxicity.

long term toxicity test: select SPF level kunming mice, Mouse feeder is in square transparent mouse cage, and the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.The feeding room to mice, cage tool, drinking bottle etc. is needed to carry out disinfection before raising.Before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, same guarantee is female does not produce, without pregnant.Take embodiment 4 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule warm water to melt, every mice controls dosage 1g every day, continuous use 7 weeks, drug withdrawal was observed after 3 weeks, weighed weekly once during administration, and amount drinking-water appetite is all normal, body weight increases, without dead or moribund animals, the index such as hair, behavior, defecation, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of mice all has no significant effect, and internal organs naked eyes do not find difference change.Histological indications shows, medication 7 weeks and drug withdrawal are after 3 weeks, and Organs of Mice all without obviously changing, illustrates that aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation of the present invention is very little to toxicity after mice long-term prescription, difference reaction is not had, application safety after drug withdrawal yet.

clinical trial:in order to verify the curative effect of embodiment 4 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule, We conducted contrast test.Experiment selects rheumatic heart disease volunteer 300 people, minimal ages 38 years old, max age 72 years old, 60.7 years old mean age, and be divided into matched group and experimental group two groups randomly, wherein experimental group has 200 people, and matched group has 100 people.Experimental group: take embodiment 4 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule, each 5g, takes after melting, every day 2 times, 5 days courses for the treatment of by warm water.Matched group: adopt other treatment scheme, such as take sharp heart ball etc.Every day same equal time, medication under square one, and the health of observing simultaneously, recording every group patient.Curative effect situation criterion: cure: edema, cardiopalmus, breathe hard, the symptom such as poor sleeping quality all disappears, all diseases are normal.Effective: atrial fibrillation phenomenon disappears substantially, the heavy elephant of chi pulse makes moderate progress, and shortness of breath and palpitation, sleep, diet etc. are all greatly improved.Invalid: unchanged and later stage recurrence before and after treatment, wherein effectively comprise recovery from illness and effective.The Comparison of therapeutic of matched group and experimental group, result is as shown in table 1:

Table 1

efficacy analysis:as can be seen from Table 1, the inefficiency taking the embodiment of the present invention 4 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule is only 3%, cure rate is up to 76%, effective percentage is up to 97%, and adopt the inefficiency had up to 21% of other treatment scheme, cure rate only reaches 35%, and effective percentage is also only 79%.Experiment shows to take embodiment 4 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule and takes compared with other drug, and evident in efficacy, cure rate is high, and inefficiency is low, really solves the pain of patient.

In the time of 4 courses for the treatment of of patient on medication, record the health of every group patient, observe and add up the alleviation situation of each symptom, can obtain: the ratio that each symptom of experimental group taking embodiment 4 gained aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule is eased is apparently higher than the matched group taking other medicine (as sharp heart ball etc.), after taking 2 courses for the treatment of, experimental group has each malaise symptoms of the patient of more than 61% to take a turn for the better to some extent, and matched group only has each malaise symptoms of the patient of 36% to be eased; After taking 4 courses for the treatment of, experimental group has each malaise symptoms of the patient up to 97% to be eased, and matched group only has each malaise symptoms of the patient of 58% to be eased.Thus, can conclude that aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation granule of the present invention has better curative effect to rheumatic heart disease, each crude drug of said preparation mixes, meet Chinese drug preparation theory, each drug effect complements each other, evident in efficacy, be the safe and effective medicine for the treatment of rheumatic heart disease, clinic is applied.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 20-40 part; Radix Stephaniae Tetrandrae 10-15 part; Rhizoma Phragmitis 6-12 part; Radix Aconiti Lateralis Preparata 8-16 part; Rhizoma Atractylodis Macrocephalae 10-15 part; Rhizoma Chuanxiong 9-12 part; Herba Haloragidis Micranthae 10-15 part; Semen Lepidii (Semen Descurainiae) 9-15 part; Radix Capparis Membranaceae 5-12 part; Poria cum Radix Pini 8-14 part; Rhizoma Alismatis 6-9 part; Radix Salviae Miltiorrhizae 12-18 part; Ramulus Cinnamomi 6-13 part; (Rhizoma Zingiberis Recens) Fructus Gardeniae 5-10 part; Radix Notoginseng 3-6 part (punching).

2. aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation according to claim 1, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Astragali 25-35 part; Radix Stephaniae Tetrandrae 11-14 part; Rhizoma Phragmitis 8-10 part; Radix Aconiti Lateralis Preparata 10-14 part; Rhizoma Atractylodis Macrocephalae 11-14 part; Rhizoma Chuanxiong 10-11 part; Herba Haloragidis Micranthae 11-14 part; Semen Lepidii (Semen Descurainiae) 11-13 part; Radix Capparis Membranaceae 7-10 part; Poria cum Radix Pini 10-12 part; Rhizoma Alismatis 7-8 part; Radix Salviae Miltiorrhizae 14-16 part; Ramulus Cinnamomi 8-11 part; (Rhizoma Zingiberis Recens) Fructus Gardeniae 6-9 part; Radix Notoginseng 4-5 part (punching).

3. aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation according to claim 1, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: the Radix Astragali 30 parts; Radix Stephaniae Tetrandrae 12 parts; Rhizoma Phragmitis 9 parts; Radix Aconiti Lateralis Preparata 12 parts; The Rhizoma Atractylodis Macrocephalae 13 parts; Rhizoma Chuanxiong 10.5 parts; Herba Haloragidis Micranthae 13 parts; Semen Lepidii (Semen Descurainiae) 12 parts; Radix Capparis Membranaceae 8 parts; Poria cum Radix Pini 11 parts; Rhizoma Alismatis 7.5 parts; Radix Salviae Miltiorrhizae 15 parts; Ramulus Cinnamomi 9 parts; (Rhizoma Zingiberis Recens) Fructus Gardeniae 8 parts; Radix Notoginseng 4.5 parts (punching).

4., according to the arbitrary described aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation of claim 1-3, it is characterized in that: be made into pharmaceutically acceptable decoction, thick paste agent, concentrated pill and granule.

5. aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation according to claim 4, is characterized in that: the preparation method of described decoction is:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 600-800 mesh sieve (preferred 650-750 mesh sieve, is more preferably 700 mesh sieves);

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water and soaks 1-2 days, be placed in pot, slow fire infusion 5-15 minute (preferred 8-12 minute, be more preferably 10 minutes), taking-up is dried in the air cool, mashes, be placed in glass container, with the preferred 33o-37o of 30o-40o(, be more preferably 35o) rice wine moistening 3-7 days (preferred 4-6 days is more preferably 5 days);

(3) respectively with the preferred 88%-92% of 85%-95%(, be more preferably 90%) and the preferred 53%-57% of 50%-60%(, be more preferably 55%) ethanol by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux, each 2 hours, filter, filtrate merges, reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue to decoct 20-40 minute (preferred 25-35 minute is more preferably 30 minutes);

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferred 13-17 minute is more preferably 15 minutes), sterile packaged.

6. the preparation method of aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation according to claim 5, it is characterized in that: the consumption of step (5) sodium benzoate is the 0.1%-0.3%(preferably 0.2% of concentrated solution quality), correctives uses sucrose, and consumption is the 6%-8%(preferably 7% of concentrated solution quality).

7. aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation according to claim 4, is characterized in that: the preparation method of described thick paste agent is:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 600-800 mesh sieve (preferred 650-750 mesh sieve, is more preferably 700 mesh sieves);

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water and soaks 1-2 days, be placed in pot, slow fire infusion 5-15 minute (preferred 8-12 minute, be more preferably 10 minutes), taking-up is dried in the air cool, mashes, be placed in glass container, with the preferred 33o-37o of 30o-40o(, be more preferably 35o) rice wine moistening 3-7 days (preferred 4-6 days is more preferably 5 days);

(3) respectively with the preferred 88%-92% of 85%-95%(, be more preferably 90%) and the preferred 53%-57% of 50%-60%(, be more preferably 55%) ethanol by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux, each 2 hours, filter, filtrate merges, reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue to decoct 20-40 minute (preferred 25-35 minute is more preferably 30 minutes);

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into the preferred 1.25-1.35 of relative density 1.20-1.40(, be more preferably 1.30), add sucrose, mix homogeneously, sterile packaged.

8. aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation according to claim 4, is characterized in that: the preparation method of described concentrated pill is:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 600-800 mesh sieve (preferred 650-750 mesh sieve, is more preferably 700 mesh sieves);

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water and soaks 1-2 days, be placed in pot, slow fire infusion 5-15 minute (preferred 8-12 minute, be more preferably 10 minutes), taking-up is dried in the air cool, mashes, be placed in glass container, with the preferred 33o-37o of 30o-40o(, be more preferably 35o) rice wine moistening 3-7 days (preferred 4-6 days is more preferably 5 days);

(3) respectively with the preferred 88%-92% of 85%-95%(, be more preferably 90%) and the preferred 53%-57% of 50%-60%(, be more preferably 55%) ethanol by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux, each 2 hours, filter, filtrate merges, reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue to decoct 20-40 minute (preferred 25-35 minute is more preferably 30 minutes);

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into the preferred 1.25-1.35 of relative density 1.20-1.40(, be more preferably 1.30), add sucrose, mix homogeneously, makes concentrated pill by standard pharmaceutically, sterile packaged.

9. aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation according to claim 4, is characterized in that: the preparation method of described granule is:

(1) cleaned by Radix Notoginseng, dry, smash, squeeze to surperficial brown color with vegetable oil, taking-up is dried in the air cool, is ground into fine powder, crosses 600-800 mesh sieve (preferred 650-750 mesh sieve, is more preferably 700 mesh sieves);

(2) Semen Lepidii (Semen Descurainiae) is placed in clear water and soaks 1-2 days, be placed in pot, slow fire infusion 5-15 minute (preferred 8-12 minute, be more preferably 10 minutes), taking-up is dried in the air cool, mashes, be placed in glass container, with the preferred 33o-37o of 30o-40o(, be more preferably 35o) rice wine moistening 3-7 days (preferred 4-6 days is more preferably 5 days);

(3) respectively with the preferred 88%-92% of 85%-95%(, be more preferably 90%) and the preferred 53%-57% of 50%-60%(, be more preferably 55%) ethanol by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Rhizoma Chuanxiong reflux, each 2 hours, filter, filtrate merges, reclaim ethanol, filtrate filtering residue is for subsequent use;

(4) step (2) gains, step (3) gained filtering residue and Radix Stephaniae Tetrandrae, Rhizoma Phragmitis, Radix Aconiti Lateralis Preparata, Radix Capparis Membranaceae, Poria cum Radix Pini, Radix Salviae Miltiorrhizae and Ramulus Cinnamomi are placed in marmite, intense fire is fried open, turn slow fire boiling 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Alismatis, Herba Haloragidis Micranthae and (Rhizoma Zingiberis Recens) Fructus Gardeniae, continue to decoct 20-40 minute (preferred 25-35 minute is more preferably 30 minutes);

(5) by step (3) gained filtrate and step (4) gained decocting liquid mix homogeneously, pour the Radix Notoginseng powder of step (1) gained, be concentrated into the preferred 1.25-1.35 of relative density 1.20-1.40(, be more preferably 1.30), add sucrose and dextrin, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.

10. the preparation method of aversion to cold due to YANG-insufficiency type rheumatic heart disease yang invigorating Huoxue preparation according to claim 7, is characterized in that: the amount ratio of step (5) sucrose and dextrin is 1:1, and the 5%-7%(being concentrated solution quality preferably 6%).