CN104288252B - 一种治疗关节疼痛的药剂 - Google Patents

一种治疗关节疼痛的药剂 Download PDF

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CN104288252B
CN104288252B CN201410568916.7A CN201410568916A CN104288252B CN 104288252 B CN104288252 B CN 104288252B CN 201410568916 A CN201410568916 A CN 201410568916A CN 104288252 B CN104288252 B CN 104288252B
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田桂昌
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Abstract

本发明涉及一种治疗关节疼痛的药剂，它包含下列物质：没药、乳香、牛膝、桂枝、威灵仙等。本发明所述的药剂互相影响，协同作用，治疗关节疼痛效果显著，值得临床推广。

Description

一种治疗关节疼痛的药剂
技术领域
本发明涉及医药领域，具体来说涉及一种治疗关节疼痛的药剂。
背景技术
腰腿痛病是一种危害人们健康的常见病、多发病，引起的原因多是脊柱畸形、骨质疏松、腰椎间盘突出症、腰椎管狭窄等。此病尤以中老年发病率高，且病程长、发病原因复杂，严重影响了广大患者的身心健康，而目前市场上治疗此病的药物品种繁多，副作用多，疗效不太确切，作用短暂。
发明内容
本发明的目的是提供一种治疗关节疼痛的药剂。
为了实现本发明的目的，本发明提供一种治疗关节疼痛的药剂，它包含下列重量份的物质：没药100-150份、乳香100-150份、牛膝100-200份、桂枝150-200份和威灵仙150-200份。
优选地，本发明所述的治疗关节疼痛的药剂包含下列重量份的物质：没药120份、乳香120份、牛膝150份、桂枝180份和威灵仙160份。
更优选地，本发明所述的治疗关节疼痛的药剂还包含下列重量份的物质：护心草100-150份、血竭150-200份、香石藤150-200份、透骨草100-150份、南烛叶50-150份、赤楠根50-100份、五加皮100-150份、伸筋草100-150份、鸡血藤150-200份、芙蓉花100-150份、白芷150-250份、金腰带100-150份、川芎150-200份、扶桑叶200-250份、白术100-200份、孩儿草150-250份、女贞子100-200份、地桃花150-250份、茯苓100-200份、黄芪200-300份、向日葵子200-250份、陈皮100-200份、合萌100-200份和钩藤50-150份。
最优选地，本发明所述的治疗关节疼痛的药剂还包含下列重量份的物质：护心草120份、血竭160份、香石藤190份、透骨草110份、南烛叶70份、赤楠根80份、五加皮140份、伸筋草130份、鸡血藤170份、芙蓉花110份、白芷200份、金腰带110份、川芎180份、扶桑叶210份、白术150份、孩儿草160份、女贞子120份、地桃花180份、茯苓190份、黄芪230份、向日葵子220份、陈皮150份、合萌170份和钩藤80份。
优选地，所述药剂可以是片剂、分散片、胶囊剂、软胶囊剂或膏剂。
本发明还提供药剂在制备治疗关节疼痛的药物中的用途，所述药剂包含下列重量份的物质：没药100-150份、乳香100-150份、牛膝100-200份、桂枝150-200份和威灵仙150-200份。
优选地，所述药剂包含下列重量份的物质：没药120份、乳香120份、牛膝150份、桂枝180份和威灵仙160份。
更优选地，所述药剂还包含下列重量份的物质：护心草100-150份、血竭150-200份、香石藤150-200份、透骨草100-150份、南烛叶50-150份、赤楠根50-100份、五加皮100-150份、伸筋草100-150份、鸡血藤150-200份、芙蓉花100-150份、白芷150-250份、金腰带100-150份、川芎150-200份、扶桑叶200-250份、白术100-200份、孩儿草150-250份、女贞子100-200份、地桃花150-250份、茯苓100-200份、黄芪200-300份、向日葵子200-250份、陈皮100-200份、合萌100-200份和钩藤50-150份。
最优选地，所述药剂还包含下列重量份的物质：护心草120份、血竭160份、香石藤190份、透骨草110份、南烛叶70份、赤楠根80份、五加皮140份、伸筋草130份、鸡血藤170份、芙蓉花110份、白芷200份、金腰带110份、川芎180份、扶桑叶210份、白术150份、孩儿草160份、女贞子120份、地桃花180份、茯苓190份、黄芪230份、向日葵子220份、陈皮150份、合萌170份和钩藤80份。
优选地，所述药剂可以是片剂、分散片、胶囊剂、软胶囊剂或膏剂。
目前已公认“整体观念”、“辨证施治”、“复方使用”、“复方配伍用药如用兵”是中医最科学最有效的几大优势，其中“复方配伍用药如用兵”是非常科学的中医药原创理论。中医组方中各药如行兵布阵那样环环相扣的严密配伍，是其优于西药配方的有效手段。中医方剂理论认为，每一方剂，不仅需要根据病因病机选择合适的药剂妥善配伍，同时也应该符合方剂的基本结构，即“君、臣、佐、使”的组方配伍理论，所谓“君、臣、佐、使”的组方配伍，就是其建立在对疾病病机的全方位判断基础上的科学配比。中医用方通过多环节、多靶点整合调节的生物学机制，可以取得比西药更持久、更绿色天然无毒副作用的治疗效果，而这种疗效是建立在上述中医传统原创理论的正确指导之上的，本发明正遵循了这一原则。
在本发明的组合物中，南烛叶和孩儿草为君药；没药、乳香、牛膝、桂枝、威灵仙、护心草、血竭、香石藤、透骨草、赤楠根、五加皮、伸筋草、鸡血藤、芙蓉花、白芷为臣药；金腰带、扶桑叶、白术、女贞子、地桃花、茯苓、黄芪、向日葵子、陈皮、合萌、钩藤为佐药；川芎调和诸药，为使药。本发明所述的药物组合物互相影响，协同作用，相辅相成，共奏君臣佐使之功，治疗关节疼痛效果显著，值得临床推广。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例本发明的膏剂
称取没药120克、乳香120克、牛膝150克、桂枝180克、威灵仙160克、护心草120克、血竭160克、香石藤190克、透骨草110克、南烛叶70克、赤楠根80克、五加皮140克、伸筋草130克、鸡血藤170克、芙蓉花110克、白芷200克、金腰带110克、川芎180克、扶桑叶210克、白术150克、孩儿草160克、女贞子120克、地桃花180克、茯苓190克、黄芪230克、向日葵子220克、陈皮150克、合萌170克和钩藤80克，加入8000毫升水，在装有冷凝管的烧瓶中加热回流5小时，然后过滤，得到滤液1和滤渣1；向滤渣1中加入4000毫升水，在装有冷凝管的烧瓶中加热3小时，过滤，得到滤液2和滤渣2；合并所述滤液1、滤液2，蒸干，粉碎，加入羊毛脂350克，搅拌均匀，即得本发明所述的膏剂。
实验例
一般资料
选择各类疾病致骨关节疼痛3个月以上(严重心、肝、肾功能不全及重度高血压除外)者作为治疗对象。100例患者中，男50例，女50例；年龄42-77岁，平均60.7岁；病程最长18年，最短6个月，平均8.5年；疾病种类：骨质增生21例，腰椎间盘突出22例，风湿性关节炎22例，痛风性关节炎21例，腰肌劳损及肌腱、韧带损伤等其他类骨关节痛14例；疼痛情况：静止状态下持续性疼痛33例，活动状态下间断性疼痛25例，剧烈疼痛长期靠镇痛药维持者42例。体格检查触及压痛点者73例。
使用实施例中制备的膏剂来进行治疗，每日2次，每次在疼痛处均匀涂抹5克的膏剂。连续治疗30天。治疗期间停用其他相关药物，根据治疗前后自觉疼痛改善、压痛点变化判定疗效。
疗效评价标准
痊愈：自觉疼痛及压痛点消失，遇剧烈活动及寒冷等相关因素不复发；显效：自觉症状消失，局部压痛点疼痛减轻，遇到相关因素仍感不适，但无需服用止痛药物；有效：自觉症状减轻，压痛点仍存在，遇到相关因素仍需服止痛药物；无效：临床症状及特征无改善或加重。
结果
经过治疗，100例患者中痊愈63例，显效27例，有效10例，总有效率100％。
典型案例
章某某，女，55岁，2013年5月22日初诊。患者腰腿疼痛多年，现膝关节酸疼，时轻时重，屈伸小利，面色黄无光，心慌乏力，短气，形体消瘦，纳呆，眠差，大便溏，脉濡弱。现仍腰腿酸软，并伴时有抽搞，得暖则缓，小便清长，眠差，活动受限，关节屈伸小利。使用实施例中制备的膏剂来进行治疗，每日2次，每次在疼痛处均匀涂抹5克的膏剂。连续治疗30天。诸证好转，自觉疼痛及压痛点消失，遇剧烈活动及寒冷等相关因素不复发。随访半年无复发，并嘱平素注意补钙、保暖。

Claims (1)

1.一种治疗关节疼痛的膏剂，其特征在于，它通过下列方法制成：称取没药120克、乳香120克、牛膝150克、桂枝180克、威灵仙160克、护心草120克、血竭160克、香石藤190克、透骨草110克、南烛叶70克、赤楠根80克、五加皮140克、伸筋草130克、鸡血藤170克、芙蓉花110克、白芷200克、金腰带110克、川芎180克、扶桑叶210克、白术150克、孩儿草160克、女贞子120克、地桃花180克、茯苓190克、黄芪230克、向日葵子220克、陈皮150克、合萌170克和钩藤80克，加入8000毫升水，在装有冷凝管的烧瓶中加热回流5小时，然后过滤，得到滤液1和滤渣1；向滤渣1中加入4000毫升水，在装有冷凝管的烧瓶中加热3小时，过滤，得到滤液2和滤渣2；合并所述滤液1、滤液2，蒸干，粉碎，加入羊毛脂350克，搅拌均匀，即得。
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