CN104288244A - Traditional Chinese medicine composition for treating bone and joint tuberculosis, preparation method and combination of Chinese and Western medicines - Google Patents

Traditional Chinese medicine composition for treating bone and joint tuberculosis, preparation method and combination of Chinese and Western medicines Download PDF

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CN104288244A
CN104288244A CN201410181427.6A CN201410181427A CN104288244A CN 104288244 A CN104288244 A CN 104288244A CN 201410181427 A CN201410181427 A CN 201410181427A CN 104288244 A CN104288244 A CN 104288244A
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chinese medicine
radix
bone
tuberculosis
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邱相君
赵建龙
李珂
赵会军
冯建芳
吴银萍
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Henan University of Science and Technology
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Henan University of Science and Technology
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Abstract

The invention discloses a traditional Chinese medicine composition for treating bone and joint tuberculosis, a preparation method and a combination of Chinese and Western medicines, and belongs to the technical field of medicines. The traditional Chinese medicine composition is composed of the following raw materials by weight: 10-15 parts of poria, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of radix codonopsis, 15-30 parts of raw radix astragali, 5-15 parts of angelica sinensis, 5-15 parts of cassia twig, 5-10 parts of radix platycodi, 5-15 parts of radix angelicae dahuricae, 5-15 parts of red peony root, 5-15 parts of white peony root and 5-10 parts of Chinese honeylocust spine. According to the theory of traditional Chinese medicine, the traditional Chinese medicine composition combines the medicines reasonably. For internal causes of the bone and joint tuberculosis, a plurality of qi-tonifying components such as the raw radix astragali, white peony root and angelica sinensis are used, which can effectively improve vital qi deficiency of a patient; and for external causes, the radix platycodi and Chinese honeylocust spine are used, which have good functions of activating blood to disperse swelling, and expelling toxin and pus. The traditional Chinese medicine composition has a definite curative effect, small toxic and side effect, can increase resistance of a patient by being taken for a long time, and can effectively treat the bone and joint tuberculosis.

Description

A kind of be used for the treatment of tuberculosis of bone and joint Chinese medicine composition, preparation method and Chinese medicine and western medicine coupling
Technical field
The present invention is specifically related to a kind of Chinese medicine composition being used for the treatment of tuberculosis of bone and joint, and the preparation method of this Chinese medicine composition, also relates to a kind of Chinese medicine and western medicine coupling being used for the treatment of tuberculosis of bone and joint simultaneously, belongs to medical art.
Background technology
Tuberculosis of bone and joint invades by tubercule bacillus the purulent disease that people's bone or joint cause.Chinese medicine is thought, its etiology and pathogenesis is nothing more than four aspects: one is that cold-evil is objective among meridians, and with the passing of time poison caves in, and is attached to bone; Two is seven emotions pent-ups, inside accumulates internal organs, kidney virtual loss, the tender fragility of skeleton; Three is burden weights, and tumbling down damages, and causes qi-blood disharmony, then feels the turbid cohesion of wind and cold expectorant again, stays in skeleton; Four is eating and drinking without temperances, and stagnation of QI expectorant coagulates.In a word, " the weakened body resistance basic reason being primary disease and falling ill, exopathogen and damage are common inducements.Congenital defect, lack of proper care after one's birth, caused by liver and kidney deficiency be primary disease this, wind and cold invasion and attack, disharmony between QI and blood, the turbid cohesion of expectorant are the marks of primary disease.
Tuberculosis of bone and joint is apt to occur in child and youth, and except systemic effects, fragile bone marrow and joint, especially comparatively large on the growth promoter impact of child, that causes is invalid comparatively serious, is that a kind of infection of murther is sick.
The treatment of tuberculosis of bone and joint disease comprises TCM Therapy and antituberculotics amic therapy method.Wherein, antituberculotics amic therapy method advocates drug combination at present, with different cigarette umbilicus, rifampicin and ethambutol for first-line drug, especially with different cigarette umbilicus and rifampicin for choice drug, along with the deterioration of environment and increasing of Mycobacterium tuberculosis drug-resistant bacterial strain, there is comparatively serious drug resistance problems in this several antituberculotics, chemotherapy effect worse and worse, has become a difficult problem for clinical treatment.Meanwhile, the abnormal liver function of patient is easily caused because drug combination Time of Administration is long.
Chinese medicine has unique organic conception, and for endogenous cause of ill and the exopathogenic factor of tuberculosis of bone and joint, existing a large amount of clinical research has proved that Chinese medicine has unique advantage at treatment tuberculosis of bone and joint.Therefore, clinical for meeting better, need a kind of curative effect certainly, toxic and side effects little, easy to use and patient's economic capability Chinese medicine for the treatment of tuberculosis of bone and joint that can bear.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition being used for the treatment of tuberculosis of bone and joint.
Meanwhile, the present invention also provides a kind of preparation method being used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint.
In order to realize above object, the technical solution adopted in the present invention is:
Be used for the treatment of a Chinese medicine composition for tuberculosis of bone and joint, be made up of the crude drug of following parts by weight: Poria 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, Radix Astragali 15 ~ 30 parts, Radix Angelicae Sinensis 5 ~ 15 parts, Ramulus Cinnamomi 5 ~ 15 parts, Radix Platycodonis 5 ~ 10 parts, the Radix Angelicae Dahuricae 5 ~ 15 parts, Radix Paeoniae Rubra 5 ~ 15 parts, the Radix Paeoniae Alba 5 ~ 15 parts, Spina Gleditsiae 5 ~ 10 parts.
Preferably, be used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint, be made up of the crude drug of following parts by weight: Poria 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Codonopsis 12 parts, Radix Astragali 20 parts, Radix Angelicae Sinensis 10 parts, Ramulus Cinnamomi 10 parts, Radix Platycodonis 6 parts, the Radix Angelicae Dahuricae 10 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 10 parts, Spina Gleditsiae 6 parts.
Described Spina Gleditsiae preferably fries Spina Gleditsiae.
Be used for the treatment of a Chinese medicine and western medicine coupling for tuberculosis of bone and joint, comprise Western medicine isoniazid, rifampicin and ethambutol and above-mentioned Chinese medicine composition, with weight parts, isoniazid 1 ~ 1.5 part, rifampicin 1 ~ 1.5 part, ethambutol 2 ~ 4 parts.
Preferably, isoniazid 1.2 parts, rifampicin 1.35 parts, ethambutol 3 parts.
Each crude drug effect is summarized as follows:
Poria: for Polyporaceae hole of crouching belongs to the sclerotium of fungus Poria; Containing triterpenes as pachymic acid, 16 Alpha-hydroxy eburicoic acids, β-para hydroxybenzene acyl group dehydroeburicoic acid etc., polysaccharide as the callose etc. of pachyman, pachymaran and height, branch, also containing the various active composition such as ergosterol, sad, hendecanoic acid, lauric acid, dodecenoic acid, Palmic acid, dodecenoic acid fat, sad fat and inorganic elements; Nature and flavor are sweet, light, flat, GUIXIN, spleen, lung, kidney channel; Energy promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming; Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, have loose bowels, palpitation and restlessness, insomnia forgetfulness etc.; Modern pharmacology proves that Poria has diuresis, anticancer and immunological enhancement etc.
The Rhizoma Atractylodis Macrocephalae: be the rhizome of the Compositae [WTBX plant Rhizoma Atractylodis Macrocephalae; Containing volatile oil as atractylone, α and β-Humuleno, α-curcumene, Palmic acid, hinesol etc., sesquiterpene lactones compound is as atractyloide-I, II, III, IV etc., polyacetylene alcohol compound, also containing scopoletin, there is immunocompetent mannan AM-3, and more than ten seed amino acid such as aspartic acid, serine; Rhizoma Atractylodis Macrocephalae nature and flavor are bitter, sweet, and temperature, returns spleen, stomach warp; Can invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive; Cure mainly weak, the lack of appetite abdominal distention of deficiency-weakness of spleen-QI, have loose bowels, constipation, fluid-retention stagnating in the interior dysuria, edema, dizziness due to fluid-retention, Korean style numbness, general pain, spontaneous sweating due to deficiency of QI etc.; Modern pharmacology proves the effects such as the Rhizoma Atractylodis Macrocephalae has antioxidation and slow down aging, antitumor, blood sugar lowering, diuresis and anti-ascites, protects the liver, function of gallbladder promoting, can also facilitating digestion system, immune system, cardiac muscle and cardiovascular system.
Radix Codonopsis: be the root of campanulaceae Codonopsis plant Radix Codonopsis, element flower Radix Codonopsis, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, C. canescens; Containing saccharide as fructose, inulin, polysaccharide and 4 kinds of heteropolysaccharide CP 1, CP 2, CP 3, CP 4glycoside is as ligustrin, n-hexyl-β-pyranglucoside, ethyl-α-D-fructofuranoside, tangshenoside, alkaloid and nitrogen containing component, as choline, loline etc., also contain the various active compositions such as syringic aldehyde, vanillic acid, pyromucic acid, atractyloide I, II; Radix Codonopsis nature and flavor are sweet, flat, return spleen, lung meridian; Energy strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid; Cure mainly weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung are breathed with cough, all cards of spontaneous perspiration of breathing hard, deficiency of both QI and blood; Modern pharmacology proves that Radix Codonopsis has enhancing body stress ability, enhancing human body immunity function, slow down aging, antiulcer, antitumor assosting effect etc.
Radix Astragali: be the root of pulse family Astragalus Radix Astagali and Radix Astragali; Containing saponin component as astragaloside, isoflavones components is as calycosin, and fatty acid is as Palmic acid and linoleic acid, and polysaccharide is as astragalus polysaccharides, heteropolysaccharide etc., and nearly 20 various trace elements; Radix Astragali nature and flavor are sweet, and temperature, returns lung, spleen channel; Energy benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening; Cure mainly the disease of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or is burst for a long time and do not hold back; Modern pharmacology proves that the Radix Astragali can affect organism metabolism, has the effects such as antioxidation, antithrombotic, antiviral, arthritis, anticancer, anti-inflammatory and antalgic, can also protect cardio-cerebrovascular and promote hemopoietic function.
Radix Angelicae Sinensis: be the root of Umbelliferae archangel Radix Angelicae Sinensis; Containing multiple volatile oil and organic acid, also containing more than 20 kind of inorganic elements and polysaccharide composition; Radix Angelicae Sinensis nature and flavor are sweet, pungent, bitter, and temperature, returns liver, the heart, spleen channel; Can enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation; Cure mainly all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea ， mass in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down etc.; Modern pharmacology proves that Radix Angelicae Sinensis can affect blood and hemopoietic system, has the effects such as blood fat reducing, arteriosclerosis, radioprotective, antitumor, anti-inflammatory and antalgic, antibody Monoclonal.
Ramulus Cinnamomi: be the twig of Lauraceae cinnamon Cortex Cinnamomi; Containing volatile oil as cinnamic aldehyde, benzyl benzoate, cinnamyl acetate, β-cadinene, Rhizoma Acori Graminei alkene, coumarin, cinnamic acid, o-methoxy-3-phenyl-2-propenoic acid, 1,4-diphenyl-diacetyl, syringic aldehyde, steroid is as cupreol, 5 α, 8 α-Ergosterol Peroxide, 6 beta-hydroxy-4-alkene-3-stigmasterones, again containing protocatechuic acid, daucosterol etc.; Nature and flavor acrid, sweet, warm, return bladder, the heart, lung meridian; Can expelling cold and relieving exterior syndrome, warming the meridian, activate yang; Cure mainly wind and cold sign, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea, mass in the abdomen caking, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria etc.; Modern pharmacology proves that Ramulus Cinnamomi has the effects such as antibacterial, antiviral, antipyretic, analgesia, calmness, convulsion, antiinflammatory.
Radix Platycodonis: be the root of campanulaceae Platycodon grandiflouorum Platycodon grandiflouorum; Containing saponin as platycodin A, C, D, D 2, D 3deng, sapogenin as platycodigenin, Polygalacic acid etc., prosapogenin, sterols is as various active compositions such as hitodesterols; Nature and flavor are bitter, pungent, flat, attach to the lung and stomach meridians; Energy lung qi dispersing eliminates the phlegm, sore-throat relieving evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache etc.; Modern pharmacology prove Radix Platycodonis have eliminate the phlegm, the effect such as antitussive, antiinflammatory, antiulcer, blood sugar lowering, to cardiovascular system, central nervous system, there is regulating action.
The Radix Angelicae Dahuricae: be the root of the Umbelliferae archangel Radix Angelicae Dahuricae and Radix angelicae dahuricae; Containing Coumarins as imperatorin, different imperatorin etc., phellopterin, byak-angelicins etc., also contain coumarin glucose glycoside as various active compositions such as nodakenins; Nature and flavor are pungent, and temperature, returns lung, spleen, stomach warp; Energy expelling wind and removing dampness, understand things pain-stopping, detumescence and apocenosis; Cure mainly headache due to common cold, supraorbital bone pain, ulcer sores etc., modern pharmacology proves that the Radix Angelicae Dahuricae has the effects such as antalgic and sedative, antipyretic and anti-inflammatory, Tumor suppression, antimicrobial, can also anticoagulant, coronary artery dilating, excited respiratory center.
Radix Paeoniae Rubra: be the root of Paeoniaceae Paeonia plant peony, river Radix Paeoniae Rubra; Containing monoterpenes as Radix Paeoniae Rubra glycosides, oxidation Radix Paeoniae Rubra glycosides etc., organic acid, as benzoic acid, gallic acid etc., also contains the plurality of active ingredients such as catechin, cupreol; Nature and flavor are bitter, be slightly cold, and return Liver Channel; Energy clearing away heat and cooling blood, clots absorbing pain relieving, dissipating blood stasis for subsidence of swelling; Cure mainly amenorrhea dysmenorrhea, hernia abdominal mass gathered, maculae caused by violent heat pathogen, hematemesis and epistaxis, hypochondriac pain due to stagnation of liverQI, discharging fresh blood stool, conjunctival congestion and swelling pain, injury from falling down, carbuncle skin infection, can be used for the diseases such as amenorrhea; Modern pharmacology proves that Radix Paeoniae Rubra has antithrombotic, antiplatelet aggregation, arteriosclerosis, the effect such as to protect the liver.
The Radix Paeoniae Alba: be the root of Paeoniaceae Paeonia plant peony (cultivation product) and Peony; Containing iridoid glycosides as peoniflorin, oxypaeoniflorin, benzoylpaeoniflorin, albiflorin etc., sterols is as cupreol, daucosterol, tannin is as 1,2,3,6-tetra-galloyl glucose, gallic acid, cianidanol etc., also containing volatile oil such as benzoic acid, paeonol and other alcohols, phenols component isoreactivity composition; Nature and flavor are bitter, sour, are slightly cold, return liver, spleen channel; Can nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver; Cure mainly blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhea, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, dysentery had loose bowels, have a headache dizzy etc.; Modern pharmacology proves that the Radix Paeoniae Alba has antiinflammatory, analgesia, resisting pathogenic microbes, antimutagenic, antitumor, resisting oxygen lack etc.
Spina Gleditsiae: be the Spina jujubae of pulse family Gleditsia plant Fructus Gleditsia and mountain Fructus Gleditsia; Nature and flavor are pungent, warm, return liver, lung, stomach warp; Can detumescence saturating pus, search wind, parasite killing; Cure mainly swollen ulcer drug, scrofula, leprosy, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention etc.
A kind of Chinese medicine composition being used for the treatment of tuberculosis of bone and joint, conventional method can be adopted to be prepared into the form of Chinese drug such as oral liquid, granule, powder, pill, tablet, capsule, also drink after can directly brewing, or decocting method is directly taken after making decoction routinely, the change of dosage form does not affect the therapeutic effect of Chinese medicine composition.The present invention provides the preparation method of a kind of oral liquid and capsule respectively.
Be used for the treatment of a preparation method for the Chinese medicine composition of tuberculosis of bone and joint, comprise the following steps: accurately get each crude drug according to parts by weight, concentrate after adding the soak by water of 3 ~ 5 times amount and obtain oral liquid.
A kind of preparation method being used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint, comprise the following steps: accurately get each crude drug according to parts by weight, decoct with water rear collecting decoction, filter, get filtrate and be concentrated into the soft material (water content is 30 ~ 60%) that relative density under room temperature is 1.1 ~ 1.3, add excipient mixing, namely dry, pulverizing rear packing obtains capsule.
The described number of times decocted with water is 3 ~ 5 times, preferably 4 times, each decoction 2 hours.
Described excipient can adopt this area common excipients kind, and as dextrin, sucrose etc., the addition of excipient is 1 ~ 4 times of soft material quality, and excipient preferred mass is than the dextrin of 1:2 and sucrose.
Beneficial effect of the present invention:
The paathogenic factor of tuberculosis of bone and joint is made up of endogenous cause of ill and exopathogenic factor two aspects, and exopathogenic factor is that consumptive disease worm is infected, and endogenous cause of ill is deficiency of vital QI, and deficiency of vital QI intrinsic factor are but the keys that can human body fall ill, the weakened body resistance inherent key factor being tuberculosis of bone and joint and causing a disease.The present invention is directed to the endogenous cause of ill of tuberculosis of bone and joint, use multiple QI invigorating composition as Radix Astragali, the Radix Paeoniae Alba, Radix Angelicae Sinensis etc., effectively can improve the weakened body resistance of patient; For the exopathogenic factor of tuberculosis of bone and joint, use Radix Platycodonis and Spina Gleditsiae, there is good promoting blood circulation and detumescence, effect of expelling pus and toxin by strengthening QI; Take this Chinese medicine composition for a long time and can improve patient's resistance, effectively treatment tuberculosis of bone and joint is sick.
The present invention is according to theory of Chinese medical science, emphasize organic conception, the all medicines of reasonable compatibility, in side, Radix Platycodonis and Spina Gleditsiae have good promoting blood circulation and detumescence, effect of expelling pus and toxin by strengthening QI, and the Radix Astragali is aided with the QI invigorating such as the Radix Paeoniae Alba, Radix Angelicae Sinensis composition, and it is weakened body resistance effectively can to improve patient, enhancing human body immunity power, reduce the drug resistance of antagonism structure medicine, its determined curative effect, toxic and side effects is little.This Chinese medicine composition and Western medicine coupling effective, Chinese medicine is supporting treatment, can build up resistance, and can reduce the drug resistance of tubercule bacillus, improve curative effect, this is because the bone tuberculosis National People's Congress has a delicate constitution more.
Due to the raw material of Chinese medicine wide material sources used in formula, with low cost, and preparation method is simple, is suitable for large-scale industrial production and application.
Detailed description of the invention
Following embodiment is only described in further detail the present invention, but does not form any limitation of the invention.
Embodiment 1
Be used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint in the present embodiment, be made up of the crude drug of following weight: Poria 10 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Codonopsis 10 grams, Radix Astragali 30 grams, Radix Angelicae Sinensis 5 grams, Ramulus Cinnamomi 15 grams, Radix Platycodonis 5 grams, the Radix Angelicae Dahuricae 15 grams, Radix Paeoniae Rubra 5 grams, the Radix Paeoniae Alba 15 grams, Spina Gleditsiae 5 grams.
The preparation method of the Chinese medicine composition of tuberculosis of bone and joint is used for the treatment of in the present embodiment, comprise the following steps: accurately get each crude drug according to parts by weight, decoct with water 4 times, each decoction 2 hours, collecting decoction, filters, getting filtrate, to be concentrated into relative density under room temperature be the soft material of 1.1, add the excipient (excipient is dextrin and the sucrose of mass ratio 1:2) of 4 times of soft material quality, dry after mixing, pulverizing, load capsulae vacuus and namely obtain capsule (0.3 gram /).
The usage of capsule and consumption: oral, one day 3 times, one time 5.
Embodiment 2
Be used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint in the present embodiment, be made up of the crude drug of following weight: Poria 10 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Radix Codonopsis 10 grams, Radix Astragali 15 grams, Radix Angelicae Sinensis 5 grams, Ramulus Cinnamomi 5 grams, Radix Platycodonis 5 grams, the Radix Angelicae Dahuricae 5 grams, Radix Paeoniae Rubra 5 grams, the Radix Paeoniae Alba 5 grams, stir-fry Spina Gleditsiae 5 grams.
Be used for the treatment of the preparation method of the Chinese medicine composition of tuberculosis of bone and joint in the present embodiment, comprise the following steps: accurately get each crude drug according to parts by weight, be concentrated into 300ml after adding the soak by water of 3 times amount and namely obtain oral liquid.
The usage of oral liquid and consumption: every day 1 dose, every agent 100ml, points 2 times oral.
Embodiment 3
Be used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint in the present embodiment, be made up of the crude drug of following weight: Poria 12 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, Radix Codonopsis 12 grams, Radix Astragali 20 grams, Radix Angelicae Sinensis 10 grams, Ramulus Cinnamomi 10 grams, Radix Platycodonis 6 grams, the Radix Angelicae Dahuricae 10 grams, Radix Paeoniae Rubra 10 grams, the Radix Paeoniae Alba 10 grams, stir-fry Spina Gleditsiae 6 grams.
Be used for the treatment of the preparation method of the Chinese medicine composition of tuberculosis of bone and joint in the present embodiment, comprise the following steps: accurately get each crude drug according to parts by weight, be concentrated into 350ml after adding the soak by water of 4 times amount and namely obtain oral liquid.
The usage of oral liquid and consumption: every day 1 dose, every agent 100ml, points 2 times oral.
Embodiment 4
Be used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint in the present embodiment, be made up of the crude drug of following weight: Poria 15 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Radix Codonopsis 15 grams, Radix Astragali 15 grams, Radix Angelicae Sinensis 15 grams, Ramulus Cinnamomi 5 grams, Radix Platycodonis 10 grams, the Radix Angelicae Dahuricae 5 grams, Radix Paeoniae Rubra 15 grams, the Radix Paeoniae Alba 5 grams, Spina Gleditsiae 10 grams.
The preparation method of the Chinese medicine composition of tuberculosis of bone and joint is used for the treatment of in the present embodiment, comprise the following steps: accurately get each crude drug according to parts by weight, decoct with water 4 times, each decoction 2 hours, collecting decoction, filters, getting filtrate, to be concentrated into relative density under room temperature be the soft material of 1.2, add the excipient (excipient is dextrin and the sucrose of mass ratio 1:2) of 3 times of soft material quality, dry after mixing, pulverizing, load capsulae vacuus and namely obtain capsule (0.3 gram /).
The usage of capsule and consumption: oral, one day 3 times, one time 5.
Embodiment 5
Be used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint in the present embodiment, be made up of the crude drug of following weight: Poria 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Codonopsis 15 grams, Radix Astragali 30 grams, Radix Angelicae Sinensis 15 grams, Ramulus Cinnamomi 15 grams, Radix Platycodonis 10 grams, the Radix Angelicae Dahuricae 15 grams, Radix Paeoniae Rubra 15 grams, the Radix Paeoniae Alba 15 grams, stir-fry Spina Gleditsiae 10 grams.
Be used for the treatment of the preparation method of the Chinese medicine composition of tuberculosis of bone and joint in the present embodiment, comprise the following steps: accurately get each crude drug according to parts by weight, be concentrated into 400ml after adding the soak by water of 4 times amount and namely obtain oral liquid.
The usage of oral liquid and consumption: every day 1 dose, every agent 100ml, points 2 times oral.
Embodiment 6
Be used for the treatment of the Chinese medicine and western medicine coupling of tuberculosis of bone and joint in the present embodiment, comprise the Chinese medicine composition in Western medicine isoniazid, rifampicin and ethambutol and embodiment 3, with weight parts, isoniazid 1.2g, rifampicin 1.35g, ethambutol 3g.Described Chinese medicine composition is prepared into oral liquid according to the method for embodiment 3.
The usage of Chinese medicine and western medicine coupling in the present embodiment and consumption are: oral western medicine isoniazid 0.4g, rifampicin 0.45g and ethambutol 1.0g, be and take once a day, within 6 months, are a course for the treatment of; Chinese medicine oral liquid prepared by oral embodiment 3, every day 1 dose, every agent 100ml, divide and take for 2 times, January is a course for the treatment of.
Test example
1, clinical trial
(1) physical data
Choose tuberculosis of bone and joint patient totally 60 examples, wherein man 36 example, female 24 example, tuberculosis of spine 36 example, tuberculosis of spine 12 example, tuberculosis of knee joint 10 example, articulations digitorum manus tuberculosis 2 example.The course of disease is the longest 2 years, the shortest March, and all cases all meet the diagnostic criteria of tuberculosis of bone and joint.
(2) research method
The selected patient of 60 example is divided into two groups, treatment group 30 example, matched group 30 example.
Matched group: simple western medicine is treated, and taking isoniazid 0.4g, rifampicin 0.45g and ethambutol 1.0g, be and take once a day, 6 months is a course for the treatment of.
Treatment group: collaborative treatment of Chinese and western medicines, namely on the basis of matched group drug administration, take oral liquid prepared by the embodiment of the present invention 2, every day 1 dose, divide and take for 2 times, January is a course for the treatment of.
Above two groups of patients monthly check routine blood test, liver function, erythrocyte sedimentation rate during medication, monthly check X-ray, with the toxic and side effects of observe the curative effect and medicine.
(3) result of study
The routine tuberculosis of bone and joint patient for the treatment of group 30, all adopts therapy of combining Chinese and Western medicine, and 30 routine patient 1 year are fully recovered afterwards (pain disappears, and X-ray display is normal, and erythrocyte sedimentation rate is normal), and matched group only 20 routine patient fully recover after 1 year.All there is not the untoward reaction such as hepatic and renal function injure in period in a medicine patient, shows that Chinese medicine composition of the present invention has good safety.
2, model case
Case: Huan Zhenv, 45 years old, occurred whole body heating, giddy before 3 years, attached most importance in the afternoon, cough, sputum mixed with blood silk, hospital diagnosis is pulmonary tuberculosis, adhere to antituberculosis therapy a year and a half always, pulmonary Mycobacterium takes a turn for the better to some extent on inspection, but time have lumbago, go to see a doctor, suspection is prolapse of lumbar intervertebral disc, after physical therapy and massage treatment are given in outpatient service, do not feel any better, pain increases the weight of on the contrary, can not bend over or walk, by ultrasound diagnosis, find a large cystic dark space after left kidney, radiology department's lumbar vertebra film making finds, there is destruction at lumbar vertebra 2-3 sclerotin edge, be diagnosed as tuberculosis of spine, oral liquid prepared by the embodiment of the present invention 2 is taken while the conventional resistive connection structure medicine of application, after taking 30 days, patient's lumbago transference cure, radiology department's lumbar vertebra film making check, lumbar vertebra 2-3 sclerotin edge is complete.

Claims (9)

1. be used for the treatment of a Chinese medicine composition for tuberculosis of bone and joint, it is characterized in that: be made up of the crude drug of following parts by weight: Poria 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, Radix Astragali 15 ~ 30 parts, Radix Angelicae Sinensis 5 ~ 15 parts, Ramulus Cinnamomi 5 ~ 15 parts, Radix Platycodonis 5 ~ 10 parts, the Radix Angelicae Dahuricae 5 ~ 15 parts, Radix Paeoniae Rubra 5 ~ 15 parts, the Radix Paeoniae Alba 5 ~ 15 parts, Spina Gleditsiae 5 ~ 10 parts.
2. the Chinese medicine composition being used for the treatment of tuberculosis of bone and joint according to claim 1, is characterized in that: be made up of the crude drug of following parts by weight: Poria 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Codonopsis 12 parts, Radix Astragali 20 parts, Radix Angelicae Sinensis 10 parts, Ramulus Cinnamomi 10 parts, Radix Platycodonis 6 parts, the Radix Angelicae Dahuricae 10 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 10 parts, Spina Gleditsiae 6 parts.
3. be used for the treatment of a preparation method for the Chinese medicine composition of tuberculosis of bone and joint as claimed in claim 1 or 2, it is characterized in that: comprise the following steps: accurately get each crude drug according to parts by weight, concentrate after adding the soak by water of 3 ~ 5 times amount and obtain oral liquid.
4. one kind is used for the treatment of the preparation method of the Chinese medicine composition of tuberculosis of bone and joint as claimed in claim 1 or 2, it is characterized in that: comprise the following steps: accurately get each crude drug according to parts by weight, decoct with water rear collecting decoction, filter, getting filtrate, to be concentrated into relative density under room temperature be the soft material of 1.1 ~ 1.3, add excipient mixing, namely dry, pulverizing rear packing obtains capsule.
5. the preparation method being used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint according to claim 4, is characterized in that: the described number of times decocted with water is 3 ~ 5 times, each decoction 2 hours.
6. the preparation method being used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint according to claim 4, is characterized in that: the addition of described excipient is 1 ~ 4 times of soft material quality.
7. the preparation method being used for the treatment of the Chinese medicine composition of tuberculosis of bone and joint according to claim 6, is characterized in that: described excipient is dextrin and the sucrose of mass ratio 1:2.
8. one kind is used for the treatment of the Chinese medicine and western medicine coupling of tuberculosis of bone and joint, it is characterized in that: comprise the Chinese medicine composition described in Western medicine isoniazid, rifampicin and ethambutol and claim 1 or 2, with weight parts, isoniazid 1 ~ 1.5 part, rifampicin 1 ~ 1.5 part, ethambutol 2 ~ 4 parts.
9. the Chinese medicine and western medicine coupling being used for the treatment of tuberculosis of bone and joint according to claim 8, is characterized in that: isoniazid 1.2 parts, rifampicin 1.35 parts, ethambutol 3 parts in described Western medicine.
CN201410181427.6A 2014-04-30 2014-04-30 Traditional Chinese medicine composition for treating bone and joint tuberculosis, preparation method and combination of Chinese and Western medicines Pending CN104288244A (en)

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Application publication date: 20150121