CN104288109B - Florfenicol supermolecule preparation and preparation method thereof - Google Patents
Florfenicol supermolecule preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a florfenicol supermolecule preparation and a preparation method thereof. The preparation is prepared from the following raw materials in parts by weight: 5-10 parts of florfenicol, 5-20 parts of soybean protein isolate, 5-20 parts of maltodextrin, 10-40 parts of ethyl alcohol-purified water with the ratio of 1 to 1, and 20-80 parts of one or several of glucose, cane sugar with particle diameter of 80 meshes, or HPMC (Hydroxypropyl Methylcellulose). The preparation technology comprises the steps as follows: firstly, the soybean protein isolate and the maltodextrin are mixed into graft polymer of the soybean protein isolate and the maltodextrin as a supermolecule object; secondly, obtained florfenicol emulsion is put into a reaction kettle so as to be subjected to ultrasound for 30-60 minutes, and supermolecule micro emulsion is formed with florfenicol molecules being embedded in the graft polymer object of the soybean protein isolate and the maltodextrin, and dried; thirdly, after the drying, auxiliary materials are put in additionally for obtaining the preparation. The florfenicol supermolecule preparation obtained through the method provided by the invention is high in bioavailability, simple, convenient and economic in technology, high in production efficiency, safe and environmental-friendly, and good in reproducibility; moreover, the obtained products can be mixed with feeds or be mixed with drinks, and the preparation is convenient for pharmacy, and can be mixed with feeds or water, thereby receiving welcome from the majorities of farmers deeply.
Description
Technical field
The present invention relates to a kind of veterinary drug production technology preparation is and in particular to a kind of florfenicol supermolecule preparation and its preparation
Method.
Background technology
Florfenicol（Florfenicol）Chinese：Fluprofen, florfenicol or Florfenicol, are in 80 years
The broad spectrum antibiotic of a kind of new special chloromycetin of veterinary successfully developed for the later stage, nineteen ninety lists in Japan first,
Norway in 1993 ratifies the furunculosis that salmon treated by this medicine, nineteen ninety-five France, Britain, Austria, Mexico and Spain ratifies to be used for
Treatment cattle respiratory system bacterial disease.Also ratify the feed additive as pig in Japan and Mexico, prevent and treat pig
Bacterial disease（Qiu Yinsheng etc., 1996）.The simple production process of florfenicol powder, only by with adjuvant be simply mixed system
Standby, but exist and feedstuff mixing time and effort consuming during using, easily cause mixing inequality, mixed feeding dosage inaccurate etc. scarce
Point, bioavailability is relatively low.In the prior art of retrieval：The Chinese invention patent of Application No. 201210138126 discloses one
Plant florfenicol soluble powder and preparation method thereof, this preparation method can make soluble powder, convenient during laboratory preparation
Feasible, but its preparation process is loaded down with trivial details, is unfavorable for Industry Promotion.Application No. 201010160013 discloses one kind and contains fluorine
Water-soluble micropowder that benzene Buddhist nun examines and preparation method thereof, simply simple physical mixed, its palatability difference and water-soluble effect is not
Good.And disclosed patent recently：The Chinese invention patent of Application No. 201310099557 discloses one kind and prepares florfenicol
The production method of microcrystal, the method contains organic solvent and consumption is big, there is toxicity and zest is all larger, during clinical practice
Dangerous, big to animal body infringement, and the problems such as organic solvent high cost.
Content of the invention
It is an object of the invention to overcoming the defect of above-mentioned prior art, provide a kind of florfenicol supermolecule preparation and its
Preparation method, its simple production process is easy, safety and environmental protection, and medicine stability is strong, and duration of efficacy is long, bioavailability
Height, can be water-soluble, and medication is convenient.
For achieving the above object, the present invention adopts the following technical scheme that：A kind of florfenicol supermolecule preparation, said preparation by
Hereinafter raw material by weight is made：Florfenicol 5-10 part, soybean protein isolate 5-20 part, maltodextrin 5-20 part, ratio
1:1 ethanol-purified water 10-40 part, one or more 20-80 of the cane sugar powder of glucose or 80 mesh or Hypromellose
Part.The florfenicol supermolecule preparation that the present invention provides, product is solid it is easy to preserve and transport.
Based on technique scheme, described above-mentioned preparation is made up of the raw material of following weight portion：Florfenicol 5-10 part, greatly
Bean separation albumen 5-20 part, maltodextrin 5-20 part, ratio 1:1 ethanol-purified water 10-40 part, glucose or hydroxypropyl first are fine
The plain 20-80 part of dimension.
Based on technique scheme, described above-mentioned preparation is made up of the raw material of following weight portion：7 parts of florfenicol, Semen sojae atricolor
Separate protein 10 part, 10 parts of maltodextrin, ratio 1:35 parts of 1 ethanol-purified water, the cane sugar powder of glucose or 80 mesh or hydroxypropyl
50 parts of one or more of methylcellulose.
Based on technique scheme, described above-mentioned preparation is made up of the raw material of following weight portion：5 parts of florfenicol, Semen sojae atricolor
Separate 5 parts of albumen, 5 parts of maltodextrin, ratio 1:20 parts of 1 ethanol-purified water, glucose, the cane sugar powder of 80 mesh and hydroxypropyl
Methylcellulose adds up to 35 parts.
Based on technique scheme,
A kind of preparation method preparing florfenicol supermolecule preparation, the method comprises the following steps：
Step one, gets the raw materials ready：Weigh raw material by following parts by weight：Florfenicol 5-10 part, soybean protein isolate 5-20 part,
Maltodextrin 5-20 part, ratio 1:The cane sugar powder of 1 ethanol-purified water 10-40 part, glucose or 80 mesh or Hypromellose
One or more 20-80 parts；
Step 2, first soybean protein isolate, maltodextrin is dissolved in 5-10 times of purified water, with 50-70 DEG C of heating
Temperature heats 40-60 minute, and it is soybean protein isolate and maltodextrin graft polymers that stirring forms supermolecule object.
Florfenicol is separately added to the ratio 1 of 10-40 part by step 3:In 1 ethanol-purified water, stirring makes uniformly to divide
Dissipate, and refined by 300 mesh colloid mills, make formation emulsion；
Step 4, the florfenicol obtaining emulsion is poured into the Semen sojae atricolor equipped with heater in step 2 separate in step 3
In the reactor of albumen-maltodextrin graft polymers, 200-1000KW ultrasonic 30-60 minute, make formation florfenicol molecule
It is entrenched in the supermolecule micro emulsion of soybean protein isolate-maltodextrin graft polymers molecule object；
Step 5, by the supermolecule micro emulsion obtaining in step 4 at 50-60 DEG C drying under reduced pressure 2-4 hour, prepare fluorobenzene
Buddhist nun examines supermolecule；
Step 6, finally adds adjuvant by proportioning in the florfenicol supermolecule of preparation in step 5：Glucose or 80
One or more of purpose cane sugar powder or Hypromellose, prepared supermolecule granule, 50-60 DEG C of drying under reduced pressure 1-2 hour, 40
Mesh carries out granulate, obtains supermolecule preparation, and technique finishes.
Based on technique scheme, in described above-mentioned steps one, get the raw materials ready：Weigh raw material by following parts by weight：Fluorobenzene Buddhist nun
Examine 5 parts, 5 parts of soybean protein isolate, 5 parts of maltodextrin, ratio 1:20 parts of 1 ethanol-purified water, glucose, the sucrose of 80 mesh
Powder and Hypromellose add up to 35 parts.
Beneficial effects of the present invention：The bioavailability of product of the present invention is high, and medication is convenient, and water-soluble speed is fast, changes simultaneously
It has been apt to the palatability of medicine.In the florfenicol supermolecule preparation that the present invention provides, soybean protein isolate is surfactant,
The surface tension of water and air, soybean protein isolate and the graft polymers of maltodextrin can be reduced, have stronger emulsifying and divide
Dissipate effect, in stirring mixing, substantially increase the reaction between florfenicol microemulsion and soybean protein isolate, maltodextrin,
So that the dispersibility of florfenicol, emulsibility is substantially increased, this polymeric water-soluble is good, nontoxic, with florfenicol, chemistry does not occur
Reaction, has the good compatibility again, no any stimulation to animal itself, and using safety, it is good, no that maltodextrin has dissolubility
The easily moisture absorption, good stability, it is difficult to rotten characteristic, is prevented from the florfenicol supermolecule preparation moisture absorption so as to be easy to preserve；Medicine
With the double solventss of ethanol-purified water, be conducive to the emulsifying of florfenicol so as to be more easy to be fitted to soybean protein isolate and Fructus Hordei Germinatus
In the graft polymers of dextrin, improve florfenicol by inclusion rate, make drug effect more longlasting, release evenly, bioavailability
Higher.The carrier of the present invention is soybean protein isolate, maltodextrin, can form supramolecular structure with florfenicol, both of which has
Have the advantage that：Nontoxic, non-carcinogenesis, there is not chemical change with medicine, do not affect the chemical stability of principal agent, do not affect medicine
The drug effect of thing and content detection, medicine can be made to obtain optimum dispersion state, cheap and easy to get.In addition, florfenicol is dispersed in
In carrier material, play the effect improving bioavailability while covering its original drug flavor.Present invention process is easy
Economy, production efficiency is high, safety and environmental protection, favorable reproducibility, and prepared product not only with mixed feeding but also can mix drink, because it uses prescription
Just, can spice, can drink water, deep welcome by numerous raisers.
Specific embodiment
With reference to specific embodiment, the invention will be further described.
Embodiment 1：A kind of florfenicol supermolecule preparation, said preparation is made up of the raw material of following weight portion：
8 parts of florfenicol, 15 parts of soybean protein isolate, 15 parts of maltodextrin, ratio 1:30 parts of 1 ethanol-purified water,
Glucose or 60 parts of Hypromellose.
The preparation method of above-mentioned florfenicol supermolecule preparation, comprises the concrete steps that：
1）Each 15 parts of soybean protein isolate, maltodextrin are added in 5 times of purified water, stir, 60 DEG C of heating
40 minutes, it was soybean protein isolate and maltodextrin graft polymers that stirring forms supermolecule object；
2）Separately 8 parts of florfenicols are added 30 parts of medicinal ratios 1:In 1 solvent of ethanol-purified water, stirring makes uniformly
Dispersion, and refined by 300 mesh colloid mills, make formation emulsion；
3）The florfenicol obtaining emulsion is poured into the soybean protein isolate-maltodextrin glycerol polymerization equipped with heater
In the reactor of thing；
4）Ultrasonic 30 minutes of 900KW, makes florfenicol molecule be entrenched in soybean protein isolate-maltodextrin graft polymers
In molecule object, form florfenicol supermolecule emulsion；
5）By above-mentioned supermolecule emulsion at 50 DEG C drying under reduced pressure 2-3 hour, preparation forms loose florfenicol oversubscription
Son；
6）Add adjuvant：Glucose or 60 parts of Hypromellose, prepared supermolecule granule, 60 DEG C of drying under reduced pressure 1 hour,
40 mesh carry out granulate, obtain final product this supermolecule preparation.
Embodiment 2：A kind of florfenicol supermolecule preparation, it is made up of the raw material of following weight portion：Florfenicol 10
Part, 20 parts of soybean protein isolate, 20 parts of maltodextrin, ratio 1:40 parts of 1 ethanol-purified water, the sucrose of glucose or 80 mesh
80 parts of one kind of powder or Hypromellose.
The preparation method of above-mentioned florfenicol supermolecule preparation, comprises the concrete steps that：
1）Each 20 parts of soybean protein isolates, maltodextrin are added in 7 times of purified water, stir, 70 DEG C of heating 30
Minute；
2）The another medicinal ratio 1 that 10 parts of florfenicols are added 40 parts:In 1 solvent of ethanol-purified water, stirring makes all
Even dispersion, and refined by 300 mesh colloid mills, make formation emulsion；
3）Florfenicol emulsion is poured into the anti-of soybean protein isolate-maltodextrin graft polymers equipped with heater
Answer in kettle；
4）It is poly- that 1000KW makes formation florfenicol molecule be entrenched in soybean protein isolate-maltodextrin grafting for ultrasonic 20 minutes
In adduct molecule object, form florfenicol supermolecule micro emulsion；
5）By above-mentioned supermolecule micro emulsion at 60 DEG C drying under reduced pressure 2-3 hour, preparation forms loose florfenicol oversubscription
Son；
6）80 parts of one kind of addition adjuvant glucose, the cane sugar powder of 80 mesh or Hypromellose, prepared supermolecule granule,
50 DEG C of drying under reduced pressure 2 hours, 40 mesh carry out granulate, obtain supermolecule preparation.
Embodiment 3：A kind of florfenicol supermolecule preparation, it is made up of the raw material of following weight portion：5 parts of florfenicol,
5 parts of soybean protein isolate, 5 parts of maltodextrin, ratio 1:20 parts of 1 ethanol-purified water, glucose, the cane sugar powder of 80 mesh and
Total 35 parts of Hypromellose；
The preparation method of above-mentioned florfenicol supermolecule preparation, comprises the concrete steps that：
1）Each 5 parts of soybean protein isolates, maltodextrin are added in 8 times of purified water, stir, 50 DEG C are heated 50 points
Clock；
2）In addition 5 parts of florfenicols are dissolved in 20 parts of medicinal ratios 1:In 1 solvent of ethanol-purified water, stirring makes all
Even dispersion, and refined by 300 mesh colloid mills, make formation emulsion；
3）Florfenicol emulsion is poured into the anti-of soybean protein isolate-maltodextrin graft polymers equipped with heater
Answer in kettle；
4）It is poly- that 800KW makes formation florfenicol molecule be entrenched in soybean protein isolate-maltodextrin grafting for ultrasonic 40 minutes
In adduct molecule object, form florfenicol supermolecule micro emulsion；
5）By above-mentioned supermolecule micro emulsion at 55 DEG C drying under reduced pressure 3-4 hour, prepare florfenicol supermolecule；
6）Add adjuvant：Glucose, the cane sugar powder of 80 mesh or Hypromellose add up to 35 parts, prepared supermolecule granule,
60 DEG C of drying under reduced pressure 1.5 hours, 40 mesh carry out granulate, obtain supermolecule preparation.
Embodiment 4：A kind of florfenicol supermolecule preparation, it is made up of the raw material of weight portion once：7 parts of florfenicol,
10 parts of soybean protein isolate, 10 parts of maltodextrin, ratio 1:35 parts of 1 ethanol-purified water, the cane sugar powder of glucose or 80 mesh or
50 parts of one or more of Hypromellose.
The preparation method of above-mentioned florfenicol supermolecule preparation, comprises the concrete steps that：
1）Each 10 parts of soybean protein isolates, maltodextrin are added in 6 times of purified water, stir, 60 DEG C of heating 50
Minute；
2）In addition 7 parts of florfenicols are dissolved in 35 parts of medicinal ratios 1:In 1 solvent of ethanol-purified water, stirring makes all
Even dispersion, and refined by 300 mesh colloid mills, make formation emulsion；
3）Florfenicol emulsion is poured into the anti-of soybean protein isolate-maltodextrin graft polymers equipped with heater
Answer in kettle；
4）It is poly- that 700KW makes formation florfenicol molecule be entrenched in soybean protein isolate-maltodextrin grafting for ultrasonic 50 minutes
In adduct molecule object, form florfenicol supermolecule micro emulsion；
5）By above-mentioned supermolecule micro emulsion at 50 DEG C drying under reduced pressure 3-4 hour, prepare florfenicol supermolecule；
6）Add one or more 50 parts of adjuvant glucose, the cane sugar powder of 80 mesh or Hypromellose, prepared oversubscription
Sub- granule, 60 DEG C of drying under reduced pressure 1.2-1.5 hours, 40 mesh carry out granulate, obtain supermolecule preparation.
Embodiment 5：The palatability testing on pig farm for the product is as follows：
Test method：The applicant carries out palatability on the honest pig farm in Henan Xinxiang to above-mentioned florfenicol supermolecule preparation
Test.Choose healthy fattening pig 45, be randomly divided into 3 groups of A, B, C, every group 15.A group is blank control group, is not administered and only raises
Feed material；B group gives the florfenicol supermolecule preparation of embodiment 1 preparation（Zhengzhou He Run Biology Pharmacy Co., Ltd provides, batch
Numbers 20140901）, by 0.1% mixed feeding, C group gives the common flour bought on market（Certain beast is bought on 10% florfenicol powder market
Pharmaceutical factory produces, lot number 20140902）By 0.1% mixed feeding；3 groups of feedings and managements of A, B, C are identical, material all quilts of two groups of A, B in 4h
Eat up, and about the material of C group residue half.Experiment conclusion：Florfenicol supermolecule preparation of the present invention does not have to the palatability of pig feed
Have an impact.
Embodiment 6：Florfenicol supermolecule preparation of the present invention is to mycoplasmal pneumonia of swine（Asthma）Clinical trial：
Material：A：10% florfenicol supermolecule preparation, the product of embodiment 1 preparation.
B：10% florfenicol powder, purchased from market products.
Test method：Choose the honest pig farm in Henan Xinxiang home-bred and autophytic, age in days is close, feeding and management condition is essentially identical,
It is diagnosed as mycoplasmal pneumonia of swine（Asthma）, the fattening pig of recent non-administration 60, it is randomly divided into 2 groups, i.e. experimental group, comparison
Group, every group 30.Experimental group presses 0.1% spice, gives florfenicol supermolecule preparation A by embodiment 1 preparation（Zhengzhou He Run
Biology Pharmacy Co., Ltd provides, lot number 20140901）, it is used in conjunction 5 days；Matched group presses 0.1% spice, gives purchase on market
Common flour B（10% florfenicol powder, market is bought certain animal pharmaceutical factory and produces, lot number 20140902）, it is used in conjunction 5 days, raise pipe for two groups
Reason is identical.
Outcome measure method：
Cure rate：During medication, dosing pig clinical symptoms are wholly absent, and spirit, appetite, body temperature, feces, breathing etc. recover
Normally it is healing, number is cured according to each group animal and calculates its cure rate.
Effective percentage：During medication, dosing pig spirit, appetite take a turn for the better, symptom mitigation, and symptom of breathing substantially mitigates as effective,
Its effective percentage is calculated according to the significant figure in every group of animal.
Inefficiency：During test, after medication, clinical symptoms have no that the pig mitigating or continuing deterioration and death is all judged to no
Effect, calculates its inefficiency according to the invalid number in every group of animal.
Table 1 florfenicol supermolecule preparation is to mycoplasmal pneumonia of swine（Asthma）Clinical trial result
As can be seen from the test results：The therapeutic effect of 10% florfenicol supermolecule preparation is better than 10% florfenicol powder
Therapeutic effect.
Experiment conclusion：The effective percentage of experimental group and cure rate high all than matched group it can be seen that the florfenicol of the present invention
Supermolecule preparation is in treatment mycoplasmal pneumonia of swine（Asthma）Disease aspect embodies good clinical effectiveness.
Compared with florfenicol powder, florfenicol supermolecule preparation of the present invention adds water when using and dissolves rapidly, overcomes
Powder is mixed with feedstuff uneven and leads to that local drug concentration is too low not to reach therapeutic effect and during local excessive concentration causes
The shortcomings of poison reaction.Meanwhile, florfenicol supermolecule preparation good palatability of the present invention, after improve poultry morbidity, feed intake declines
And affect the problem of ingestion of medicines, be conducive to improving therapeutic effect.
In sum, florfenicol supermolecule preparation simple production process of the present invention, Environmental Safety, good palatability, slow release
Medicine, bioavailability is higher, and clinical application effect is notable.
Claims (6)
1. a kind of florfenicol supermolecule preparation, is characterized in that：Said preparation is made up of the raw material of following weight portion：Florfenicol 5-
10 parts, soybean protein isolate 5-20 part, maltodextrin 5-20 part, ratio 1:1 ethanol-purified water 10-40 part, glucose or 80
One or more 20-80 parts of purpose cane sugar powder or Hypromellose；Concrete preparation method comprises the following steps：
Step one, gets the raw materials ready：Weigh raw material by following parts by weight：Florfenicol 5-10 part, soybean protein isolate 5-20 part, Fructus Hordei Germinatus
Dextrin 5-20 part, ratio 1:The cane sugar powder of 1 ethanol-purified water 10-40 part, glucose or 80 mesh or the one of Hypromellose
Plant or several 20-80 part；
Step 2, first soybean protein isolate, maltodextrin is dissolved in 5-10 times of purified water, with 50-70 DEG C of heating-up temperature
Heating 40-60 minute, it is soybean protein isolate and maltodextrin graft polymers that stirring forms supermolecule object；
Florfenicol is separately added to the ratio 1 of 10-40 part by step 3:In 1 ethanol-purified water, stirring make dispersed,
And refined by 300 mesh colloid mills, make formation emulsion；
Step 4, the florfenicol obtaining in step 3 emulsion is poured into the soybean separation protein equipped with heater in step 2
In the reactor of in vain-maltodextrin graft polymers, 200-1000KW ultrasonic 30-60 minute, make formation florfenicol molecule embedding
It is combined in the supermolecule micro emulsion of soybean protein isolate-maltodextrin graft polymers molecule object；
Step 5, by the supermolecule micro emulsion obtaining in step 4 at 50-60 DEG C drying under reduced pressure 2-4 hour, prepare florfenicol
Supermolecule；
Step 6, finally adds adjuvant by proportioning in the florfenicol supermolecule of preparation in step 5：Glucose or 80 purposes
One or more of cane sugar powder or Hypromellose, prepared supermolecule granule, 50-60 DEG C of drying under reduced pressure 1-2 hour, 40 mesh enter
Row granulate, obtains supermolecule preparation, and technique finishes.
2. florfenicol supermolecule preparation according to claim 1, is characterized in that：Described preparation is former by following weight portion
Material is made：Florfenicol 5-10 part, soybean protein isolate 5-20 part, maltodextrin 5-20 part, ratio 1:1 ethanol-purified water
10-40 part, glucose or Hypromellose 20-80 part.
3. florfenicol supermolecule preparation according to claim 1, is characterized in that：Described preparation is former by following weight portion
Material is made：7 parts of florfenicol, 10 parts of soybean protein isolate, 10 parts of maltodextrin, ratio 1:35 parts of 1 ethanol-purified water, Portugal
Grape sugar or the cane sugar powder of 80 mesh or one or more 50 parts of Hypromellose.
4. florfenicol supermolecule preparation according to claim 1, is characterized in that：Described preparation is former by following weight portion
Material is made：5 parts of florfenicol, 5 parts of soybean protein isolate, 5 parts of maltodextrin, ratio 1:20 parts of 1 ethanol-purified water, Fructus Vitis viniferae
Sugar, the cane sugar powder of 80 mesh and Hypromellose add up to 35 parts.
5. a kind of preparation method preparing florfenicol supermolecule preparation, is characterized in that：The method comprises the following steps：
Step one, gets the raw materials ready：Weigh raw material by following parts by weight：Florfenicol 5-10 part, soybean protein isolate 5-20 part, Fructus Hordei Germinatus
Dextrin 5-20 part, ratio 1:The cane sugar powder of 1 ethanol-purified water 10-40 part, glucose or 80 mesh or the one of Hypromellose
Plant or several 20-80 part；
Step 2, first soybean protein isolate, maltodextrin is dissolved in 5-10 times of purified water, with 50-70 DEG C of heating-up temperature
Heating 40-60 minute, it is soybean protein isolate and maltodextrin graft polymers that stirring forms supermolecule object；
Florfenicol is separately added to the ratio 1 of 10-40 part by step 3:In 1 ethanol-purified water, stirring make dispersed,
And refined by 300 mesh colloid mills, make formation emulsion；
Step 4, the florfenicol obtaining in step 3 emulsion is poured into the soybean separation protein equipped with heater in step 2
In the reactor of in vain-maltodextrin graft polymers, 200-1000KW ultrasonic 30-60 minute, make formation florfenicol molecule embedding
It is combined in the supermolecule micro emulsion of soybean protein isolate-maltodextrin graft polymers molecule object；
Step 5, by the supermolecule micro emulsion obtaining in step 4 at 50-60 DEG C drying under reduced pressure 2-4 hour, prepare florfenicol
Supermolecule；
Step 6, finally adds adjuvant by proportioning in the florfenicol supermolecule of preparation in step 5：Glucose or 80 purposes
One or more of cane sugar powder or Hypromellose, prepared supermolecule granule, 50-60 DEG C of drying under reduced pressure 1-2 hour, 40 mesh enter
Row granulate, obtains supermolecule preparation, and technique finishes.
6. preparation method according to claim 5, is characterized in that：In described step one, get the raw materials ready：Claim by following parts by weight
Take raw material：5 parts of florfenicol, 5 parts of soybean protein isolate, 5 parts of maltodextrin, ratio 1:20 parts of 1 ethanol-purified water, Fructus Vitis viniferae
Sugar, the cane sugar powder of 80 mesh and Hypromellose add up to 35 parts.
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