CN1943679A - A spiny grape seed extract preparation and its preparation method - Google Patents
A spiny grape seed extract preparation and its preparation method Download PDFInfo
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- 235000002532 grape seed extract Nutrition 0.000 title claims abstract description 30
- 229940087603 grape seed extract Drugs 0.000 title claims abstract description 29
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 13
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 8
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 8
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- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
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- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 4
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 description 4
- TVQGDYNRXLTQAP-UHFFFAOYSA-N ethyl heptanoate Chemical compound CCCCCCC(=O)OCC TVQGDYNRXLTQAP-UHFFFAOYSA-N 0.000 description 4
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- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 4
- 229920002414 procyanidin Polymers 0.000 description 4
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000020778 linoleic acid Nutrition 0.000 description 3
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 3
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- 150000002632 lipids Chemical class 0.000 description 2
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- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- 208000032928 Dyslipidaemia Diseases 0.000 description 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 1
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- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
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- FMMOOAYVCKXGMF-MURFETPASA-N ethyl linoleate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC FMMOOAYVCKXGMF-MURFETPASA-N 0.000 description 1
- 229940031016 ethyl linoleate Drugs 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
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- 230000006870 function Effects 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
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- FMMOOAYVCKXGMF-UHFFFAOYSA-N linoleic acid ethyl ester Natural products CCCCCC=CCC=CCCCCCCCC(=O)OCC FMMOOAYVCKXGMF-UHFFFAOYSA-N 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
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- 239000008117 stearic acid Substances 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
This invention provides a spiny grape seed extract preparation and its preparation method. Weight ratio of the effective ingredients in the said spiny grape seed extract preparation is: spiny grape seed oiling capsule powder (60-70wt%), extracts of spiny grape seed (10-20wt%), lecithin(10-15wt%),E vitamin E(1-5wt%).The preparing method is as the following steps:(1). Extracting spiny grape seed oil and spiny grape seed extracts from the spiny grape seeds by using the super critical line CO2 extracting technology.(2). Implement capsule processing to the extracted spiny grape seed oil. (3).Weighing the extracted ingredients according to the given ratio, and evenly mix the extracted ingredients, the mixed ingredients is the spiny grape seed extract preparation. The spiny grape seed extract preparation of this invention of this invention can effectively decrease the contents of tracyglycerol of the total cholesterol in blood serum, increase the contents of high density lipoprotein (HDL) cholesterol and upgrade the energy and total anti-oxidation ability of blood serum superoxide dismutase (SOD), glutathione cholesterol enzyme. The spiny grape seed extract preparation is easy for storage.
Description
Technical field
The present invention relates to a kind of spiny grape seed extract preparation and preparation method thereof, especially relating to a kind of is spiny grape seed extract preparation of primary raw material making and preparation method thereof with seed of Radix vitis romanetii oil and spiny grape seed extract.
Background technology
Vitis davidi (Vitis davidii Fo x.) is a kind under the population of Vitis East Asia, is distributed widely in ground such as Shaanxi, Gansu, Central China, south China and southwest.The Vitis davidi seed accounts for the 4-6% of fruit fresh weight, the oils and fats that contains 14%-17% in the seed, the composition of seed of Radix vitis romanetii oil mainly is a unsaturated fatty acid, wherein linoleic acid content is up to 82.3%, linoleic acid belongs to polyunsaturated fatty acid, can promote cholesterol metabolism, prevents that lipid is in liver and arterial wall deposition, and can improve serum middle-high density lipoprotein content, blood fat reducing there is certain effect.Spiny grape seed extract contains natural polyphenol class materials such as procyanidin, oleanolic acid, flavonoid, has extremely strong antioxidant activity, is a kind of good radical scavenger and lipid peroxidation inhibitor.Therefore, be that the preparations such as capsule of raw material production quite get consumer reception on market with Oleum Vitis viniferae or Semen Vitis viniferae extract.But present grape seed preparation exists effective active component more single, the easy oxidation of product, and the destroyed or loss of Oleum Vitis viniferae effective ingredient, effect is owed shortcomings such as ideal.As: Chinese invention patent 01128126.X discloses a kind of grape seed preparation and extracting method thereof, and the effective active composition of its grape seed preparation is exactly an Oleum Vitis viniferae; And the mechanical expression method is adopted in the extraction of Oleum Vitis viniferae, extracts the temperature height, and adds organic solvent in the leaching process, the leaching process complexity.
Summary of the invention
The objective of the invention is to overcome that existing grape seed preparation effective active composition is more single, the easy oxidation of product, effect owe defectives such as ideal, provide a kind of effective active composition more comprehensive, be difficult for oxidation, effective active composition height, more significant spiny grape seed extract preparation of effect and preparation method thereof.
The objective of the invention is to be achieved through the following technical solutions.
The weight proportion of each effective active component of the present invention's spiny grape seed extract preparation is: seed of Radix vitis romanetii oil microcapsule powder 60-70wt%, spiny grape seed extract 10-20wt%, lecithin 10-15wt%, vitamin E 1-5wt%.
Preparation method may further comprise the steps: (1) adopts supercritical CO
2Abstraction technique extracts seed of Radix vitis romanetii oil and spiny grape seed extract from seed of Radix vitis romanetii, because whole leaching process carries out in closed system, the operating condition gentleness, leaching process is simple, the product effective ingredient that is extracted destroys few, can realize that full constituent extracts, effective ingredient is active high, and the product organic solvent-free is residual; (2) the seed of Radix vitis romanetii oil that extracts being carried out micro encapsulation handles: the wall material adopts 1: 1 soybean protein isolate and maltodextrin, the proportioning of core and wall material is 1: 1.5, the feed liquid total solids content is 25%, homogenizing is handled under high pressure homogenizer 30MPa-35MPa pressure, 180 ℃ of spray drying inlet temperature, 80 ℃ of leaving air temps, the seed of Radix vitis romanetii oil microcapsule that makes is Powdered; (3) take by weighing each composition weight, mix homogeneously by preset blending ratio.
The present invention's spiny grape seed extract preparation, available known method is made various dosage forms such as capsule, tablet.
The present invention's spiny grape seed extract preparation is a main component with seed of Radix vitis romanetii oil and spiny grape seed extract, by adding auxiliary elements such as lecithin, vitamin E, makes the various ingredients synergism, has improved effect; Wherein seed of Radix vitis romanetii oil adopts micro-encapsulation technology to handle, and can not only prevent Oxidation of Fat and Oils, and it is Powdered that oils and fats is formed, and stores convenient.
Clinical test results shows that the present invention's Vitis davidi extract formulation can effectively reduce T-CHOL in the serum, content of triglyceride, improves serum middle-high density lipoprotein cholesterol content, has tangible blood fat reducing function.
Vitis davidi extract formulation antioxidant effect is obvious, can improve serum superoxide dismutases, glutathione peroxidase activity and Total antioxidant capacity.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1
The present embodiment spiny grape seed extract preparation contains effective active component seed of Radix vitis romanetii oil microcapsule powder 60wt%, seed of Radix vitis romanetii procyanidin 20wt%, lecithin 18wt%, vitamin E 2wt%.
Preparation method: preparation method may further comprise the steps: (1) uses supercritical CO
2Abstraction technique extracts seed of Radix vitis romanetii oil and spiny grape seed extract from seed of Radix vitis romanetii (after testing, the seed of Radix vitis romanetii oil that is extracted contains linoleic acid 82.32wt%, Ethyl linoleate 5.39wt%, Palmic acid 3.26wt%, stearic acid 9.03wt%; Semen Vitis viniferae extract contains procyanidin etc. more than polyphenols＞90wt%); (2) the seed of Radix vitis romanetii oil that extracts being carried out micro encapsulation handles: the wall material adopts 1: 1 soybean protein isolate and maltodextrin, the proportioning of core and wall material is 1: 1.5, the feed liquid total solids content is 25%, homogenizing is handled under high pressure homogenizer 30MPa pressure, spray drying, 180 ℃ of inlet temperature, 80 ℃ of leaving air temps make seed of Radix vitis romanetii oil microcapsule powder; (3) take by weighing seed of Radix vitis romanetii oil microcapsule powder 600g, add spiny grape seed extract 200g, lecithin 180g, vitamin E 20g, mix homogeneously is made 1000 of capsules with known method.Every contains unsaturated fatty acid 〉=200mg, polyphenols＞180mg such as procyanidin.
Present embodiment product clinical test results:
(1) case alternative
According to the whole nation in 1997 " dyslipidemia control suggestion " standard: T-CHOL (TC) 〉=5.72mmol/L, triglyceride (TG) 〉=1.7mmol/L, highdensity lipoprotein-cholesterol (HDL-C)≤0.91mmol/L, LDL-C (LDL-C) 〉=3.64mmol/L, unusual person more than 1 or 1 wherein is promptly as study subject.Adopt placebo, the patient is divided into test group and matched group.
(2) treatment and observational technique
The oral Vitis davidi extract capsule of test group patient, each 2, every day is early, middle and late after meal respectively once, and observing the course of treatment is 60 days.Matched group patient oral placebo, every capsules outward appearance and curative are in full accord, instructions about how to take medicine and observe the course of treatment with the treatment group.
(3) curative effect determinate standard
Judge by " new Chinese medicine clinical research guideline " that Ministry of Health of the People's Republic of China issued in 1993.Produce effects: TC descends 〉=15%; TG descends 〉=30%; HDL-C 〉=0.26mmol/L; Effectively: TC descends 10%～14%; TG descends 10%～29%; HDL-C 0.156～the 0.26mmol/L that raises; Invalid: every index does not all reach effective standard.
(4) result
Blood Lipid (seeing Table 1) before and after two groups of treatments
Table 1 Vitis davidi extract capsule blood fat reducing clinical efficacy
| The example number | Produce effects example number | Obvious effective rate (%) | Total effective routine number | Total effective rate (%) | ||
| T-CHOL | Test group | 58 | 17 | 29.31 | 37 | 63.79 |
| Matched group | 50 | 7 | 14.00 | 8 | 16.00 | |
| Triglyceride | Test group | 58 | 8 | 13.79 | 19 | 32.78 |
| Matched group | 50 | 4 | 8.00 | 9 | 18.00 | |
| HDL-C | Test group | 58 | 11 | 18.97 | 23 | 39.66 * |
| Matched group | 50 | 3 | 9.09 | 9 | 22.73 | |
It is 63.79% that the T-CHOL total effective rate falls in the treatment group, compares (16.00%) difference with matched group and reaches utmost point significant level (P＜0.01), illustrates that the Vitis davidi extract capsule can obviously reduce total cholesterol level in the serum.
(5) side effect and untoward reaction: tangible untoward reaction does not appear in the patient in treatment, blood, urine, just conventional, and hepatic and renal function is all no abnormal.
Embodiment 2
The present embodiment spiny grape seed extract preparation contains effective active component seed of Radix vitis romanetii oil microcapsule 65wt%, spiny grape seed extract 15wt%, lecithin 17wt%, vitamin E 3wt%.
Preparation method: homogenization pressure 35MPa, surplus with embodiment 1.
Embodiment 3
The present embodiment spiny grape seed extract preparation contains effective active component seed of Radix vitis romanetii oil microcapsule 70wt%, spiny grape seed extract 10wt%, lecithin 15wt%, vitamin E 5wt%.
Preparation method: with embodiment 1.
Embodiment 2,3 products have curative effect similar to Example 1.
Claims (2)
1, a kind of spiny grape seed extract preparation is characterized in that, the weight proportion of each effective active component is: seed of Radix vitis romanetii oil microcapsule powder 60-70wt%, spiny grape seed extract 10-20wt%, lecithin 10-15wt%, vitamin E 1-5wt%.
2, the preparation method of spiny grape seed extract preparation according to claim 1 is characterized in that, may further comprise the steps: (1) adopts supercritical CO
2Abstraction technique extracts seed of Radix vitis romanetii oil and spiny grape seed extract from seed of Radix vitis romanetii; (2) the seed of Radix vitis romanetii oil that extracts being carried out micro encapsulation handles: the wall material adopts 1: 1 soybean protein isolate and maltodextrin, the proportioning of core and wall material is 1: 1.5, the feed liquid total solids content is 25%, homogenizing is handled under high pressure homogenizer 30MPa-35MPa pressure, 180 ℃ of spray drying inlet temperature, 80 ℃ of leaving air temps make Powdered seed of Radix vitis romanetii oil microcapsule; (3) take by weighing each composition weight, mix homogeneously by preset blending ratio.
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| CN101586062B (en) * | 2009-06-10 | 2011-11-23 | 石曙光 | Technique of brewing grape dry red wine from spine grape |
| CN101253976B (en) * | 2008-04-09 | 2011-12-21 | 黎秋萍 | Sand sagebrush seed oil beauty treatment anti-aging health care food |
| CN101715913B (en) * | 2008-12-02 | 2013-04-24 | 天津天狮生物发展有限公司 | Capsule for regulating blood fat and production process thereof |
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| CN106174528A (en) * | 2016-08-10 | 2016-12-07 | 韩晖 | Wild grape seed sheet and preparation method |
| CN106509893A (en) * | 2016-11-04 | 2017-03-22 | 无限极（中国）有限公司 | Essence oil microcapsules and preparation method thereof |
| CN112043822A (en) * | 2020-09-25 | 2020-12-08 | 福建省春秋刺明珠葡萄酒庄园有限公司 | Vitis davidii plant extract preparation rich in anthocyanin and preparation method thereof |
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2006
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