CN104258402B - 一种汉黄芩素组合物及其制备方法 - Google Patents
一种汉黄芩素组合物及其制备方法 Download PDFInfo
- Publication number
- CN104258402B CN104258402B CN201410505621.5A CN201410505621A CN104258402B CN 104258402 B CN104258402 B CN 104258402B CN 201410505621 A CN201410505621 A CN 201410505621A CN 104258402 B CN104258402 B CN 104258402B
- Authority
- CN
- China
- Prior art keywords
- wogonin
- ethanol
- histidine
- sodium stearyl
- stearyl fumarate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- HIMJIPRMECETLJ-UHFFFAOYSA-N Wogonin Natural products COc1cc(O)c(O)c2C(=O)C=C(Oc12)c3ccccc3 HIMJIPRMECETLJ-UHFFFAOYSA-N 0.000 title claims abstract description 52
- XLTFNNCXVBYBSX-UHFFFAOYSA-N wogonin Chemical compound COC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=CC=C1 XLTFNNCXVBYBSX-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 62
- 239000006185 dispersion Substances 0.000 claims abstract description 33
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims abstract description 19
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 229940079593 drug Drugs 0.000 claims abstract description 16
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims abstract description 5
- 239000002671 adjuvant Substances 0.000 claims description 15
- 239000012467 final product Substances 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 6
- 238000001035 drying Methods 0.000 abstract description 3
- 238000003304 gavage Methods 0.000 description 13
- 238000004108 freeze drying Methods 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 101000905241 Mus musculus Heart- and neural crest derivatives-expressed protein 1 Proteins 0.000 description 1
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 1
- 229960003321 baicalin Drugs 0.000 description 1
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003870 intestinal permeability Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- -1 wogonin group Compound Chemical class 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
样品 | 生物利用度(%) |
第1组 | 65.1 |
第2组 | 72.7 |
第3组 | 75.3 |
第4组 | 37.8 |
第5组 | 44.1 |
第6组 | 28.6 |
第7组 | 21.9 |
第8组 | 15.0 |
第9组 | 13.4 |
第10组 | 12.7 |
第11组 | 17.8 |
第12组 | 19.5 |
第13组 | 5.2 |
第14组 | - |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410505621.5A CN104258402B (zh) | 2014-09-28 | 2014-09-28 | 一种汉黄芩素组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410505621.5A CN104258402B (zh) | 2014-09-28 | 2014-09-28 | 一种汉黄芩素组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104258402A CN104258402A (zh) | 2015-01-07 |
CN104258402B true CN104258402B (zh) | 2017-01-11 |
Family
ID=52150057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410505621.5A Expired - Fee Related CN104258402B (zh) | 2014-09-28 | 2014-09-28 | 一种汉黄芩素组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104258402B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1556101A (zh) * | 2003-12-31 | 2004-12-22 | 中国药科大学 | 汉黄芩素的提取工艺、药用组合物及制剂制备工艺 |
CN1562147A (zh) * | 2004-03-24 | 2005-01-12 | 杭州华东医药集团生物工程研究所有限公司 | 黄芩提取物冻干粉针剂及其制备方法 |
CN101088523A (zh) * | 2006-06-12 | 2007-12-19 | 大百汇生物科技(深圳)有限公司 | 黄芩天然活性成分的固体脂质纳米粒及其制备方法和制剂 |
-
2014
- 2014-09-28 CN CN201410505621.5A patent/CN104258402B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1556101A (zh) * | 2003-12-31 | 2004-12-22 | 中国药科大学 | 汉黄芩素的提取工艺、药用组合物及制剂制备工艺 |
CN1562147A (zh) * | 2004-03-24 | 2005-01-12 | 杭州华东医药集团生物工程研究所有限公司 | 黄芩提取物冻干粉针剂及其制备方法 |
CN101088523A (zh) * | 2006-06-12 | 2007-12-19 | 大百汇生物科技(深圳)有限公司 | 黄芩天然活性成分的固体脂质纳米粒及其制备方法和制剂 |
Also Published As
Publication number | Publication date |
---|---|
CN104258402A (zh) | 2015-01-07 |
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PB01 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20161014 Address after: 266045 room A, building, No. 43 Zhengzhou Road, Sifang District, Shandong, China, Qingdao Applicant after: Qingdao Rubber Valley Intellectual Property Co.,Ltd. Address before: 215000 Jiangsu City, Suzhou hi tech Zone Jinfeng Road, building 8, No. 15 Applicant before: Suzhou Pu Luo Da Biotechnology Co., Ltd. |
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GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20191213 Address after: 266033 Department of oncology, Haici medical group, No.4 Renmin Road, Qingdao, Shandong Province Patentee after: Fu Wensheng Address before: 266045 room A, building, No. 43 Zhengzhou Road, Sifang District, Shandong, China, Qingdao Patentee before: Qingdao Rubber Valley Intellectual Property Co.,Ltd. |
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TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170111 Termination date: 20200928 |
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CF01 | Termination of patent right due to non-payment of annual fee |