CN104257560B - Aloe facial cleanser and preparation method thereof - Google Patents
Aloe facial cleanser and preparation method thereof Download PDFInfo
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- CN104257560B CN104257560B CN201410539505.5A CN201410539505A CN104257560B CN 104257560 B CN104257560 B CN 104257560B CN 201410539505 A CN201410539505 A CN 201410539505A CN 104257560 B CN104257560 B CN 104257560B
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- aloe
- acid
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- salt
- disodium
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- YAQXGBBDJYBXKL-UHFFFAOYSA-N iron(2+);1,10-phenanthroline;dicyanide Chemical compound [Fe+2].N#[C-].N#[C-].C1=CN=C2C3=NC=CC=C3C=CC2=C1.C1=CN=C2C3=NC=CC=C3C=CC2=C1 YAQXGBBDJYBXKL-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 description 1
- 239000000626 magnesium lactate Substances 0.000 description 1
- 229960004658 magnesium lactate Drugs 0.000 description 1
- 235000015229 magnesium lactate Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- YIXPUAYMZURQJH-UHFFFAOYSA-N non-2-enedioic acid Chemical compound OC(=O)CCCCCC=CC(O)=O YIXPUAYMZURQJH-UHFFFAOYSA-N 0.000 description 1
- 239000001702 nutmeg Substances 0.000 description 1
- QWIDXEUVWSDDQX-SVMKZPJVSA-N octadecanoic acid;(z)-octadec-9-enoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O QWIDXEUVWSDDQX-SVMKZPJVSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000012045 salad Nutrition 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 150000003388 sodium compounds Chemical class 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 208000023088 sudden sensorineural hearing loss Diseases 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- XWNXEWLCHSLQOI-UHFFFAOYSA-K trisodium;triacetate Chemical compound [Na+].[Na+].[Na+].CC([O-])=O.CC([O-])=O.CC([O-])=O XWNXEWLCHSLQOI-UHFFFAOYSA-K 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides aloe facial cleanser which is prepared by raw materials in parts by weight as follows: 2-4 parts of aloe extracts, 4-6 parts of geniposide, 3-5 parts of puerarin, 5-7 parts of acetyltalatisamine achyranthan, 20-30 parts of hexadecyl(sulfophenoxy) benzenesulfonic acid, disodium salt, 10-15 parts of coconut monoethanol amide, 5-7 parts of caprylic capric triglyceride and 150-180 parts of distilled water. The aloe facial cleanser has fine and stable foam, is mild in property, stable in viscosity and convenient to use, has low stimulation on skin, good environmental protection property and good use effect, and the aloe facial cleanser can have a better skin whitening effect after other extracts are added particularly.
Description
Technical field
The present invention relates to a kind of aloe facial cleaner and preparation method thereof, belong to daily-use chemical industry technical field.
Background technology
Along with the raising of people's living standard, the demand for cosmetics is more and more higher, the most extensively sells
Cleansing milk, major part utilizes chemicals to make, and easily causes skin allergy, also has other some side effect, and
And the most costly, be not suitable for using in a large number, skin is had the less of protective effect, even skin can be secreted
Fatty protective ingredient wash so that skin is the driest, serious meeting injury skin.Aloe facial cleaner also has a lot of report
Road.As CN102772322 A discloses a kind of betaplex gentle cleansing milk, it includes following components: amino acid/11 0-16 part, transparent fat acid
2-6 part, cleansing 1-5 part of alkalescence, Aloe gel 2-4 part, Mentholum 1-3 part, preservative 0.1-0.5 part, Flos Osmanthi Fragrantis are extracted
Thing 0.1-1 part, natural marine polysaccharide 2-8 part, wetting agent 5-7 part, Semen Vitis viniferae extract 0.5-2 part, remaining is deionized water.
CN102860952 A discloses a kind of absolute oil cleansing milk, and it is by amine-oxides, sorbitol, Aloe gel, cocos nucifera oil diethanol acyl
Amine, triethanolamine, hydrolytic collagen and deionized water are formulated, and the weight portion of described each component is: amine-oxides: 30-40
Part；Sorbitol: 8-10 part；Aloe gel: 4-5 part；Cocos nucifera oil diglycollic amide: 15-25 part；Triethanolamine: 10-12 part CN
103006507 A disclose a kind of aloe facial cleaner, including the raw material of following mass fraction: Aloe extraction solution 12-14 part, Petiolus Trachycarpi
Acid potassium 2-4 part, triethanolamine 1-3 part, sodium N-lauroyl sarcosinate 1-3 part, glycerol 3-5 part, lanoline 2-4 part, emulsifying agent 1-3
Part, preservative 3-5 part, distilled water 50-60 part.Aloe facial cleaner of the present invention uses aloe composition, has no side effect,
Effectively can also retain skin moisture while cleaning dirt, existing preferable face cleaning effect has again skin protection moisture-keeping functions.
The open a kind of aloe facial cleaner of CN103356437 A, is made up of the raw material of following component: Aloe 4-7 part, red wine 2-3 part, salt
2-3 part, vinegar 2-3 part, water 40-60 part.Many aloe facial cleaner use single Aloe effective ingredient, and relaxes from skin
Appropriateness, moistens degree aspect effect bad.
Summary of the invention
Goal of the invention: it is an object of the invention to provide a kind of aloe facial cleaner and preparation method thereof.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of aloe facial cleaner, is prepared by the raw materials in: Aloe extract 2-4 part, geniposide 4-6 part,
Puerarin 3-5 part, Inokopolyose 5-7 part, cetyl sulfophenoxy benzenesulfonic acid disodium salt 20-30 part, coco-nut oil fatty acid
Single ethanol amide 10-15 part, N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt 30-36 part, hydrogenated cotton seeds oil glyceride
Disodium sulfosuccinate salt 15-20 part, decanoyl/octanoyl glycerides 5-7 part, distilled water 150-180 part.
Described aloe facial cleaner, is prepared by the raw materials in: Aloe extract 2-4 part, geniposide 4-6 part,
Puerarin 3-5 part, Inokopolyose 5-7 part, cetyl sulfophenoxy benzenesulfonic acid disodium salt 20-30 part, coco-nut oil fatty acid
Single ethanol amide 10-15 part, N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt 30-36 part, hydrogenated cotton seeds oil glyceride
Disodium sulfosuccinate salt 15-20 part, decanoyl/octanoyl glycerides 5-7 part, glutamic acid diacetic acid four sodium 2-4 part, succinyl glycyrrhetin
Acid disodium 3-5 part, glucose fatty acid phosphate 2-4 part, Hydroxypropyl phosphate ester starch 1-3 part, distilled water 150-180 part.
The present invention can add chelating agen, and described chelating agen is disodium EDTA, tetrasodium ethylenediamine tetraacetate
Salt, ethylenediamine tetramethylene phosphonic acid, hydroxymethyl phosphonic acid diethylester, diethylenetriamine penta sodium, hexamethylene diamine four methene
Phosphonic acids, two hexene triamine five methylenephosphonic acids, diethylenetriamine pentamethylenophosphonic acid seven sodium salt, EDTMP
Six sodium salts, sodium ethylenediamine tetramethylenephosphonate, glutamic acid diacetic acid four sodium, succinyl glycyrrhetinic acid disodium, methylglycine two
One in acetic acid trisodium salt and hydroxyethyl diamine tetraacethyl trisodium salt or its mixture.
The preparation method of described aloe facial cleaner, the preparation method of Aloe extract comprises the following steps: take fresh in
State's Aloe kind, peeling, Aloe mesophyll is homogenized, centrifugal, obtain Aloe juice, hydro-oxidation sodium regulation pH value is 7.0-7.4, spray dried
Dry Aloe extract.
The application in preparing skin-lightening cosmetic of the described aloe facial cleaner.
Aloe facial cleaner preparation method, containing following steps:
A) take Aloe extract, geniposide, puerarin, Inokopolyose respectively, cross 100 mesh sieves, mix homogeneously, add distillation
Water, stirs 1-10min；
B) cetyl sulfophenoxy benzenesulfonic acid disodium salt, coconut oil fatty acid monoethanolamide, N-cocos nucifera oil acyl are added
Amine propyl group-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate salt, decanoyl/octanoyl glycerides, paddy
Propylhomoserin oxalic acid four sodium, succinyl glycyrrhetinic acid disodium, glucose fatty acid phosphate, Hydroxypropyl phosphate ester starch, stirring is mixed
Close uniformly,.
Beneficial effect:
Aloe is commonly referred to as Aloe, originates in Mediterranean, Africa, for Liliaceae herbaceos perennial, according to the open country of textual criticism
Raw Aloe kind kind more than 300, is distributed mainly on the ground such as Africa, is a kind of Liliaceae herbaceous plant, and it is perennial Liliaceae meat
Matter herbaceous plant.Containing abundant polysaccharide, protein, aminoacid, vitamin, organized enzyme and the trace unit highly beneficial to human body
Element.Its characteristic component is Aloe anthraquinones etc., and Aloe is due to containing various bioactivators, at folks of china just by as U.S.
Holding, take care of hair and treat the natural drug of dermatosis, Aloe leafage is raw, and in seat shape or be born in stem top, the normal lanceolar of leaf or leaf are short
Width, edge has sharp tooth to sting.Inflorescence is umbrella shape, total shape, spike, cone etc., and color is red, yellow or tool redness of the skin or complexion speckle, petal six
Sheet, gynoecium six pieces.The many Colaesces of perianth base portion become tubular.
The Aloe vera L.var. chinensis(Haw.)Berg. that the present invention uses is the mutation of Aloe vulgaris, has another name called the Chinese aloe aloe.Aloe vera L.var. chinensis(Haw.)Berg. stem is short, Ye Jin
Bunch life, seedling leaf becomes two row, blade face blade back to have white dot.After leaf grows up to, white macula does not takes off.Leaf is about 35 centimetres, wide
5-6 centimetre, plant likeness in form Aloe Barbadensis Miller.The Aloe vera L.var. chinensis(Haw.)Berg. individual plants in the south of Fujian Province is substantially little than Aloe Barbadensis Miller.The place of production: Fujian, wide
East, Guangxi, Yunnan, Sichuan, Taiwan etc. save.Also have in In Yuanjiang Area, Yunnan Province, Hainan and island, Leizhou.There is certain medicinal valency
Value.Tender leaf can do the raw material of Aloe salad and eat.
Aloe main component: anthraquinone analog compound: aloin, aloe-emodin, different aloin, B aloin, product luxuriant growth Radix Et Rhizoma Rhei
The double glycoside of element, aloe-emodin-8-glycoside, Aloearbonaside, Aloe resin B, alomycin, alochrysine, aloietic acid,
Aloaresic acid, aloresinotannol, aloxanthine, chrysophanol, chrysophanol monoglucoside, rear Mo Nate aloin, anthrol, different Chinese mugwort
Pomegranate brain glycoside, aloe saponaria glycoside I, II, helminthosporin, 7-hydroxyl aloin, tetrahydro anthracene Fructus Vitis viniferae glycoside.
Carbohydrate: arabinose, galactose, glucose, mannose, rhamnose, xylose, alduronic acid, galacturonic acid, glucose
Aldehydic acid, mannuronic acid, arabinose, cellulose, lignin.Aminoacid: galactosamine, glucamine amino acid alanine, bad ammonia
Acid, proline, hydroxyproline, cystine, arginine, aspartic acid, glycine, glutamic acid, threonine, agedoite, group
Propylhomoserin, tyrosine, tryptophan, valine, leucine, serine, isoleucine, phenylalanine, c-alanine, methionine, fall
Sugar propylhomoserin.Vitamin: VA, VB1, VB2, VB6, VC, VE, VH, nicotinic acid, folic acid, carotene, metal ion and the change of vitamin
Compound.Organic acid: malic acid, citric acid, tartaric acid, succinic acid, cinnamic acid, fatty acid, succinic acid, lactic acid, P-coumaric acid, second
Acid, octanoic acid, capric acid, lauric acid, nonendioic acid, dodecylic acid, nutmeg acid pentadecanoic acid, Palmic acid, tridecanoic acid, stearic acid
Oleic acid, linoleic acid, arachidonic acid, magnesium lactate, calcium oxalate, 1-Hydroxy-1,2,3-propanetricarboxylic acid..Enzyme (peptide): amylase, cellulase, hydrogen peroxide
Enzyme, oxidase, lactic acid dehydrogenase, alkaline phosphatase, acid p'tase, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, Kallidin I enzyme
Allinase, angiotensin, lectins.
Geniposide is a kind of iridoid glucoside, soluble in water, is the main pharmacodynamics composition of Fructus Gardeniae.Geniposide
Digestive system, cardiovascular system and central nervous system disease all there is significant curative effect, additionally, geniposide also has certain resisting
The scorching effect with treatment soft tissue injury.No. CAS: 24512-63-8, molecular weight: 388.37, density: 1.49g/cm3, boiling point:
622.2 DEG C, flash-point: 224 DEG C, Fructus Gardeniae derives from being dried to of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis
Ripe fruit.There is cathartic, analgesia, function of gallbladder promoting, antiinflammatory, treatment soft tissue injury and suppression gastric secretion and reduce pancreatic amylase etc.
Effect.Jasminoidin has multiple use, the fermentation of different condition, can make natural edible coloring agent gardenia blue and gardenia red, also
It it is the material medicine for treating the disease such as cardiovascular and cerebrovascular vessel, liver and gall and diabetes.It is a kind of iridoid glucoside, is soluble in
Water, is the main pharmacodynamics composition of Fructus Gardeniae, content with the difference in the place of production at about 3%-8%.Geniposide can be by beta-glucosidase
Enzyme hydrolysis is genipin.Modern study shows, geniposide is equal to digestive system, cardiovascular system and central nervous system disease
There is significant curative effect, additionally, geniposide also has certain antiinflammatory and the effect for the treatment of soft tissue injury.Geniposide is except medicinal
In addition, also it is widely used in other field, as can be used as plant promoter, biological detection agent etc..
At present, the extracting method of geniposide typically uses the organic solvent such as chloroform, dehydrated alcohol in surname extraction bottle
Extract, obtain active component Fructus Gardeniae total glycosides total in Fructus Gardeniae, go up silicagel column the most again and separate, with a certain proportion of methanol, chloroform
Mixed liquor eluting, eluent carries out recrystallization in acetone and obtains geniposide crystal, separable in general 100g fruit of Fructus Gardeniae obtains
About 4.0g geniposide.
Puerarin is yellow crystal, is dissolved in water, methanol, ethanol, pyridine, is soluble in hot water, is insoluble in benzene, chloroform, ether
Deng, react displaing yellow with magnesium acetate, react in yellow mercury oxide with lead acetate.High-load is white, needle-shaped crystals powder, belongs to different
Flavonoid.There is raising immunity, strengthen myocardial contraction, protecting myocardial cell, reduce blood pressure, there is antiplatelet aggregation etc. and make
With.No. CAS: 3681-99-0, molecular formula: C21H20O9, molecular weight: 416.38, physicochemical property: yellow crystal, it is dissolved in water, first
Alcohol, ethanol, pyridine, be soluble in hot water, is insoluble in benzene, chloroform, ether etc., reacts displaing yellow with magnesium acetate, react with lead acetate
In yellow mercury oxide.Radix Puerariae derives from leguminous plant Pueraria lobota Pueraria lobata (Willd.) Ohwi root, Herba Gelsemii Elegantis
P.thunbergiana Benth. root.Fusing point 187-189 DEG C.Low content for brown ceramic powder, high-load is white, needle-shaped crystals
Powder, has raising immunity, strengthens myocardial contraction, protecting myocardial cell, reduce blood pressure, and has antiplatelet aggregation etc. and makees
With.The puerarin impact on liver system: puerarin contains saponins compound, has protection and makees hepatic tissue immune impairment
With, C-29 position hydroxyl and C-5 " oxy radical can strengthen liver-protecting activity.Puerarin is absorbed by stomach can protect hepatic injury, and induction is lived
Change apoptosis on hepatic stellate cells, effectively reverse the hepatic fibrosis of chemical induction, the acute liver damage of tetrachloro-methane induction is also had
Protective effect, has many physiologically actives simultaneously.The puerarin impact on cardiovascular system: the total flavones in Radix Puerariae can increase
Add brain and blood flow coronarius.Animal and the cerebral circulation of human body and peripheral circulation are had and significantly promote to make by puerarin
With.Radix Puerariae total flavones improve the cerebrovascular tension force of hypertension and patients with coronary heart disease, elastic and Pulsating quality for because of etc. aspect all have
Gentle facilitation.Puerarin not only improves the normal brain activity microcirculation of human body, and also has microcirculation disturbance and significantly change
Kind effect, the amplitude mainly showing as local microvascular blood flow and motion increases.The puerarin nail fold to patients with sudden sensorineural hearing loss
Microcirculation also has improvement result, can accelerate microvascular blood flow velocity, removes blood vessel loop congestion, improves the audition of patient.Puerarin
Have protective effect to hypoxic cardiac muscle, puerarin can substantially reduce the oxygen consumption of ischemic myocardium, and cardioprotection is from ischemia port again
Ultrastructure damage caused by perfusion.Puerarin is the one single composition flavonoid glycoside extracted from legume pueraria lobata root, tool
There is blood circulation promoting and blood stasis dispelling, improve the effect such as microcirculation, coronary artery dilator and cerebrovascular, reduction myocardial oxygen consumption, its preparation puerarin
Injection is clinically used for treating cardiovascular and cerebrovascular disease and retinal vascular disease, retinopathy and sudden deafness etc..c
Inokopolyose is to separate from Radix Achyranthis Bidentatae, extract a kind of micromolecular polysaccharide compound obtained, and pharmacological testing shows it
Having raising body's immunity, leukocyte increasing, suppression neoplasm metastasis and the liver protecting function, long-term taking is secondary without any poison
Effect.Inokopolyose be China's reported first there is immunocompetent micromolecular polysaccharide, compared with some known polysaccharide, Radix Achyranthis Bidentatae
It is little that polysaccharide has molecular weight, no antigen, good water solubility, and human body easily absorbs, chemical extraction steady quality, not only can be as one
The disease of Drug therapy immunologic hypofunction, such as tumor, hepatitis etc., and can develop into health care as a kind of immunostimulant
Product.Clinical preliminary test shows effectively to promote leukocyte, and the stomach to patient is received simultaneously, the symptom such as weak has clear improvement.
Above-mentioned Aloe is Aloe vera L.var. chinensis(Haw.)Berg., Classification system Aloe chinensis Berger, geniposide, puerarin, Radix Achyranthis Bidentatae
Polysaccharide is all purchased from Xi'an and continuous heavy rain biological engineering company limited, and content is more than 98%.
Cetyl sulfophenoxy benzenesulfonic acid disodium salt, CA registration number: 65143-89-7, molecular formula is
C28H42O7S2.2Na, English name: 51842 Hexadecyl (sulfophenoxy) benzenesulfonic acid,
disodium salt。
Coconut oil fatty acid monoethanolamide CA registration number: 68140-00-1.
N-cocamidopropyl propyl amide-DMG inner salt, CA registration number: 86438-79-1, molecular formula is
C19H38N2O3。
Hydrogenated cotton seeds oil glyceride disodium sulfosuccinate salt, trade name: Emcol 4072 Coemulsifier, the U.S.
Witco company produces.
Succinyl glycyrrhetinic acid disodium, cas number: 38841-48-4
Glutamic acid diacetic acid four sodium, cas number: 51981-21-6, molecular formula is C9H9NNa4O8, English name: 16896
L-Glutamic acid,N,N-bis(carboxymethyl)-,sodium salt(1:4)。
Decanoyl/octanoyl glycerides, cas number: 65381-09-1, English name: 45755 Decanoyl/octanoyl-
glycerides。
Glucose fatty acid phosphate, cas number: 1739-84-0.
Hydroxypropyl phosphate ester starch, cas number: 53124-00-8.
Above-mentioned surfactant, antioxidant, chelating agen raw material are purchased from Shanghai Fei Ge Chemical Co., Ltd..
The aloe facial cleaner of the present invention, foam exquisiteness is stable, and performance is gentle, and viscosity stablization is low to the zest of skin, special
After not adding other extracts, more can play whitening function, the feature of environmental protection is good, and using effect is good and convenient.
Detailed description of the invention
Form by the following examples, is described in further detail the foregoing of the present invention again, but should be by this
Being interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to Examples below, all technology realized based on foregoing of the present invention are equal
Belong to the scope of the present invention.
1, combining detailed description of the invention, the present invention is further described as follows:
Needed raw material weight proportion (unit: g) in table 1 various embodiments of the present invention
2, preparation embodiment
The preparation of Aloe extract: take fresh Aloe vera L.var. chinensis(Haw.)Berg. kind 1000g, peeling, Aloe mesophyll is homogenized, centrifugal,
Aloe juice, hydro-oxidation sodium regulation pH value is 7.2, is spray-dried to obtain Aloe extract, and spray drying condition is that inlet temperature is
100 DEG C, leaving air temp is 80 DEG C, and temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.
Embodiment 1: by upper table 1, takes Aloe extract, geniposide, puerarin, Inokopolyose respectively, crosses 100 mesh sieves,
Mix homogeneously, adds distilled water, stirs 10min；Add cetyl sulfophenoxy benzenesulfonic acid disodium salt, coco-nut oil fatty acid list
Glycollic amide, N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate
Salt, decanoyl/octanoyl glycerides, glutamic acid diacetic acid four sodium, succinyl glycyrrhetinic acid disodium, glucose fatty acid phosphate, hydroxypropyl
Phosphate ester starch, is uniformly mixed,.
Embodiment 2: by upper table 1, takes Aloe extract, puerarin, Inokopolyose respectively, excessively 100 mesh sieves, mix homogeneously,
Add distilled water, stir 10min；Add cetyl sulfophenoxy benzenesulfonic acid disodium salt, coconut oil fatty acid monoethanolamide,
N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate salt, pungent capric acid are sweet
Grease, glutamic acid diacetic acid four sodium, succinyl glycyrrhetinic acid disodium, glucose fatty acid phosphate, Hydroxypropyl phosphate ester starch,
It is uniformly mixed,.
Embodiment 3: by upper table 1, takes Aloe extract, geniposide, Inokopolyose respectively, crosses 100 mesh sieves, and mixing is all
Even, add distilled water, stir 10min；Add cetyl sulfophenoxy benzenesulfonic acid disodium salt, coco-nut oil fatty acid monoethanol acyl
Amine, N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate salt, the pungent last of the ten Heavenly stems
Acid glyceride, glutamic acid diacetic acid four sodium, succinyl glycyrrhetinic acid disodium, glucose fatty acid phosphate, Hydroxypropyl phosphate ester
Starch, is uniformly mixed,.
Embodiment 4: by upper table 1, takes Aloe extract, geniposide, puerarin respectively, excessively 100 mesh sieves, mix homogeneously,
Add distilled water, stir 10min；Add cetyl sulfophenoxy benzenesulfonic acid disodium salt, coconut oil fatty acid monoethanolamide,
N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate salt, pungent capric acid are sweet
Grease, glutamic acid diacetic acid four sodium, succinyl glycyrrhetinic acid disodium, glucose fatty acid phosphate, Hydroxypropyl phosphate ester starch,
It is uniformly mixed,.
Embodiment 5: by upper table 1, takes Aloe extract, geniposide, puerarin, Inokopolyose respectively, crosses 100 mesh sieves,
Mix homogeneously, adds distilled water, stirs 10min；Add cetyl sulfophenoxy benzenesulfonic acid disodium salt, N-coconut oleoyl amine third
Base-N, N-dimethylglycine inner salt, decanoyl/octanoyl glycerides, glutamic acid diacetic acid four sodium, succinyl glycyrrhetinic acid disodium, Fructus Vitis viniferae
Sugar fatty acid phosphate, Hydroxypropyl phosphate ester starch, be uniformly mixed,.
Embodiment 6: by upper table 1, takes Aloe extract, geniposide, puerarin, Inokopolyose respectively, crosses 100 mesh sieves,
Mix homogeneously, adds distilled water, stirs 10min；Add coconut oil fatty acid monoethanolamide, hydrogenated cotton seeds oil glyceride sulfo group amber
Amber acid disodium salt, decanoyl/octanoyl glycerides, glutamic acid diacetic acid four sodium, succinyl glycyrrhetinic acid disodium, glucose fat acid phosphoric acid
Salt, Hydroxypropyl phosphate ester starch, be uniformly mixed,.
Embodiment 7: by upper table 1, takes Aloe extract, geniposide, puerarin, Inokopolyose respectively, crosses 100 mesh sieves,
Mix homogeneously, adds distilled water, stirs 10min；Add cetyl sulfophenoxy benzenesulfonic acid disodium salt, coco-nut oil fatty acid list
Glycollic amide, N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate
Salt, decanoyl/octanoyl glycerides, glutamic acid diacetic acid four sodium, glucose fatty acid phosphate, be uniformly mixed.
Embodiment 8: by upper table 1, takes Aloe extract, geniposide, puerarin, Inokopolyose respectively, crosses 100 mesh sieves,
Mix homogeneously, adds distilled water, stirs 10min；Add cetyl sulfophenoxy benzenesulfonic acid disodium salt, coco-nut oil fatty acid list
Glycollic amide, N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate
Salt, decanoyl/octanoyl glycerides, succinyl glycyrrhetinic acid disodium, Hydroxypropyl phosphate ester starch, be uniformly mixed,.
3, effect example
Test one: to face's chloasma, freckle, senile plaque, the clinical research of butterfly spot
Test method: select face to have chloasma respectively, freckle, senile plaque, volunteer 30 example of butterfly spot are tried
Test, the one bottle of about 150g of cleansing milk prepared by embodiment 1-8 respectively, with the warm water of 25-45 DEG C after getting up early morning every day and before sleeping
Wash one's face once, wash one's face every time and fully massage face, make cleansing milk stop about 1 minute in face, repeat above operation every time.Examination
Test and after carrying out 40 days, add up its effective percentage (%).Criterion of therapeutical effect: the most effective: subjective symptoms has and alleviates significantly or disappear.
The most effective: subjective symptoms has a certain degree of alleviating but the most obvious.3.: invalid: face's speckle the most substantially or does not alleviates.Test
Result see table 2:
Table 2 embodiment 1-8 is to face's speckle dispelling result of the test
| Sample source | Volunteer (example) | Effective | Effectively | Invalid | Total effective rate (%) |
| Embodiment 1 | 30 | 15 | 12 | 3 | 90 |
| Embodiment 2 | 30 | 11 | 13 | 6 | 80 |
| Embodiment 3 | 30 | 10 | 16 | 4 | 86.7 |
| Embodiment 4 | 30 | 12 | 13 | 5 | 83.3 |
| Embodiment 5 | 30 | 14 | 14 | 2 | 93.3 |
| Embodiment 6 | 30 | 12 | 15 | 3 | 90 |
| Embodiment 7 | 30 | 10 | 18 | 2 | 93.3 |
| Embodiment 8 | 30 | 10 | 17 | 3 | 90 |
Table 2 shows: embodiment 1-8 all has preferable effect to face's chloasma, freckle, senile plaque, butterfly spot；Wherein real
Executing example 1,5-8 is better than embodiment 2-4, Aloe extract, geniposide, puerarin, Inokopolyose compatibility using effect is described more
Good.
Test two: the clinical research to face's whitening
Test method: volunteer 50 example selecting face, the wing of nose to have obvious blackhead respectively is tested, respectively with implementing
One bottle of about 150g of cleansing milk that example 1-8 prepares, after getting up early morning every day and washes one's face once, every time with the warm water of 25-45 DEG C before sleeping
Wash one's face and fully massage face, make cleansing milk stop about 1 minute in face, repeat above operation every time.After test carries out 30 days
Add up its effective percentage (%).Criterion of therapeutical effect: the most effective: blackhead thoroughly disappears.The most effective: blackhead has a certain degree of desalination.3.:
Invalid: blackhead the most substantially or does not alleviates.Result of the test see table 3:
Table 3 embodiment 1-8 result of the test to blackhead
| Sample source | Volunteer (example) | Effective | Effectively | Invalid | Total effective rate (%) |
| Embodiment 1 | 30 | 12 | 18 | 0 | 100 |
| Embodiment 2 | 30 | 12 | 15 | 3 | 90 |
| Embodiment 3 | 30 | 14 | 13 | 3 | 90 |
| Embodiment 4 | 30 | 14 | 12 | 4 | 86.7 |
| Embodiment 5 | 30 | 16 | 14 | 0 | 100 |
| Embodiment 6 | 30 | 18 | 10 | 2 | 93.3 |
| Embodiment 7 | 30 | 10 | 19 | 1 | 96.7 |
| Embodiment 8 | 30 | 14 | 16 | 0 | 100 |
Table 3 shows: blackhead is all had good cleaning to dispel effect by embodiment 1-8；Wherein embodiment 1,5-8 is better than implementing
Example 2-4, illustrates that Aloe extract, geniposide, puerarin, Inokopolyose compatibility using effect are more preferable.
Test three: on cleaning test, gentle zest test, the impact of stability test
Test method: the test of described cleaning is: will prepare embodiment 1-8, is respectively issued to 50 testers and uses.Test
Being carried out in the same manner during librarian use sample, every kind of sample uses 2 weeks.Tester according to oneself feel into
Row scoring.Standards of grading take ten point system, and 1 point worst, and 10 points best.
The concrete clean method of tester is: after first using clear water to drench skin, use product of the present invention in right amount in hands
The heart, after rubbing out foam gently, is coated with and face, and gently rubs face skin one minute；Then rinse well with clear water, repeat above-mentioned step
Suddenly, each sample determination 6 times, the results are shown in Table 3.
Described gentle zest test is: will prepare case study on implementation 1-8, and be respectively issued to 50 testers and contrast use.
Every kind of sample uses 2 weeks, tester according to oneself feel appraise through comparison.Content on probation includes: with or without excitement, with or without scabies
Itch, facial skin with or without general red, contact eyes around with or without general red.Evaluation criterion taked, slightly, nothing, test result is shown in 4.
The concrete method of testing of tester is: after first using clear water to drench skin, use product of the present invention in right amount in hands
The heart, after rubbing out foam gently, is coated with and face and circumference of eyes, and gently rubs face skin one minute, then rinse well with clear water,
Circumference of eyes is also skin one minute around massaging eyes gently, then rinses well with clear water, repeat the above steps, often as
Product are tested six times.(remarks: the test of above Ocular irritation is because with in clear water flushing process, not avoiding eyes, generation general red
Phenomenon)
Table 4 cleansing milk of the present invention using effect evaluation table
| Sample source | Skin comfort degree | Bath skinfeel | Clean up sense | Moisturizing effect after dry | Foaming abundancy sense |
| Embodiment 1 | 9 | 9.2 | 9.5 | 9.2 | 9 |
| Embodiment 2 | 9.2 | 9.3 | 9 | 9.1 | 9.2 |
| Embodiment 3 | 9.7 | 9.5 | 9.1 | 8.5 | 8.9 |
| Embodiment 4 | 9.1 | 9.1 | 9.4 | 9.3 | 9.1 |
| Embodiment 5 | 7.5 | 7.8 | 8.6 | 8.8 | 7.4 |
| Embodiment 6 | 8.1 | 7.6 | 7.9 | 7.3 | 8.2 |
| Embodiment 7 | 7.9 | 7.8 | 8.3 | 7.8 | 8.4 |
| Embodiment 8 | 7.4 | 8.2 | 8.0 | 7.8 | 7.6 |
Table 4 shows: embodiment 1-4 skin comfort degree, bath skinfeel, clean up sense, dry moisturizing effect, foaming abundancy afterwards
Sense, significantly better than embodiment 5-8, illustrates cetyl sulfophenoxy benzenesulfonic acid disodium salt, coco-nut oil fatty acid monoethanol acyl
Amine, N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate salt, the pungent last of the ten Heavenly stems
After the surfactant compounds such as acid glyceride, chelating agen glutamic acid diacetic acid four sodium compounds with succinyl glycyrrhetinic acid disodium, tool
There is gentle non-stimulated effect, than being used alone one of which or several surfactant or chelating agen effect is more preferable.
Test four: the impact on cleansing milk viscosity
Test method: viscosity measurement of the present invention uses rotor-type Rotary Viscosimeter (the Shanghai limited public affairs of Ping Xuan scientific instrument
The NDJ-8S rotational viscometer that department produces) measure, select No. 4 rotors, rotating speed is 3rpm, and measuring temperature is 25 DEG C.With
10ml disposable syringe draws test sample 10ml, and syringe needle one end seals, and is perpendicularly fixed in the environment of 25 DEG C, is revolved by NDJ-8S
No. 4 rotors turning viscosimeter supporting are installed on rotational viscometer, and regulation rotational viscometer, in level, is dipped vertically into and fills for examination
In the 10ml syringe of product, the graduation mark of rotor maintains an equal level with the liquid level of test sample, after standing 10 minutes, opens rotor, and regulation turns
Speed is 3rpm, starts to measure.Measure the k value of 0h, 24h, 48h, 72h respectively.The results are shown in Table 5.
Table 5 cleansing milk of the present invention viscosity affect evaluation table (3 revs/min) unit: Pa.s
| Sample source | 0h | 24h | 48h | 72h |
| Embodiment 1 | 14 | 13 | 15 | 14 |
| Embodiment 2 | 15 | 16 | 15 | 14 |
| Embodiment 3 | 14 | 13 | 16 | 13 |
| Embodiment 4 | 14 | 16 | 14 | 14 |
| Embodiment 5 | 13 | 15 | 15 | 13 |
| Embodiment 6 | 14 | 15 | 13 | 15 |
| Embodiment 7 | 16 | 15 | 13 | 10 |
| Embodiment 8 | 15 | 14 | 10 | 8 |
Table 5 shows: embodiment 1-6 stability of viscidity is significantly better than embodiment 7-8, and glutamic acid diacetic acid four sodium and amber are described
Amber acyl glycyrrhetinic acid disodium compounds, and after glucose fatty acid phosphate and Hydroxypropyl phosphate ester starch thickener compound, viscosity is steady
Fixed, than being used alone, one of which effect is more preferable.Above-mentioned distinguishing feature did not the most have open, the most not
Common knowledge.
Claims (3)
1. an aloe facial cleaner, it is characterised in that be prepared by the raw materials in: Aloe extract 2-4 part, genipin
Glycosides 4-6 part, puerarin 3-5 part, Inokopolyose 5-7 part, cetyl sulfophenoxy benzenesulfonic acid disodium salt 20-30 part, Cortex cocois radicis
Fatty acid oil single ethanol amide 10-15 part, N-cocamidopropyl propyl amide-N, N-dimethylglycine inner salt 30-36 part, hydrogenated cotton seeds
Oil glyceride disodium sulfosuccinate salt 15-20 part, decanoyl/octanoyl glycerides 5-7 part, glutamic acid diacetic acid four sodium 2-4 part, succinum
Acyl glycyrrhetinic acid disodium 3-5 part, glucose fatty acid phosphate 2-4 part, Hydroxypropyl phosphate ester starch 1-3 part, distilled water 150-
180 parts.
2. the preparation method of an aloe facial cleaner as claimed in claim 1, it is characterised in that the preparation method of Aloe extract
Comprise the following steps: take fresh Aloe vera L.var. chinensis(Haw.)Berg. kind, peeling, Aloe mesophyll is homogenized, centrifugal, obtain Aloe juice, hydro-oxidation sodium
Regulation pH value is 7.0-7.4, is spray-dried to obtain Aloe extract, aloe facial cleaner preparation method, containing following steps:
A) take Aloe extract, geniposide, puerarin, Inokopolyose respectively, cross 100 mesh sieves, mix homogeneously, add distilled water,
Stirring 1-10min；
B) cetyl sulfophenoxy benzenesulfonic acid disodium salt, coconut oil fatty acid monoethanolamide, N-coconut oleoyl amine third are added
Base-N, N-dimethylglycine inner salt, hydrogenated cotton seeds oil glyceride disodium sulfosuccinate salt, decanoyl/octanoyl glycerides, glutamic acid
Oxalic acid four sodium, succinyl glycyrrhetinic acid disodium, glucose fatty acid phosphate, Hydroxypropyl phosphate ester starch, stirring mixing is all
It is even,.
3. aloe facial cleaner application in preparing skin-lightening cosmetic as claimed in claim 1.
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| WO2019209223A3 (en) * | 2017-12-27 | 2020-01-02 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | Sensitive care and cleansing compositions |
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| CN106361646A (en) * | 2016-11-08 | 2017-02-01 | 全椒先奇医药科技有限公司 | Hydrating mask and preparation method thereof |
| KR102139328B1 (en) * | 2018-10-24 | 2020-07-30 | 에스케이바이오랜드 주식회사 | Cosmetic composition for skin cooling or improving skin redness with the extract of Eucommia Ulmoides bark |
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