CN104256651A - Composition for improving male sexual function and preparation method and application thereof - Google Patents
Composition for improving male sexual function and preparation method and application thereof Download PDFInfo
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- CN104256651A CN104256651A CN201410566061.4A CN201410566061A CN104256651A CN 104256651 A CN104256651 A CN 104256651A CN 201410566061 A CN201410566061 A CN 201410566061A CN 104256651 A CN104256651 A CN 104256651A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention provides a composition for improving male sexual function and a preparation method and application thereof. On one hand, the invention provides a composition for improving male sexual function, wherein the composition comprises the following components in parts by weight: 10-25 parts of bis-arginine alpha-ketoglutarate, 10-25 parts of citrulline and 5-10 parts of vitamin C. On the other hand, the invention provides a preparation method for preparing the male sexual function, wherein the preparation method comprises four steps of taking materials, crushing, granulating and obtaining finished products. The invention further provides application of the composition for improving male sexual function in preparing nutritional supplements for improving and repairing the male sexual function. According to the invention, the composition for improving male sexual function can effectively improve the body vitality, obviously improve the sexual capacity and the quality of sexual life, and improve and repair the sexual function, and has no side effects.
Description
Technical field
The present invention relates to technical field of functional food, relate to a kind of composition and method of making the same and the application that improve male's sexual particularly.
Background technology
Society dog-eat-dog, the male sex works, life stress is large, or due to some disease (as prostatic disorders etc.), cause many people appearance sex dysfunction in various degree, there is bibliographical information, Chinese male sex dysfunction illness rate be 32%, 50-59 years old is 36%, 60-69 years old at 40-49 year age bracket is then 74%.In 300,000,000 Chinese Male Adults of the whole nation, there is the nearly suffering from sexual dysfunction of people more than 100,000,000 disease, especially overstrain one's nerves, the middle age that long campaigns mental labour is, life stress is large, the people at highest risk of sex dysfunction especially.Sex dysfunction main manifestations is sexual hypoesthesia, jerk unable, impotence, premature ejaculation etc., causes very large stress to the life of people.And some the elderlys, due to old, sickness wasted, accelerates the retrogression pathological changes of each organ, system, occurs aging prematurely and stopped sexual life, causes very big shade to me and family.
Many so-called kidney-nourishing yang-strengthening medicine in the market, what have has no curative effect, and some curative effects are suspicious, though people's long-term taking is without any effect; Though meeting of having is joyous for the moment, great majority all can bring serious side effect, and as Blushing, blood vessel dilatation, severe headache etc., frequent use also can produce or increase the weight of sex dysfunction.
Japan Patent Shen Qing Shu – publication number H10-245340 describes has excitability wish, and make the composition of energetic effect, it hot water extract comprising the mycelia of the cultivation of Cordyceps sinensis is as active component.The functional food that Japan Patent Shen Qing Shu – publication number 2004-000171 describes the alcohol extract comprising agate card adds the haemoconcentration being considered to the growth hormone suppressing the active effect that goes down of reproduction.Japan Patent Shen please describe a kind of following composition etc. by book – publication number 2005-306754, and it comprises the benzyl glucosinolate deriving from agate card and the BITC that rely on the testosterone concentration increased in blood to give Male sexual functional rehabilitation effect.Japan Patent Shen please describe a kind of following composition by book – publication number 2007-112782, and it concentration comprised by increasing female hormone in blood can improve the not genial sterile benzyl glucosinolate deriving from agate card of menstruation and/or BITC.
But the product bought about the most compositions in these reports and business is all the property endurance reinforcing agent being designed to enhancing sexual function.Also do not know now to have by using the material being similar to the component forming health to carry out inhibition deterioration from the approach of trophic function or recovering the product of property function of decline.
Therefore, in order to solve above-mentioned deficiency of the prior art, the present invention proposes a kind of new solution.
Summary of the invention
In order to solve the aforementioned problems in the prior, the invention provides a kind of composition and method of making the same and the application that improve male's sexual.According to the composition improving male's sexual provided by the invention, effectively can improve body energy, significantly improve sexuality and life quality, can improve and prosthetic function, and have no side effect.
One aspect of the present invention provides a kind of composition improving male's sexual, comprises the vitamin C that parts by weight are the KG double arginine of 10-25 part, the citrulling of 10-25 part and 5-10 part.
Further, the composition (hereinafter referred to as composition) improving male's sexual provided by the invention also comprises pharmaceutic adjuvant, and described pharmaceutic adjuvant comprises: malic acid, maltodextrin, sweet mellow wine and essence.
Further, described composition is the formulation being easy to take, absorb and carry.
Further, the formulation of described composition is effervescent tablet, buccal tablet, granule, capsule or oral liquid.
Alternatively, the formulation of described composition is effervescent tablet, comprises the component of following parts by weight: the KG double arginine of 12-25 part, the citrulling of 12-25 part, the vitamin C of 5-10 part, the malic acid of 7-10 part, the maltodextrin of 8-12 part, the sweet mellow wine of 10-15 part, the citric acid of 10-15 part, the sodium acid carbonate of 10-15 part, the essence of 0.2 part, the PVP of the lubricant of 0.5 part and 0.5 part.
Alternatively, the formulation of described composition is buccal tablet, comprise the component of following parts by weight: the KG double arginine of 10-20 part, the citrulling of 10-20 part, the vitamin C of 5-10 part, the malic acid of 10-20 part, the maltodextrin of 10-20 part, the sweet mellow wine of 10-20 part, the soluble starch of 15-30 part, the protein sugar of 3-6 part, the essence of 0.2 part and the dolomol of 0.3-0.7 part.
The present invention provides on the other hand and a kind ofly prepares the described preparation method improving the composition of male's sexual, comprises the following steps:
(1) feeding: take raw material and pharmaceutic adjuvant;
(2) pulverize: the raw material beyond removing protein sugar, essence, lubricant or dolomol and pharmaceutic adjuvant are pulverized for 80-200 order fine powder;
(3) granulate: after described fine powder is mixed, adopt wet granulation, 40-60 DEG C of dry 0.5-1.5 hour, cross the whole grain of 16-20 mesh sieve;
(4) finished product is obtained: added proteins sugar, essence, lubricant or dolomol mix rear compressing tablet, obtain described composition.
Further, described wet granulation is spray PVP, and makes wetting agent with the ethanol of 95%.
Another aspect of the invention provides the described application of composition in the nutritious supplementary pharmaceutical of preparation improvement, reparation male's sexual improving male's sexual.
According to the composition and method of making the same and the application that improve male's sexual provided by the invention, one of at least following beneficial effect can be brought:
1, significantly improve sexuality, improve, repair male's sexual, be mainly manifested in and occur that vigorous or morning in morning, vigorous number of times increased;
2, life quality improves, and is mainly manifested in sexual desire and strengthens, and jerks effectively and time lengthening;
3, persistent, can not produce the side effects such as Blushing, blood vessel dilatation, severe headache, and after sexual intercourse, without having palpitation, the heart tires out, the sensation of fatigue and weak.
Accompanying drawing explanation
Fig. 1 shows the schematic flow sheet of the preparation method of the composition of the improvement male's sexual that the embodiment of the present invention provides.
Detailed description of the invention
Introduce exemplary embodiment of the present invention in detail with reference to the accompanying drawings.There is provided the object of these exemplary embodiments to be to make those of ordinary skill in the art to be expressly understood the present invention, and can the present invention be realized according to description here.The drawings and specific embodiments are not intended to limit the present invention, and scope of the present invention is defined by the following claims.
One aspect of the present invention provides a kind of composition improving male's sexual, comprises the vitamin C that parts by weight are the KG double arginine of 10-25 part, the citrulling of 10-25 part and 5-10 part.
It should be noted that above-mentioned KG double arginine can be special specially according to specific needs, also can be existing KG double arginine product in prior art.
KG double arginine: KG double arginine can be dissociated into L-arginine and KG in aqueous, can as the donor of KG or L-arginine.L-arginine is two amino acid, is a composition in ornithine circulation, is conditionally essential amino acid, because L-arginine is described as star molecule nitric oxide precursors in life science, thus causes the concern of medical circle.L-arginine is the precursor substance of the neurotransmitters such as endogenous nitric oxide, current proof nitric oxide is signaling molecule, the male sex is in telotism process, first be, by brain, sexual stimulus signal is sent to neural blood vessel system by chemical mediators such as nitric oxides, make smooth muscle relaxation in corpora cavernosa penis, make parteriole blood vessel dilatation, cavernosa blood flow and pressure sharply increase, the fibr tissue of adding penis shrinks, stop parteriole blood backflow in corpus cavernosal smooth muscle, thus penis hyperemia is expanded, erect strong.According to another report, United States Medicine expert studies discovery, due to nitric oxide energy hemangiectasis, therefore the blood vessel in penis can also be acted on, make telotism adhere to treating impotence, apply this effect, the medicine " vigour " of world-famous pharmacy corporation Pfizer research and development treatment impotence is just containing arginine composition, because it has magical effect to treatment impotence, and supply falls short of demand.KG is the precursor substance of glutamine and the important intermediate of tricarboxylic acid cycle, have good stability, be a kind of energy carrier in body, can deliver again nitrogen, storage nitrogen, change body nitrogen metabolism, alleviate the metabolic stress in animal productiong process.Current research shows, KG can strengthen cell metabolic activity, reduce the active o content of Cell culture invitro system and body generation, has obvious antioxidation, effectively maintains body total nitrogen.
Citrulling: be not the amino acid forming protein in live organism, but a kind of intermediate in urea cycle, it is produced by L-arginine and the known material nitric oxide (NO) with vasorelaxation action, and is regenerated as L-arginine with aspartic acid condensation.Known citrulling show useful effect as promoted ammonia metabolism, to be improved blood flow by vasodilation, reduce blood pressure, neurotransmission, Immune-enhancing effect and Scavenging active oxygen.
Vitamin C: vitamin C is also known as ascorbic acid, it is the one in the middle of antioxidant vitamins, it participates in hydroxylation reaction in body, required by forming sticky thing between bone, tooth, connective tissue and non-Epithelial cell, the normal function of tooth, bone, blood vessel can be maintained, increase the resistivity to disease
Under KG double arginine, citrulling, vitamin C synergy, playing nitric oxide production strong effect by suppressing the toxic action of oxidation reaction largely, making endothelial cell start self-regeneration, improve the nitric oxide production level of body.
The composition improving male's sexual provided by the invention, also comprises pharmaceutic adjuvant, and described pharmaceutic adjuvant comprises: malic acid, maltodextrin, sweet mellow wine and essence.In addition, the composition improving male's sexual provided by the invention is the formulation being easy to take, absorb and carry, and the formulation of said composition is effervescent tablet, buccal tablet, granule, capsule or oral liquid, preferably, the formulation of said composition is effervescent tablet or buccal tablet.
It should be noted that, above-mentioned pharmaceutic adjuvant can according to above-mentioned improve the composition of male's sexual the formulation selected and selecting.In addition, the composition of this improvement male's sexual is the formulation being easy to take, absorb and carry, preferably, said composition is effervescent tablet or buccal tablet, but be not limited to effervescent tablet and buccal tablet, can be other formulations existing in prior art, as long as can be easy to take, absorb and carry, as pulvis, granule, oral liquid, capsule etc.
The formulation of above-mentioned composition is effervescent tablet, comprise the component of following parts by weight: the KG double arginine of 12-25 part, the citrulling of 12-25 part, the vitamin C of 5-10 part, the malic acid of 7-10 part, the maltodextrin of 8-12 part, the sweet mellow wine of 10-15 part, the citric acid of 10-15 part, the sodium acid carbonate of 10-15 part, the essence of 0.2 part, the PVP of the lubricant of 0.5 part and 0.5 part.
The formulation of above-mentioned composition is buccal tablet, comprise the component of following parts by weight: the KG double arginine of 10-20 part, the citrulling of 10-20 part, the vitamin C of 5-10 part, the malic acid of 10-20 part, the maltodextrin of 10-20 part, the sweet mellow wine of 10-20 part, the soluble starch of 15-30 part, the protein sugar of 3-6 part, the essence of 0.2 part and the dolomol of 0.3-0.7 part.
Fig. 1 shows the schematic flow sheet of the preparation method of the composition of the improvement male's sexual that the embodiment of the present invention provides.With reference to Fig. 1, the present invention provides on the other hand and a kind ofly prepares the above-mentioned preparation method improving the composition of male's sexual, comprises the following steps:
(1) feeding: take raw material and pharmaceutic adjuvant;
(2) pulverize: the raw material beyond removing protein sugar, essence, lubricant or dolomol and pharmaceutic adjuvant are pulverized for 80-200 order fine powder;
(3) granulate: after above-mentioned fine powder is mixed, adopt wet granulation, 40-60 DEG C of dry 0.5-1.5 hour, cross the whole grain of 16-20 mesh sieve;
(4) finished product is obtained: added proteins sugar, essence, lubricant or dolomol mix rear compressing tablet, obtain above-mentioned nutritious supplementary pharmaceutical.
Preferably, above-mentioned wet granulation is spray PVP, and make wetting agent with the ethanol of 95%, but binder is not limited to PVP, wetting agent be not limited to 95% ethanol, can be the binder and wetting agent that in prior art, existing wet granulation is used, as water, starch slurry etc., only otherwise affect provided by the invention improve the composition of male's sexual effect, contribute to its preparation and its disintegration in water.
The formulation of above-mentioned composition is the preparation method of effervescent tablet: the above raw material outside removing protein sugar, essence, lubricant and pharmaceutic adjuvant are all pulverized as 80-120 order fine powder, mix, adopt wet granulation, 40-50 DEG C of dry 0.5-1.5 hour, cross the whole grain of 16-20 mesh sieve, additional essence, protein sugar, mix lubricant be rear compressing tablet evenly.
The formulation of above-mentioned composition is the preparation method of buccal tablet: pulverize as 100-200 order fine powder by the above raw material outside removing protein sugar, essence, dolomol, mix, adopt wet granulation, 50-60 DEG C of dry 0.5-1.5 hour, cross the whole grain of 20 mesh sieve, additional essence, protein sugar, dolomol mix rear compressing tablet.
It should be noted that, above-mentioned tableting processes adopts tablet press machine to be existing medicament tablet press machine in prior art, and above-mentioned crushing process adopts pulverizer to be existing high speed disintegrator in prior art.
Another aspect of the invention provides the above-mentioned application of composition in the nutritious supplementary pharmaceutical of preparation improvement, reparation male's sexual improving male's sexual.
Specific embodiment is implemented under premised on technical solution of the present invention, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following specific embodiment.In following specific embodiment, method therefor is conventional method if no special instructions.
Specific embodiment 1:
With parts by weight, unit is kilogram, takes KG double arginine 20 parts respectively, citrulling 20 parts, vitamin C 5 parts, malic acid 7.5 parts, maltodextrin 8 parts, 12 parts, sweet mellow wine, citric acid 12 parts, sodium acid carbonate 12.5 parts, protein sugar 6 parts, 0.2 part, essence, lubricant 0.3 part, PVP 0.5 part.
KG double arginine, citrulling, vitamin C, malic acid, maltodextrin, sweet mellow wine, citric acid, sodium acid carbonate are pulverized with high speed disintegrator respectively, fineness is made to reach 100 orders, mix by weight, spray PVP 95% ethanol makes it soak, granulate, 45 DEG C of dry 45-60 minute, cross the whole grain of 20 mesh sieve, protein sugar, essence, lubricant are additional mixes rear compressing tablet.
Make the tablet of 4.0g/ sheet.
Usage and dosage: get this product and put into 30-40 DEG C of warm water, rapid disintegration and thawing, complete to disintegration and thawing, can take.
This product is taken before can sleeping every day, every day 1 time, each 1.
Disintegration time limited checks: (Chinese Pharmacopoeia 2010 editions)
Get effervescent tablet 6, put in 250ml beaker, in beaker, fill 200ml water, water temperature is 15-25 DEG C, has numerous air-bubble to release, when the gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the particle assembled, each all disintegration in 3-5 minute.
Specific embodiment 2:
With parts by weight, unit is kilogram, takes KG double arginine 10 parts respectively, citrulling 10 parts, vitamin C 5 parts, malic acid 13 parts, maltodextrin 15 parts, 12 parts, sweet mellow wine, soluble starch 29.3 parts, protein sugar 4.5 parts, 0.2 part, essence, dolomol 0.5 part, PVP 0.5 part.
KG double arginine, citrulling, vitamin C, malic acid, maltodextrin, sweet mellow wine, soluble starch are pulverized with high speed disintegrator respectively, fineness is made to reach 200 orders, mix by weight, spray PVP 95% ethanol makes it soak, granulate, 55 DEG C of dry 45-60 minute, cross the whole grain of 20 mesh sieve, protein sugar, essence, dolomol are additional mixes rear compressing tablet.
Make the tablet of 1.0g/ sheet.
Usage and dosage: get this product and directly put into product containing clothes.
This product can be taken ante cibum or 1 hour after meal, every day each 1 time sooner or later, each 2-4 sheet.
Disintegration time limited checks: (Chinese Pharmacopoeia 2010 editions)
Adopt lift disintegration tester, regulate water temperature 37 ± 1 DEG C, get buccal tablet 6, put in the glass tube of hanging basket, start automatic disintegration tester and check, each all whole disintegration or dissolve in 10-15 minute.
The improvement prepared according to the composition improving male's sexual provided by the invention, repair the nutritious supplementary pharmaceutical of male's sexual, its taking dose has two kinds of methods: method one, once a day, take 1 effervescent tablet (following effervescent tablet is the tablet described in above-mentioned specific embodiment 1) before sleeping; Method two, every day twice, morning and respectively take 2-4 sheet buccal tablet (following buccal tablet is the tablet described in above-mentioned specific embodiment 2) before sleeping.
Take effect observation:
(1) Wang, man, 54 years old, chronicity function can be low, has the shade of impotence, premature ejaculation, and suffer from hypertension, insomnia, soreness and weakness of waist and knees, body void.Take effervescent tablet after one week, soreness of waist and knee joint weakens, and physique obviously strengthens, after two weeks, insomnia disappears, after three weeks, have suddenly occur morning, with sexual behaviour, premature ejaculation fades, after surrounding, love life is normal, and satisfaction as before, and next day non fatigue feeling, blood pressure also recovers normal condition, now continues to drink, reaches continuation health-care effect.
(2) shut out certain, man, 53 years old, because live and work pressure is large, he or she is felt exhausted, and sexual life feels unable to do what one wishes gradually.Take effervescent tablet after one week, feel energetic gradually, love life obviously improves, next day non fatigue feeling; After taking two weeks, frequent urination reduces, and the urine stand-by period shortens, and sprays strong; After surrounding, feel gradually as before, sexual life is normal, urinates unable, urine wait disappearance, and suddenly occurs with morning.
(3) Zhang, man, 54 years old, because being engaged in heavy physical labor, total sense was tired standby, and love life is abnormal, suffers from premature ejaculation, is also like this during winter slack.Take effervescent tablet after two weeks, love life is cumulative, and after surrounding, love life increases to 20-30 minute, and next day, non fatigue feeling, and and suddenly occurred with morning.
(4) Guo, man, 52 years old, unmarried 5 years, has masturbation history, sexual disorder, hyperplasia of prostate, right kidney silt shape calculus.Take buccal tablet after two weeks, physique strengthens, and after taking three weeks, prostatic disorders are improved, and vigorous with morning, and after surrounding, prostatic disorders are obviously improved, and have sexual demand.
(5) sternly certain, man, 55 years old, body was empty, and immunity extreme difference, often catches a cold, and Ye Daohan suffers from a deficiency of the kidney, frequency of micturition, urinates unable, unclean.Take buccal tablet after one week, total urination time reduces, after taking two weeks, urine sense is strong than before, and night sweat alleviates, and times of common cold reduces, after three weeks, have suddenly occur morning, after surrounding, night sweat disappears, and without flu during general weather, urine is normal, urine is strong, urine retention disappears substantially, sexual life strengthen, next day non fatigue feeling.
(6) Liu, man, 46 years old, excessive drinking, frequency of micturition, urinary stuttering, urine were waited for, sexual disorder, and normal sense is had a pain in the back, vigorous without morning for a long time, through TCM pulse diagnosis, are typical kidney deficiencies, and suffer from prostatitis.Take after effervescent tablet takes two weeks, have morning vigorous, total urination time reduces, and urinary stuttering, urine wait alleviate, and after three weeks, aching pain in waist and back number of times reduces, and appetite increases, and sexual life is normal, and after surrounding, sexual life number of times increases, time lengthening, next day non fatigue feeling.
Separately attachedly take effect in more detail, refer to table 1.
Table 1 prepare according to the composition improving male's sexual provided by the invention improvement, repair male's sexual nutritious supplementary pharmaceutical take effect
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. improve a composition for male's sexual, it is characterized in that, comprise the vitamin C that parts by weight are the KG double arginine of 10-25 part, the citrulling of 10-25 part and 5-10 part.
2. the composition improving male's sexual according to claim 1, is characterized in that, also comprise pharmaceutic adjuvant, and described pharmaceutic adjuvant comprises: malic acid, maltodextrin, sweet mellow wine and essence.
3. the composition improving male's sexual according to claim 2, is characterized in that, described composition is the formulation being easy to take, absorb and carry.
4. the composition improving male's sexual according to claim 3, is characterized in that, the formulation of described composition is effervescent tablet, buccal tablet, granule, capsule or oral liquid.
5. the composition improving male's sexual according to claim 4, is characterized in that, the formulation of described composition is effervescent tablet, comprise the component of following parts by weight: the KG double arginine of 12-25 part, the citrulling of 12-25 part, the vitamin C of 5-10 part, the malic acid of 7-10 part, the maltodextrin of 8-12 part, the sweet mellow wine of 10-15 part, the citric acid of 10-15 part, the sodium acid carbonate of 10-15 part, the essence of 0.2 part, the PVP of the lubricant of 0.5 part and 0.5 part.
6. the composition improving male's sexual according to claim 4, it is characterized in that, the formulation of described composition is buccal tablet, comprises the component of following parts by weight: the KG double arginine of 10-20 part, the citrulling of 10-20 part, the vitamin C of 5-10 part, the malic acid of 10-20 part, the maltodextrin of 10-20 part, the sweet mellow wine of 10-20 part, the soluble starch of 15-30 part, the protein sugar of 3-6 part, the essence of 0.2 part and the dolomol of 0.3-0.7 part.
7. prepare a preparation method for the composition of the improvement male's sexual according to claim 5 or 6, it is characterized in that, comprise the following steps:
(1) feeding: take raw material and pharmaceutic adjuvant;
(2) pulverize: the raw material beyond removing protein sugar, essence, lubricant or dolomol and pharmaceutic adjuvant are pulverized for 80-200 order fine powder;
(3) granulate: after described fine powder is mixed, adopt wet granulation, 40-60 DEG C of dry 0.5-1.5 hour, cross the whole grain of 16-20 mesh sieve;
(4) finished product is obtained: added proteins sugar, essence, lubricant or dolomol mix rear compressing tablet, obtain described composition.
8. preparation method according to claim 7, is characterized in that, described wet granulation is spray PVP, and makes wetting agent with the ethanol of 95%.
9. the composition of the improvement male's sexual according to any one of claim 1 to 6 improves in preparation, the application of repairing in the nutritious supplementary pharmaceutical of male's sexual.
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