CN100553640C - Arthritic new method of D-glucosamine external curing and D-glucosamine external preparation - Google Patents
Arthritic new method of D-glucosamine external curing and D-glucosamine external preparation Download PDFInfo
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Abstract
The invention provides arthritic new method of D-glucosamine external curing and D-glucosamine external preparation, D-glucosamine hydrochlorate and/or D-glucosamine sulfate are combined with transdermal agent, by the local topical treatment of arthritis.Usually D-glucosamine, transdermal agent and substrate are mixed into external preparation, preferably: 2～20 parts of D-glucosamine hydrochlorates and/or D-glucosamine sulfate, 2～5 parts of transdermal agents and 65～85 parts of substrate are mixed into external preparation, by the local topical treatment of arthritis, described umber is a weight portion.Described external preparation can be processed as: the liniment of unguentum, spray, film preparation or other types.This method and D-glucosamine external preparation can make D-glucosamine directly arrive affected part, instant effect, and the D-glucosamine good absorbing has remedied the slower deficiency of oral D-glucosamine produce effects.
Description
Technical field
The present invention relates to the arthritic method of a kind of external curing, be specifically related to the D-glucosamine external is used for the treatment of arthritic new method.The invention further relates to the D-glucosamine external preparation of treatment of arthritis.
Background technology
People's health possesses motion mobility freely, it is body health whether flag sign, and the joint guarantees body kinematics " bearing " flexibly exactly, if " bearing " not working or corrosion even breaking releasing, the ability of autonomic activities has just been lost.
The joint disease of broad scope comprises: all kinds of arthritis, synovitis, bursitis, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, hyperosteogeny, rheumatic arthritis, rheumatoid arthritis, femur head necrosis or the like.The common soreness of waist of person in middle and old age, have a back ache, arthritis, lower limb are soft etc. all belongs to the symptom of joint disease.
Arthritic clinical manifestation comprise diseased region local red, swollen, hot, bitterly, send out deadlock and functional disorder etc., develop into the serious stage and can invade tissue on every side such as facies articularis ossium and synovial membrane, can cause joint deformity, finally cause the forfeiture of joint motions function.
Osteoarthritis is the common a kind of osteoarticular retrograde affection of middle-aged and elderly people, and it is one of most important reason of disabling of middle-aged and elderly people, and social harm is very big.
Add up according to WHO, arthritic's sickness rate is that prevalence is that prevalence is old people more than 80%, 60 years old among the crowd more than 50%, 55 years old among the crowd more than 50 years old, nearly all suffer from osteoarthritis disease in various degree, the joint disease patient of China has surpassed 1.5 hundred million people.
In the past, this sick traditional treatment drug main will be used salicylic acid, NSAID (non-steroidal anti-inflammatory drug) class etc., but pay effect greatly to liver, hemopoietic system and gastrointestinal tract poison, and curative effect is dissatisfied, and can only the respite symptom.In recent years, the countries in the world scientist uses sophisticated technology to extract a kind of pure natural specially good effect active substance that prevents with treatment of arthritis from marine organism: D-glucosamine hydrochlorate and D-glucosamine sulfate, being called for short D-glucosamine, is the important component part of the very strong proteoglycan of hydrophilic.D-glucosamine is not only and is participated in the synthetic main matter of making articular cartilage and knuckle synovia, and can stimulate chondrocyte to generate these compositions, and then forms new articular cartilage.D-glucosamine not only affects the osteoarticular health of human body, also affects the cartilage in joint and the metabolic balance of synovial membrane.D-glucosamine has following three functions;
Expedite the emergence of function: D-glucosamine can expedite the emergence of and additional knuckle synovia in a large number for human body, thereby constantly lubricated cartilage aspect reduces wear, and makes joint part nimbly and freely, also provides enough nutrient substance for articular cartilage.
Generate repair function: D-glucosamine is by promoting collagen protein and the hyaluronic acid in the chondrocyte synthesized human consumingly, the articular cartilage that continuous reparation has been worn, and can generate new articular cartilage and synovial membrane, thereby recover the normal physiological function and the motor function of joint part.Simultaneously, for because of taking the damage of the articular chondrocytes that anti-inflammatory drug causes for a long time, also has good repair.
Eliminate function: this is the immunoloregulation function of D-glucosamine uniqueness.D-glucosamine is " street cleaner " in the articular cavity, can not only suppress the inflammatory reaction of joint for nonspecific factor, removes pain, and can remove the harmful enzyme in the articular cavity, improves the immunity of joint and body.By replenishing the raising that D-glucosamine brings immunity, be to eliminate arthritic important prerequisite.
Gondola research worker comment: " no matter what end that affacts of D-glucosamine is, this material is outstanding to the arthritis effect, and its avirulence, and this point is particularly important, because arthritic treatment is not overnight just achievable ".Existing D-glucosamine treatment of arthritis all adopts mode for oral administration, after D-glucosamine is absorbed, arrive the joint part of being treated by the employing of health blood circulation, and arrive limited with respect to the D-glucosamine ratio of taking by the D-glucosamine of therapentic part, further owing to take the metabolism burden that D-glucosamine can increase human body, increase the load-bearing capacity of human body, for this reason, we have developed the new method of D-glucosamine with treatment of arthritis.
Summary of the invention
The invention provides the new method of a kind of D-glucosamine with treatment of arthritis, this method can make D-glucosamine directly arrive affected part, instant effect, and the D-glucosamine good absorbing has remedied the slower deficiency of oral D-glucosamine produce effects.
The present invention further provides the D-glucosamine external preparation of treatment of arthritis, said preparation is easy to use, and the treatment of arthritis effect is obvious.
For achieving the above object, the present invention has adopted following technical proposals.
The invention discloses the arthritic new method of a kind of D-glucosamine external curing, D-glucosamine hydrochlorate and/or D-glucosamine sulfate are combined with transdermal agent, by the local topical treatment of arthritis.
By with D-glucosamine, transdermal agent combination, D-glucosamine is directly put on the affected part, by simple massage, rub, the accelerate blood circulation, D-glucosamine can directly be penetrated into affected part, and D-glucosamine can directly be repaired disease sites at affected part, and can carry out pain relieving, antiinflammatory to diseased region, instant effect, D-glucosamine good absorbing, treatment short treating period.Be readily appreciated that summary of the invention of the present invention is used for the treatment of joint disease for by the D-glucosamine external, therefore in the above-mentioned D-glucosamine external agent, as long as adopted D-glucosamine, transdermal agent combination to be coated with and to put on the skin in the affected part, can realize the treatment of joint disease, its proportion of composing can be adjusted arbitrarily as required.
For ease of D-glucosamine external agent is processed as finished product, popularize use, D-glucosamine hydrochlorate and/or D-glucosamine sulfate, transdermal agent and substrate are mixed into external preparation, by the local topical treatment of arthritis.
Preferably D-glucosamine hydrochlorate and/or D-glucosamine sulfate, transdermal agent and substrate are mixed with exterior-applied formulation by a certain percentage, be about to 2～20 parts of D-glucosamine hydrochlorates and/or D-glucosamine sulfate, 2～5 parts of transdermal agents and 65～85 parts of substrate and be mixed into external preparation, external preparation can be processed into the liniment of unguentum, spray, liniment or other types.
The present invention further discloses a kind of D-glucosamine external preparation of treatment of arthritis, comprise D-glucosamine hydrochlorate and/or D-glucosamine sulfate, transdermal agent and substrate.
Preferred described D-glucosamine hydrochlorate and/or 2～20 parts in D-glucosamine sulfate, 2～5 parts of described transdermal agents, 65～85 parts of described substrate, described umber is a weight portion.
External preparation can be processed as various forms:
1, D-glucosamine hydrochlorate and/or D-glucosamine sulfate, transdermal agent are combined with substrate and be processed into unguentum.
The processing method of externally used paste can adopt the prior art of common making medicine for external application or cosmetics unguentum, being about to D-glucosamine at first mixes with water-soluble substances in the substrate, mix with liposoluble substance after the fusion in the substrate afterwards, under certain mixing speed, carry out saponification, make water-soluble substances and liposoluble substance mixing, obtain unguentum, common water-soluble substances is a water, liposoluble substance is generally stearic acid and lanoline, after saponification, add a certain amount of transdermal agent, transdermal agent can adopt red ketone commonly used etc.
2, D-glucosamine hydrochlorate and/or D-glucosamine sulfate, transdermal agent are combined with substrate and be processed into spray.
The production method of D-glucosamine spray is for dissolving in D-glucosamine canned get final product of pressurization after the substrate, and as common pain relieving spray processing mode, substrate adopts the water of routine, harmless propellant and cosolvent (CONSOLVENT), and passes through emulsifier.
Among the present invention, the D-glucosamine external preparation also can be processed as ointment commonly used or liniment, and liniment is pressed mixed commonly used with common substrate PVA and D-glucosamine, during use, smears film forming on the affected part surface, and the affected part is treated.
For therapeutic effect of the present invention is described, the spy provides following clinical data.
Case:
1, congratulate certain: the woman, 58 years old, suffer from synovitis, degenerative osteoarthritis, the joint pain, difficulty in walking uses the D-glucosamine external application paste, every day 3～4 times, use sx on the same day, the patella edema disappeared in 20 days, can the same one-time continuous with the normal person walk 50～60 meters.
2, Guo, the man, 60 years old, suffer from chondromalacia patella, rheumatic arthritis, the joint pain, difficulty in walking uses the D-glucosamine external application paste, uses three days sxs every day 3～4 times, and the patella edema disappeared in 30 days, can walk with the normal person.
3, Liu, man 40 years old suffers from rheumatic arthritis, and cold, cloudy pain is met in the joint, should walk inconvenience, uses D-glucosamine external application spray, uses two days sxs every day 3～4 times, and it is normal to walk after 20 days, uses March continuously afterwards, every day 1 time, does not see recurrence so far.
4, mound, woman, 65 years old suffers from synovitis, and long bony spur arranged, the bimester before be diagnosed as degenerative osteoarthritis, the joint pain, can not squat down, difficulty in walking uses the D-glucosamine external application paste, every day 3～4 times, use sx on the same day, pain disappears after 20 days, the joint is no longer stiff, and is flexibly movable, can walk 50～60 meters with normal person one all borderlands, use January continuously afterwards, every day 1 time, do not see recurrence so far.
5, Lu: the man, 38 years old, suffer from brothers' arthritis, brothers' arthroncus, pain, stiff, inconvenient activity were used the D-glucosamine external application paste 30 days, and every day 3～4 times, swelling, pain disappear, and brothers' joint motion is flexible.
6, Lee: the man, 55 years old, lumbar vertebra, cervical vertebra swelling, pain were sat the minister difficulty, used D-glucosamine external application spray 30 days, and each the use massaged several minutes, and per 3～4 times, swelling, pain disappear, and can walk, sit for sleeping in as people from political party.
7, Feng: the man, 43 years old, shoulder joint swelling, pain, the arm tire plays difficulty, can not lift weight, uses D-glucosamine external application liniment 30 days, and every day 3～4 times, swelling, pain disappear, and arm can freely rise and fall, and can lift 5 kilograms of weights.
The specific embodiment 1
The new method of a kind of D-glucosamine external curing joint material is mixed into unguentum with 10 parts of D-glucosamine hydrochlorates, 2 parts of transdermal agents and 85 parts of substrate, is used for the treatment of rheumatic arthritis.
The specific embodiment 2
A kind of D-glucosamine external preparation of treatment of arthritis mixes 20 parts of D-glucosamine hydrochlorates, 2 parts of transdermal agents the back pressurized canister and dresses up spray with 65 parts of substrate.Be used for the treatment of rheumatoid arthritis by D-glucosamine being sprayed on the surface, affected part.
The specific embodiment 3
A kind of D-glucosamine external preparation of treatment of arthritis is mixed into emulsifiable paste with 8 parts of D-glucosamine hydrochlorates and 1 part of D-glucosamine sulfate, 2 parts of transdermal agents and 65 parts of substrate.Be used for the treatment of arthritis by external application.
The specific embodiment 4
The arthritic new method of a kind of D-glucosamine external curing is mixed 20 parts of D-glucosamine hydrochlorates, 5 parts of transdermal agents the back pressurized canister and is dressed up spray with 70 parts of substrate, by D-glucosamine being sprayed on the surface, affected part, be used for the treatment of cervical vertebra and lumbar vertebra, gonarthritis.
The specific embodiment 5
The arthritic new method of a kind of D-glucosamine external curing, 10 parts of D-glucosamine hydrochlorates and 10 parts of D-glucosamine sulfate, 5 parts of transdermal agents are mixed the back pressurized canister and dress up spray with 70 parts of substrate, by D-glucosamine being sprayed on the surface, affected part, be used for the treatment of brothers' arthritis.
The specific embodiment 6
A kind of D-glucosamine external preparation of treatment of arthritis, it is liniment that 15 parts of D-glucosamine hydrochlorates and 5 parts of D-glucosamine sulfate, 2 parts of transdermal agents are mixed post-treatment with 80 parts of substrate that comprise the PVA composition.By D-glucosamine being sprayed on the affected part surface filming, be used for the treatment of degenerative osteoarthritis.
The specific embodiment 7
The arthritic new method of a kind of D-glucosamine external curing is mixed the post-treatment unguentum with 1 part of D-glucosamine hydrochlorate and 1 part of D-glucosamine sulfate, 0.2 part of transdermal agent with 80 parts of substrate, and the D-glucosamine unguentum is spread upon the surface, affected part, is used for the treatment of arthritis.
The specific embodiment 8
The arthritic new method of a kind of D-glucosamine external curing, with an amount of D-glucosamine hydrochlorate and D-glucosamine sulfate, add an amount of transdermal agent and different substrate, substrate can be profit hands agent or other emollient types, be coated with and put on the skin, be used for the treatment of arthritis on the affected part surface.
In the above-mentioned specific embodiment, be coated with put on the skin, spray or film after, but combination with massaging, rub wiping, rub and can accelerate blood circulation, improve the absorption of D-glucosamine, further improve therapeutic effect.
Purpose of the present invention is intended to be used for the treatment of various arthritis by D-glucosamine is combined external with transdermal agent; and external preparation is processed as finished product; therefore all belong to protection scope of the present invention so long as adopt said method to be used for the treatment of arthritis, no matter and the type of the external preparation that it adopts or external curing method.
Claims (4)
1, a kind of D-glucosamine external preparation of treatment of arthritis is characterized in that it contains in weight portion 2-20 part D-glucosamine hydrochlorate and/or D-glucosamine sulfate, 2-5 part transdermal agent and 65-85 part substrate.
2, D-glucosamine external preparation according to claim 1 is characterized in that D-glucosamine hydrochlorate and/or D-glucosamine sulfate, transdermal agent are combined with substrate and be processed into unguentum.
3, D-glucosamine external preparation according to claim 1 is characterized in that D-glucosamine hydrochlorate and/or D-glucosamine sulfate, transdermal agent are combined with substrate and be processed into spray.
4, D-glucosamine external preparation according to claim 1 is characterized in that D-glucosamine hydrochlorate and/or D-glucosamine sulfate, transdermal agent are combined with substrate and be processed into liniment.
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| CN101416734B (en) * | 2008-12-02 | 2012-06-27 | 河北金汉方生物科技开发有限公司 | Health-care products capable of improving skeleton and joint function and preparation method thereof |
| CN101721422B (en) * | 2009-10-23 | 2013-05-29 | 贾世哲 | Medicine for treating arthritis and preparation method thereof |
| CN105456049A (en) * | 2015-11-17 | 2016-04-06 | 广东医学院 | Coenzyme Q10 massage balm with functions of diminishing inflammation, relieving pain and protecting skin |
| CN106890188A (en) * | 2015-12-18 | 2017-06-27 | 苏波 | A kind of method of plant source ammonia sugar external preparation and treatment bone and joint diseases |
| CN107970247A (en) * | 2016-10-24 | 2018-05-01 | 许乃红 | A kind of feature small molecule Bones and joints repair health-care nutrient liquor |
| CN107362177A (en) * | 2017-09-07 | 2017-11-21 | 威海盛朗生物科技有限公司 | Drug component, ointment and plaster for treatment of arthritis |
| CN108324591B (en) * | 2018-02-13 | 2021-03-30 | 佛山市安安美容保健品有限公司 | A hair composition containing marine bioactive substances |
| CN109568267B (en) * | 2018-12-28 | 2021-01-05 | 中山市天图精细化工有限公司 | Freezing analgesic aerosol and preparation method thereof |
| CN116459238B (en) * | 2023-05-08 | 2023-12-05 | 乐明药业(苏州)有限公司 | Composition for promoting sustained release of glucosamine and application thereof |
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| 骨关节火及其药物治疗的最佳选择. 施性英.中华风湿病学杂志，第7卷第3期. 2003 * |
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