CN104254537B - 用于治疗性功能障碍的Phragmalin柠檬苦素类化合物 - Google Patents

用于治疗性功能障碍的Phragmalin柠檬苦素类化合物 Download PDF

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Publication number
CN104254537B
CN104254537B CN201380006854.4A CN201380006854A CN104254537B CN 104254537 B CN104254537 B CN 104254537B CN 201380006854 A CN201380006854 A CN 201380006854A CN 104254537 B CN104254537 B CN 104254537B
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compound
compounds
hydrogen
isobutyryl
methyl
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CN201380006854.4A
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Chinese (zh)
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CN104254537A (zh
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贾尔勒·维克贝格
艾加尔斯·伊尔格根森斯
爱德华·利平什
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Dai Color Co
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DICOTYLEDON AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201380006854.4A 2012-01-25 2013-01-25 用于治疗性功能障碍的Phragmalin柠檬苦素类化合物 Expired - Fee Related CN104254537B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
SE1200052-7 2012-01-25
SE1200052 2012-01-25
SE1200678 2012-11-06
SE1200678-9 2012-11-06
SE1300011-2 2013-01-04
SE1300011 2013-01-04
PCT/EP2013/051413 WO2013110744A2 (en) 2012-01-25 2013-01-25 Novel compounds, their manufacture and uses (ii)

Publications (2)

Publication Number Publication Date
CN104254537A CN104254537A (zh) 2014-12-31
CN104254537B true CN104254537B (zh) 2017-06-30

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CN201380006854.4A Expired - Fee Related CN104254537B (zh) 2012-01-25 2013-01-25 用于治疗性功能障碍的Phragmalin柠檬苦素类化合物

Country Status (11)

Country Link
US (1) US9403841B2 (enExample)
EP (1) EP2807170B1 (enExample)
CN (1) CN104254537B (enExample)
AU (1) AU2013213580B2 (enExample)
CA (1) CA2861045A1 (enExample)
DK (1) DK2807170T3 (enExample)
ES (1) ES2723248T3 (enExample)
IN (1) IN2014DN05615A (enExample)
NZ (1) NZ626736A (enExample)
PL (1) PL2807170T3 (enExample)
WO (1) WO2013110744A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104628692B (zh) * 2015-02-09 2016-02-10 庄爱华 柠檬苦素类化合物，其药物组合物及其制备方法和用途
CN208336488U (zh) * 2015-07-31 2019-01-04 株式会社村田制作所 线圈天线以及天线装置
CN109394732A (zh) * 2017-08-16 2019-03-01 安徽中医药大学 盐酸青藤碱肠溶定位渗透泵控释胶囊及其制备方法
CN110903912B (zh) * 2019-11-29 2022-01-28 华东理工大学 一种芳基油脂及其制备方法与应用
CN111755072B (zh) * 2020-08-04 2021-02-02 深圳吉因加医学检验实验室 一种同时检测甲基化水平、基因组变异和插入片段的方法及装置
CN112898263B (zh) * 2021-01-28 2022-03-08 江西中医药大学 一种从佛手中分离的香豆素骈木脂素化合物及其保肝用途
SE2251130A1 (en) * 2022-09-30 2024-03-31 Dicot Ab New compounds and methods of their manufacturing
WO2025040810A1 (en) 2023-08-23 2025-02-27 Dicot Pharma Ab Therapeutic compounds, a method of manufacturing thereof as well as uses thereof
WO2025141142A1 (en) * 2023-12-29 2025-07-03 Dicot Pharma Ab A novel method for recovering limonoid compounds

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1513853A (zh) * 2003-08-07 2004-07-21 中国科学院南海海洋研究所 柠檬苦素化合物－木果楝内酯及其用途
WO2008145996A2 (en) * 2007-05-29 2008-12-04 Dicotyledon Ab Novel compounds and pharmaceutical preparations

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EP1318825A2 (de) 2000-07-26 2003-06-18 Vitaplant AG Piper methysticum pflanzenextrakt
JP2005213202A (ja) 2004-01-29 2005-08-11 Maruzen Pharmaceut Co Ltd 抗酸化剤、抗老化剤及び抗炎症剤、並びに、皮膚化粧料
CA2623831A1 (en) 2005-09-12 2007-03-22 Council Of Scientific And Industrial Research An extract from xylocarpus useful for the treatment of diabetes and dyslipidemia
GB0710230D0 (en) 2007-05-30 2007-07-11 Reckitt Benckiser Nv Detergent dosing device
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1513853A (zh) * 2003-08-07 2004-07-21 中国科学院南海海洋研究所 柠檬苦素化合物－木果楝内酯及其用途
WO2008145996A2 (en) * 2007-05-29 2008-12-04 Dicotyledon Ab Novel compounds and pharmaceutical preparations

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Chukvelutilides A-F, phragmalin limonoids from the stem barks of Chukrasia tabularis var. velutina;Jun Luo，等;《Tetrahedron》;20090425;第65卷(第17期);第3425-3431页，尤其参见第3429页合成路线1及右栏第1段，第3425页化合物结构 *
D-Ring-Opened Phragmalin-Type Limonoids from Chukrasia tabularis var. velutina;Jun Luo，等;《CHEMISTRY & BIODIVERSITY》;20111208;第8卷(第12期);第2261-2269页，尤其参见第2262页 *
Kv1.2 potassium channel inhibitors from Chukrasia tabularis;Hong-Bing Liu，等;《Org. Biomol. Chem.》;20120101;第10卷(第7期);第1448-1458页，尤其参见第1449页 *
Phragmalin Limonoids from Chukrasia tabularis var. velutina;Xue-Lian Chen，等;《Planta Medica》;20111201;第78卷(第03期);第286-290页，尤其参见第286页 *
Phragmalin Limonoids from the Madagascan Meliaceae Neobeguea leandreana;Philip H. Coombes，等;《Journal of Natural Products》;20030524;第66卷(第6期);第735-738页 *
Plant Orthoesters;Shang-Gao Liao，等;《Chemical Reviews》;20090130;第109卷(第3期);第1092-1140页 *
Two new C-15 enolic acyl phragmalin-type limonoids from Chukrasia tabularis var. velutina;Jun Luo，等;《Natural Product Research》;20120427;第27卷(第7期);第597-602页，尤其参见第598页图1 *
Two new limonoids from the stem barks of Chukrasia tabularis var. velutina;Yi Li，等;《Journal of Asian Natural Products Research》;20110930;第13卷(第9期);第781-786页，尤其参见第782页图1 *

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Publication number Publication date
AU2013213580B2 (en) 2017-06-15
EP2807170A2 (en) 2014-12-03
NZ626736A (en) 2016-11-25
CA2861045A1 (en) 2013-08-01
DK2807170T3 (da) 2019-05-27
AU2013213580A1 (en) 2014-07-24
EP2807170B1 (en) 2019-03-13
US20150011616A1 (en) 2015-01-08
ES2723248T3 (es) 2019-08-22
IN2014DN05615A (enExample) 2015-04-03
PL2807170T3 (pl) 2019-09-30
CN104254537A (zh) 2014-12-31
WO2013110744A2 (en) 2013-08-01
HK1204325A1 (en) 2015-11-13
WO2013110744A3 (en) 2013-10-31
US9403841B2 (en) 2016-08-02

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