CN104254531B - 环状二氨基嘧啶衍生物 - Google Patents

环状二氨基嘧啶衍生物 Download PDF

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Publication number
CN104254531B
CN104254531B CN201280070330.7A CN201280070330A CN104254531B CN 104254531 B CN104254531 B CN 104254531B CN 201280070330 A CN201280070330 A CN 201280070330A CN 104254531 B CN104254531 B CN 104254531B
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tumor
formula
compound
compounds
syk
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CN104254531A (zh
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H.余
L.C.德塞尔姆
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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  • Tropical Medicine & Parasitology (AREA)
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  • Obesity (AREA)
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CN201280070330.7A 2012-02-21 2012-12-18 环状二氨基嘧啶衍生物 Expired - Fee Related CN104254531B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261601101P 2012-02-21 2012-02-21
US61/601,101 2012-02-21
PCT/US2012/070252 WO2013126132A1 (en) 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives

Publications (2)

Publication Number Publication Date
CN104254531A CN104254531A (zh) 2014-12-31
CN104254531B true CN104254531B (zh) 2017-05-03

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US (1) US9073944B2 (https=)
EP (1) EP2817306B1 (https=)
JP (1) JP6059260B2 (https=)
CN (1) CN104254531B (https=)
AR (1) AR090103A1 (https=)
AU (1) AU2012370450B2 (https=)
CA (1) CA2865040C (https=)
ES (1) ES2552518T3 (https=)
IL (1) IL233986A (https=)
WO (1) WO2013126132A1 (https=)

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US20220143049A1 (en) 2019-03-21 2022-05-12 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
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WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
KR20220153582A (ko) * 2020-02-14 2022-11-18 솔크 인스티튜트 포 바이올로지칼 스터디즈 마크로시클릭 ulk1/2 억제제
CN116528877A (zh) * 2020-10-05 2023-08-01 默克专利股份公司 用于治疗血液障碍和实体瘤的lmp7选择性抑制剂
JP7556310B2 (ja) * 2021-02-26 2024-09-26 スズキ株式会社 電動車両
EP4312978A2 (en) 2021-03-27 2024-02-07 TRX Biosciences Limited Compositions having improved bioavailability of therapeutics
US20250000859A1 (en) 2021-08-25 2025-01-02 Alesta Therapeutics BV Use of gcn2 inhibitors in treating cancer
JP2025509680A (ja) * 2022-03-14 2025-04-11 ティーアールエックス バイオサイエンシズ リミテッド 治療薬のバイオアベイラビリティを改善した組成物およびその使用
TW202404979A (zh) * 2022-07-18 2024-02-01 大陸商江蘇恆瑞醫藥股份有限公司 抑制並誘導ｅｇｆｒ降解的大環類化合物、其製備方法及其在醫藥上的應用

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JP6059260B2 (ja) 2017-01-11
AU2012370450A1 (en) 2014-10-02
EP2817306A1 (en) 2014-12-31
JP2015508099A (ja) 2015-03-16
US9073944B2 (en) 2015-07-07
AU2012370450B2 (en) 2017-02-02
CA2865040A1 (en) 2013-08-29
WO2013126132A1 (en) 2013-08-29
ES2552518T3 (es) 2015-11-30
CN104254531A (zh) 2014-12-31
AR090103A1 (es) 2014-10-22
EP2817306B1 (en) 2015-09-16
US20150025066A1 (en) 2015-01-22

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