CN104237544B - 一种生物芯片检测器 - Google Patents

一种生物芯片检测器 Download PDF

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Publication number
CN104237544B
CN104237544B CN201410508609.XA CN201410508609A CN104237544B CN 104237544 B CN104237544 B CN 104237544B CN 201410508609 A CN201410508609 A CN 201410508609A CN 104237544 B CN104237544 B CN 104237544B
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China
Prior art keywords
biochip
detector
shell
runner
accommodating cavity
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CN201410508609.XA
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English (en)
Chinese (zh)
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CN104237544A (zh
Inventor
薛源
张冠斌
陈铖
赵凯军
董宇
程京
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Tsinghua University
CapitalBio Corp
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CapitalBio Corp
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Priority to CN201410508609.XA priority Critical patent/CN104237544B/zh
Publication of CN104237544A publication Critical patent/CN104237544A/zh
Priority to US15/511,216 priority patent/US10309977B2/en
Priority to PCT/CN2015/000661 priority patent/WO2016045234A1/en
Priority to JP2017516743A priority patent/JP6656236B2/ja
Priority to EP15844745.8A priority patent/EP3198260B1/en
Application granted granted Critical
Publication of CN104237544B publication Critical patent/CN104237544B/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00306—Housings, cabinets, control panels (details)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/88—Investigating the presence of flaws or contamination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN201410508609.XA 2014-09-28 2014-09-28 一种生物芯片检测器 Active CN104237544B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201410508609.XA CN104237544B (zh) 2014-09-28 2014-09-28 一种生物芯片检测器
US15/511,216 US10309977B2 (en) 2014-09-28 2015-09-25 Device for detecting and/or analyzing bio-chip
PCT/CN2015/000661 WO2016045234A1 (en) 2014-09-28 2015-09-25 Device for detecting and/or analyzing bio-chip
JP2017516743A JP6656236B2 (ja) 2014-09-28 2015-09-25 バイオチップを検出および／または分析するための装置
EP15844745.8A EP3198260B1 (en) 2014-09-28 2015-09-25 Device for detecting and/or analyzing bio-chip

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410508609.XA CN104237544B (zh) 2014-09-28 2014-09-28 一种生物芯片检测器

Publications (2)

Publication Number Publication Date
CN104237544A CN104237544A (zh) 2014-12-24
CN104237544B true CN104237544B (zh) 2016-05-11

Family

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Country Status (5)

Country Link
US (1) US10309977B2 (enExample)
EP (1) EP3198260B1 (enExample)
JP (1) JP6656236B2 (enExample)
CN (1) CN104237544B (enExample)
WO (1) WO2016045234A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104237544B (zh) 2014-09-28 2016-05-11 博奥生物集团有限公司 一种生物芯片检测器
CN104833812B (zh) * 2015-05-12 2016-05-11 天津微纳芯科技有限公司 便携式全自动生化分析装置
JP6849405B2 (ja) 2016-11-14 2021-03-24 浜松ホトニクス株式会社 分光計測装置及び分光計測システム
JP6867785B2 (ja) * 2016-11-14 2021-05-12 浜松ホトニクス株式会社 分光計測装置及び分光計測システム
CN110646625A (zh) * 2018-06-27 2020-01-03 成都亿方世佳科技有限公司 一种生物芯片检测器
CN109613286A (zh) * 2018-12-27 2019-04-12 宁波大学 一种定性/定量生物芯片检测装置
CN109613289B (zh) * 2018-12-27 2024-10-29 浙江正合谷生物科技有限公司 一种定性/定量生物芯片检测系统
CN109613288A (zh) * 2018-12-27 2019-04-12 宁波大学 一种定性/定量生物芯片检测系统
CN213148721U (zh) * 2019-11-22 2021-05-07 京东方科技集团股份有限公司 分析仪及检测系统
CN111774115B (zh) * 2020-05-29 2021-09-07 东南大学 一种用于固定带电极微流控芯片的夹具装置
CN111632637B (zh) * 2020-06-05 2021-12-17 上海探实生物科技有限公司 一种生物芯片检测装置
CN111830020A (zh) * 2020-07-22 2020-10-27 中国人民解放军总医院 一种医用试纸检测系统
CA3197077A1 (en) * 2020-10-30 2022-05-05 Ronald Chang Diagnostic assay system with replaceable processing modules and remote monitoring
CN116371488A (zh) * 2023-04-12 2023-07-04 上海森联微通工业装备有限公司 一种微流控芯片及其应用

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CN202135203U (zh) * 2011-07-20 2012-02-01 深圳市普瑞康生物技术有限公司 一种生物芯片扫描仪
CN102633112A (zh) * 2012-04-19 2012-08-15 德清明裕照明电器有限公司 上料盘的驱动机构

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CN2775339Y (zh) * 2004-12-15 2006-04-26 王兆珉 手动双向旋转驱动装置
CN101126715A (zh) * 2007-09-21 2008-02-20 博奥生物有限公司 一种微纳升体系流体芯片的检测系统及检测方法
CN202135203U (zh) * 2011-07-20 2012-02-01 深圳市普瑞康生物技术有限公司 一种生物芯片扫描仪
CN102633112A (zh) * 2012-04-19 2012-08-15 德清明裕照明电器有限公司 上料盘的驱动机构

Also Published As

Publication number Publication date
EP3198260B1 (en) 2023-02-22
JP2017530361A (ja) 2017-10-12
WO2016045234A1 (en) 2016-03-31
US10309977B2 (en) 2019-06-04
CN104237544A (zh) 2014-12-24
EP3198260A4 (en) 2018-06-06
US20170285050A1 (en) 2017-10-05
EP3198260A1 (en) 2017-08-02
JP6656236B2 (ja) 2020-03-04

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Effective date of registration: 20240920

Address after: 102206 No. 18, life science Road, Beijing, Changping District

Patentee after: CAPITALBIO Corp.

Country or region after: China

Patentee after: TSINGHUA University

Address before: 102206 No. 18, life science Road, Beijing, Changping District

Patentee before: CAPITALBIO Corp.

Country or region before: China