CN104224763A - Composition for improving dandruff - Google Patents

Composition for improving dandruff Download PDF

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Publication number
CN104224763A
CN104224763A CN201310232382.6A CN201310232382A CN104224763A CN 104224763 A CN104224763 A CN 104224763A CN 201310232382 A CN201310232382 A CN 201310232382A CN 104224763 A CN104224763 A CN 104224763A
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CN
China
Prior art keywords
constituent
dandruff
improving
molecular weight
low molecular
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Pending
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CN201310232382.6A
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Chinese (zh)
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徐其旿
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徐其旿
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Priority to CN201310232382.6A priority Critical patent/CN104224763A/en
Publication of CN104224763A publication Critical patent/CN104224763A/en
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Abstract

The invention relates to a composition capable of improving dandruff. The composition comprises glycerin with concentration being not more than 10 wt%, second low molecular weight polyol with concentration being not more than 10 wt% and water. As the composition for improving dandruff doesn't contain chemical interface activators, antibacterial agents or foaming agents at all, allergy will not be caused. In addition, the composition has advantages of simple ingredient, low cost and excellent effect, and is suitable for long-term use.

Description

Improve the constituent of the dandruff
[technical field]
The present invention relates to the formula improving desquamation situation, relate to the constituent that effectively can improve the dandruff especially.
[background technology]
Dermatitis means the disease of chafing.The patient of dermatitis, except usual along with except vesicle, erythema, transudate, exfoliation erythra or incrustation pathological changes in appearance, more may occur that play is itched hard to bear phenomenon.Therefore, dermatitis, for quality of life and the physically and mentally healthy negative effect produced, should not be underestimated.
The horny layer of skin is positioned at health outermost layer, and major function is for isolating extraneous harmful substance and being held in body by moisture content.The time that normal skin needs about one month just can be ripe gradually, and come off in the mode that naked eyes cannot be discovered, with metabolism aging cutin layer.Generally speaking, when the relative humidity of environment is less than 50 %, keratodermatitis water content is just lower than 10 %, and therefore horny layer loses pliability, and then drying comes off and causes skin injury, inflammation.General dermatitis, can by temporary transient partial smearing steroid ointment as hydrocortisone (Cort. S), Cutivate (Cutivate), reduce the stimulation (such as use the cleaning supplies of nonirritant or have a bath with clear water as far as possible) in environment simultaneously, and effectively obtain alleviation.
The dandruff is extremely common and irritating scalp problems, although can not health risk, the scurf that the scalp itch be accompanied, head come off such as to increase at the symptom, but often causes social obstacle with inter personal contact and puzzlement.The possible cause of the dandruff comprises: seborrheic dermatitis, chronic eczema, some chemical substance (as hair dye, send out carving or send out cured) the contact dermatitis, the fungal infection (tinea capitis) that cause, do not wash hair for a long time.In addition, pressure, nervous, nutritional disorder, do not have enough sleep, overwork, be also considered to accelerate the dandruff and formed.
With general place skin unlike, the scalp sites of dandruff patient, within average two to seven days, namely form the bulk white scurf that naked eyes are obviously visible.Seborrheic dermatitis is for causing the No.1 reason of dandruff generation, and the dandruff is also for scalp leaks the most common symptom of fat atopic dermatitis patient.The origin cause of formation of known this type dandruff, excessively grows relevant with the fungus (i.e. scurf sporeformer comprises Malassezia furfur and Malassezia globosa) on skin.Point out according to research, producing the position of the dandruff, the bacterium amount of scurf brood cell bacterium can up to 1.5 to 2 of normal level times.These funguses are understood the triglyceride in metabolism sebum and form oleic acid (oleic acid), after oleic acid infiltrates through the horny layer of epidermis, the chafing of some body constitution comparatively sensitive subjects will be lured into, and then the Homeostasis of Interference angle cell plastid, cause abnormal reaction that comes off, thus produce the dandruff.
Some contains the shampoo that tar (tar) becomes to divide, all effective for the dandruff suppressing scalp chronic eczema and seborrheic dermatitis to be caused, but most " anti-bits shampoo " then poor effect.The composition of commercially available anti-bits shampoo mainly contains: but gram more than that frustrates (ketoconazole), ZPT (zinc pyrithione, ZP), salicylic acid (salicylic acid), selenium sulfide (selenium sulfide, SeS 2), ciclopirox olamine (ciclopirox olamine, CPO), Piroctone Olamine (piroctone olamine), pyrithione salt (pyridinethione salts), can see, for example US 4,835,148 and US 6,538, person disclosed by 011.
Have academic research to show, at any position of health, all visible fat is present between horn cell, and it is so-called to be formed " bricks and mortar " structure of (fragment of brick and mud).The fat molecule vertical with skin surface is in (parallel fatty rete) arranged in parallel each other, and between each row fat molecule, form the interval of wide-narrow-wide (4 nm-2 nm-4 nm), this kind of kenel effectively to prevent in body moisture content outwards penetrating (Bouwstra JA et al., J Lipid Res:39:186-196).If this is destructurized or change, prevent the function of water evaporates from namely obviously declining.Some chemical substance known can destroy the normal-fat layer arrangement mode in horn cell gap, such as emulsifying agent inferior and interfacial agent, makes the drying of skin hydropenia or becomes responsive, even red and swollen, desquamation.
Research is separately had to point out (Xu Yaling, Taiwan National Cheng Kung University clinical pharmacy institute Master's thesis, 2007): continue every day to smear human sebum on normal nude mouse skin, skin surface will produce inflammatory response, and scurf increases, percutaneous moisture content scatters and disappears in one week increases 3-4 doubly, and 1/3rd when epidermis water content is reduced to normal.After stopping smearing human sebum, namely skin recovered normal shielding (barrier) function gradually in five days.In addition, smear unsaturated fatty acid and also can reduce skin barrier function, the structure of epidermal hyperplasia and corneocyte gap fat molecule is changed, releiving of dermatitis is harmful on the contrary.
Anti-bits mode known at present mostly focuses on rinse scalp or kills scurf sporeformer; But these class methods are still " taking stopgap measures " and " do not effect a permanent cure ".Therefore, being necessary to develop one can help scalp to recover normal function of shielding and character is gentle, the medicament or the constituent that are even applicable to newborn baby.
[summary of the invention]
Because the problems referred to above, the present invention aims to provide the constituent that one improves the dandruff, and it can form hydrogen bond with hydrone in body, and strengthens the lock water moisture-keeping function of skin, make the function that skin recovers original, to solve the unevident disappearance of known anti-dandruff formulation efficacy.
The constituent improving the dandruff of the present invention, comprises concentration and is not more than with total weight the glycerol of 10 wt%, concentration to be not more than 10 wt% the second low molecular weight polyols and water with total weight.Second low molecular weight polyols system is selected from propylene glycol (Propylene Glycol, PG), 1,3 butylene glycol (1,3-Butylene Glycol, BG), hexanhexol (Sorbital), Polyethylene Glycol (PolyEthylene Glycol, PEG) wherein one or combination above both it.
In a preferred embodiment, glycerol concentration is 5 below wt% with total weight, and the total concentration of the second low molecular weight polyols is 7 below wt% by weight.
In another preferred embodiment, glycerol concentration take total weight as 2-3 wt%, and the total concentration of the second low molecular weight polyols is 5-7 wt% by weight.
In a further preferred embodiment, glycerol concentration take total weight as 2-3 wt%, and the total concentration of the second low molecular weight polyols is 5-7 wt% by weight, and the second low molecular weight polyols comprises hexanhexol.
The constituent improving the dandruff of the present invention is of many uses.Not only directly external can be applied in scalp, more can be used for manufacturing pharmaceuticals, hair care articles, makeups product, skin care products or skin protection perfume.
Effect of the present invention is the environment that can provide skin self-regeneration, and make the fat molecule in skin keratinocytes gap maintain normal alignment, so, scalp can maintain normal water content naturally, and the unlikely generation dandruff.Again, the constituent improving the dandruff of the present invention, owing to not containing interfacial agent, antibacterial or foaming agent completely, therefore can not cause allergy, and have the advantage that composition is simple, with low cost, effect is remarkable.
[accompanying drawing explanation]
Nothing
[detailed description of the invention]
Feature for the present invention, implementation and effect, hereby coordinate each embodiment of graphic detailed description as follows.
Person disclosed by prior art, smears sebum at skin surface, can destroy the normal alignment of horny layer fat molecule on the contrary, and skin barrier ability is declined.Inventor researches and develops one then can make skin keep the constituent of normal screening ability, for improvement or to treat the irritating dandruff especially effective.This constituent comprise 10 wt% with purgation glycerol, 10 wt% with another (second) low molecular weight polyols of purgation, all the other are for water.
As everyone knows, glycerol (formal name used at school: glycerol) is trihydroxylic alcohol, is conventional micromolecular water dissolubility moisturizing ingredient; 1 gram of glycerol about can hold the water of 0.6 gram.The glycerol that the present invention is used, its source is not limited, for example, can be the glycerol produced in synthetic glycerine, vegetable glycerides, Fermentation ferment glycerol or soapmaking industrial process.The concentration of glycerol is no more than 10 wt% of overall constituent, such as, can be 8 wt%, and 1 wt%, 0.1 wt%, be preferably 5 below wt%, and the best is 2-3 wt%.
In the present invention, the example of the second low molecular weight polyols comprises propylene glycol (Propylene Glycol, PG), 1,3 butylene glycol (1,3-Butylene Glycol, BG), hexanhexol (molecular formula C 6h 14o 6, comprise sorbitol (sorbitol) and mannitol (mannitol) two class of mirror image isomerism thing each other), Polyethylene Glycol (PolyEthylene Glycol, PEG) or combination above both it.Second polyhydric alcohol of right the present invention is not limited with above-mentioned, has usually know that the knowledgeable can adopt any low-molecular-weight and polyhydric alcohol to skin nonirritant in this field; In addition, the source of the second polyhydric alcohol is also unrestricted, and its total concentration also accounts for 10 below wt% of overall constituent, such as, can be 10 wt%, 6 wt%, and 0.7 wt% is preferably 7 below wt%, and the best is 5-7 wt%.
In a preferred embodiment, the second low molecular weight polyols can be made up of the propylene glycol of proper proportion and 1,3 butylene glycol, and its total concentration is that 5 wt%(such as propylene glycol accounts for 2.1 wt%, and 1,3 butylene glycol accounts for 2.9 wt%); In another preferred embodiment, the second low molecular weight polyols can be made up of the 1,3 butylene glycol of proper proportion, hexanhexol and Polyethylene Glycol, and its total concentration is that 6 wt%(such as 1,3 butylene glycol, hexanhexol, Polyethylene Glycol respectively account for 2 wt%); In a further preferred embodiment, second low molecular weight polyols can by the propylene glycol of proper proportion, 1,3-butanediol, hexanhexol and Polyethylene Glycol formed, its total concentration is that 7 wt%(such as propylene glycol accounts for 1.7 wt%, 1,3-butanediol accounts for 1 wt%, and hexanhexol accounts for 4 wt%, and Polyethylene Glycol accounts for 0.3 wt%); In a further preferred embodiment, the second low molecular weight polyols only comprises hexanhexol, and concentration is 5 wt%.
But have in this field and usually know that the knowledgeable should bright Liao: these are only citing, not in order to limit the present invention, we can use the second low molecular weight polyols of other Individual concentrations, ratio or combination.
Again, Ying Ming Liao person, it " low-molecular-weight " general proxy about 400 of this case indication below Da; Only for Polyethylene Glycol, because it belongs to polymer molecule, considering its chemical property and purposes, is represent molecular weight about 600 below Da person.
Should the person of attention, the composition because of constituent of the present invention is simple and to health or skin without danger, have and usually know the disclosure of the knowledgeable according to this description, how can prepare by bright Liao, therefore do not repeat in this in this field.
Because glycerol and the second low molecular weight polyols are all water solublity, and water content soprano in constituent for this reason, therefore the constituent of the present invention is a transparent aqueous solution being close in even phase in appearance.Therefore, when being applied on scalp, puzzlement can't be caused to user; Even if life-time service also can not cause burden or injury to health, be not only a safety but also effective anti-dandruff formula in fact.
The constituent improving the dandruff of the present invention is of many uses.Not only directly external can be applied in scalp, more can be used as the composition made an addition in pharmaceuticals, hair care articles, makeups product, skin care products or skin protection perfume, provide effective protection to skin.
The constituent (aqueous solution) improving the dandruff of the invention described above is provide hydrogen bond for means, indirectly maintains the normal alignment of the fat molecule in skin keratinocytes gap.In addition, composition is simple, with low cost, effect is remarkable advantage that it has, and completely containing interfacial agent, antibacterial or foaming agent that general skincare product is conventional, therefore without causing the anxiety of allergy, extremely applicable life-time service.When scalp can keep normal water content, nature can not produce the dandruff, also can not itch because of dry.
Although the embodiment of the present invention discloses as mentioned above; so and be not used to limit the present invention; anyly have the knack of relevant art; in the spirit not departing from the present invention and scope; when implementing a little adjustment or change; therefore, the scope of patent protection of the present invention must be as the criterion with claims person of defining appended by this description.

Claims (10)

1. improve a constituent for the dandruff, it is characterized in that, described constituent comprises:
Glycerol, concentration is not more than 10 wt% by weight;
Second low molecular weight polyols, concentration is not more than 10 wt% by weight; And water.
2. the constituent improving the dandruff according to claim 1, it is characterized in that, wherein said second low molecular weight polyols is propylene glycol (Propylene Glycol, PG), 1,3-butanediol (1,3-Butylene Glycol, BG), wherein one or both the above combination of hexanhexol (Sorbital), Polyethylene Glycol (PolyEthylene Glycol, PEG).
3. the constituent improving the dandruff according to claim 1 and 2, is characterized in that, the total concentration of wherein said second low molecular weight polyols is 5-7 wt% by weight.
4. the constituent improving the dandruff according to claim 1 and 2, is characterized in that, the concentration of wherein said glycerol is 2-3 wt% by weight, and the total concentration of described second low molecular weight polyols is 5-7 wt% by weight.
5. the constituent improving the dandruff according to claim 1 and 2, is characterized in that, wherein said second low molecular weight polyols comprises hexanhexol.
6. the constituent improving the dandruff according to claim 3, is characterized in that, wherein said second low molecular weight polyols comprises hexanhexol.
7. the constituent improving the dandruff according to claim 6, is characterized in that, wherein said second low molecular weight polyols is hexanhexol.
8. the purposes of constituent for the manufacture of pharmaceuticals improving the dandruff according to claim 1.
9. the purposes of constituent for the manufacture of hair care articles improving the dandruff according to claim 1.
10. the constituent improving the dandruff according to claim 1 is for the manufacture of the purposes of cosmetics or skin care products.
CN201310232382.6A 2013-06-13 2013-06-13 Composition for improving dandruff Pending CN104224763A (en)

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Application Number Priority Date Filing Date Title
CN201310232382.6A CN104224763A (en) 2013-06-13 2013-06-13 Composition for improving dandruff

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Application Number Priority Date Filing Date Title
CN201310232382.6A CN104224763A (en) 2013-06-13 2013-06-13 Composition for improving dandruff

Publications (1)

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CN104224763A true CN104224763A (en) 2014-12-24

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101785745A (en) * 2010-03-19 2010-07-28 北京欧凯纳斯科技有限公司 Shampoo containing chlorine dioxide
CN102018648A (en) * 2010-12-03 2011-04-20 江晨 Formula of hair conditioner
CN102836097A (en) * 2012-08-21 2012-12-26 伊国群 Liquid shampoo containing tea saponin
CN102871859A (en) * 2012-09-21 2013-01-16 荣成百合生物技术有限公司 Two-color double-layer cream rinse and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101785745A (en) * 2010-03-19 2010-07-28 北京欧凯纳斯科技有限公司 Shampoo containing chlorine dioxide
CN102018648A (en) * 2010-12-03 2011-04-20 江晨 Formula of hair conditioner
CN102836097A (en) * 2012-08-21 2012-12-26 伊国群 Liquid shampoo containing tea saponin
CN102871859A (en) * 2012-09-21 2013-01-16 荣成百合生物技术有限公司 Two-color double-layer cream rinse and preparation method thereof

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Application publication date: 20141224