CN104215474A - Two-pipe saliva sampling device - Google Patents

Two-pipe saliva sampling device Download PDF

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Publication number
CN104215474A
CN104215474A CN201410446330.3A CN201410446330A CN104215474A CN 104215474 A CN104215474 A CN 104215474A CN 201410446330 A CN201410446330 A CN 201410446330A CN 104215474 A CN104215474 A CN 104215474A
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China
Prior art keywords
silicone tube
outer shroud
saliva
interior plug
silicone
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Granted
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CN201410446330.3A
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CN104215474B (en
Inventor
康学军
李晨
沈康维
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Southeast University
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Southeast University
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Abstract

The invention discloses a two-pipe saliva sampling device. When the sampling device is used for sampling, inner threads (6) on an outer ring (1) are matched with outer threads (8) on an opening end of a centrifugal pipe (5), an inner plug (3) is positioned in the outer ring (1), the lower part of a silicone pipe (4) is connected with the inner plug (3) into a whole, the upper part of the silicone pipe (4) penetrates out of the outer ring (1), and filling fibers (9) are arranged in the silicone pipe (4); when the sampling device is used for storage, the inner threads (6) on the outer ring (1) are matched with outer threads (8) on the opening end of the centrifugal pipe (5), a washer (2) is positioned on the topmost end in the outer ring, the inner plug (3) is arranged below the washer, the silicone pipe (4) is connected with the inner plug into a whole, the lower part of the silicone pipe (4) penetrates out of the outer ring to be arranged in the centrifugal pipe (5), and the filling fibers (9) are arranged in the silicone pipe. By adopting the two-pipe saliva sampling device, the saliva sampling process is simplified, the discomfort in the sampling process is eliminated, the saliva sampling amount is increased, the sampling process is safe and sanitary, and the two-pipe saliva sampling device is particularly applicable to babies or tested crowds having diseases and being difficult to sample.

Description

Double hose saliva sampler
Technical field
The present invention is a kind of double hose saliva sampler, belongs to the technical field of biochemical analysis checkout equipment.
Background technology
In recent years, saliva is paid attention in multiple fields such as medical diagnosis on disease, psychology monitoring, sports medical science as a kind of human blood glucose sample.Component in saliva often has good corresponding relation with blood, and saliva sample has without advantages such as wounds, easily sampling, is easily received by experimenter.But in saliva, often concentration is significantly lower than blood for target components, and therefore saliva gathers and enoughly must could meet instrument detection needs (being generally a milliliter magnitude).The method that current saliva gathers still allows experimenter directly spue in appropriate containers the saliva of q.s or the sampling paper slip made with sampling rod or the filter paper of outer likeness in form cotton swab mostly, but these methods have certain difficulty for tested especially children or the sufferer that has disease to be difficult to coordinate.Such as, the method directly spued is difficult to operation for infant, and sampling rod or sampling paper slip make subject perception discomfort coordinate, and even have the risk of swallowing, are also difficult to collect the sample size of satisfying the demand.
At present, in the patent of saliva sample harvester, there is the patent of invention of having authorized: CN1703615A, CN102032998A, CN203490113U; Utility model is invented: CN200948144Y, CN2776296Y, CN201188066Y, CN201852719U, CN2912528Y.Wherein CN201852719U and CN102032998A designs mainly for the analysis of gene in saliva, and sampling quantity is less; CN1703615A solves sampling quantity and health and security problems preferably, and shortcoming is that device is too large, is inconvenient to the sampling being used for large sample crowd; CN200948144Y is mainly used in the diagnosis of mouth disease, and therefore sampling quantity is also not enough to the detection carrying out some composition in saliva.Existing patent can solve certain saliva acquisition problems, but the saliva gatherer process not for infant's study subject does particular design, fail to alleviate the sense of discomfort of children in sampling process, the problem that sampling quantity is inadequate and sample quality is not high is also there will be in actual samples with in analyzing, and the design of existing patent reckons without the pre-treatment problem of saliva sample, and it is convenient not thus to use.
For these problems, the present invention takes into full account the feature of infant's study subject, design double hose sampling thief, use material and the sample mode of children and the more receptible safety and sanitation of the head of a family, children, by natural chewing activity, coordinate food-grade citric acid to the normal stimulus of salivary gland, make children can secrete more saliva comparatively like a cork, therefore whole sampling process safety and sanitation are convenient, and the saliva volume of collection is comparatively large, may be used for the mensuration of Multiple components.
Summary of the invention
Technical matters: the object of the present invention is to provide a kind of double hose saliva sampler, solves the sense of discomfort in current tested crowd's saliva sample sampling process, security, and the problem of sampling quantity deficiency.
Technical scheme: for solving these problems of the prior art, technical scheme provided by the invention is:
Double hose saliva sampler of the present invention comprises outer shroud, pad, interior plug, silicone tube, centrifuge tube, fiberfill fibers; During sampling, the external thread of the internal thread on outer shroud and centrifuge tube openend coincide, and interior plug is positioned at outer shroud, and bottom and the interior plug of silicone tube are connected as a single entity, and top passes outer shroud, in silicone tube, be provided with fiberfill fibers; When preserving, the external thread of the internal thread on outer shroud and centrifuge tube openend coincide, and pad is positioned at the top of outer shroud, side is interior plug under the shim, silicone tube and interior plug are connected as a single entity, and bottom passes outer shroud and is positioned at centrifuge tube, in silicone tube, be provided with fiberfill fibers.
The upper plane of described interior plug is sieve pore structure.
Described silicone tube is that top is sparse, the porous structure of lower dense.
Described fiberfill fibers is cotton fiber or the nano-fiber material having special adsorption function, and fiberfill fibers uses 5% citric acid solution process in advance.
Described silicone tube uses food grade silicone material, and be about 4.5cm, external diameter and internal diameter are respectively 1cm and 0.9cm, and on silicone tube, the external diameter on edge is 1.6cm.
Described interior plug is acrylic plastering material, hollow structure, one end open, and the other end is sieve pore structure, and the external diameter of plug body is 0.95cm, and internal diameter is 0.85cm, and the upper external diameter along part of interior plug is 1.6cm.
Using method is: when not sampling, and is filled with the packing material of certain mass in silicone tube, then is inserted in interior plug from silicone tube opening part, interior beyond the Great Wall along shell tool, is finally fixed by screw thread and centrifuge tube by outer shroud.When sampling, screwed out by outer shroud, pad takes off, and the silicone tube that interior plug connects is taken out upset and is placed on centrifuge tube, then exterior ring cap is crossed silicone tube be spun on centrifuge tube, thus silicone tube and Nei Sai are fixed on centrifuge tube namely available.When gathering saliva, silicone tube is put into tested mouth, and the tested aperture making saliva on tube wall by chewing silicone tube enters the fiber-based material in pipe and is adsorbed.After sampling, the whole device shape of assembling back when not sampling is put into hydro-extractor centrifugal, thus make the saliva of having adsorbed centrifugal in centrifuge tube.This invention simplifies saliva sampling process, eliminate the sense of discomfort in sampling process, add saliva sampling quantity, sampling process safety and sanitation, be especially applied to infant or suffer from the tested crowd having disease to be difficult to coordinate sampling.The analysis that the saliva sample adopted may be used for multiple biochemical component detects.
Beneficial effect: relative to prior art, advantage of the present invention is:
1. children are by chewing silicone tube, and saliva just flows into the packing material in silicone tube by the aperture on pipe, reaches the object of sorption enrichment.The material of silicone tube is food grade silicone, safe and reliable, and silicone tube made of soft, and hemispherical configuration has been processed in bottom, tested when chewing oral sensation comfortable, more acceptant psychologically.When being made to carry out centrifugal after sampling terminates by the close structure to dredging, saliva can successfully flow to centrifuge tube bottom after fiberfill fibers departs from, thus retains in centrifuge tube;
2. the fiber adsorbing material using citric acid treatment to fill, can make tested manyly to salivate quickly, shortens the sampling time, increases sampling volume;
3. the security of sampling apparatus is secure.According to the sampling apparatus figure in Fig. 2, when sampling, centrifuge tube can serve as handle, can by the hand-held control of sampler for the experimenter (such as infant) being difficult to coordinate.And screwed by screw thread in the middle of silicone tube and centrifuge tube, firm difficult drop-off, prevent sampling head in sampling process from missing by the risk of swallowing;
4. twin-tube type structure design makes the process of sample more convenient.After the internal silicone tube of children is chewed, interior silicone tube is put back to outer centrifuge tube together with interior plug, shell tool, screw on outer shroud again, whole device assembling is returned to the form of Fig. 1, can directly put into hydro-extractor carries out centrifugal, saliva sample can be put into refrigerator and preserve after centrifuging, convenient and swift.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described:
Fig. 1 is the structural representation of double hose saliva sampler,
Structural representation when Fig. 2 is the sampling of double hose saliva sampler,
Fig. 3 is the schematic diagram of interior silicone tube,
Fig. 4 is the schematic diagram of interior plug,
Fig. 5 is the schematic diagram of outer shroud.
Have in above figure: outer shroud 1, pad 2, interior plug 3, silicone tube 4, centrifuge tube 5, internal thread 6, sieve pore structure 7, external thread 8, fiberfill fibers 9, porous structure 10.
Embodiment
The saliva sampler of double hose of the present invention.(1) use food grade silicone pipe as the saliva enriching apparatus of per os, silica gel tube wall is processed into dredges lower close cell texture, and the hemispherical configuration that similar nipple is processed on top makes mastication processes comparatively comfortable; (2) use the sorbing material of the citric acid solution process fibrous type of 5% as the packing material in silicone tube; (3) the twin-tube type structure design of interior silicone tube, outer centrifuge tube; Specific as follows:
This sampling thief comprises outer shroud, pad, interior plug, silicone tube, centrifuge tube, fiberfill fibers; During sampling, the external thread of the internal thread on outer shroud and centrifuge tube openend coincide, and interior plug is positioned at outer shroud, and bottom and the interior plug of silicone tube are connected as a single entity, and top passes outer shroud, in silicone tube, be provided with fiberfill fibers; When preserving, the external thread of the internal thread on outer shroud and centrifuge tube openend coincide, and pad is positioned at the top of outer shroud, side is interior plug under the shim, silicone tube and interior plug are connected as a single entity, and bottom passes outer shroud and is positioned at centrifuge tube, in silicone tube, be provided with fiberfill fibers.
The upper plane of described interior plug is sieve pore structure.
Described silicone tube is that top is sparse, the porous structure of lower dense.
Described fiberfill fibers is cotton fiber or the nano-fiber material having special adsorption function, and fiberfill fibers uses 5% citric acid solution process in advance.
1. silicone tube in, use food grade silicone material, be about 4.5cm, external diameter and internal diameter are approximately 1cm and 0.9cm respectively, and on silicone tube, the external diameter on edge is 1.6cm.Inner fiberfill fibers sexual type sorbing material.The hemispherical configuration of bottom, and from silicone tube top-to-bottom, is processed into that top is sparse, the cell texture of lower dense (being as the criterion with the direction of placing in Fig. 1);
2. plug in, acrylic plastering material, hollow structure, one end open, the other end is sieve pore structure, and the external diameter of plug body is 0.95cm, and internal diameter is 0.85cm, and the upper external diameter along part of interior plug is 1.6cm;
3. fiberfill fibers, can be cotton fiber or the nano-fiber material having special adsorption function, fiber can use 5% citric acid solution process in advance.
Below in conjunction with specific embodiment, such scheme is described further.Should be understood that these embodiments are for illustration of the present invention instead of limit the scope of the invention.The implementation condition adopted in embodiment can be for further adjustments according to the condition of concrete producer, and not marked implementation condition is generally the condition in normal experiment.
Embodiment as depicted in figs. 1 and 2.This sampling thief comprises outer shroud 1, pad 2, interior plug 3, silicone tube 4, centrifuge tube 5, fiberfill fibers 9; During sampling, the internal thread 6 on outer shroud 1 coincide with the external thread 8 of centrifuge tube 5 openend, and interior plug 3 is positioned at outer shroud 1, and bottom and the interior plug 3 of silicone tube 4 are connected as a single entity, and top passes outer shroud 1, is provided with fiberfill fibers 9 in silicone tube 4; When preserving, the internal thread 6 on outer shroud 1 coincide with the external thread 8 of centrifuge tube 5 openend, and pad 2 is positioned at the top of outer shroud 1, it is interior plug 3 below pad 2, silicone tube 4 and interior plug 3 are connected as a single entity, and bottom passes outer shroud 1 and is positioned at centrifuge tube 5, is provided with fiberfill fibers 9 in silicone tube 4.
The upper plane of described interior plug 3 is sieve pore structure 7.
Described silicone tube 4 is that top is sparse, the porous structure of lower dense 10.
Described fiberfill fibers 9 is cotton fiber or the nano-fiber material having special adsorption function, and fiberfill fibers uses 5% citric acid solution process in advance.
Outer centrifuge tube is acrylic plastering material (PP), and length is 7.5cm, and internal-and external diameter is approximately 1.4cm and 1.6cm respectively, from the top of centrifuge tube outer wall down until 2cm carves all have external thread;
As shown in Figure 3, interior silicone tube is food grade silicone tubing matter, long 4cm, internal-and external diameter are approximately 0.9cm and 1cm respectively, and silicone tube lower end is hemispherical configuration, be processed into by the close cell texture to dredging from silicone tube top, the edge shape that the processing of silicone tube port is extended, the diameter at edge is approximately 1.6cm.Silicone tube inside is filled with fibrous type sorbing material, and the material of this material is the functional nano-fiber of pure natural cotton or food-grade macromolecule electrospinning, and the former has sorption to saliva, can depart from after centrifugal with liquid phase, is convenient to collect saliva; The latter also can have efficient adsorption effect to some object in saliva, after making sampling, in saliva, test target thing can well by enrichment, the saliva be separated after centrifugal can be used for the detection of some index, and nano-fiber material can measure some specific indexes with proper method parsing after taking out;
As shown in Figure 4, the material of interior plug is acrylic plastering, is about 2cm.Its inside is hollow structure, one end open, and the other end is processed into sieve pore structure and has the edge of extension, the internal-and external diameter that the plug of interior plug is in is approximately 0.85cm and 0.95cm respectively, sieve aperture is equally distributed aperture, and aperture is about 1mm, and the external diameter of edge is about 1.6cm;
As shown in Figure 5, the material of outer shroud is acrylic plastering.The internal-and external diameter of outer shroud is approximately 1.6cm and 1.8cm respectively, and length is 2cm, and outer shroud is hollow circuit cylinder body structure, and the diameter of one end open is smaller, is about 1.2cm, and other end opening diameter is identical with internal diameter, is 1.6cm, is carved with internal thread in ring;
Pad is the disc-shaped structure of quality of rubber materials, and diameter is about 1.6cm, and thickness is 0.5-1mm.
Foregoing invention, only for technical conceive of the present invention and feature are described, its object is to person skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.The equivalence that all Spirit Essences according to the present invention do exchanges or modifies, and all should be encompassed within protection scope of the present invention.

Claims (6)

1. a double hose saliva sampler, it is characterized in that, this sampling thief comprises outer shroud (1), pad (2), interior plug (3), silicone tube (4), centrifuge tube (5), fiberfill fibers (9); During sampling, internal thread (6) on outer shroud (1) coincide with the external thread (8) of centrifuge tube (5) openend, interior plug (3) is positioned at outer shroud (1), bottom and the interior plug (3) of silicone tube (4) are connected as a single entity, top passes outer shroud (1), is provided with fiberfill fibers (9) in silicone tube (4); When preserving, internal thread (6) on outer shroud (1) coincide with the external thread (8) of centrifuge tube (5) openend, pad (2) is positioned at the top of outer shroud (1), interior plug (3) below pad (2), silicone tube (4) and interior plug (3) are connected as a single entity, bottom passes outer shroud (1) and is positioned at centrifuge tube (5), is provided with fiberfill fibers (9) in silicone tube (4).
2. a kind of double hose saliva sampler according to claim 1, is characterized in that, the upper plane of described interior plug (3) is sieve pore structure (7).
3. a kind of double hose saliva sampler according to claim 1, is characterized in that, described silicone tube (4) is for top is sparse, the porous structure of lower dense (10).
4. a kind of double hose saliva sampler according to claim 1, is characterized in that, described fiberfill fibers (9) is cotton fiber or the nano-fiber material having special adsorption function, and fiberfill fibers uses 5% citric acid solution process in advance.
5. a kind of double hose saliva sampler according to claim 1, is characterized in that, described silicone tube (4) uses food grade silicone material, and be about 4.5cm, external diameter and internal diameter are respectively 1cm and 0.9cm, and on silicone tube, the external diameter on edge is 1.6cm.
6. a kind of double hose saliva sampler according to claim 1, it is characterized in that, described interior plug (3) is acrylic plastering material, hollow structure, one end open, the other end is sieve pore structure, and the external diameter of plug body is 0.95cm, internal diameter is 0.85cm, and the upper external diameter along part of interior plug is 1.6cm.
CN201410446330.3A 2014-09-03 2014-09-03 Two-pipe saliva sampling device Active CN104215474B (en)

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Cited By (5)

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Publication number Priority date Publication date Assignee Title
CN104964848A (en) * 2015-07-24 2015-10-07 焉春华 Centrifugal sputum case for induced sputum tubercle bacillus detection
CN105911198A (en) * 2016-06-07 2016-08-31 云南中烟工业有限责任公司 Pretreatment device for furfural substance detection and application thereof
CN106053648A (en) * 2016-06-07 2016-10-26 云南中烟工业有限责任公司 Pretreatment device for detection of phenolic substances and application
CN106053682A (en) * 2016-06-07 2016-10-26 云南中烟工业有限责任公司 Pretreatment device for detection of dihydroxybenzene substances and application
CN108309358A (en) * 2018-01-31 2018-07-24 上海交通大学医学院附属上海儿童医学中心 Nipple type detection device

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104964848A (en) * 2015-07-24 2015-10-07 焉春华 Centrifugal sputum case for induced sputum tubercle bacillus detection
CN105911198A (en) * 2016-06-07 2016-08-31 云南中烟工业有限责任公司 Pretreatment device for furfural substance detection and application thereof
CN106053648A (en) * 2016-06-07 2016-10-26 云南中烟工业有限责任公司 Pretreatment device for detection of phenolic substances and application
CN106053682A (en) * 2016-06-07 2016-10-26 云南中烟工业有限责任公司 Pretreatment device for detection of dihydroxybenzene substances and application
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CN108309358A (en) * 2018-01-31 2018-07-24 上海交通大学医学院附属上海儿童医学中心 Nipple type detection device

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