CN203705198U - Device and system for collecting and processing saliva sample - Google Patents

Abstract

The utility model discloses a device and system for collecting and processing saliva samples. The device includes a saliva sampler placed in a centrifugal device, a filter tube and a liquid storage tube; One end of the rod; both ends of the filter tube are open, and a filter membrane is provided at the lower opening; the saliva sampler is placed in the filter tube through the upper opening of the filter tube, and the liquid storage tube supports the filter tube; the part of the liquid storage tube that supports the filter tube In the state, there is an accommodating space between the filter tube and the liquid storage tube. Through the above method, the utility model can hardly cause discomfort and fear of the collected person, and the operation is simple and convenient.

Description

Saliva sample collection and processing device and system

technical field

The utility model relates to the technical field of biochemical sample collection and processing, in particular to a saliva sample collection and processing device and system. the

Background technique

The epithelium of human oral mucosa is stratified squamous epithelium, which has the characteristics of vigorous metabolism, rapid renewal and easy shedding. It is composed of multiple layers of cells, the basal layer has a strong ability to divide, and the superficial keratinized layer is prone to aging and degeneration, and continuously falls off into saliva, and can also be peeled off to the carrier under the action of external force. These exfoliated cells have the complete DNA sequence of the human genome. the

About 4.5 micrograms of genomic DNA can be extracted from 0.1 milliliter of saliva, which is sufficient for downstream polymerase chain PCR reactions and various molecular biology studies. The extraction of genomic DNA in the prior art is achieved through the traditional way of drawing blood to collect DNA. the

However, drawing blood is harmful to the human body, and it is a very painful method to obtain DNA, which is likely to cause discomfort and fear in the collected persons. the

Utility model content

The technical problem mainly solved by the utility model is to provide a saliva sample collection and processing device and system, which can not easily cause discomfort and fear of the collected person, and is simple and convenient to operate. the

In order to solve the above technical problems, a technical solution adopted by the utility model is to provide a saliva sample collection and processing device, the device includes a saliva sampler placed in a centrifugal device, a filter tube and a liquid storage tube; the saliva sampler It includes a sampling stick and a liquid-absorbing element, the liquid-absorbing element is at one end of the sampling stick; both ends of the filter tube are open, and a filter membrane is provided at the opening of the lower end; the saliva sampler passes through the upper end of the filter tube Placed in the filter tube, the liquid storage tube supports the filter tube; in the state where the liquid storage tube supports the filter tube, there is a space between the filter tube and the liquid storage tube space. the

Wherein, the filter tube is cylindrical, the opening at the lower end of the filter tube is composed of inner and outer layers, and the inner layer is a cone-shaped funnel structure, and the filter membrane is arranged at the opening of the cone of the cone-shaped funnel structure. the

Wherein, the saliva sampler also includes a tube cover, the other end of the sampling rod is fixed on a surface of the tube cover, the tube cover is provided with an internal thread structure, and the upper opening of the filter tube is provided with an external thread structure , the upper opening of the filter tube is combined with the internal thread structure of the tube cap of the saliva sampler through the external thread structure. the

Wherein, the upper end of the liquid storage tube is provided with an external thread structure, and the outer layer of the lower opening of the filter tube is provided with an internal thread structure, and the liquid storage tube passes through the external thread structure and the lower end opening of the filter tube. The outer layer is combined with the internal thread structure. the

Wherein, the device further includes a connection part, and the connection part connects the filter tube and the liquid storage tube. the

Wherein, the upper end of the connecting part is provided with a film, and the lower end of the conical funnel structure in the inner layer of the filter tube is provided with a protruding annular thorn-like structure, and the filter tube pierces through the protruding annular thorn-like structure. The film on the upper end of the connecting part is connected with the connecting part. the

Wherein, the liquid storage tube is a cryopreservation tube. the

Wherein, the volume of the cryopreservation tube is 2 milliliters. the

Wherein, the length of the device is less than or equal to 11 centimeters. the

In order to solve the above technical problems, another technical solution adopted by the utility model is to provide a saliva sample collection and processing system, which includes: a centrifugal device and any saliva sample collection and processing device as described above. the

The beneficial effects of the utility model are: different from the situation of the prior art, the utility model device includes a saliva sampler placed in a centrifugal device, a filter tube and a liquid storage tube; the saliva sampler collects saliva from the human body, which is not easy to cause discomfort and fear, the filter tube has openings at both ends, and a filter membrane is provided at the lower opening; the saliva sampler is placed in the filter tube through the upper opening of the filter tube, and the liquid storage tube supports the filter tube; in this way, it can The acquisition and processing are integrated, the operation is simple and convenient, and the work efficiency can be improved. the

Description of drawings

Fig. 1 is the structural representation of an embodiment of the utility model saliva sample collection processing device;

Fig. 2 is the structural representation of another embodiment of the utility model saliva sample collection processing device;

Fig. 3 is a schematic structural view of the device for collecting and processing saliva samples of the present invention in actual use. the

Detailed ways

The utility model will be described in detail below in conjunction with the accompanying drawings and embodiments. the

Referring to Fig. 1 and Fig. 2, Fig. 1 and Fig. 2 are structural schematic diagrams of two implementations of the saliva sample collection and processing device of the present invention. the

The saliva sample collection and processing device comprises: a saliva sampler 11 placed in a centrifugal device, a filter tube 12 and a liquid storage tube 13; One end; the two ends of the filter tube 12 are open, and the lower end opening 121 is provided with a filter membrane 123; the saliva sampler 11 is placed in the filter tube 12 through the upper opening 122 of the filter tube 12, and the liquid storage tube 13 supports the filter tube 12; When the liquid pipe 13 supports the filter pipe 12 , there is an accommodation space 131 between the filter pipe 12 and the liquid storage pipe 13 . the

The material of the liquid absorbing element 112 can be made of absorbent cotton, sponge or any other material that can absorb water. Substances such as sodium citrate that can stimulate saliva secretion without affecting saliva components and test results can be attached to the liquid-absorbing element 112 . Collecting saliva is a non-invasive way of collecting human samples, which is easily accepted by the collectors and will not cause discomfort and fear to the collectors. the

The operation process of the device in this embodiment is: first collect saliva through the saliva collector 11, after the saliva sampler 11 collects the saliva sample, place it in the filter tube 12, then place the device in a centrifugal device, and under the action of centrifugal force After the saliva collected in the liquid suction element 112 of the saliva sampler 11 is filtered through the filter membrane 123 of the filter tube 12, the saliva sample flows into the liquid storage tube 13. Under the effect of centrifugation, the saliva and the processing solution or preservation solution in the liquid storage tube 13 are evenly mixed, so as to facilitate the processing or preservation of the saliva sample. Therefore, through the saliva sample collection and processing device of this embodiment, the collection and processing can be completed in one, the operation is simple and convenient, and the work efficiency can be improved; and no other consumables are used during the collection and processing process, which is more environmentally friendly; in the whole process, Only simple centrifugation is required to achieve the purpose of saliva sample transportation, laboratory testing or storage. the

Wherein, the filter tube 12 is cylindrical, the lower opening 121 of the filter tube 12 is composed of inner and outer layers 1211, 1212, the inner layer 1211 is a conical funnel structure, and the filter membrane 123 is arranged at the opening of the cone of the conical funnel structure. the

The structure of the filter tube 12 in the device of this embodiment, on the one hand, the conical funnel structure is conducive to placing the saliva sampler 11 in the filter tube 12, which is conducive to centrifugation; The outer layer 1212 can prevent the filter membrane 123 disposed at the opening of the cone of the conical funnel structure from being damaged. the

Certainly, the structure of filter pipe 12 in the present embodiment device also can be other structures, for example, when not needing outer layer 1212 to prevent the filter membrane 123 that is arranged on the opening of the conical funnel structure cone from being damaged, outer layer 1212 is It can be removed. At this time, the maximum outer diameter of the conical funnel structure can be greater than or equal to the inner diameter of the liquid storage tube 13, so as to ensure that the filter tube 12 can be supported on the liquid storage tube 13. the

Wherein, the saliva sampler 11 also includes a tube cover 113, the other end of the sampling rod 111 is fixed on a surface of the tube cover 113, the tube cover 113 is provided with an internal thread structure, the upper opening 122 of the filter tube 12 is provided with an external thread structure, and the filter tube The upper end opening 122 of 12 is combined with the internal thread structure of the tube cover 113 of the saliva sampler 11 through the external thread structure. the

The upper end of the filter tube 12 is open, which is easily polluted during the centrifugation process, and the tube cap can prevent additional pollution. In practical applications, the other end of the sampling stick 111 can be fixed on the center of a surface of the tube cover 113, and the upper opening 122 of the filter tube 12 can be combined with the tube cover 113 of the saliva sampler 11 through a threaded structure, or can be connected in other ways such as Snap-fit, snap-fit and other ways to combine. the

Wherein, the upper end of the liquid storage pipe 13 is provided with an external thread structure, and the outer layer of the lower opening 121 of the filter tube 12 is provided with an internal thread structure, and the liquid storage pipe 13 is connected with the outer layer of the lower end opening 121 of the filter pipe 12 through the external thread structure. Combination of internal thread structure. the

Similarly, in practical applications, the liquid storage tube 13 is combined with the lower opening 121 of the filter tube 12 through a threaded structure, and can also be combined in other ways such as snap-fit, snap-fit and the like. the

Referring to FIG. 2 , the device further includes a connection part 14 that connects the filter tube 12 and the liquid storage tube 13 . The connection part 14 can connect the filter tube 12 and the liquid storage tube 13 through the above-mentioned threaded structure, snap-fit or snap-fit, and the like. the

Wherein, the upper end of connecting part 14 is provided with thin film 141, and the lower end of the conical funnel structure of filter pipe 12 inner layer 1211 is provided with protruding annular thorn-like structure 12111, and filter pipe 12 pierces connecting part through protruding ring-shaped thorn-like structure 12111 The thin film 141 at the upper end of the 14 is connected with the connection part 14 . the

When the liquid storage tube 13 is pre-stored with processing liquid or storage liquid, in order to prevent the processing liquid or storage liquid from flowing out and facilitate storage, a thin film 141 can be arranged on the upper end of the connecting part 14, and the connecting part is tightly sealed with the liquid storage tube through a threaded structure. connected, the film 141 can prevent the treatment liquid or preservation liquid from flowing out, and is convenient for storage. the

Wherein, the above-mentioned liquid storage tube 13 may be a cryopreservation tube, and the volume of the cryopreservation tube may be 2 milliliters. the

Wherein, the length of the saliva sample collection and processing device may be less than or equal to 11 centimeters and not exceed the height of a 15ml centrifuge tube. the

The operation process of the saliva sample collection and processing device in this embodiment is: when collecting a saliva sample, hold the tube cover 113 part of the sampling stick 111, extend the liquid suction element 112 into the oral cavity and suck saliva, and wait for the liquid suction element 112 to suck enough saliva When taking a sample, insert the liquid absorption element 112 of the sampling rod 111 into the cylindrical filter tube 12, and the cap 113 is combined with the filter tube 12 through a thread structure; then the lower opening 121 of the filter tube 12 forms a sealing structure with the liquid storage tube 13 The upper end of the connecting part 14 is combined by a threaded structure. In this combining process, the ring thorn-like structure 12111 protruding from the lower part of the cone of the inner layer 1211 of the filter tube 12 pierces the film 141 of the connecting part 14, and the lower end of the filter tube 12 is open. 121 protrudes into it. Now that the saliva sample collection is complete, put the entire saliva sample collection and processing device into the 15ml centrifuge tube 21 of the customized fixed module 22 and centrifuge together. Mix with the treatment solution/preservation solution in the storage tube 13. After the centrifugation is completed, the liquid storage tube 13 is left, and the remaining parts are discarded, and the matching cryopreservation tube cover is sealed and combined with the liquid storage tube 13, and sent to a laboratory or a gene bank for preservation. the

Referring to Fig. 3, in practical application, the centrifuge supporting the centrifugal device of the saliva sample collection and processing device can be a centrifuge with a 15ml centrifuge tube 21, and a fixed module 22 is added inside the 15ml centrifuge tube 21, and the fixed module 22 can be foam or other Plastic material, fixed module 22 can make this device can be put into 15ml centrifuge tube 21 more stably, put this device into the fixed module 22 of the 15ml centrifuge tube 21 of this centrifuge stably during centrifugation, then centrifuge tube 21 Place in a centrifuge for centrifugation. the

It should be noted that, as required, the size of the saliva sample collection and processing device can be adjusted according to actual needs. the

The present invention also provides a saliva sample collection and processing system, which includes: a centrifugal device and a saliva sample collection and processing device, wherein the saliva sample collection and processing device can be any one of the above-mentioned saliva sample collection and processing devices, which will not be repeated here Let's talk about it one by one. the

The above is only the embodiment of the utility model, and does not limit the patent scope of the utility model. Any equivalent structure or equivalent process transformation made by using the utility model specification and accompanying drawings, or directly or indirectly used in other Related technical fields are all included in the patent protection scope of the present utility model in the same way. the

Claims (10)

1. A saliva sample collection and processing device, characterized in that, The device includes a saliva sampler placed in a centrifugal device, a filter tube and a liquid storage tube; The saliva sampler includes a sampling stick and a liquid-absorbing element, and the liquid-absorbing element is at one end of the sampling stick; the filter tube has openings at both ends, and a filter membrane is provided at the opening at the lower end; The saliva sampler is placed in the filter tube through the upper opening of the filter tube, and the liquid storage tube supports the filter tube; When the liquid storage tube supports the filter tube, there is an accommodation space between the filter tube and the liquid storage tube. the 2. The device according to claim 1, wherein the filter tube is cylindrical, the lower opening of the filter tube is made of two layers inside and outside, the inner layer is a conical funnel structure, and the filter membrane is arranged on The opening of the cone of the cone funnel structure. the 3. The device according to claim 2, wherein the saliva sampler also includes a cap, the other end of the sampling rod is fixed on a surface of the cap, and the cap is provided with an internal thread structure The upper opening of the filter tube is provided with an external thread structure, and the upper end opening of the filter tube is combined with the internal thread structure of the tube cap of the saliva sampler through the external thread structure. the 4. The device according to claim 2, characterized in that, the upper end of the liquid storage tube is provided with an external thread structure, and the outer layer of the opening at the lower end of the filter tube is provided with an internal thread structure, and the liquid storage tube passes through The external thread structure is combined with the internal thread structure of the outer layer of the lower opening of the filter tube. the 5. The device according to claim 2, characterized in that the device further comprises a connection part, the connection part connects the filter tube and the liquid storage tube. the 6. The device according to claim 5, characterized in that, the upper end of the connecting part is provided with a film, and the lower end of the conical funnel structure of the inner layer of the filter tube is provided with a protruding annular thorn-like structure, and the filter tube The film piercing the upper end of the connecting part through the protruding annular thorn-like structure is connected with the connecting part. the 7. The device according to any one of claims 1 to 6, wherein the liquid storage tube is a cryopreservation tube. the 8. The device according to claim 7, wherein the cryovial has a volume of 2 ml. the 9. The device of claim 8, wherein the length of the device is less than or equal to 11 centimeters. the 10. A saliva sample collection and processing system, characterized in that the system comprises: a centrifugal device and the saliva sample collection and processing device according to any one of claims 1 to 9. the