CN104215474B - Two-pipe saliva sampling device - Google Patents
Two-pipe saliva sampling device Download PDFInfo
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- CN104215474B CN104215474B CN201410446330.3A CN201410446330A CN104215474B CN 104215474 B CN104215474 B CN 104215474B CN 201410446330 A CN201410446330 A CN 201410446330A CN 104215474 B CN104215474 B CN 104215474B
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- silica gel
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- interior plug
- gel tube
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Abstract
The invention discloses a two-pipe saliva sampling device. When the sampling device is used for sampling, inner threads (6) on an outer ring (1) are matched with outer threads (8) on an opening end of a centrifugal pipe (5), an inner plug (3) is positioned in the outer ring (1), the lower part of a silicone pipe (4) is connected with the inner plug (3) into a whole, the upper part of the silicone pipe (4) penetrates out of the outer ring (1), and filling fibers (9) are arranged in the silicone pipe (4); when the sampling device is used for storage, the inner threads (6) on the outer ring (1) are matched with outer threads (8) on the opening end of the centrifugal pipe (5), a washer (2) is positioned on the topmost end in the outer ring, the inner plug (3) is arranged below the washer, the silicone pipe (4) is connected with the inner plug into a whole, the lower part of the silicone pipe (4) penetrates out of the outer ring to be arranged in the centrifugal pipe (5), and the filling fibers (9) are arranged in the silicone pipe. By adopting the two-pipe saliva sampling device, the saliva sampling process is simplified, the discomfort in the sampling process is eliminated, the saliva sampling amount is increased, the sampling process is safe and sanitary, and the two-pipe saliva sampling device is particularly applicable to babies or tested crowds having diseases and being difficult to sample.
Description
Technical field
The present invention is a kind of double hose saliva sampler, belongs to the technical field of biochemical analysis and detection equipment.
Background technology
In recent years, saliva as a kind of human blood glucose sample in multiple necks such as medical diagnosis on disease, psychological monitoring, sports medical science
Domain is paid attention to.Component in saliva often has preferable corresponding relation with blood, and saliva sample has noinvasive, easily sampling etc. excellent
Point, is easily received by experimenter.But in saliva, often concentration is substantially less than blood to target components, and therefore saliva collection must foot
Amount could meet instrument detection needs (usually milliliter magnitude).The method of saliva collection at present still allows experimenter direct mostly
The sampling paper slip that the saliva of discharge q.s or the sampling rod with outer likeness in form cotton swab or filter paper are made in appropriate containers, but
It is that these methods for tested especially child or have the sufferer that disease is difficult to coordinate to have certain difficulty.For example, directly spue
Method is difficult to operate for infant, sampling rod or sampling paper slip make that subject perception is uncomfortable to be refused to coordinate, or even has and swallow
Risk is it is also difficult to collect the sample size meeting needs.
At present, in terms of the patent of saliva sample harvester, there is the patent of invention of mandate：CN1703615A,
CN102032998A, CN203490113U；Utility model is invented：CN200948144Y, CN2776296Y, CN201188066Y,
CN201852719U, CN2912528Y.Wherein CN201852719U and CN102032998A mainly in saliva gene point
Analyse and design, sampling quantity is less；CN1703615A preferably solves sampling quantity and health and security problems, and shortcoming is dress
Put too greatly it has not been convenient to be used for the sampling of large sample crowd；CN200948144Y is mainly used in the diagnosis of oral disease, therefore samples
Amount is also not enough to carry out the detection of some compositions in saliva.Existing patent can solve certain saliva acquisition problems, but not pin
Particular design is done to the saliva gatherer process of infant study subject, fails to mitigate sense of discomfort in sampling process for the child,
There is also the problem that sampling quantity is inadequate and sample quality is not high in actual samples and analysis, and the design of existing patent is not examined
Consider the pre-treatment problem of saliva sample, thus use not convenient.
For these problems, the present invention takes into full account the feature of infant study subject, designs double hose sampler, makes
With material and the sample mode of child and the more receptible safety and sanitation of the head of a family, child can pass through natural chewing activity, cooperation
Food stage citric acid to the normal stimulus of salivary gland so that child more can easily secret out of more saliva, therefore entirely
Sampling process safety and sanitation facilitate, and the saliva volume of collection is larger, can be used for the mensure of Multiple components.
Content of the invention
Technical problem:It is an object of the invention to provide a kind of double hose saliva sampler, solve tested crowd's saliva at present
The not enough problem of sense of discomfort during liquid sample, safety, and sampling quantity.
Technical scheme：For solving these problems of the prior art, the technical scheme that the present invention provides is：
The double hose saliva sampler of the present invention includes outer shroud, pad, interior plug, silica gel tube, centrifuge tube, fiberfill fibers；Adopt
During sample, female thread on outer shroud is coincide with the external screw thread of centrifuge tube opening, and interior plug is located in outer shroud, the bottom of silica gel tube with interior
Plug is connected as a single entity, and top passes outer shroud, is provided with fiberfill fibers in silica gel tube；When stored, the female thread on outer shroud and centrifugation
The external screw thread at tube opening end coincide, the top that pad is located in outer shroud, and side is interior plug under the shim, and silica gel tube is linked as with interior plug
Integrally, bottom passes outer shroud and is located in centrifuge tube, is provided with fiberfill fibers in silica gel tube.
The upper plane of described interior plug is sieve pore structure.
Described silica gel tube is that top is sparse, lower dense loose structure.
Described fiberfill fibers are cotton fiber or the nano-fiber material having special adsorption function, and fiberfill fibers are in advance
Processed using 5% citric acid solution.
Described silica gel tube uses food grade silicone material, is about 4.5cm, and external diameter and internal diameter are respectively 1cm and 0.9cm, silicon
On sebific duct, the external diameter on edge is 1.6cm.
Described interior fill in for polypropylene plastics material, hollow structure, one end open, the other end is sieve pore structure, plug body outer
Footpath is 0.95cm, and internal diameter is 0.85cm, and on interior plug, the external diameter along part is 1.6cm.
Using method is：When not sampling, it is filled with the packing material of certain mass in silica gel tube, then at silica gel tube opening
It is inserted in interior plug, interior beyond the Great Wall along shell tool, finally outer shroud is fixed with centrifuge tube by screw thread.In sampling, outer shroud is revolved
Go out, pad takes off, by interior plug connect silica gel tube take out upset after be placed on centrifuge tube, then by exterior ring cap cross silica gel tube be spun on from
On heart pipe, thus silica gel tube and Nei Sai are fixed on i.e. available on centrifuge tube.During collection saliva, silica gel tube is put into tested
Mouthful in, tested by chew silica gel tube make saliva through on tube wall aperture enter pipe in fiber-based material and be adsorbed.Sampling
Afterwards, the shape whole device group being reinstalled when not sampling puts in centrifuge centrifugation so that the saliva of absorption be centrifuged to
In centrifuge tube.This invention simplifies saliva sampling process, eliminate the sense of discomfort in sampling process, increased saliva sampling quantity,
Sampling process safety and sanitation, are applied especially to infant or have disease to be difficult to coordinate the tested crowd of sampling.Adopt
Saliva sample can be used for the analysis detection of multiple biochemical components.
Beneficial effect：With respect to prior art, it is an advantage of the invention that：
1. child passes through to chew silica gel tube, and the aperture that saliva will pass through on pipe flows into the packing material in silica gel tube, reaches
The purpose of sorption enrichment.The material of silica gel tube is food grade silicone, safe and reliable, and silica gel tube made of soft, and bottom processes
Become hemispherical configuration, tested when chewing oral sensation comfortable, psychological be easier to accept.Made to thin structure by close
Sampling terminate after when being centrifuged, saliva can successfully flow to centrifuge tube bottom after departing from from fiberfill fibers, thus from
Retain in heart pipe；
2. use citric acid treatment filling fiber adsorbing material so that tested more quickly salivate, contracting
In the short sampling time, increase sampling volume；
3. the safety of sampling apparatuses is secure.According to the sampling apparatuses figure in Fig. 2, in sampling, centrifuge tube can fill
Work as handle, can be by the hand-held control of sampler for the experimenter's (such as infant) being difficult to coordinate.And silica gel tube and centrifugation
Screwed by screw thread in the middle of pipe, firmly difficult for drop-off, prevent the risk that sampling head is swallowed by mistake in sampling process；
4. twin-tube type structure design makes the process of sample more convenient.After the internal silica gel tube of child is chewed,
Interior silica gel tube is put back to outer centrifuge tube, shell tool together with interior plug, then screws on outer shroud, whole device assembling is returned to Fig. 1's
Form, can be directly placed in centrifuge and be centrifuged, and can put into saliva sample in refrigerator and preserve after centrifugation, convenient fast
Prompt.
Brief description
Below in conjunction with the accompanying drawings and embodiment the invention will be further described：
Fig. 1 is the structural representation of double hose saliva sampler,
Structural representation when Fig. 2 samples for double hose saliva sampler,
Fig. 3 is the schematic diagram of interior silica gel tube,
Fig. 4 is the schematic diagram of interior plug,
Fig. 5 is the schematic diagram of outer shroud.
Above in figure has：Outer shroud 1, pad 2, interior plug 3, silica gel tube 4, centrifuge tube 5, female thread 6, sieve pore structure 7, outer spiral shell
Stricture of vagina 8, fiberfill fibers 9, loose structure 10.
Specific embodiment
The saliva sampler of the double hose of the present invention.(1) food grade silicone pipe is used as oral saliva enriching apparatus,
Silica gel tube wall is processed into close vesicular texture under dredging, and the hemispherical configuration that similar nipple is processed on top makes mastication processes
More comfortable；(2) citric acid solution being used 5% processes the adsorbing material of fibrous type as the packing material in silica gel tube；(3)
Interior silica gel tube, the twin-tube type structure design of outer centrifuge tube；Specific as follows：
This sampler includes outer shroud, pad, interior plug, silica gel tube, centrifuge tube, fiberfill fibers；Interior spiral shell during sampling, on outer shroud
Stricture of vagina is coincide with the external screw thread of centrifuge tube opening, and interior plug is located in outer shroud, and the bottom of silica gel tube is connected as a single entity with interior plug, and top is worn
Go out outer shroud, be provided with fiberfill fibers in silica gel tube；When stored, the female thread on outer shroud and the external screw thread of centrifuge tube opening are kissed
Close, the top that pad is located in outer shroud, side is interior plug under the shim, and silica gel tube is connected as a single entity with interior plug, and bottom passes outer shroud
In centrifuge tube, it is provided with fiberfill fibers in silica gel tube.
The upper plane of described interior plug is sieve pore structure.
Described silica gel tube is that top is sparse, lower dense loose structure.
Described fiberfill fibers are cotton fiber or the nano-fiber material having special adsorption function, and fiberfill fibers are in advance
Processed using 5% citric acid solution.
1. silica gel tube in, using food grade silicone material, is about 4.5cm, external diameter and internal diameter be about respectively 1cm and
0.9cm, on silica gel tube, the external diameter on edge is 1.6cm.Internal fiberfill fibers type adsorbing material.The hemispherical configuration of bottom, and
From silica gel tube top-to-bottom, it is processed into that top is sparse, the cellular knot of lower dense (direction placed in Fig. 1 is defined)
Structure；
2. plug in, polypropylene plastics material, hollow structure, one end open, the other end is sieve pore structure, and the external diameter of plug body is
0.95cm, internal diameter is 0.85cm, and on interior plug, the external diameter along part is 1.6cm；
3. fiberfill fibers, can be cotton fiber or the nano-fiber material having special adsorption function, fiber can be pre-
First processed using 5% citric acid solution.
Below in conjunction with specific embodiment, such scheme is described further.It should be understood that these embodiments are for illustrating
The present invention rather than restriction the scope of the present invention.In embodiment adopt implementation condition can according to the condition of concrete producer make into
One successive step, not marked implementation condition is usually the condition in normal experiment.
Embodiment is as depicted in figs. 1 and 2.This sampler includes outer shroud 1, pad 2, interior plug 3, silica gel tube 4, centrifuge tube 5, fills out
Fill fiber 9；During sampling, the female thread 6 on outer shroud 1 is coincide with the external screw thread 8 of centrifuge tube 5 opening, and interior plug 3 is located in outer shroud 1,
The bottom of silica gel tube 4 is connected as a single entity with interior plug 3, and top passes outer shroud 1, is provided with fiberfill fibers 9 in silica gel tube 4；When stored,
Female thread 6 on outer shroud 1 is coincide with the external screw thread 8 of centrifuge tube 5 opening, and the top that pad 2 is located in outer shroud 1, in pad 2
Lower section is interior plug 3, and silica gel tube 4 is connected as a single entity with interior plug 3, and bottom passes outer shroud 1 and is located in centrifuge tube 5, is provided with silica gel tube 4
Fiberfill fibers 9.
The upper plane of described interior plug 3 is sieve pore structure 7.
Described silica gel tube 4 is that top is sparse, lower dense loose structure 10.
The nano-fiber material that described fiberfill fibers 9 are cotton fiber or have special adsorption function, fiberfill fibers are pre-
First processed using 5% citric acid solution.
Outer centrifuge tube be polypropylene plastics material (PP), length be 7.5cm, internal-and external diameter respectively be about 1.4cm and
1.6cm, down all has external screw thread until 2cm carves from the top of centrifugation pipe outer wall；
As shown in figure 3, interior silica gel tube be food grade silicone tubing matter, long 4cm, internal-and external diameter respectively be about 0.9cm and
1cm, and silica gel tube lower end is hemispherical configuration, is initially processed as by close to thin vesicular texture, silicon from silica gel tube top
The edge shape that the processing of sebific duct port is extended, the diameter at edge is about 1.6cm.It is filled with fibrous type adsorption material inside silica gel tube
Material, the material of this material is the functional nano-fiber of pure natural Cotton Gossypii or food stage macromolecule electrospinning, and the former has to saliva
Sorption, can depart from liquid phase after centrifugation, be easy to collect saliva；The latter also can have efficiently to objects some in saliva
So that test target thing can be enriched with well in saliva after sampling, after centrifugation, detached saliva can be used for adsorption
The detection of some indexs, and nano-fiber material can measure some specific indexes with proper method parsing after taking out；
As shown in figure 4, the material of interior plug is polypropylene plastics, it is about 2cm.It is internal to be hollow structure, one end open, separately
One end is processed into sieve pore structure and is had the edge of extension, the internal-and external diameter that the plug of interior plug is in be about respectively 0.85cm and
0.95cm, sieve aperture is equally distributed aperture, and aperture is about 1mm, and the external diameter of edge is about 1.6cm；
As shown in figure 5, the material of outer shroud is polypropylene plastics.The internal-and external diameter of outer shroud is about 1.6cm and 1.8cm respectively,
Length is 2cm, and outer shroud is hollow circular cylinder structure, and the diameter of one end open is smaller, about 1.2cm, other end opening diameter with
Internal diameter is identical, is 1.6cm, is carved with female thread in ring；
Pad is the disc-shaped structure of quality of rubber materials, diameter about 1.6cm, and thickness is 0.5-1mm.
Foregoing invention only technology design to illustrate the invention and feature, its object is to allow person skilled in the art's energy
Enough understand present disclosure and implement according to this, can not be limited the scope of the invention with this.All essences according to the present invention
Equivalent exchange or modification that god's essence is done, all should be included within the scope of the present invention.
Claims (4)
1. a kind of double hose saliva sampler is it is characterised in that this sampler includes outer shroud (1), pad (2), interior plug (3), silicon
Sebific duct (4), centrifuge tube (5), fiberfill fibers (9)；During sampling, female thread (6) on outer shroud (1) and centrifuge tube (5) opening
External screw thread (8) coincide, and interior plug (3) is located in outer shroud (1), and the bottom of silica gel tube (4) is connected as a single entity with interior plug (3), and top passes
Outer shroud (1), is provided with fiberfill fibers (9) in silica gel tube (4)；When stored, the female thread (6) on outer shroud (1) and centrifuge tube (5)
The external screw thread (8) of opening coincide, and the top that pad (2) is located in outer shroud (1), is interior plug (3) below pad (2), silicon
Sebific duct (4) is connected as a single entity with interior plug (3), and bottom passes outer shroud (1) and is located in centrifuge tube (5), is provided with filling in silica gel tube (4)
Fiber (9)；
The upper plane of described interior plug (3) is sieve pore structure (7)；
Described silica gel tube (4) is that top is sparse, lower dense loose structure (10).
2. a kind of double hose saliva sampler according to claim 1 is it is characterised in that described fiberfill fibers (9) are
Cotton fiber or have adsorbing nano-fiber material to object in saliva, fiberfill fibers are in advance using 5% Fructus Citri Limoniae
Acid solution is processed.
3. a kind of double hose saliva sampler according to claim 1 is it is characterised in that described silica gel tube (4) is using food
Grade silica gel material, long 4.5cm, external diameter and internal diameter are respectively 1cm and 0.9cm, and on silica gel tube, the external diameter on edge is 1.6cm.
4. a kind of double hose saliva sampler according to claim 1 is it is characterised in that described interior plug (3) is polypropylene
Plastic material, hollow structure, one end open, the other end is sieve pore structure, and the external diameter of plug body is 0.95cm, and internal diameter is 0.85cm,
On interior plug, the external diameter along part is 1.6cm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410446330.3A CN104215474B (en) | 2014-09-03 | 2014-09-03 | Two-pipe saliva sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410446330.3A CN104215474B (en) | 2014-09-03 | 2014-09-03 | Two-pipe saliva sampling device |
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| CN104215474A CN104215474A (en) | 2014-12-17 |
| CN104215474B true CN104215474B (en) | 2017-02-22 |
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| CN201410446330.3A Active CN104215474B (en) | 2014-09-03 | 2014-09-03 | Two-pipe saliva sampling device |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104964848B (en) * | 2015-07-24 | 2016-11-09 | 焉春华 | A kind of for induction of sputum tulase inspection can centrifugal phlegm box |
| CN106053648B (en) * | 2016-06-07 | 2018-07-24 | 云南中烟工业有限责任公司 | A kind of pretreating device of aldehydes matter detection and application |
| CN106053682B (en) * | 2016-06-07 | 2018-07-24 | 云南中烟工业有限责任公司 | A kind of pretreating device of benzenediol substance detection and application |
| CN105911198B (en) * | 2016-06-07 | 2018-03-09 | 云南中烟工业有限责任公司 | A kind of pretreating device of chaff aldehyde material detection and application |
| CN108309358A (en) * | 2018-01-31 | 2018-07-24 | 上海交通大学医学院附属上海儿童医学中心 | Nipple type detection device |
Citations (4)
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|---|---|---|---|---|
| US4774962A (en) * | 1985-09-23 | 1988-10-04 | Walter Sarstedt Kunststoff-Spritzgusswerk | Method of extracting human saliva |
| US7387899B1 (en) * | 1995-07-11 | 2008-06-17 | D Angelo Joseph P | Saliva sample collection system |
| CN201152833Y (en) * | 2007-11-02 | 2008-11-19 | 中国农业科学院北京畜牧兽医研究所 | Animals sputum collecting device |
| CN203705198U (en) * | 2013-12-17 | 2014-07-09 | 深圳华大基因研究院 | Device and system for collecting and processing saliva sample |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003014733A (en) * | 2001-07-03 | 2003-01-15 | Iatron Lab Inc | Saliva sample preparation set |
| US20060245977A1 (en) * | 2005-05-02 | 2006-11-02 | Saliva Diagnostic Systems Inc. | Collection device for a fluid specimen |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4774962A (en) * | 1985-09-23 | 1988-10-04 | Walter Sarstedt Kunststoff-Spritzgusswerk | Method of extracting human saliva |
| US7387899B1 (en) * | 1995-07-11 | 2008-06-17 | D Angelo Joseph P | Saliva sample collection system |
| CN201152833Y (en) * | 2007-11-02 | 2008-11-19 | 中国农业科学院北京畜牧兽医研究所 | Animals sputum collecting device |
| CN203705198U (en) * | 2013-12-17 | 2014-07-09 | 深圳华大基因研究院 | Device and system for collecting and processing saliva sample |
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