CN104208328A - Traditional Chinese medicine composition for preventing and treating infectious pleurisy of pigs and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating infectious pleurisy of pigs and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing and treating infectious pleurisy of pigs. The traditional Chinese medicine composition is prepared by scutellaria baicalensis, common andrographis herb, white mulberry root barks, Chinese wolfberry root barks, licorice, ginkgo, ephedra, perillaseed, pinellia ternate, almonds and Chinese magnoliavine fruits and can be powder. A preparation method comprises the steps of 1 smashing traditional Chinese medicine to be at 40-60 meshes, weighing the traditional Chinese medicine according to a formula and performing three-dimentional mixing to obtain traditional Chinese medicine powder; 2 throwing the mixed traditional Chinese medicine powder and 2-3 times of amount of water into an extraction tank to stay overnight for dipping; 3 heating hydrolysate to be at the temperature ranging from 40 DEG C to 100 DEG C and performing extraction for 8-12 hours; 4 filtering and removing medicine residues and standing filtrate for standby; 5 re-throwing the medicine residues into the extraction tank, adding water to repeat the step 3; 6 filtering and removing the medicine residues, mixing obtained liquid with the liquid extracted for the first time, and performing direct filling to obtain finished product, wherein the packing specification is 100-200 ml/per bag. The traditional Chinese medicine composition can effectively prevent and treat the infectious pleurisy of the pigs and has the effects of removing heat from the lung to relieve cough, resolving sputum and relieving asthma, and the recovery rate is higher than 90%.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially pleuritic Chinese medicine composition of a kind of control pig transmissible and preparation method thereof.
Background technology
Porcine contagious pleuropneumonia (PCP), also known as pig pleuropneumonia, is a kind of serious contagious disease of the respiratory diseases in pigs caused by Actinobacillus pleuropneumoniae (APP).Primary disease is widely current all over the world from the eighties in 20th century, causes huge economic loss to intensive pig production, is one of Important Infectious Diseases of internationally recognized harm Pig Industry industry.The generation that temperature sharply changes, the stressors such as the sudden change of improper ventilation, weather and long-distance transport can promote primary disease.The equal susceptible of pig at various age, usually comparatively multiple with the pig at 6 weeks-6 monthly ages.Its sickness rate is 5%-80%, mortality rate 6%-20%.Primary disease occurs suddenly, propagates rapidly, and the high heat that occurs together, anorexia, spirit depressed, cough and the symptom such as severe dyspnea, mortality rate is high.Most acute, acute, subacute type and chronic type can be divided into according to the course of disease.Acute case body temperature can rise to more than 42 DEG C, rapid breathing, great difficulty, often stands or dog sits and is reluctant sleeping ground, and dehisce to loll, shape is in anguish, if treat not in time, and often death by suffocation in 24-48 hour.Also can not see symptom before having the most acute person dead.If symptom comparatively relaxes when starting, it's more than 4 days pasts ability, and symptom progressively disappears, often can rehabilitation voluntarily, but the course of disease is longer.In addition, the easy secondary other diseases of pig pleuropneumonia, causes growth retardation, reduces the price of deed.
Common antibiotics (as tilmicosin and penicillin etc.) treats pig pleuropneumonia to reducing mortality rate and improving average daily gain clinically at present, but usually continues to carry disease germs through the pig for the treatment of, becomes the source of infection of other pigs.And often there is Resistant strain, make antibiotherapy become a long-term insoluble problem.
It is low that Chinese medicine has toxic and side effects, no drug residue, the advantage of environmental protection.Therefore develop treatment by Chinese herbs PCP medicine, overcome the defect of antibiotics, become China's pig industry and be badly in need of one of problem solved.China's natural resources of Chinese medicinal materials enriches in addition, and exploitation Chinese medicine preparation has wide market prospect.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provides a kind of good effect, no drug residue, safe and reliable pig Chinese medicine composition.
Another technical problem that the present invention will solve is: provide a kind of control pig transmissible pleuritic Chinese medicine formula.
Another technical problem that the present invention will solve is: the preparation method providing the water preparation of above-mentioned pig Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: the pleuritic Chinese medicine composition of a kind of control pig transmissible, is characterized in that: be prepared from by the raw material of following mass fraction: Radix Scutellariae 10-20 part, Herba Andrographis 5-15 part, Cortex Mori 5-15 part, Cortex Lycii 5-15 part, Radix Glycyrrhizae 5-15 part, Semen Ginkgo 5-20 part, Herba Ephedrae 10-20 part, Fructus Perillae 5-15 part, Rhizoma Pinelliae 5-15 part, Semen Armeniacae Amarum 5-15 part, Fructus Schisandrae Chinensis 5-15 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows:
Radix Scutellariae 15 parts, Herba Andrographis 10 parts, Cortex Mori 5 parts, Cortex Lycii 5 parts, 5 parts, Radix Glycyrrhizae, Semen Ginkgo 20 parts, 10 parts, Herba Ephedrae, Fructus Perillae 5 parts, the Rhizoma Pinelliae 5 parts, 10 parts, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis 10 parts.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, described preparation can be water preparation.
Further, the preparation method of the powder of said composition is: Chinese medicine powder is broken to 40-60 order by [1], takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; [2] mixed Chinese medicine powder, a 2-3 times water gaging are put in extraction pot, soaked overnight; [3] hydrolyzed solution is heated to 40-100 DEG C and extracts 8-12 hour; [4] excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; [5] medicinal residues are put in extraction pot again, add water, repeat step 3; [6] excessively filter medicinal residues, mixed with first time extracting liq by gained liquid, direct fill gets product, and packing specification is 100-200ml/ bag.
The advantage that the present invention has and good effect are:
(1) the present invention is according to the dialectical theory of Chinese medicine, and scientific compatibility, has effect of clearing away heat-fire, depressed lung-energy dispersing, relieving cough and resolving phlegm, is more than 90% through clinical verification cure rate.And adopt preparation method simple and easy to operate, for the clinical one that provides conveniently treats the pleuritic Chinese medicine preparation of pig transmissible.
(2) this prescription adopts pure Chinese medicinal preparation, and environmental protection, effectively prevent drug resistance and the drug residue problem of conventional antibiotic class medicine.
(3) pharmacology of each raw material of Chinese medicine of the present invention is:
Radix Scutellariae: bitter in the mouth is cold in nature.There is heat clearing and damp drying, effect of eliminating fire and detoxication.Master enters lung meridian, and kind clear purte the white and part of the body cavity above the diaphragm housing the heart and lungs excess-heat, join Semen Armeniacae Amarum, Cortex Mori, Fructus Perillae, can control cough due to lung-heat's asthma.
Herba Andrographis: bitter in the mouth is cold in nature.There is heat-clearing and toxic substances removing, removing heat from blood, effect of dampness.Kind lung heat clearing fire, removing heat from blood is subsided a swelling, and share with Radix Scutellariae, Cortex Mori, Cortex Lycii, can treat cough due to lung-heat's asthma.
Cortex Mori: sweet in the mouth is cold in nature.There is eliminating pathogen from the lung for relieving asthma, effect of inducing diuresis to remove edema.Main enter lung meridian, can to hold concurrently aqueous vapor in eliminating the pathogens from the lung and relievining asthma by clear purte the white.Control lung-heat cough with asthma, normal and Cortex Lycii is same to be used.
Cortex Lycii: sweet in the mouth is cold in nature.There is removing heat from blood except steaming, effect of lung heat clearing pathogenic fire reducing.Kind eliminating heat from the lung, except the lung fire second of the three ten-day periods of the hot season, then voluntarily, normal and Cortex Mori, Radix Glycyrrhizae is equal to use, the pent-up for the treatment of lung-fire, cough and asthma in respectful clearly order.
Radix Glycyrrhizae: sweet in the mouth is put down.There is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, effect of coordinating the actions of various ingredients in a prescription.The cough-relieving of this product energy, doublely can eliminate the phlegm, also somewhat antiasthmatic effect.
Semen Ginkgo: sweet in the mouth, hardship, puckery, property is put down.There is effect of astringing lung-QI and dissipating phlegm Dingchuan.This moral character is puckery and receive, energy astringing lung QI for relieving asthma, and has the merit of necessarily reducing phlegm concurrently.Join Herba Ephedrae, Radix Scutellariae be equal to use, affection of exogenous wind-cold can be treated and in have intrinsic heat and the person of breathing heavily.
Herba Ephedrae: acrid in the mouth, micro-hardship, warm in nature.There is relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, effect of inducing diuresis to remove edema.Main enter lung meridian, can the closing of external-open fur, smooth to make lung qi declare, inside fall the gas of superinverse, fall normal so that multiple lung department is respectful, therefore kindly to relieving asthma, and be often auxiliary with medicines for the treatment of cough and asthma such as Semen Armeniacae Amarums.
Fructus Perillae: acrid in the mouth is warm in nature.Return lung, large intestine channel.There is sending down the abnormal ascending QI expectorant, effect of relieving cough and asthma.Can be used for treatment expectorant and stop up QI rising in reverse order, cough and asthma, dryness of the intestine constipation.
The Rhizoma Pinelliae: acrid in the mouth is warm in nature.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass.For drying dampness to eliminate phlegm, warming for resolving cold-phlegm key medicine, outstanding being apt to controls the bottom of heart damp-phlegm.
Semen Armeniacae Amarum: bitter in the mouth, tepor.There is relieving cough and asthma, effect of loosening bowel to relieve constipation.Main enter lung meridian, bitter in the mouth falls to be let out, respectful fall to hold concurrently should send out lung qi and can relieving cough and asthma, for controlling the key medicine of cough with asthma.
Fructus Schisandrae Chinensis: sour in the mouth is restrained, Gan Wen and moistening, can on to astringe the lung gas, lower nourishing kidney-yin, is longer than astringing lung-QI and relieving cough, is the key medicine for the treatment of chronic cough dyspnea due to deficiency.
The traditional Chinese medical science is thought, pig transmissible pleuritis belongs in exopathogen criminal, and heresy enters lung meridian, causes lung-fire void prosperous.Among formula, Radix Scutellariae, Herba Andrographis, Cortex Mori, Cortex Lycii master enters lung meridian, and the clear part of the body cavity above the diaphragm housing the heart and lungs lung-fire of energy, has effect of eliminating fire and detoxication.Semen Ginkgo is relievingd asthma and can reduce phlegm, and with Herba Ephedrae, the same use of Fructus Perillae, can improve antiasthmatic effect, the compatibility Rhizoma Pinelliae, Semen Armeniacae Amarum, Radix Glycyrrhizae preventing phlegm from forming and stopping coughing.Radix Glycyrrhizae can also coordinating the actions of various ingredients in a prescription.Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, astringing lung-QI and relieving cough.All medicines share, and have the effect of depressed lung-energy dispersing, clearing away heat-fire, relieving cough and resolving phlegm.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
The pleuritic Chinese medicine powder of a kind of control pig transmissible, the parts by weight of each raw material are as follows: Radix Scutellariae 15 parts, Herba Andrographis 10 parts, Cortex Mori 5 parts, Cortex Lycii 5 parts, 5 parts, Radix Glycyrrhizae, Semen Ginkgo 20 parts, 10 parts, Herba Ephedrae, Fructus Perillae 5 parts, the Rhizoma Pinelliae 5 parts, 10 parts, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis 10 parts.Its preparation method is as follows: Chinese medicine powder is broken to 40-60 order by [1], takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; [2] mixed Chinese medicine powder, a 2-3 times water gaging are put in extraction pot, soaked overnight; [3] hydrolyzed solution is heated to 40-100 DEG C and extracts 8-12 hour; [4] excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; [5] medicinal residues are put in extraction pot again, add water, repeat step 3; [6] excessively filter medicinal residues, mixed with first time extracting liq by gained liquid, direct fill gets product, and packing specification is 100-200ml/ bag.
Embodiment 2
The pleuritic Chinese medicine powder of a kind of control pig transmissible, the parts by weight of each raw material are as follows: Radix Scutellariae 20 parts, Herba Andrographis 5 parts, Cortex Mori 10 parts, Cortex Lycii 10 parts, 10 parts, Radix Glycyrrhizae, Semen Ginkgo 5 parts, 10 parts, Herba Ephedrae, Fructus Perillae 10 parts, the Rhizoma Pinelliae 10 parts, 5 parts, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis 5 parts.Its preparation method is as follows: Chinese medicine powder is broken to 40-60 order by [1], takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; [2] mixed Chinese medicine powder, a 2-3 times water gaging are put in extraction pot, soaked overnight; [3] hydrolyzed solution is heated to 40-100 DEG C and extracts 8-12 hour; [4] excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; [5] medicinal residues are put in extraction pot again, add water, repeat step 3; [6] excessively filter medicinal residues, mixed with first time extracting liq by gained liquid, direct fill gets product, and packing specification is 100-200ml/ bag.
Embodiment 3
Radix Scutellariae 10 parts, Herba Andrographis 10 parts, Cortex Mori 5 parts, Cortex Lycii 5 parts, 15 parts, Radix Glycyrrhizae, Semen Ginkgo 15 parts, 20 parts, Herba Ephedrae, Fructus Perillae 5 parts, the Rhizoma Pinelliae 5 parts, 5 parts, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis 5 parts.Its preparation method is as follows: Chinese medicine powder is broken to 40-60 order by [1], takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; [2] mixed Chinese medicine powder, a 2-3 times water gaging are put in extraction pot, soaked overnight; [3] hydrolyzed solution is heated to 40-100 DEG C and extracts 8-12 hour; [4] excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; [5] medicinal residues are put in extraction pot again, add water, repeat step 3; [6] excessively filter medicinal residues, mixed with first time extracting liq by gained liquid, direct fill gets product, and packing specification is 100-200ml/ bag.
Embodiment 4
Radix Scutellariae 15 parts, Herba Andrographis 10 parts, Cortex Mori 10 parts, Cortex Lycii 5 parts, 10 parts, Radix Glycyrrhizae, Semen Ginkgo 5 parts, 10 parts, Herba Ephedrae, Fructus Perillae 5 parts, the Rhizoma Pinelliae 10 parts, 10 parts, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis 10 parts.Its preparation method is as follows: Chinese medicine powder is broken to 40-60 order by [1], takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; [2] mixed Chinese medicine powder, a 2-3 times water gaging are put in extraction pot, soaked overnight; [3] hydrolyzed solution is heated to 40-100 DEG C and extracts 8-12 hour; [4] excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; [5] medicinal residues are put in extraction pot again, add water, repeat step 3; [6] excessively filter medicinal residues, mixed with first time extracting liq by gained liquid, direct fill gets product, and packing specification is 100-200ml/ bag.
Embodiment 5
Radix Scutellariae 10 parts, Herba Andrographis 10 parts, Cortex Mori 5 parts, Cortex Lycii 10 parts, 10 parts, Radix Glycyrrhizae, Semen Ginkgo 10 parts, 20 parts, Herba Ephedrae, Fructus Perillae 5 parts, the Rhizoma Pinelliae 5 parts, 10 parts, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis 5 parts.Its preparation method is as follows: Chinese medicine powder is broken to 40-60 order by [1], takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; [2] mixed Chinese medicine powder, a 2-3 times water gaging are put in extraction pot, soaked overnight; [3] hydrolyzed solution is heated to 40-100 DEG C and extracts 8-12 hour; [4] excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; [5] medicinal residues are put in extraction pot again, add water, repeat step 3; [6] excessively filter medicinal residues, mixed with first time extracting liq by gained liquid, direct fill gets product, and packing specification is 100-200ml/ bag.
Clinical trial
Experiment 1:
Pig farm, Henan, raise 300 body weight 40-50 kilogram of growing and fattening pigs, have 2 pig sudden onset at first, disease sees that body temperature is increased to 42 DEG C, rapid breathing, great difficulty, stand and be reluctant that shape is in anguish, and nasal cavity has purulent secretion or spumescence secretions sleepingly, fail to respond to any medical treatment with penicillin, dead after 2 days.It is purple that pig cuts open inspection lung, and tangent plane is like liver, and interstitial is full of color glue sample liquid body.All the other pigs are fallen ill successively.Cuing open inspection tentative diagnosis in conjunction with sick pig symptom and dead pig is infectious pleurisy.Sick pig is divided into three groups, adopts three kinds of therapeutic schemes respectively, observe its curative effect.Use the product obtained by embodiment 1 to the pig of 100 wherein, stomach tube gavages, one day twice, is used in conjunction three days, and most of sick temperature of pig body recovers normal, and eupnea, mental restoration, had no recurrence after one week, and cure rate, up to 92%, does not occur death.Other 100 give enrofloxacin treatment, are used in conjunction three days, and except the heavier death of symptom, jumpbogroup is cured, cure rate 88%.Remaining 98 give tilmicosin treatment, serve on three days, cure rate 83%, mortality rate 2%.
Experiment proves that product obtained by embodiment 1 is for treatment pig transmissible pleuritis determined curative effect, and is better than the antibiotics commonly used on the market.
Experiment 2:
Pig farm, Heilungkiang
Pig farm, Guangdong Province is bought from other places and is fattened piglet 200.After buying one week, pig appetite declines, and spirit is depressed, and there is foam in nostril, rapid breathing, sometimes has sitting position of dog gesture, paroxysmal cough, and body temperature raises more than 41 DEG C.Clinical diagnosis is pig transmissible pleuritis.Use the product obtained by embodiment 1 to the pig of 70 wherein, stomach tube gavages, one day twice, is used in conjunction three days, and most of sick temperature of pig body recovers normal, eupnea, and mental restoration, normally takes food, cure rate up to 94.3%, and without dead pig.Other 70 give enrofloxacin treatment, and be used in conjunction three days, jumpbogroup is cured, cure rate 87.1%, mortality rate 2.9%.Remaining 60 give tilmicosin treatment, serve on three days, cure rate 80%, mortality rate 8.3%.
Experiment proves that product obtained by embodiment 1 is for treatment pig transmissible pleuritis determined curative effect, and is obviously better than the antibiotics commonly used on the market.
Other result of the tests are in table 1.
Table 1
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (8)
1. prevent and treat the pleuritic Chinese medicine composition of pig transmissible, it is characterized in that: be prepared from by the raw material of following mass fraction: Radix Scutellariae 10-20 part, Herba Andrographis 5-15 part, Cortex Mori 5-15 part, Cortex Lycii 5-15 part, Radix Glycyrrhizae 5-15 part, Semen Ginkgo 5-20 part, Herba Ephedrae 10-20 part, Fructus Perillae 5-15 part, Rhizoma Pinelliae 5-15 part, Semen Armeniacae Amarum 5-15 part, Fructus Schisandrae Chinensis 5-15 part.
2. the pleuritic Chinese medicine composition of control pig transmissible according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
Radix Scutellariae 15 parts, Herba Andrographis 10 parts, Cortex Mori 5 parts, Cortex Lycii 5 parts, 5 parts, Radix Glycyrrhizae, Semen Ginkgo 20 parts, 10 parts, Herba Ephedrae, Fructus Perillae 5 parts, the Rhizoma Pinelliae 5 parts, 10 parts, Semen Armeniacae Amarum, Fructus Schisandrae Chinensis 10 parts.
3. the pleuritic Chinese medicine composition of control pig transmissible according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
4. the pleuritic Chinese medicine composition of control pig transmissible according to claim 3, is characterized in that: described preparation can be water preparation.
5. prepare a method for the pleuritic Chinese medicine composition of control pig transmissible as claimed in claim 4, it is characterized in that: preparation method is: Chinese medicine powder is broken to 40-60 order by [1], takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; [2] mixed Chinese medicine powder, water are put in extraction pot, soaked overnight; [3] hydrolyzed solution heating extraction; [4] excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; [5] medicinal residues are put in extraction pot again, add water, repeat step 3; [6] excessively filter medicinal residues, mixed with first time extracting liq by gained liquid, direct fill gets product.
6. the preparation method of the pleuritic Chinese medicine composition of control pig transmissible according to claim 5, is characterized in that: soak Chinese medicine powder water consumption for its quality 2-3 times.
7. the preparation method of the pleuritic Chinese medicine composition of control pig transmissible according to claim 5, is characterized in that: Extracting temperature is 40-100 DEG C.
8. the preparation method of the pleuritic Chinese medicine composition of control pig transmissible according to claim 5, is characterized in that: extraction time is 8-12 hour.
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| CN110251653A (en) * | 2019-08-01 | 2019-09-20 | 郑州赛科药业科技有限公司 | For preventing and treating the Chinese medicine composition and preparation method of Porcine contagious pleuropneumonia |
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| CN107095962A (en) * | 2017-07-06 | 2017-08-29 | 四川省景盛边城生态农业有限责任公司 | One kind takes precautions against the pleuritic Chinese medicine health-care medicinal powder of sheep infective |
| CN110251653A (en) * | 2019-08-01 | 2019-09-20 | 郑州赛科药业科技有限公司 | For preventing and treating the Chinese medicine composition and preparation method of Porcine contagious pleuropneumonia |
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