CN104435675A - Traditional Chinese medicine composition for treating infectious bronchitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating infectious bronchitis and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention relates to a traditional Chinese medicine composition for treating infectious bronchitis. The traditional Chinese medicine composition for treating infectious bronchitis disclosed by the invention is prepared from semen lepidii, Chinese-date, tuber of dwarf lilyturf, pinellia ternate, ginseng, liquorice, platycodon grandiflorum, ephedra and gypsum. The traditional Chinese medicine composition can be powder. A preparation method disclosed by the invention comprises the following steps of: (1), weighing various traditional Chinese medicines according to the formula ratio; (2), using 2-3 times of water to slowly flow into the traditional Chinese medicines by using an infiltration method till the traditional Chinese medicines are infiltrated and water is exhausted; (3), drying under reduced pressure at 40-70 DEG C till completely drying; (4), crushing dried traditional Chinese medicines, and sieving through a 40-100mesh sieve; and (5), split-charging and bagging so as to obtain the traditional Chinese medicine composition, wherein each bag is 100-200 g. The traditional Chinese medicine composition provided by the invention can be used for effectively treating infectious bronchitis; the curative ratio is above 95%; and the traditional Chinese medicine composition provided by the invention has the effects of eliminating dampness, reducing phlegm, relieving cough, preventing asthma, tonifying spleen and benefiting lung.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind of Chinese medicine composition for the treatment of infectious bronchitis of chicken and preparation method thereof.
Background technology
Infectious bronchitis of chicken is the respiratory tract disease of a kind of acute, the high degree in contact caused by avian infectious bronchitis virus.With cough, sneeze, chickling stream nose liquid, laying hen egg production reduces, and respiratory mucosa is serosity, catarrhal inflammation is feature.Primary disease only betides chicken, other poultry all not easy infections.The chicken at various age all can fall ill, but the most serious with chickling, and mortality rate is also high, generally multiple with the chicken within 40 ages in days.Primary disease mainly through respiratory tract infection, also by contaminated feedstuff, drinking-water and raise apparatus through digestive tract infection.All can occur throughout the year, but multiple with winter-spring season.The usual sudden onset of chicken group, lassitude, appetite decline or do not eat, necking down of bowing, feather are inverse vertical, do not like activity, have loose bowels, feces is stench, time have cough, sneeze, nose stream clear liquid, stretch neck, get rid of head, mouth breathing, send " rumble " abnormal breathing sound, especially night more very, and breathing is more obvious, just as drawing bellows, along with the prolongation of the course of disease, General Symptoms aggravates, down in spirits, appetite is useless absolutely, wing is sagging, drowsiness, be afraid of cold beat heap, sick chicken becomes thin gradually, loses weight.Infectious bronchitis of chicken is popular commonplace in recent years, although mortality rate is not high, the General Symptoms caused due to respiratory system disease is relatively more serious, cause lay eggs, growth promoter is affected, thus the economic loss caused is huge, should cause enough attention.
Primary disease there is no specificity therapeutic method at present, can only by improving feeding and management condition, reduces chicken population density, adds antibiotic and prevent secondary infection in feedstuff or drinking-water.Vaccination is important method, but the serotype of avian infectious bronchitis virus is more, and new serotype and variant constantly occur, add unsuitable immune programme for children, often cause immuning failure, cause this disease not to be effectively controlled, bring about great losses to poultry husbandry.China's natural resources of Chinese medicinal materials enriches, and therefore exploitation is a kind of evident in efficacy, and the Chinese medicine preparation that cure rate is high has wide market prospect.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provide a kind of evident in efficacy, cure rate is high, the Chinese medicine composition that has no side effect.
Another technical problem that the present invention will solve is: provide a kind of Chinese medicine formula for the treatment of infectious bronchitis of chicken.
Another technical problem that the present invention will solve is: the preparation method providing the powder of above-mentioned Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of infectious bronchitis of chicken, is characterized in that: be prepared from by the raw material of following mass fraction: Semen Lepidii (Semen Descurainiae) 10-25 part, Fructus Jujubae 5-10 part, Radix Ophiopogonis 5-15 part, Rhizoma Pinelliae 5-15 part, Radix Ginseng 5-15 part, Radix Glycyrrhizae 5-10 part, Radix Platycodonis 10-25 part, Herba Ephedrae 10-25 part, Gypsum Fibrosum 5-15 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows: Semen Lepidii (Semen Descurainiae) 16 parts, 6 parts, Fructus Jujubae, Radix Ophiopogonis 8 parts, the Rhizoma Pinelliae 11 parts, Radix Ginseng 10 parts, 9 parts, Radix Glycyrrhizae, Radix Platycodonis 13 parts, 18 parts, Herba Ephedrae, 9 parts, Gypsum Fibrosum.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, described preparation can be powder.
Further, the preparation method of the powder of said composition is: (1) takes each Chinese medicine by formula ratio; (2) with 2-3 times of water gaging use soaking method make water blow slowly in reach medicine permeable most; (3) 40 DEG C of-70 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverizing medicinal materials of will dry, crosses 40-100 mesh sieve; (5) be distributed into bag, every bag of 100-200g, gets product.
The advantage that the present invention has and good effect are:
(1) this prescription is according to tcm theory, and scientific compatibility, has effect of drying dampness to eliminate phlegm, relieving cough and asthma, invigorating the spleen to benefit the lung, through clinical verification determined curative effect, cure rate can reach more than 95%, solves clinical treatment chicken biography and props up without specific drug, can only rely on antibiotic present situation.
(2) compared to antibiotic therapy, traditional Chinese medicine composition for treating chicken provided by the present invention passes to prop up and can also regulate body metabolism, strengthens immunocompetence, has the growth promoter promoting laying hen, improve the effects such as laying rate.
(3) pharmacology of each raw material of Chinese medicine of the present invention is:
Semen Lepidii (Semen Descurainiae): eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema;
Fructus Jujubae: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind;
Radix Ophiopogonis: nourishing YIN and moistening the lung, reinforcing stomach reg fluid, clear away heart-fire relieving restlessness;
The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass;
Radix Ginseng: strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promotes the production of body fluid, Fructus Alpiniae Oxyphyllae of calming the nerves;
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription;
Radix Platycodonis: lung qi dispersing, eliminates the phlegm, sore-throat relieving, evacuation of pus;
Herba Ephedrae: relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema;
Gypsum Fibrosum: clearing away heat-fire, relieving restlessness is quenched the thirst.
Among formula, Semen Lepidii (Semen Descurainiae) hardship is fallen pungent loose, heat clearing away cold in nature, and diseases caused by retention of fluid and phlegm-fire in special eliminating the pathogens from the lung and relievining asthma is coughed, and helps and delays its property with Fructus Jujubae.Simultaneously Fructus Jujubae can also invigorating the spleen and replenishing QI, is applicable to deficiency-weakness of spleen-QI, becomes thin, fatigue and weakness, the diseases such as loose stool.Radix Ophiopogonis sweet in the mouth is soft and moist, the inclined bitter cold of property, kind yin nourishing lung, clearing away lung-heat.Rhizoma Pinelliae acrid in the mouth is warm in nature and dry, is drying dampness to eliminate phlegm, warming for resolving cold-phlegm key medicine, and outstanding being apt to controls internal organs damp-phlegm.Radix Ginseng invigorating the spleen to benefit the lung, can improve the decline of lung-QI symptoms such as dyspnea with rapid and short breath of losing heart, and also can improve fatigue and weakness, and the deficiency of spleen-QI such as lack of appetite loose stool decline symptom.Radix Glycyrrhizae sweet in the mouth, is apt to, into middle Jiao, to have the power of invigorating the spleen and replenishing QI; And can cough-relieving, doublely to eliminate the phlegm, also slightly antiasthmatic effect; Also can coordinating the actions of various ingredients in a prescription.The pungent loose hardship of Radix Platycodonis is let out, and open lung qi dispersing gas, eliminate the phlegm promoting the circulation of QI.The pungent loose hardship of Herba Ephedrae is let out, and Wen Tongxuan is smooth, main enter lung meridian, can the closing of external-open fur, smooth to make lung qi declare, inside fall the gas of superinverse, falling normal so that multiple lung department is respectful, therefore kindly to relieving asthma, for treating key medicine of breathing with cough.Gypsum Fibrosum is pungent trembles with fear into lung meridian, and kind lung heat clearing is through excess-heat, and with Herba Ephedrae, the medicines for the treatment of cough and asthma such as Radix Glycyrrhizae, with controlling dyspnea and cough due to lung-heat, generate heat thirsty.Above-mentioned nine taste medicines share, and have effect of drying dampness to eliminate phlegm, relieving cough and asthma, invigorating the spleen to benefit the lung, have specially good effect to treatment infectious bronchitis of chicken.
Detailed description of the invention
Be further described the present invention below by specific embodiment, following examples are descriptive, are not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
Treat a Chinese powder medicine for infectious bronchitis of chicken, the parts by weight of each raw material are as follows:
Semen Lepidii (Semen Descurainiae) 25 parts, 5 parts, Fructus Jujubae, Radix Ophiopogonis 10 parts, the Rhizoma Pinelliae 5 parts, Radix Ginseng 5 parts, 10 parts, Radix Glycyrrhizae, Radix Platycodonis 15 parts, 15 parts, Herba Ephedrae, 10 parts, Gypsum Fibrosum are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) with 2 times of water gagings use soaking methods make water blow slowly in reach medicine permeable most; (3) 60 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverizing medicinal materials of will dry, crosses 60 mesh sieves; (5) be distributed into bag, 200g/ bag, obtains finished product.
Embodiment 2
Treat a Chinese powder medicine for infectious bronchitis of chicken, the parts by weight of each raw material are as follows:
Semen Lepidii (Semen Descurainiae) 16 parts, 6 parts, Fructus Jujubae, Radix Ophiopogonis 8 parts, the Rhizoma Pinelliae 11 parts, Radix Ginseng 10 parts, 9 parts, Radix Glycyrrhizae, Radix Platycodonis 13 parts, 18 parts, Herba Ephedrae, 9 parts, Gypsum Fibrosum are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) with 2 times of water gagings use soaking methods make water blow slowly in reach medicine permeable most; (3) 60 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverizing medicinal materials of will dry, crosses 60 mesh sieves; (5) be distributed into bag, 200g/ bag, obtains finished product.
Embodiment 3
Treat a Chinese powder medicine for infectious bronchitis of chicken, the parts by weight of each raw material are as follows:
Semen Lepidii (Semen Descurainiae) 10 parts, 10 parts, Fructus Jujubae, Radix Ophiopogonis 5 parts, the Rhizoma Pinelliae 12 parts, Radix Ginseng 8 parts, 6 parts, Radix Glycyrrhizae, Radix Platycodonis 16 parts, 25 parts, Herba Ephedrae, 8 parts, Gypsum Fibrosum are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) with 2 times of water gagings use soaking methods make water blow slowly in reach medicine permeable most; (3) 60 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverizing medicinal materials of will dry, crosses 60 mesh sieves; (5) be distributed into bag, 200g/ bag, obtains finished product.
Embodiment 4
Treat a Chinese powder medicine for infectious bronchitis of chicken, the parts by weight of each raw material are as follows:
Semen Lepidii (Semen Descurainiae) 20 parts, 8 parts, Fructus Jujubae, Radix Ophiopogonis 7 parts, the Rhizoma Pinelliae 6 parts, Radix Ginseng 6 parts, 8 parts, Radix Glycyrrhizae, Radix Platycodonis 25 parts, 13 parts, Herba Ephedrae, 7 parts, Gypsum Fibrosum are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) with 2 times of water gagings use soaking methods make water blow slowly in reach medicine permeable most; (3) 60 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverizing medicinal materials of will dry, crosses 60 mesh sieves; (5) be distributed into bag, 200g/ bag, obtains finished product.
Embodiment 5
Treat a Chinese powder medicine for infectious bronchitis of chicken, the parts by weight of each raw material are as follows:
Semen Lepidii (Semen Descurainiae) 12 parts, 9 parts, Fructus Jujubae, Radix Ophiopogonis 12 parts, the Rhizoma Pinelliae 15 parts, Radix Ginseng 12 parts, 5 parts, Radix Glycyrrhizae, Radix Platycodonis 10 parts, 20 parts, Herba Ephedrae, 5 parts, Gypsum Fibrosum are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) with 2 times of water gagings use soaking methods make water blow slowly in reach medicine permeable most; (3) 60 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverizing medicinal materials of will dry, crosses 60 mesh sieves; (5) be distributed into bag, 200g/ bag, obtains finished product.
Embodiment 6
Treat a Chinese powder medicine for infectious bronchitis of chicken, the parts by weight of each raw material are as follows:
Semen Lepidii (Semen Descurainiae) 18 parts, 7 parts, Fructus Jujubae, Radix Ophiopogonis 15 parts, the Rhizoma Pinelliae 10 parts, Radix Ginseng 7 parts, 7 parts, Radix Glycyrrhizae, Radix Platycodonis 20 parts, 10 parts, Herba Ephedrae, 6 parts, Gypsum Fibrosum are prepared from.Its preparation method is: (1) takes each Chinese medicine by formula ratio; (2) with 2 times of water gagings use soaking methods make water blow slowly in reach medicine permeable most; (3) 60 DEG C of blood pressure lowerings are dry until dry completely; (4) pulverizing medicinal materials of will dry, crosses 60 mesh sieves; (5) be distributed into bag, 200g/ bag, obtains finished product.
Clinical trial
Experiment 1:
Only lay eggs broiler in certain hurdle 1000 that chicken farm, Hebei province is raised, full group almost falls ill simultaneously.Sick chicken lethargy, drop-head, close one's eyes drowsiness, wing is sagging, and feather is loose unglazed, dehisces to breathe, and can hear with breathing the sound of stridulating sent when night is quiet.According to characteristics of incidence and clinical symptoms, be judged to be infectious bronchitis of chicken.Sick chicken is divided into two groups at random, and wherein one group 500 only gives the Chinese medicine obtained by embodiment 2, and spice is fed, and every bag of 200g evenly admixes in 150kg feedstuff, allows and suffers from chicken free choice feeding, one day 3 times, be used in conjunction 7 days.Another group 500 gives amoxicillin soluble powder, is used in conjunction 7 days.Within 10 days, respectively weigh in once before administration He after administration.Medication after ten days tested sick chicken spirit, appetite all recover normal, can't hear during breathing and breathe heavily toot sound, without symptoms such as cough, ramming heads, egg production rising, body weight also slightly rises to recovery from illness; The mental status of medication tested sick chicken after ten days, appetite and feces situation all take a favorable turn, but sick chicken still also exists breathing breathes heavily toot sound, or have slight cough symptom for effective; If suffer from after medication ten days of chicken, its mental status, appetite still have no and take a turn for the better, and toot the symptom such as sound and cough of breathing heavily of sick chicken has no and weakens, and the trend increased the weight of even in addition on the contrary, then it is invalid to be judged to be.Curative effect, body weight and laying rate that duration of test is respectively organized are in table 1.
Table 1 Chinese medicine and penicillin treatment chicken pass a Comparison of experiment results
From table 1, the total effective rate of Chinese drug-treated group and amoxicillin group treatment infectious bronchitis of chicken is respectively 97.2% and 96.8%, without significant difference (P > 0.05).Illustrate that Chinese medicine composition of the present invention and amoxicillin pass Zhi Jun to chicken and have good therapeutical effect.Meanwhile, before and after Chinese drug-treated group treatment, weight average increases 0.08kg, and amoxicillin group on average increases 0.02kg.And laying rate Chinese drug-treated group improves 5%, amoxicillin group have dropped 2%, and two groups have significant significant difference (P < 0.01).In sum, Chinese medicine is substantially identical with amoxicillin therapeutic effect, but amoxicillin is obvious not as good as Chinese medicine in recovery weightening finish and laying rate.Illustrate that Chinese medicine preparation not only has good therapeutical effect to chicken biography, but also body metabolism can be regulated, strengthen immunocompetence, there is the growth promoter promoting laying hen, improve effects such as laying eggs.
Experiment 2
The red assorted broiler of a collection of 39 ages in days of Zhao Qiao township of Shanxi Province Zhao, about 1500, just started indivedual chicken performance respiratory tract and had slight rale, the 3rd day there is dyspnea, cough, rhinorrhea, eyelid enlargement, arranges the symptoms such as HUANGBAI(sic) loose stool, feather pine is random, feed intake declines, chicken feet of dying of illness is dry in full group chicken.Cut open in the visible trachea-bronchial epithelial cell of inspection, nose and paranasal sinuses and have serosity, bronchus bottom has cheesy thing to block, the pale enlargement of kidney, in typical piebaldism kidney, is diagnosed as chicken biography.Satisfy the Chinese powder medicine that full group's spice is fed obtained by embodiment 2, every bag of 200g spice 150kg feedstuff, one day 3 times, is used in conjunction 7 days.Chicken group takes an evident turn for the better in the 3rd day health status of medication, and feed intake increases, and dyspnea symptom is eased, and after medication 5, clinical symptoms disappears substantially, and feed intake and amount of drinking water all recover normal, and dyspnea symptom disappears, and chicken group act normally.The treatment continuously through 7 days, chicken group return to one's perfect health.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (7)
1. one kind is used for the treatment of the Chinese medicine composition of infectious bronchitis of chicken, it is characterized in that, be prepared from by the raw material of following mass fraction: Semen Lepidii (Semen Descurainiae) 10-25 part, Fructus Jujubae 5-10 part, Radix Ophiopogonis 5-15 part, Rhizoma Pinelliae 5-15 part, Radix Ginseng 5-15 part, Radix Glycyrrhizae 5-10 part, Radix Platycodonis 10-25 part, Herba Ephedrae 10-25 part, Gypsum Fibrosum 5-15 part.
2. the Chinese medicine composition for the treatment of infectious bronchitis of chicken according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
Semen Lepidii (Semen Descurainiae) 16 parts, 6 parts, Fructus Jujubae, Radix Ophiopogonis 8 parts, the Rhizoma Pinelliae 11 parts, Radix Ginseng 10 parts, 9 parts, Radix Glycyrrhizae, Radix Platycodonis 13 parts, 18 parts, Herba Ephedrae, 9 parts, Gypsum Fibrosum.
3. the Chinese medicine composition for the treatment of infectious bronchitis of chicken according to claim 3, is characterized in that: described preparation can be powder.
4. prepare a method for the Chinese medicine composition for the treatment of infectious bronchitis of chicken as claimed in claim 3, it is characterized in that, preparation method is: (1) takes each Chinese medicine by formula ratio; (2) with 2-3 times of water gaging use soaking method make water blow slowly in reach medicine permeable most; (3) low temperature blood pressure lowering is dry until dry completely; (4) pulverizing medicinal materials of will dry, sieves; (5) be distributed into bag, get product.
5. the preparation method of the Chinese medicine composition for the treatment of infectious bronchitis of chicken according to claim 4, is characterized in that: blood pressure lowering baking temperature is 40-70 DEG C.
6. the preparation method of the Chinese medicine composition for the treatment of infectious bronchitis of chicken according to claim 4, is characterized in that: passing-screen size is 40-100 order.
7. the preparation method of the Chinese medicine composition for the treatment of infectious bronchitis of chicken according to claim 4, is characterized in that: packing specification is 100-200g/ bag.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528921A (en) * | 2017-09-21 | 2019-03-29 | 扬中牧乐药业有限公司 | A kind of oral solution for treating infectious bronchitis of chicken |
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| CN1128148A (en) * | 1993-11-29 | 1996-08-07 | 诸城市家禽研究所 | Jichuankang-medicine for asthma of chicken |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109528921A (en) * | 2017-09-21 | 2019-03-29 | 扬中牧乐药业有限公司 | A kind of oral solution for treating infectious bronchitis of chicken |
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