CN104208069A - 双炔失碳酯组合物和疾病治疗方法 - Google Patents

双炔失碳酯组合物和疾病治疗方法 Download PDF

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Publication number
CN104208069A
CN104208069A CN201410192569.2A CN201410192569A CN104208069A CN 104208069 A CN104208069 A CN 104208069A CN 201410192569 A CN201410192569 A CN 201410192569A CN 104208069 A CN104208069 A CN 104208069A
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China
Prior art keywords
anordrin
certain embodiments
alkyl
agent
alkenyl
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Pending
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CN201410192569.2A
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English (en)
Chinese (zh)
Inventor
杨军
施惠娟
徐文平
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Shanghai Institute of Planned Parenthood Research
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Shanghai Institute of Planned Parenthood Research
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Application filed by Shanghai Institute of Planned Parenthood Research filed Critical Shanghai Institute of Planned Parenthood Research
Priority to CN201410192569.2A priority Critical patent/CN104208069A/zh
Priority to CN202010899146.XA priority patent/CN111956653B/zh
Priority to CN202110246492.2A priority patent/CN113101292B/zh
Publication of CN104208069A publication Critical patent/CN104208069A/zh
Priority to US15/309,426 priority patent/US10231978B2/en
Priority to EP15788674.8A priority patent/EP3139928B1/en
Priority to JP2016566286A priority patent/JP6594339B2/ja
Priority to PCT/CN2015/077942 priority patent/WO2015169173A1/en
Priority to US16/262,617 priority patent/US10857158B2/en
Priority to JP2019089931A priority patent/JP2019142969A/ja
Priority to US16/953,168 priority patent/US11911397B2/en
Priority to JP2020219768A priority patent/JP7084467B2/ja
Priority to JP2022042432A priority patent/JP2022078330A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201410192569.2A 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法 Pending CN104208069A (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN201410192569.2A CN104208069A (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法
CN202010899146.XA CN111956653B (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法
CN202110246492.2A CN113101292B (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法
PCT/CN2015/077942 WO2015169173A1 (en) 2014-05-08 2015-04-30 Anordrin compositions and methods for treating diseases
EP15788674.8A EP3139928B1 (en) 2014-05-08 2015-04-30 Anordrin compositions and methods for treating diseases
US15/309,426 US10231978B2 (en) 2014-05-08 2015-04-30 Anordrin compositions and methods for treating diseases
JP2016566286A JP6594339B2 (ja) 2014-05-08 2015-04-30 アノルドリン組成物および疾患を処置するための方法
US16/262,617 US10857158B2 (en) 2014-05-08 2019-01-30 Anordrin compositions and methods for treating diseases
JP2019089931A JP2019142969A (ja) 2014-05-08 2019-05-10 アノルドリン組成物および疾患を処置するための方法
US16/953,168 US11911397B2 (en) 2014-05-08 2020-11-19 Anordrin compositions and methods for treating diseases
JP2020219768A JP7084467B2 (ja) 2014-05-08 2020-12-29 アノルドリン組成物および疾患を処置するための方法
JP2022042432A JP2022078330A (ja) 2014-05-08 2022-03-17 アノルドリン組成物および疾患を処置するための方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410192569.2A CN104208069A (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法

Related Child Applications (2)

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CN202010899146.XA Division CN111956653B (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法
CN202110246492.2A Division CN113101292B (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法

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CN201410192569.2A Pending CN104208069A (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法
CN202110246492.2A Active CN113101292B (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法
CN202010899146.XA Active CN111956653B (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法

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CN202110246492.2A Active CN113101292B (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法
CN202010899146.XA Active CN111956653B (zh) 2014-05-08 2014-05-08 双炔失碳酯组合物和疾病治疗方法

Country Status (5)

Country Link
US (3) US10231978B2 (cg-RX-API-DMAC7.html)
EP (1) EP3139928B1 (cg-RX-API-DMAC7.html)
JP (4) JP6594339B2 (cg-RX-API-DMAC7.html)
CN (3) CN104208069A (cg-RX-API-DMAC7.html)
WO (1) WO2015169173A1 (cg-RX-API-DMAC7.html)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015169173A1 (en) * 2014-05-08 2015-11-12 Shanghai Institute Of Planned Parenthood Research Anordrin compositions and methods for treating diseases
CN105279394A (zh) * 2015-10-13 2016-01-27 山西农业大学 用于神经肽受体筛选的方法
WO2019041078A1 (en) * 2017-08-28 2019-03-07 Zhejiang Jiachi Pharmaceutical Development Ltd. ASYMMETRIC SYNTHESIS AND USES OF COMPOUNDS IN TREATMENT OF DISEASES
WO2019072014A1 (zh) * 2017-10-13 2019-04-18 上海奥奇医药科技有限公司 含A-失碳-5α雄甾烷化合物的升白制剂及其应用
CN117425478A (zh) * 2021-05-25 2024-01-19 浙江嘉驰医药开发有限公司 治疗失眠的组合物及其应用

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JP6788255B2 (ja) * 2015-11-19 2020-11-25 国立大学法人信州大学 新規ベクター及びこれを用いた可溶化タンパク質の製造方法
CN110099680B (zh) 2016-10-11 2021-02-05 杜克大学 Er+乳腺癌的拉索昔芬治疗
WO2018090049A1 (en) * 2016-11-14 2018-05-17 The Brigham And Women's Hospital, Inc. Estrogen sensing through gper1 regulates normal and malignant liver growth
CN115844877B (zh) 2017-01-10 2024-07-23 浙江嘉驰医药开发有限公司 拉索昔芬调节膜结合雌激素信号的应用及治疗癌症的方法
CN117771239A (zh) 2018-04-10 2024-03-29 杜克大学 乳腺癌的拉索昔芬治疗
CN111773388B (zh) * 2019-04-04 2023-07-18 上海奥奇医药科技有限公司 A-失碳-5α雄甾烷化合物类药物与抗癌药物的联合应用
US20210299098A1 (en) * 2020-03-31 2021-09-30 Cipla Limited Selective estrogen receptor modulator for treatment of pancreatic cancer
GB202116903D0 (en) 2021-11-18 2022-01-05 Sermonix Pharmaceuticals Inc Lasofoxifene treatment of aromatase-resistant er+ cancer

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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015169173A1 (en) * 2014-05-08 2015-11-12 Shanghai Institute Of Planned Parenthood Research Anordrin compositions and methods for treating diseases
US11911397B2 (en) 2014-05-08 2024-02-27 Zhejiang Jiachi Development Pharmaceuticals Ltd Anordrin compositions and methods for treating diseases
US10857158B2 (en) 2014-05-08 2020-12-08 Zhejiang Jiachi Development Pharmaceuticals Ltd Anordrin compositions and methods for treating diseases
US10231978B2 (en) 2014-05-08 2019-03-19 Shanghai Institute Of Planned Parenthood Research Anordrin compositions and methods for treating diseases
CN105279394A (zh) * 2015-10-13 2016-01-27 山西农业大学 用于神经肽受体筛选的方法
CN105279394B (zh) * 2015-10-13 2017-12-26 山西农业大学 用于神经肽受体筛选的方法
CN111050771A (zh) * 2017-08-28 2020-04-21 浙江嘉驰医药开发有限公司 不对称合成及化合物在疾病治疗中的应用
WO2019042192A1 (en) * 2017-08-28 2019-03-07 Zhejiang Jiachi Pharmaceutical Development Ltd. ASYMMETRIC SYNTHESIS AND USES OF COMPOUNDS IN TREATMENT OF DISEASES
CN111050771B (zh) * 2017-08-28 2023-08-01 浙江嘉驰医药开发有限公司 不对称合成及化合物在疾病治疗中的应用
CN117281816A (zh) * 2017-08-28 2023-12-26 浙江嘉驰医药开发有限公司 不对称合成及化合物在疾病治疗中的应用
WO2019041078A1 (en) * 2017-08-28 2019-03-07 Zhejiang Jiachi Pharmaceutical Development Ltd. ASYMMETRIC SYNTHESIS AND USES OF COMPOUNDS IN TREATMENT OF DISEASES
US12403115B2 (en) 2017-08-28 2025-09-02 Zhejiang Jiachi Development Pharmaceuticals Ltd Asymmetric synthesis and uses of compounds in disease treatments
CN109662968A (zh) * 2017-10-13 2019-04-23 上海奥奇医药科技有限公司 含A-失碳-5α雄甾烷化合物的升白制剂及其应用
WO2019072014A1 (zh) * 2017-10-13 2019-04-18 上海奥奇医药科技有限公司 含A-失碳-5α雄甾烷化合物的升白制剂及其应用
CN109662968B (zh) * 2017-10-13 2021-05-18 上海奥奇医药科技有限公司 含A-失碳-5α雄甾烷化合物的升白制剂及其应用
AU2018348892B2 (en) * 2017-10-13 2022-01-27 Shanghai Ao Qi Medical Technology Co., Ltd. Formulation containing A-decarbonized-5a androstane compound for increasing white blood cell and use thereof
CN117425478A (zh) * 2021-05-25 2024-01-19 浙江嘉驰医药开发有限公司 治疗失眠的组合物及其应用

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EP3139928C0 (en) 2025-03-05
JP2017514853A (ja) 2017-06-08
JP2021050241A (ja) 2021-04-01
US20170151263A1 (en) 2017-06-01
US10857158B2 (en) 2020-12-08
US20210069212A1 (en) 2021-03-11
US20190262360A1 (en) 2019-08-29
JP7084467B2 (ja) 2022-06-14
CN113101292B (zh) 2023-07-11
CN113101292A (zh) 2021-07-13
JP2019142969A (ja) 2019-08-29
EP3139928A1 (en) 2017-03-15
CN111956653A (zh) 2020-11-20
WO2015169173A1 (en) 2015-11-12
JP6594339B2 (ja) 2019-10-23
US11911397B2 (en) 2024-02-27
EP3139928B1 (en) 2025-03-05
CN111956653B (zh) 2023-06-30
US10231978B2 (en) 2019-03-19
JP2022078330A (ja) 2022-05-24
EP3139928A4 (en) 2017-12-13

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Application publication date: 20141217