CN104203903B - 缬氨酸的连续分离装置和用其连续分离缬氨酸的方法 - Google Patents

缬氨酸的连续分离装置和用其连续分离缬氨酸的方法 Download PDF

Info

Publication number
CN104203903B
CN104203903B CN201380016046.6A CN201380016046A CN104203903B CN 104203903 B CN104203903 B CN 104203903B CN 201380016046 A CN201380016046 A CN 201380016046A CN 104203903 B CN104203903 B CN 104203903B
Authority
CN
China
Prior art keywords
valine
port
separated
rotary valve
rotary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380016046.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN104203903A (zh
Inventor
李钟昊
姜升勋
俞裁宪
金庾赆
文星蓉
南熙根
朴赞勋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry University Cooperation Foundation IUCF HYU
CJ CheilJedang Corp
Original Assignee
Industry University Cooperation Foundation IUCF HYU
CJ CheilJedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry University Cooperation Foundation IUCF HYU, CJ CheilJedang Corp filed Critical Industry University Cooperation Foundation IUCF HYU
Publication of CN104203903A publication Critical patent/CN104203903A/zh
Application granted granted Critical
Publication of CN104203903B publication Critical patent/CN104203903B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterised by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1842—Simulated moving beds characterised by apparatus features
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/12—Purification; Separation; Use of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201380016046.6A 2012-02-06 2013-02-06 缬氨酸的连续分离装置和用其连续分离缬氨酸的方法 Active CN104203903B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261595527P 2012-02-06 2012-02-06
US61/595,527 2012-02-06
KR1020120125739A KR101449808B1 (ko) 2012-02-06 2012-11-07 발린의 연속적 분리를 위한 장치 및 이를 이용한 발린의 연속적 분리 방법
KR10-2012-0125739 2012-11-07
PCT/KR2013/000945 WO2013119034A1 (en) 2012-02-06 2013-02-06 An apparatus for continuous separation of valine and a method for continuous separation of valine using the same

Publications (2)

Publication Number Publication Date
CN104203903A CN104203903A (zh) 2014-12-10
CN104203903B true CN104203903B (zh) 2016-09-28

Family

ID=49216262

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380016046.6A Active CN104203903B (zh) 2012-02-06 2013-02-06 缬氨酸的连续分离装置和用其连续分离缬氨酸的方法

Country Status (11)

Country Link
US (1) US20130204040A1 (enExample)
EP (1) EP2812309B1 (enExample)
JP (2) JP2015506958A (enExample)
KR (1) KR101449808B1 (enExample)
CN (1) CN104203903B (enExample)
BR (1) BR112014019488B1 (enExample)
ES (1) ES2882617T3 (enExample)
HU (1) HUE055656T2 (enExample)
IN (1) IN2014MN01764A (enExample)
MY (1) MY171770A (enExample)
WO (1) WO2013119034A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104744277B (zh) * 2015-02-12 2017-02-01 新疆阜丰生物科技有限公司 一种利用模拟移动床及流化床提取三支链氨基酸的方法
KR101979608B1 (ko) * 2017-04-17 2019-08-28 재단법인 탄소순환형 차세대 바이오매스 생산전환 기술연구단 푸코오스 분리방법 및 이를 위한 장치
CN112680315A (zh) * 2020-12-28 2021-04-20 江苏澳创生物科技有限公司 一种支链氨基酸共线生产系统的使用方法
KR102694723B1 (ko) * 2022-05-26 2024-08-12 경상국립대학교산학협력단 Smb 공정을 이용한 고순도 및 고효율의 베타-망고스틴 분리방법 및 이의 용도
CN116813492B (zh) * 2023-06-29 2024-01-23 山东兆光色谱分离技术有限公司 色谱分离缬氨酸的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1106602A1 (en) * 1999-12-09 2001-06-13 Archer-Daniels-Midland Company Simulated moving bed chromatographic purification of amino acids
CN1806882A (zh) * 2005-12-26 2006-07-26 卢建刚 采用双开环结构降低操作压力的模拟移动床色谱装置
CN101168512A (zh) * 2007-11-30 2008-04-30 江南大学 一种从缬氨酸液中分离提纯缬氨酸的方法
US20080149565A1 (en) * 2005-12-26 2008-06-26 Samsung Total Petrochemicals, Co. Ltd. Simultated moving bed adsorptive separation process using a plurality of adsorption chambers in parallel and crystallizer and device used therein
CN101732890A (zh) * 2009-12-08 2010-06-16 辽宁科技大学 三带模拟移动床色谱装置
CN101948399A (zh) * 2010-10-11 2011-01-19 江南大学 一种使用模拟移动床色谱连续分离纯化发酵液中缬氨酸的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2962558D1 (en) 1979-07-19 1982-06-03 Maggi Ag Process for the separation of leucine, isoleucine and valine
JPH0617344B2 (ja) 1986-04-28 1994-03-09 味の素株式会社 バリンの分離精製法
US5795398A (en) * 1994-09-30 1998-08-18 Cultor Ltd. Fractionation method of sucrose-containing solutions
JP3694921B2 (ja) 1995-06-12 2005-09-14 味の素株式会社 バリンの精製法
JPH10237030A (ja) 1997-02-26 1998-09-08 Ajinomoto Co Inc 分岐鎖アミノ酸の精製法
US20060273013A1 (en) * 2004-03-01 2006-12-07 Chin Nien-Hwa L Versatile simulated moving bed systems
DE102005026486A1 (de) * 2005-06-09 2006-12-14 Bayer Technology Services Gmbh Ein chromatographisches quasi-kontinuierliches Verfahren und entsprechende Vorrichtung zur Trennung von binären und Mehrstoffgemischen
KR101226844B1 (ko) * 2010-07-23 2013-01-25 연세대학교 산학협력단 혼합물 분리향상을 위한 유사 이동층 흡착 분리 장치에서의 부분 버림 재사용 공정 운전 방법
CN101961565B (zh) * 2010-09-21 2012-09-26 浙江大学宁波理工学院 用模拟移动床色谱分离三组分混合物的方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1106602A1 (en) * 1999-12-09 2001-06-13 Archer-Daniels-Midland Company Simulated moving bed chromatographic purification of amino acids
CN1806882A (zh) * 2005-12-26 2006-07-26 卢建刚 采用双开环结构降低操作压力的模拟移动床色谱装置
US20080149565A1 (en) * 2005-12-26 2008-06-26 Samsung Total Petrochemicals, Co. Ltd. Simultated moving bed adsorptive separation process using a plurality of adsorption chambers in parallel and crystallizer and device used therein
CN101168512A (zh) * 2007-11-30 2008-04-30 江南大学 一种从缬氨酸液中分离提纯缬氨酸的方法
CN101732890A (zh) * 2009-12-08 2010-06-16 辽宁科技大学 三带模拟移动床色谱装置
CN101948399A (zh) * 2010-10-11 2011-01-19 江南大学 一种使用模拟移动床色谱连续分离纯化发酵液中缬氨酸的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Strategy of rearranging the port locations in a three-zone simulated moving bed chromatography for binary separation with linear isotherms;Sungyong Mun;《Journal of Chromatography A》;20120204;第1230卷;100-109 *

Also Published As

Publication number Publication date
CN104203903A (zh) 2014-12-10
BR112014019488A2 (pt) 2020-10-27
WO2013119034A1 (en) 2013-08-15
US20130204040A1 (en) 2013-08-08
KR101449808B1 (ko) 2014-10-14
HUE055656T2 (hu) 2021-12-28
BR112014019488B1 (pt) 2021-08-10
ES2882617T3 (es) 2021-12-02
JP2018024679A (ja) 2018-02-15
EP2812309B1 (en) 2021-05-26
EP2812309A1 (en) 2014-12-17
IN2014MN01764A (enExample) 2015-07-03
KR20130090738A (ko) 2013-08-14
JP2015506958A (ja) 2015-03-05
EP2812309A4 (en) 2015-09-09
MY171770A (en) 2019-10-29

Similar Documents

Publication Publication Date Title
CN104203903B (zh) 缬氨酸的连续分离装置和用其连续分离缬氨酸的方法
Xie et al. Separation of FTC-ester enantiomers using a simulated moving bed
US20170322190A1 (en) Method and System for Determining the Influence of Experimental Parameters on a Liquid Chromatography Protocol
US6802969B2 (en) Preparative chromatography system and separation/purification method using same
US6551512B1 (en) Continuous method for separating substances according to molecular size
JPH06511084A (ja) 蛋白のクロマトグラフィーシステム
JPH09206502A (ja) 擬似移動床式分離装置
JP5023235B2 (ja) ２以上の多成分の混合体を分離するための準連続的クロマトグラフの方法と対応する装置
Van Duc Long et al. Separation of d‐psicose and d‐fructose using simulated moving bed chromatography
Xie et al. Design of SMB for a nonlinear amino acid system with mass‐transfer effects
Marek et al. Separation of nonracemic mixtures of enantiomers by achiral simulated moving bed chromatography
Giacobello et al. Design of a simulated moving bed unit for sucrose–betaine separations
CN101679190A (zh) 使用弱碱性或强碱性阴离子交换树脂吸附剂从发酵液中的葡萄糖酸中分离柠檬酸
JP2011214837A (ja) 液体クロマトグラフィー装置
CN111542379B (zh) 通过检测中间罐中的纯度或收率分离混合物的方法
CN111629802B (zh) 分离混合物的调节方法
US10717023B1 (en) Method for continuous purification
Lee et al. The first attempt at continuous-mode separation of racemic and meso-2, 3-butanediol with high purities using a simulated-moving-bed process
Majors Advanced topics in solid-phase extraction: chemistries
CN111565812B (zh) 用在线检测器检测纯度或收率的分离混合物的方法
Van Duc Long et al. Solvent-gradient SMB to separate o-xylene and p-xylene
Jo et al. Optimal design and experimental validation of a modified four-zone SMB process for the separation of a ternary amino acid mixture
US20250179466A1 (en) Chromatographic purification method and uses thereof
JPS6396552A (ja) 生体高分子の工業的分離法、その方法に使用する装置
Lee et al. Optimized design of recycle chromatography for separation of a single component from a ternary mixture

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant