CN104176690B - A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line - Google Patents
A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line Download PDFInfo
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- CN104176690B CN104176690B CN201410357934.0A CN201410357934A CN104176690B CN 104176690 B CN104176690 B CN 104176690B CN 201410357934 A CN201410357934 A CN 201410357934A CN 104176690 B CN104176690 B CN 104176690B
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Abstract
The invention discloses a kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line. Online freeze-drying system based on multiple stage freeze dryer, including multiple stage freeze dryer, described freeze dryer bottle inlet mouth, bottle outlet are positioned at the same side and upper and lower layered arrangement, described bottle inlet mouth is equipped with bottle inlet push rod, described bottle outlet is equipped with bottle outlet push rod, described each bottle inlet mouth is connected to same bottle inlet conveyer belt by bottle inlet bridge plate mechanism, and described each bottle outlet is connected to same bottle outlet conveyer belt by bottle outlet bridge plate mechanism. Lyophilized formulations production line includes filling and stopper-adding system and rolls convering system, described filling and stopper-adding system and roll and be provided with the above-mentioned on line freeze-drying system based on multiple stage freeze dryer between convering system. The advantage that the present invention has simple in construction, production efficiency is high.
Description
Technical field
The invention mainly relates to food, medical packaging mechanical field, refer in particular to the on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line.
Background technology
In order to improve the automaticity of freeze dryer, existing freeze dryer is substantially all and is equipped with bottle inlet push rod and bottle outlet push rod, bottle inlet push rod is for pushing the flaggy in freeze dryer by row by the cillin bottle equipped with medicine that tape transport comes, and bottle outlet push rod is for being pushed out to conveyer belt by the cillin bottle completing lyophilizing by row from the flaggy in freeze dryer. in order to improve the yield of freeze-drying system, current state-of-the-art scheme is by online for multiple stage freeze dryer use, namely multiple stage freeze dryer completes turnover bottle operation with a conveyer belt in turn, this freeze-drying system can significantly improve the yield of freeze-drying system really, but still suffer from following defect: owing to only one is used for conveyer belt in bottle inlet with bottle outlet, therefore can not realize allowing another freeze dryer bottle outlet while a freeze dryer bottle inlet, can not realize allowing another freeze dryer bottle inlet while a freeze dryer bottle outlet, this necessarily causes that the vacant waiting time of freeze dryer is longer, make the freeze dryer in freeze-drying system cannot give full play to its output efficiency.
Summary of the invention
The technical problem to be solved in the present invention is in that: the deficiency existed for prior art, it is provided that the on line freeze-drying system based on multiple stage freeze dryer that a kind of simple in construction, production efficiency are high and lyophilized formulations production line.
For solving above-mentioned technical problem, the present invention by the following technical solutions:
A kind of online freeze-drying system based on multiple stage freeze dryer, including multiple stage freeze dryer, described freeze dryer bottle inlet mouth, bottle outlet are positioned at the same side and upper and lower layered arrangement, described bottle inlet mouth is equipped with bottle inlet push rod, described bottle outlet is equipped with bottle outlet push rod, described each bottle inlet mouth is connected to same bottle inlet conveyer belt by bottle inlet bridge plate mechanism, and described each bottle outlet is connected to same bottle outlet conveyer belt by bottle outlet bridge plate mechanism.
Further improvement as technique scheme:
It is covered with shared laminar flow hood above described bottle inlet conveyer belt and bottle outlet conveyer belt.
Described freeze dryer includes freeze drying box and cold-trap, and the bottle inlet mouth of described freeze dryer, bottle outlet are located at the freeze drying box side near bottle inlet conveyer belt and bottle outlet conveyer belt, and described cold-trap is located at the freeze drying box side away from bottle inlet conveyer belt and bottle outlet conveyer belt.
Described bottle inlet conveyer belt and bottle inlet bridge plate mechanism are positioned at upper strata, and described bottle outlet conveyer belt and bottle outlet bridge plate mechanism are positioned at lower floor.
Described bottle inlet bridge plate mechanism includes bottle inlet bridge plate and controls the bottle inlet transition apparatus of bottle inlet bridge plate and bottle inlet conveyer belt clutch, and described bottle inlet transition apparatus is located between bottle inlet bridge plate and bottle inlet conveyer belt.
The bottle inlet bridge plate guide rail being connected with the flexible sliding of confession bottle inlet bridge plate of described bottle inlet bridge plate.
Described bottle inlet transition apparatus includes bottle inlet stationary platen, bottle inlet movable mold and bottle inlet movable mold actuator, described bottle inlet stationary platen side is connected with bottle inlet conveyer belt, described bottle inlet movable mold is located between bottle inlet stationary platen opposite side and bottle inlet bridge plate, described freeze dryer is under bottle inlet state, bottle inlet movable mold actuator drives bottle inlet movable mold to connect bottle inlet stationary platen and bottle inlet bridge plate, described freeze dryer is under non-bottle inlet state, and described bottle inlet movable mold actuator drives bottle inlet movable mold to depart from bottle inlet bridge plate.
Described bottle inlet stationary platen two ends are provided with the first guide plate, described first guide plate offers bottle inlet movable mold chute and bottle inlet movable mold actuator chute, described bottle inlet movable mold two ends are provided with the guide pad being slidedly arranged in bottle inlet movable mold chute, described bottle inlet movable mold actuator is provided with two pieces and is telescopic drive part, two pieces bottle inlet movable mold actuator is divided into bottle inlet movable mold two ends, each bottle inlet movable mold actuator one end is hinged with frame, the other end is hinged with the end of bottle inlet movable mold and is slidedly arranged in bottle inlet movable mold actuator chute.
Described bottle outlet bridge plate mechanism includes bottle outlet bridge plate and controls the bottle outlet transition apparatus of bottle outlet bridge plate and bottle outlet conveyer belt clutch, and described bottle outlet transition apparatus is located between bottle outlet bridge plate and bottle outlet conveyer belt.
The bottle outlet bridge plate guide rail being connected with the flexible sliding of confession bottle outlet bridge plate of described bottle outlet bridge plate.
Described bottle outlet transition apparatus includes bottle outlet stationary platen, bottle outlet movable mold and bottle outlet movable mold actuator, described bottle outlet stationary platen side is connected with bottle outlet conveyer belt, described bottle outlet movable mold is located between bottle outlet stationary platen opposite side and bottle outlet bridge plate, described freeze dryer is under bottle outlet state, bottle outlet movable mold actuator drives bottle outlet movable mold to connect bottle outlet stationary platen and bottle outlet bridge plate, described freeze dryer is under non-bottle outlet state, and described bottle outlet movable mold actuator drives bottle outlet movable mold to depart from bottle outlet bridge plate.
Described bottle outlet stationary platen two ends are provided with the second guide plate, described second guide plate offers bottle outlet movable mold chute and bottle outlet movable mold actuator chute, described bottle outlet movable mold two ends are provided with the guide pad being slidedly arranged in bottle outlet movable mold chute, described bottle outlet movable mold actuator is provided with two pieces and is telescopic drive part, two pieces bottle outlet movable mold actuator is divided into bottle outlet movable mold two ends, each bottle outlet movable mold actuator one end is hinged with frame, the other end is hinged with the end of bottle outlet movable mold and is slidedly arranged in bottle outlet movable mold actuator chute.
Described multiple stage freeze dryer is linearly arranged, and described freeze dryer bottle inlet mouth, bottle outlet are towards side.
A kind of lyophilized formulations production line, including filling and stopper-adding system with roll convering system, described filling and stopper-adding system and roll and be provided with the above-mentioned on line freeze-drying system based on multiple stage freeze dryer between convering system.
Compared with prior art, it is an advantage of the current invention that:
The on line freeze-drying system based on multiple stage freeze dryer of the present invention, bottle inlet conveyer belt and the upper and lower layered arrangement of bottle outlet conveyer belt, when bottle inlet conveyer belt is coordinating a freeze dryer bottle inlet, bottle outlet conveyer belt can coordinate another freeze dryer bottle outlet, when bottle outlet conveyer belt is coordinating a freeze dryer bottle outlet, bottle inlet conveyer belt can also coordinate another freeze dryer bottle inlet, the vacant waiting time of freeze dryer will be greatly shortened, each freeze dryer is enable to give full play to its output efficiency, thus being greatly improved the production efficiency of freeze-drying system.Further, owing to the bottle inlet conveyer belt of the present invention and bottle outlet conveyer belt are arranged on the same side of multiple stage freeze dryer, above bottle inlet conveyer belt and bottle outlet conveyer belt, shared laminar flow hood can be set, more laminar flow hood need not be set when adding a conveyer belt, such that it is able to be greatly saved equipment cost. Further, the cold-trap of freeze dryer and the both sides being divided into freeze drying box into and out of bottle conveyer belt, freeze-drying system can be reduced and send taking up room on bottle direction at conveyer belt, reduce the occupation of land demand of this freeze-drying system. The lyophilized formulations production line of the present invention, owing to being provided with the above-mentioned on line freeze-drying system based on multiple stage freeze dryer, therefore also possesses corresponding technique effect.
Accompanying drawing explanation
Fig. 1 is the plan structure schematic diagram of freeze-drying system of the present invention.
Fig. 2 is the main TV structure schematic diagram of freeze-drying system of the present invention non-turnover ampuliform state.
Fig. 3 is the main TV structure schematic diagram of freeze-drying system bottle inlet state of the present invention.
Fig. 4 is the main TV structure schematic diagram of freeze-drying system bottle outlet state of the present invention.
Fig. 5 is the enlarged drawing at bottle inlet transition apparatus and bottle outlet transition apparatus place in freeze-drying system of the present invention.
Fig. 6 is the plan structure schematic diagram of lyophilized formulations production line of the present invention.
Marginal data:
1, freeze dryer; 100, filling and stopper-adding system; 11, bottle inlet push rod; 12, bottle outlet push rod; 13, freeze drying box; 14, cold-trap; 2, bottle inlet bridge plate mechanism; 200, convering system is rolled; 21, bottle inlet bridge plate; 211, bottle inlet bridge plate guide rail; 22, bottle inlet transition apparatus; 221, bottle inlet stationary platen; 222, bottle inlet movable mold; 223, bottle inlet movable mold actuator; 224, the first guide plate; 225, bottle inlet movable mold chute; 226, bottle inlet movable mold actuator chute; 3, bottle inlet conveyer belt; 4, bottle outlet bridge plate mechanism; 41, bottle outlet bridge plate; 411, bottle outlet bridge plate guide rail; 42, bottle outlet transition apparatus; 421, bottle outlet stationary platen; 422, bottle outlet movable mold; 423, bottle outlet movable mold actuator; 424, the second guide plate; 425, bottle outlet movable mold chute; 426, bottle outlet movable mold actuator chute; 5, bottle outlet conveyer belt; 6, laminar flow hood.
Detailed description of the invention
Fig. 1 to Fig. 5 illustrates the embodiment of a kind of on line freeze-drying system based on multiple stage freeze dryer of the present invention, including multiple stage freeze dryer 1, freeze dryer 1 bottle inlet mouth, bottle outlet are positioned at the same side and upper and lower layered arrangement, bottle inlet mouth is equipped with bottle inlet push rod 11, bottle outlet is equipped with bottle outlet push rod 12, each bottle inlet mouth is connected to same bottle inlet conveyer belt 3 by bottle inlet bridge plate mechanism 2, and each bottle outlet is connected to same bottle outlet conveyer belt 5 by bottle outlet bridge plate mechanism 4. the on line freeze-drying system based on multiple stage freeze dryer of the present invention, freeze dryer 1 bottle inlet mouth, bottle outlet is positioned at the same side and upper and lower layered arrangement, each bottle inlet mouth is connected to same bottle inlet conveyer belt 3 by bottle inlet bridge plate mechanism 2, each bottle outlet is connected to same bottle outlet conveyer belt 5 by bottle outlet bridge plate mechanism 4, when bottle inlet conveyer belt 3 is coordinating freeze dryer 1 bottle inlet, bottle outlet conveyer belt 5 can coordinate another freeze dryer 1 bottle outlet, when bottle outlet conveyer belt 5 is coordinating freeze dryer 1 bottle outlet, bottle inlet conveyer belt 3 can also coordinate another freeze dryer 1 bottle inlet, the vacant waiting time of each freeze dryer 1 will be greatly shortened, make each freeze dryer 1 can give full play to its output efficiency, thus being greatly improved the production efficiency of freeze-drying system.
In the present embodiment, bottle inlet conveyer belt 3 and be covered with shared laminar flow hood 6 above bottle outlet conveyer belt 5, more laminar flow hood 6 need not be set when adding a conveyer belt, such that it is able to be greatly saved equipment cost.
In the present embodiment, freeze dryer 1 includes freeze drying box 13 and cold-trap 14, the bottle inlet mouth of freeze dryer 1, bottle outlet are located at the freeze drying box 13 side near bottle inlet conveyer belt 3 and bottle outlet conveyer belt 5, cold-trap 14 is located at the freeze drying box 13 side away from bottle inlet conveyer belt 3 and bottle outlet conveyer belt 5, by the cold-trap 14 of freeze dryer 1 and the both sides being divided into freeze drying box 13 into and out of bottle conveyer belt, freeze-drying system can be reduced and send taking up room on bottle direction at conveyer belt, reduce the occupation of land demand of this freeze-drying system.
In the present embodiment, bottle inlet conveyer belt 3 and bottle inlet bridge plate mechanism 2 are positioned at upper strata, and bottle outlet conveyer belt 5 and bottle outlet bridge plate mechanism 4 are positioned at lower floor, and the bottle desirably preventing half tamponade state is contaminated.
In the present embodiment, multiple stage freeze dryer 1 is linearly arranged, the bottle inlet mouth of multiple stage freeze dryer 1, bottle outlet are towards side, and the bottle inlet conveyer belt 3 of the present embodiment and bottle outlet conveyer belt 5 are arranged on the same side of multiple stage freeze dryer 1, can reduce the occupation of land demand of this freeze-drying system further. In other embodiments, when multiple stage freeze dryer 1 is linearly arranged, it is possible to multiple stage freeze dryer 1 is divided into bottle inlet conveyer belt 3 and the both sides of bottle outlet conveyer belt 5.
In the present embodiment, bottle inlet bridge plate mechanism 2 includes bottle inlet bridge plate 21 and controls the bottle inlet transition apparatus 22 of bottle inlet bridge plate 21 and bottle inlet conveyer belt 3 clutch, bottle inlet transition apparatus 22 is located between bottle inlet bridge plate 21 and bottle inlet conveyer belt 3, being connected with of bottle inlet bridge plate 21 is stretched the bottle inlet bridge plate guide rail 211 of sliding for bottle inlet bridge plate 21, is moved easily and position adjustment.
In the present embodiment, bottle inlet transition apparatus 22 includes bottle inlet stationary platen 221, bottle inlet movable mold 222 and bottle inlet movable mold actuator 223, bottle inlet stationary platen 221 side is connected with bottle inlet conveyer belt 3, bottle inlet movable mold 222 is located between bottle inlet stationary platen 221 opposite side and bottle inlet bridge plate 21, freeze dryer 1 is under bottle inlet state, bottle inlet movable mold actuator 223 drives bottle inlet movable mold 222 to connect bottle inlet stationary platen 221 and bottle inlet bridge plate 21, freeze dryer 1 is under non-bottle inlet state, bottle inlet movable mold actuator 223 drives bottle inlet movable mold 222 to depart from bottle inlet bridge plate 21. bottle inlet stationary platen 221 two ends are provided with the first guide plate 224, first guide plate 224 offers bottle inlet movable mold chute 225 and bottle inlet movable mold actuator chute 226, bottle inlet movable mold 222 two ends are provided with the guide pad being slidedly arranged in bottle inlet movable mold chute 225, bottle inlet movable mold actuator 223 is provided with two pieces and is telescopic drive part, two pieces bottle inlet movable mold actuator 223 is divided into bottle inlet movable mold 222 two ends, each bottle inlet movable mold actuator 223 one end is hinged with frame, the other end is hinged with the end of bottle inlet movable mold 222 and is slidedly arranged in bottle inlet movable mold actuator chute 226, bottle inlet movable mold actuator 223 is cylinder, can be electricity push rod in other embodiments, the telescopic drive parts such as hydraulic push rod.
Bottle inlet transition apparatus 22 work process:
The cylinder that bottle inlet movable mold actuator 223 is stretched out by bottle inlet movable mold 222 two ends promotes the former bottle inlet movable mold 222 being placed in bottle inlet stationary platen 221 bottom to freeze dryer 1 bottle inlet mouth, bottle outlet direction is moved, bottle inlet movable mold 222 is subject to the constraint of bottle inlet stationary platen 221 both sides the first guide plate 224 in reach simultaneously, can only along the bottle inlet movable mold chute 225 of the first guide plate 224 and bottle inlet movable mold actuator chute 226 direction action, several hook bar it is provided with bottom bottle inlet movable mold 222, top it is positioned over freeze dryer 1 bottle inlet mouth when bottle inlet movable mold 222 moves forward, during bottle inlet bridge plate 21 in bottle outlet, the slotted eye that bottle bridge plate 21 lower front end stretches out lived in by hook hook strips bottom bottle inlet movable mold 222, now, bottle inlet movable mold 222 promotes bottle inlet bridge plate 21 to continue reach, stop mobile when bottle inlet bridge plate 21 top freeze-drying plate layer, wait that medicine bottle passes through from plate face,It is placed in bottle inlet conveyer belt 3 other bottle inlet push rod 11 and the medicine bottle above bottle inlet conveyer belt 3 is released on the plate face of bottle inlet stationary platen 221 and bottle inlet movable mold 222 by row, treating that medicine bottle is accumulated to predetermined quantity, bottle inlet push rod 11 is pushed building up medicine bottle on freeze-drying plate layer by the plate face of bottle inlet stationary platen 221, bottle inlet movable mold 222 and bottle inlet bridge plate 21. Bottle inlet is complete, bottle inlet push rod 11 exits, bottle inlet movable mold actuator 223 starts to return, bottle inlet movable mold 222, bottle inlet bridge plate 21 is driven to depart from freeze-drying plate layer, under the bottle inlet movable mold chute 225 and the guiding of bottle inlet movable mold actuator chute 226 of the first guide plate 224, bottle inlet movable mold 222 and bottle inlet bridge plate 21 break off relations, and bottle inlet movable mold 222 continues back at bottle inlet stationary platen 221 bottom, and bottle inlet movable mold actuator 223 stops action.
In the present embodiment, bottle outlet bridge plate mechanism 4 includes bottle outlet bridge plate 41 and controls the bottle outlet transition apparatus 42 of bottle outlet bridge plate 41 and bottle outlet conveyer belt 5 clutch, bottle outlet transition apparatus 42 is located between bottle outlet bridge plate 41 and bottle outlet conveyer belt 5, being connected with of bottle outlet bridge plate 41 is stretched the bottle outlet bridge plate guide rail 411 of sliding for bottle outlet bridge plate 41, is moved easily and position adjustment.
In the present embodiment, bottle outlet transition apparatus 42 includes bottle outlet stationary platen 421, bottle outlet movable mold 422 and bottle outlet movable mold actuator 423, bottle outlet stationary platen 421 side is connected with bottle outlet conveyer belt 5, bottle outlet movable mold 422 is located between bottle outlet stationary platen 421 opposite side and bottle outlet bridge plate 41, freeze dryer 1 is under bottle outlet state, bottle outlet movable mold actuator 423 drives bottle outlet movable mold 422 to connect bottle outlet stationary platen 421 and bottle outlet bridge plate 41, freeze dryer 1 is under non-bottle outlet state, bottle outlet movable mold actuator 423 drives bottle outlet movable mold 422 to depart from bottle outlet bridge plate 41. bottle outlet stationary platen 421 two ends are provided with the second guide plate 424, second guide plate 424 offers bottle outlet movable mold chute 425 and bottle outlet movable mold actuator chute 426, bottle outlet movable mold 422 two ends are provided with the guide pad being slidedly arranged in bottle outlet movable mold chute 425, bottle outlet movable mold actuator 423 is provided with two pieces and is telescopic drive part, two pieces bottle outlet movable mold actuator 423 is divided into bottle outlet movable mold 422 two ends, each bottle outlet movable mold actuator 423 one end is hinged with frame, the other end is hinged with the end of bottle outlet movable mold 422 and is slidedly arranged in bottle outlet movable mold actuator chute 426, bottle outlet movable mold actuator 423 is cylinder, can be electricity push rod in other embodiments, the telescopic drive parts such as hydraulic push rod.
Bottle outlet transition apparatus 42 work process:
Bottle outlet movable mold actuator 423 is promoted by the cylinder that bottle outlet movable mold 422 two ends are stretched out while moving in bottle outlet movable mold 422, under second guide plate 424 at bottle outlet stationary platen 421 two ends guides, bottle outlet movable mold 422 rotates clockwise angle until level and hook the slotted eye that bottle outlet bridge plate 41 lower front end stretches out, now bottle outlet movable mold 422 couples with bottle outlet bridge plate 41 level, and the cylinder that bottle outlet movable mold 422 is stretched out has been enter into being placed in the groove of bottle outlet movable mold actuator 423 head at two ends bottom bottle outlet stationary platen 421; Bottle outlet movable mold actuator 423 piston is released, and is pushed into freeze-drying plate layer bottle outlet movable mold 422 and bottle outlet bridge plate 41 against being connected, and now, bottle outlet stationary platen 421, bottle outlet movable mold 422 and bottle outlet bridge plate 41 form bottle outlet table top;The medicine bottle being shelved on flaggy is pushed out on bottle outlet conveyer belt 5 from rear portion in freeze dryer 1 by bottle outlet push rod 12, bottle outlet conveyer belt 5 be transported to Cover-rolling machine and complete to roll cap seal mouth.
Fig. 6 illustrates a kind of lyophilized formulations production line embodiment of the present invention, this lyophilized formulations production line includes filling and stopper-adding system 100 and rolls convering system 200, filling and stopper-adding system 100 and roll the on line freeze-drying system based on multiple stage freeze dryer being provided with above-described embodiment between convering system 200. The lyophilized formulations production line of the present invention, owing to being provided with the on line freeze-drying system based on multiple stage freeze dryer of the present invention, therefore also possesses corresponding technique effect.
Below being only the preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-described embodiment, and all technical schemes belonged under thinking of the present invention belong to protection scope of the present invention. It should be pointed out that, for those skilled in the art, some improvements and modifications without departing from the principles of the present invention, should be regarded as protection scope of the present invention.
Claims (14)
1. the on line freeze-drying system based on multiple stage freeze dryer, including multiple stage freeze dryer (1), it is characterized in that: described freeze dryer (1) bottle inlet mouth, bottle outlet are positioned at the same side and upper and lower layered arrangement, described bottle inlet mouth is equipped with bottle inlet push rod (11), described bottle outlet is equipped with bottle outlet push rod (12), each described bottle inlet mouth is connected to same bottle inlet conveyer belt (3) by bottle inlet bridge plate mechanism (2), and each described bottle outlet is connected to same bottle outlet conveyer belt (5) by bottle outlet bridge plate mechanism (4).
2. the on line freeze-drying system based on multiple stage freeze dryer according to claim 1, it is characterised in that: described bottle inlet conveyer belt (3) and bottle outlet conveyer belt (5) top are covered with shared laminar flow hood (6).
3. the on line freeze-drying system based on multiple stage freeze dryer according to claim 1, it is characterized in that: described freeze dryer (1) includes freeze drying box (13) and cold-trap (14), the bottle inlet mouth of described freeze dryer (1), bottle outlet are located at the freeze drying box (13) side near bottle inlet conveyer belt (3) and bottle outlet conveyer belt (5), and described cold-trap (14) is located at the freeze drying box (13) side away from bottle inlet conveyer belt (3) and bottle outlet conveyer belt (5).
4. the on line freeze-drying system based on multiple stage freeze dryer according to claim 1, it is characterised in that: described bottle inlet conveyer belt (3) and bottle inlet bridge plate mechanism (2) are positioned at upper strata, and described bottle outlet conveyer belt (5) and bottle outlet bridge plate mechanism (4) are positioned at lower floor.
5. the on line freeze-drying system based on multiple stage freeze dryer according to claim 1, it is characterised in that: described multiple stage freeze dryer (1) is linearly arranged, and described freeze dryer (1) bottle inlet mouth, bottle outlet are towards side.
6. the on line freeze-drying system based on multiple stage freeze dryer according to any one of claim 1 to 5, it is characterized in that: described bottle inlet bridge plate mechanism (2) includes bottle inlet bridge plate (21) and controls the bottle inlet transition apparatus (22) of bottle inlet bridge plate (21) and bottle inlet conveyer belt (3) clutch, and described bottle inlet transition apparatus (22) is located between bottle inlet bridge plate (21) and bottle inlet conveyer belt (3).
7. the on line freeze-drying system based on multiple stage freeze dryer according to claim 6, it is characterised in that: bottle inlet bridge plate guide rail (211) being connected with the flexible sliding of confession bottle inlet bridge plate (21) of described bottle inlet bridge plate (21).
8. the on line freeze-drying system based on multiple stage freeze dryer according to claim 7, it is characterized in that: described bottle inlet transition apparatus (22) includes bottle inlet stationary platen (221), bottle inlet movable mold (222) and bottle inlet movable mold actuator (223), described bottle inlet stationary platen (221) side is connected with bottle inlet conveyer belt (3), described bottle inlet movable mold (222) is located between bottle inlet stationary platen (221) opposite side and bottle inlet bridge plate (21), described freeze dryer (1) is under bottle inlet state, bottle inlet movable mold actuator (223) drives bottle inlet movable mold (222) to connect bottle inlet stationary platen (221) and bottle inlet bridge plate (21), described freeze dryer (1) is under non-bottle inlet state, described bottle inlet movable mold actuator (223) drives bottle inlet movable mold (222) to depart from bottle inlet bridge plate (21).
9. the on line freeze-drying system based on multiple stage freeze dryer according to claim 8, it is characterized in that: described bottle inlet stationary platen (221) two ends are provided with the first guide plate (224), described first guide plate (224) offers bottle inlet movable mold chute (225) and bottle inlet movable mold actuator chute (226), described bottle inlet movable mold (222) two ends are provided with the guide pad being slidedly arranged in bottle inlet movable mold chute (225), described bottle inlet movable mold actuator (223) is provided with two pieces and is telescopic drive part, two pieces bottle inlet movable mold actuator (223) is divided into bottle inlet movable mold (222) two ends, each bottle inlet movable mold actuator (223) one end is hinged with frame, the other end is hinged with the end of bottle inlet movable mold (222) and is slidedly arranged in bottle inlet movable mold actuator chute (226).
10. the on line freeze-drying system based on multiple stage freeze dryer according to any one of claim 1 to 5, it is characterized in that: described bottle outlet bridge plate mechanism (4) includes bottle outlet bridge plate (41) and controls the bottle outlet transition apparatus (42) of bottle outlet bridge plate (41) and bottle outlet conveyer belt (5) clutch, and described bottle outlet transition apparatus (42) is located between bottle outlet bridge plate (41) and bottle outlet conveyer belt (5).
11. the on line freeze-drying system based on multiple stage freeze dryer according to claim 10, it is characterised in that: bottle outlet bridge plate guide rail (411) being connected with the flexible sliding of confession bottle outlet bridge plate (41) of described bottle outlet bridge plate (41).
12. the on line freeze-drying system based on multiple stage freeze dryer according to claim 11, it is characterized in that: described bottle outlet transition apparatus (42) includes bottle outlet stationary platen (421), bottle outlet movable mold (422) and bottle outlet movable mold actuator (423), described bottle outlet stationary platen (421) side is connected with bottle outlet conveyer belt (5), described bottle outlet movable mold (422) is located between bottle outlet stationary platen (421) opposite side and bottle outlet bridge plate (41), described freeze dryer (1) is under bottle outlet state, bottle outlet movable mold actuator (423) drives bottle outlet movable mold (422) to connect bottle outlet stationary platen (421) and bottle outlet bridge plate (41), described freeze dryer (1) is under non-bottle outlet state, described bottle outlet movable mold actuator (423) drives bottle outlet movable mold (422) to depart from bottle outlet bridge plate (41).
13. the on line freeze-drying system based on multiple stage freeze dryer according to claim 12, it is characterized in that: described bottle outlet stationary platen (421) two ends are provided with the second guide plate (424), described second guide plate (424) offers bottle outlet movable mold chute (425) and bottle outlet movable mold actuator chute (426), described bottle outlet movable mold (422) two ends are provided with the guide pad being slidedly arranged in bottle outlet movable mold chute (425), described bottle outlet movable mold actuator (423) is provided with two pieces and is telescopic drive part, two pieces bottle outlet movable mold actuator (423) is divided into bottle outlet movable mold (422) two ends, each bottle outlet movable mold actuator (423) one end is hinged with frame, the other end is hinged with the end of bottle outlet movable mold (422) and is slidedly arranged in bottle outlet movable mold actuator chute (426).
14. a lyophilized formulations production line, including filling and stopper-adding system (100) with roll convering system (200), it is characterised in that: described filling and stopper-adding system (100) and roll the on line freeze-drying system based on multiple stage freeze dryer being provided with between convering system (200) as according to any one of claim 1 to 13.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410357934.0A CN104176690B (en) | 2014-07-25 | 2014-07-25 | A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410357934.0A CN104176690B (en) | 2014-07-25 | 2014-07-25 | A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line |
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| CN104176690A CN104176690A (en) | 2014-12-03 |
| CN104176690B true CN104176690B (en) | 2016-06-08 |
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| CN201410357934.0A Active CN104176690B (en) | 2014-07-25 | 2014-07-25 | A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105800302B (en) * | 2014-12-27 | 2018-08-21 | 楚天科技股份有限公司 | A kind of freeze dryer feed process |
| CN104590857B (en) * | 2014-12-30 | 2017-01-25 | 楚天科技股份有限公司 | Bottle-feeding pushing rod device for freeze-drying agent preparation system |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63235214A (en) * | 1988-03-11 | 1988-09-30 | Yamanouchi Pharmaceut Co Ltd | Freeze dryer |
| JP5514393B2 (en) * | 2006-07-11 | 2014-06-04 | 東芝三菱電機産業システム株式会社 | Container transfer device |
| CN102252513B (en) * | 2011-05-27 | 2013-10-09 | 楚天科技股份有限公司 | Transition device for feeding and discharging of freeze dryer |
| CN102583042B (en) * | 2012-03-12 | 2014-01-08 | 楚天科技股份有限公司 | Bottle pushing device for freeze dryer |
| CN202897990U (en) * | 2012-09-26 | 2013-04-24 | 上海东富龙科技股份有限公司 | Sectional type transition bridge device |
| CN103033032B (en) * | 2013-01-15 | 2015-02-18 | 上海东富龙科技股份有限公司 | Automatic feeding and discharging device for freeze dryer |
| CN203624538U (en) * | 2013-10-12 | 2014-06-04 | 楚天科技股份有限公司 | Turning plate mechanism for automatic feeding and discharging of freeze dryer |
| CN103662709B (en) * | 2013-12-04 | 2016-06-29 | 楚天科技股份有限公司 | A kind of material conveying platform and freezing-dry line movable type discharging system |
| CN204079449U (en) * | 2014-07-25 | 2015-01-07 | 楚天科技股份有限公司 | A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations manufacturing line |
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