CN104176690A - An online freeze-drying system based on multiple freeze dryers and a production line for a freeze drying agent - Google Patents
An online freeze-drying system based on multiple freeze dryers and a production line for a freeze drying agent Download PDFInfo
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- CN104176690A CN104176690A CN201410357934.0A CN201410357934A CN104176690A CN 104176690 A CN104176690 A CN 104176690A CN 201410357934 A CN201410357934 A CN 201410357934A CN 104176690 A CN104176690 A CN 104176690A
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Abstract
The invention discloses an online freeze-drying system based on multiple freeze dryers and a production line for a freeze drying agent. The online freeze-drying system based on multiple freeze dryers comprises multiple freeze dryers. A bottle inlet and a bottle outlet of each freeze dryer are located on the same side and arranged in upper and lower layers. The bottle inlet is equipped with a bottle inlet push rod. The bottle outlet is equipped with a bottle outlet push rod. Each bottle inlet is connected to the same bottle inlet conveyor belt via a bottle inlet bridge plate mechanism. Each bottle outlet is connected to the same bottle outlet conveyor belt via a bottle outlet bridge plate mechanism. The production line for a freeze drying agent comprises a filling stopper adding system and a capping system. The abovementioned online freeze-drying system based on multiple freeze dryers is arranged between the filling stopper adding system and the capping system. The system and production line have advantages of simple structure and high production efficiency.
Description
Technical field
The present invention relates generally to food, medical packaging mechanical field, refers in particular on line freeze-drying system and lyophilized formulations manufacturing line based on many freeze dryers.
Background technology
In order to improve the degree of automation of freeze dryer, existing freeze dryer is all equipped with bottle inlet push rod and bottle outlet push rod substantially, bottle inlet push rod pushes the flaggy in freeze dryer by row for the cillin bottle that medicine is housed that tape transport is come, and bottle outlet push rod is for being pushed out to by row load-transfer device by the cillin bottle that completes freeze-drying from the flaggy in freeze dryer.In order to improve the output of freeze-drying system, current state-of-the-art scheme is by many online uses of freeze dryer, be that many freeze dryers complete the operation of turnover bottle with a load-transfer device in turn, this freeze-drying system can obviously improve the output of freeze-drying system really, but still there is following defect: due to only have one used for conveyer belt in bottle inlet and bottle outlet, therefore can not realize and in a freeze dryer bottle inlet, allow another freeze dryer bottle outlet, can not realize and in a freeze dryer bottle outlet, allow another freeze dryer bottle inlet, this must cause the vacant wait time of freeze dryer longer, make the freeze dryer in freeze-drying system cannot give full play to its output efficiency.
Summary of the invention
The technical problem to be solved in the present invention is: the deficiency existing for prior art, provides a kind of simple in structure, the on line freeze-drying system based on many freeze dryers and lyophilized formulations manufacturing line that production efficiency is high.
For solving the problems of the technologies described above, the present invention by the following technical solutions:
A kind of online freeze-drying system based on many freeze dryers, comprise many freeze dryers, described freeze dryer bottle inlet mouth, bottle outlet are positioned at the same side and upper and lower layered arrangement, described bottle inlet mouth is equipped with bottle inlet push rod, described bottle outlet is equipped with bottle outlet push rod, described each bottle inlet mouth is connected to same bottle inlet load-transfer device by bottle inlet bridge plate mechanism, and described each bottle outlet is connected to same bottle outlet load-transfer device by bottle outlet bridge plate mechanism.
Further improvement as technique scheme:
Described bottle inlet load-transfer device and bottle outlet load-transfer device top are covered with shared laminar flow hood.
Described freeze dryer comprises freeze drying box and cold-trap, and the bottle inlet mouth of described freeze dryer, bottle outlet are located at the side of freeze drying box near bottle inlet load-transfer device and bottle outlet load-transfer device, and described cold-trap is located at the side of freeze drying box away from bottle inlet load-transfer device and bottle outlet load-transfer device.
Described bottle inlet load-transfer device and bottle inlet bridge plate mechanism are positioned at upper strata, and described bottle outlet load-transfer device and bottle outlet bridge plate mechanism are positioned at lower floor.
Described bottle inlet bridge plate mechanism comprises bottle inlet bridge plate and controls the bottle inlet transition apparatus of bottle inlet bridge plate and the clutch of bottle inlet load-transfer device, and described bottle inlet transition apparatus is located between bottle inlet bridge plate and bottle inlet load-transfer device.
The below of described bottle inlet bridge plate is provided with the bottle inlet bridge plate guide rail for the flexible slippage of bottle inlet bridge plate.
Described bottle inlet transition apparatus comprises bottle inlet stationary platen, bottle inlet movable mold and bottle inlet movable mold actuator, described bottle inlet stationary platen one side is connected with bottle inlet load-transfer device, described bottle inlet movable mold is located between bottle inlet stationary platen opposite side and bottle inlet bridge plate, described freeze dryer is under bottle inlet state, bottle inlet movable mold actuator drives bottle inlet movable mold to connect bottle inlet stationary platen and bottle inlet bridge plate, described freeze dryer is under non-bottle inlet state, and described bottle inlet movable mold actuator drives bottle inlet movable mold to depart from bottle inlet bridge plate.
Described bottle inlet stationary platen two ends are provided with the first guide plate, on described the first guide plate, offer bottle inlet movable mold chute and bottle inlet movable mold actuator chute, described bottle inlet movable mold two ends are provided with the orienting lug being slidedly arranged in bottle inlet movable mold chute, described bottle inlet movable mold actuator is provided with two and be telescopic drive part, two bottle inlet movable mold actuators are divided into bottle inlet movable mold two ends, each bottle inlet movable mold actuator one end and frame are hinged, the end of the other end and bottle inlet movable mold is hinged and be slidedly arranged in bottle inlet movable mold actuator chute.
Described bottle outlet bridge plate mechanism comprises bottle outlet bridge plate and controls the bottle outlet transition apparatus of bottle outlet bridge plate and the clutch of bottle outlet load-transfer device, and described bottle outlet transition apparatus is located between bottle outlet bridge plate and bottle outlet load-transfer device.
The below of described bottle outlet bridge plate is provided with the bottle outlet bridge plate guide rail for the flexible slippage of bottle outlet bridge plate.
Described bottle outlet transition apparatus comprises bottle outlet stationary platen, bottle outlet movable mold and bottle outlet movable mold actuator, described bottle outlet stationary platen one side is connected with bottle outlet load-transfer device, described bottle outlet movable mold is located between bottle outlet stationary platen opposite side and bottle outlet bridge plate, described freeze dryer is under bottle outlet state, bottle outlet movable mold actuator drives bottle outlet movable mold to connect bottle outlet stationary platen and bottle outlet bridge plate, described freeze dryer is under non-bottle outlet state, and described bottle outlet movable mold actuator drives bottle outlet movable mold to depart from bottle outlet bridge plate.
Described bottle outlet stationary platen two ends are provided with the second guide plate, on described the second guide plate, offer bottle outlet movable mold chute and bottle outlet movable mold actuator chute, described bottle outlet movable mold two ends are provided with the orienting lug being slidedly arranged in bottle outlet movable mold chute, described bottle outlet movable mold actuator is provided with two and be telescopic drive part, two bottle outlet movable mold actuators are divided into bottle outlet movable mold two ends, each bottle outlet movable mold actuator one end and frame are hinged, the end of the other end and bottle outlet movable mold is hinged and be slidedly arranged in bottle outlet movable mold actuator chute.
Described many freeze dryers are linearly arranged, and described freeze dryer bottle inlet mouth, bottle outlet are towards a side.
A kind of lyophilized formulations manufacturing line, comprises filling and stopper-adding system and rolls convering system, described filling and stopper-adding system and roll and be provided with the above-mentioned on line freeze-drying system based on many freeze dryers between convering system.
Compared with prior art, the invention has the advantages that:
On line freeze-drying system based on many freeze dryers of the present invention, bottle inlet load-transfer device and the upper and lower layered arrangement of bottle outlet load-transfer device, in the time that bottle inlet load-transfer device is coordinating a freeze dryer bottle inlet, bottle outlet load-transfer device can coordinate another freeze dryer bottle outlet, in the time that bottle outlet load-transfer device is coordinating a freeze dryer bottle outlet, bottle inlet load-transfer device also can coordinate another freeze dryer bottle inlet, the vacant wait time of freeze dryer will shorten greatly, make each freeze dryer can give full play to its output efficiency, thereby greatly improve the production efficiency of freeze-drying system.Further, because bottle inlet load-transfer device of the present invention and bottle outlet load-transfer device are arranged on the same sides of many freeze dryers, above bottle inlet load-transfer device and bottle outlet load-transfer device, shared laminar flow hood can be set, in the situation that having increased a load-transfer device, do not need to arrange more laminar flow hood, thereby can greatly save equipment cost.Further, the cold-trap of freeze dryer and the both sides that are divided into freeze drying box into and out of bottle load-transfer device, can reduce freeze-drying system and send taking up room in bottle direction at load-transfer device, reduces the occupation of land demand of this freeze-drying system.Lyophilized formulations manufacturing line of the present invention, owing to being provided with the above-mentioned on line freeze-drying system based on many freeze dryers, therefore also possesses corresponding technique effect.
Brief description of the drawings
Fig. 1 is the plan structure schematic diagram of freeze-drying system of the present invention.
Fig. 2 is the main TV structure schematic diagram of the non-turnover ampuliform of freeze-drying system of the present invention state.
Fig. 3 is the main TV structure schematic diagram of freeze-drying system bottle inlet state of the present invention.
Fig. 4 is the main TV structure schematic diagram of freeze-drying system bottle outlet state of the present invention.
Fig. 5 is the enlarged drawing at bottle inlet transition apparatus and bottle outlet transition apparatus place in freeze-drying system of the present invention.
Fig. 6 is the plan structure schematic diagram of lyophilized formulations manufacturing line of the present invention.
Marginal data:
1, freeze dryer; 100, filling and stopper-adding system; 11, bottle inlet push rod; 12, bottle outlet push rod; 13, freeze drying box; 14, cold-trap; 2, bottle inlet bridge plate mechanism; 200, roll convering system; 21, bottle inlet bridge plate; 211, bottle inlet bridge plate guide rail; 22, bottle inlet transition apparatus; 221, bottle inlet stationary platen; 222, bottle inlet movable mold; 223, bottle inlet movable mold actuator; 224, the first guide plate; 225, bottle inlet movable mold chute; 226, bottle inlet movable mold actuator chute; 3, bottle inlet load-transfer device; 4, bottle outlet bridge plate mechanism; 41, bottle outlet bridge plate; 411, bottle outlet bridge plate guide rail; 42, bottle outlet transition apparatus; 421, bottle outlet stationary platen; 422, bottle outlet movable mold; 423, bottle outlet movable mold actuator; 424, the second guide plate; 425, bottle outlet movable mold chute; 426, bottle outlet movable mold actuator chute; 5, bottle outlet load-transfer device; 6, laminar flow hood.
Detailed description of the invention
Fig. 1 to Fig. 5 shows the embodiment of a kind of on line freeze-drying system based on many freeze dryers of the present invention, comprise many freeze dryers 1, freeze dryer 1 bottle inlet mouth, bottle outlet are positioned at the same side and upper and lower layered arrangement, bottle inlet mouth is equipped with bottle inlet push rod 11, bottle outlet is equipped with bottle outlet push rod 12, each bottle inlet mouth is connected to same bottle inlet load-transfer device 3 by bottle inlet bridge plate mechanism 2, and each bottle outlet is connected to same bottle outlet load-transfer device 5 by bottle outlet bridge plate mechanism 4.On line freeze-drying system based on many freeze dryers of the present invention, freeze dryer 1 bottle inlet mouth, bottle outlet is positioned at the same side and upper and lower layered arrangement, each bottle inlet mouth is connected to same bottle inlet load-transfer device 3 by bottle inlet bridge plate mechanism 2, each bottle outlet is connected to same bottle outlet load-transfer device 5 by bottle outlet bridge plate mechanism 4, in the time that bottle inlet load-transfer device 3 is coordinating freeze dryer 1 bottle inlet, bottle outlet load-transfer device 5 can coordinate another freeze dryer 1 bottle outlet, in the time that bottle outlet load-transfer device 5 is coordinating freeze dryer 1 bottle outlet, bottle inlet load-transfer device 3 also can coordinate another freeze dryer 1 bottle inlet, the vacant wait time of each freeze dryer 1 will shorten greatly, make each freeze dryer 1 can give full play to its output efficiency, thereby greatly improve the production efficiency of freeze-drying system.
In the present embodiment, bottle inlet load-transfer device 3 and bottle outlet load-transfer device 5 tops are covered with shared laminar flow hood 6, do not need to arrange more laminar flow hood 6 in the situation that having increased a load-transfer device, thereby can greatly save equipment cost.
In the present embodiment, freeze dryer 1 comprises freeze drying box 13 and cold-trap 14, the bottle inlet mouth of freeze dryer 1, bottle outlet are located at the side of freeze drying box 13 near bottle inlet load-transfer device 3 and bottle outlet load-transfer device 5, cold-trap 14 is located at the side of freeze drying box 13 away from bottle inlet load-transfer device 3 and bottle outlet load-transfer device 5, by the cold-trap of freeze dryer 1 14 and the both sides that are divided into freeze drying box 13 into and out of bottle load-transfer device, can reduce freeze-drying system and send taking up room in bottle direction at load-transfer device, reduce the occupation of land demand of this freeze-drying system.
In the present embodiment, bottle inlet load-transfer device 3 and bottle inlet bridge plate mechanism 2 are positioned at upper strata, and bottle outlet load-transfer device 5 and bottle outlet bridge plate mechanism 4 are positioned at lower floor, are conducive to prevent that the bottle of half tamponade state from being polluted.
In the present embodiment, many freeze dryers 1 are linearly arranged, the bottle inlet mouth of many freeze dryers 1, bottle outlet are towards a side, and the bottle inlet load-transfer device 3 of the present embodiment and bottle outlet load-transfer device 5 are arranged on the same side of many freeze dryers 1, can further reduce the occupation of land demand of this freeze-drying system.In other embodiments, in the situation that many freeze dryers 1 are linearly arranged, also many freeze dryers 1 can be divided into the both sides of bottle inlet load-transfer device 3 and bottle outlet load-transfer device 5.
In the present embodiment, bottle inlet bridge plate mechanism 2 comprises bottle inlet bridge plate 21 and controls the bottle inlet transition apparatus 22 of bottle inlet bridge plate 21 and 3 clutches of bottle inlet load-transfer device, bottle inlet transition apparatus 22 is located between bottle inlet bridge plate 21 and bottle inlet load-transfer device 3, the below of bottle inlet bridge plate 21 is provided with the bottle inlet bridge plate guide rail 211 for the 21 flexible slippages of bottle inlet bridge plate, convenient mobile and position adjustment.
In the present embodiment, bottle inlet transition apparatus 22 comprises bottle inlet stationary platen 221, bottle inlet movable mold 222 and bottle inlet movable mold actuator 223, bottle inlet stationary platen 221 1 sides are connected with bottle inlet load-transfer device 3, bottle inlet movable mold 222 is located between bottle inlet stationary platen 221 opposite sides and bottle inlet bridge plate 21, freeze dryer 1 is under bottle inlet state, bottle inlet movable mold actuator 223 drives bottle inlet movable mold 222 to connect bottle inlet stationary platen 221 and bottle inlet bridge plate 21, freeze dryer 1 is under non-bottle inlet state, bottle inlet movable mold actuator 223 drives bottle inlet movable mold 222 to depart from bottle inlet bridge plate 21.Bottle inlet stationary platen 221 two ends are provided with the first guide plate 224, on the first guide plate 224, offer bottle inlet movable mold chute 225 and bottle inlet movable mold actuator chute 226, bottle inlet movable mold 222 two ends are provided with the orienting lug being slidedly arranged in bottle inlet movable mold chute 225, bottle inlet movable mold actuator 223 is provided with two and be telescopic drive part, two bottle inlet movable mold actuators 223 are divided into bottle inlet movable mold 222 two ends, each bottle inlet movable mold actuator 223 one end and frame are hinged, the end of the other end and bottle inlet movable mold 222 is hinged and be slidedly arranged in bottle inlet movable mold actuator chute 226, bottle inlet movable mold actuator 223 is cylinder, can be electric push rod in other embodiments, the telescopic drive parts such as hydraulic push rod.
Bottle inlet transition apparatus 22 working processs:
The cylinder that bottle inlet movable mold actuator 223 stretches out by bottle inlet movable mold 222 two ends promotes the former bottle inlet movable mold 222 that is placed in bottle inlet stationary platen 221 bottoms to freeze dryer 1 bottle inlet mouth, bottle outlet direction moves, bottle inlet movable mold 222 is subject to the constraint of bottle inlet stationary platen 221 both sides the first guide plates 224 simultaneously in reach, can only be along the bottle inlet movable mold chute 225 of the first guide plate 224 and the 226 direction actions of bottle inlet movable mold actuator chute, bottle inlet movable mold 222 bottoms are provided with several hook bars, when the bottle inlet movable mold 222 top freeze dryer 1 bottle inlet mouth that is positioned over that moves forward, when bottle inlet bridge plate 21 in bottle outlet, the hook hook strips of bottle inlet movable mold 222 bottoms is lived in the slotted eye that bottle bridge plate 21 lower front ends stretch out, now, bottle inlet movable mold 222 promotes bottle inlet bridge plate 21 and continues reach, in the time of bottle inlet bridge plate 21 top freeze-drying plate layer, stop mobile, wait for that medicine bottle slave plate face passes through, being placed in the other bottle inlet push rod 11 of bottle inlet load-transfer device 3 releases bottle inlet load-transfer device 3 medicine bottle above on the plate face of bottle inlet stationary platen 221 and bottle inlet movable mold 222 by row, treat that medicine bottle is accumulated to predetermined quantity, bottle inlet push rod 11 pushes on freeze-drying plate layer by the plate face of bottle inlet stationary platen 221, bottle inlet movable mold 222 and bottle inlet bridge plate 21 building up medicine bottle.Bottle inlet is complete, bottle inlet push rod 11 exits, bottle inlet movable mold actuator 223 starts to return, drive bottle inlet movable mold 222, bottle inlet bridge plate 21 to depart from freeze-drying plate layer, under the bottle inlet movable mold chute 225 and 226 guiding of bottle inlet movable mold actuator chute of the first guide plate 224, bottle inlet movable mold 222 breaks off relations with bottle inlet bridge plate 21, and bottle inlet movable mold 222 continues to be back to bottle inlet stationary platen 221 bottoms, and bottle inlet movable mold actuator 223 stops action.
In the present embodiment, bottle outlet bridge plate mechanism 4 comprises bottle outlet bridge plate 41 and controls the bottle outlet transition apparatus 42 of bottle outlet bridge plate 41 and 5 clutches of bottle outlet load-transfer device, bottle outlet transition apparatus 42 is located between bottle outlet bridge plate 41 and bottle outlet load-transfer device 5, the below of bottle outlet bridge plate 41 is provided with the bottle outlet bridge plate guide rail 411 for the 41 flexible slippages of bottle outlet bridge plate, convenient mobile and position adjustment.
In the present embodiment, bottle outlet transition apparatus 42 comprises bottle outlet stationary platen 421, bottle outlet movable mold 422 and bottle outlet movable mold actuator 423, bottle outlet stationary platen 421 1 sides are connected with bottle outlet load-transfer device 5, bottle outlet movable mold 422 is located between bottle outlet stationary platen 421 opposite sides and bottle outlet bridge plate 41, freeze dryer 1 is under bottle outlet state, bottle outlet movable mold actuator 423 drives bottle outlet movable mold 422 to connect bottle outlet stationary platen 421 and bottle outlet bridge plate 41, freeze dryer 1 is under non-bottle outlet state, bottle outlet movable mold actuator 423 drives bottle outlet movable mold 422 to depart from bottle outlet bridge plate 41.Bottle outlet stationary platen 421 two ends are provided with the second guide plate 424, on the second guide plate 424, offer bottle outlet movable mold chute 425 and bottle outlet movable mold actuator chute 426, bottle outlet movable mold 422 two ends are provided with the orienting lug being slidedly arranged in bottle outlet movable mold chute 425, bottle outlet movable mold actuator 423 is provided with two and be telescopic drive part, two bottle outlet movable mold actuators 423 are divided into bottle outlet movable mold 422 two ends, each bottle outlet movable mold actuator 423 one end and frame are hinged, the end of the other end and bottle outlet movable mold 422 is hinged and be slidedly arranged in bottle outlet movable mold actuator chute 426, bottle outlet movable mold actuator 423 is cylinder, can be electric push rod in other embodiments, the telescopic drive parts such as hydraulic push rod.
Bottle outlet transition apparatus 42 working processs:
When moving in the cylinder promotion bottle outlet movable mold 422 that bottle outlet movable mold actuator 423 stretches out by bottle outlet movable mold 422 two ends, under second guide plate 424 guiding at bottle outlet stationary platen 421 two ends, bottle outlet movable mold 422 clockwise rotates angle until level and hook the slotted eye that bottle outlet bridge plate 41 lower front ends stretch out, now bottle outlet movable mold 422 connects with bottle outlet bridge plate 41 levels, and the cylinder that bottle outlet movable mold 422 is stretched out has entered the groove of bottle outlet movable mold actuator 423 heads that are placed in bottle outlet stationary platen 421 two ends, bottom; Bottle outlet movable mold actuator 423 pistons are released, and bottle outlet movable mold 422 and bottle outlet bridge plate 41 are pushed into freeze-drying plate layer near being connected, and now, bottle outlet stationary platen 421, bottle outlet movable mold 422 and bottle outlet bridge plate 41 form bottle outlet table top; Bottle outlet push rod 12 is pushed out on bottle outlet load-transfer device 5 from the interior rear portion of freeze dryer 1 by the medicine bottle being shelved on flaggy, is transported to Cover-rolling machine completes and roll cap seal mouth by bottle outlet load-transfer device 5.
Fig. 6 shows a kind of lyophilized formulations manufacturing line embodiment of the present invention, this lyophilized formulations manufacturing line comprises filling and stopper-adding system 100 and rolls convering system 200, filling and stopper-adding system 100 and roll the on line freeze-drying system based on many freeze dryers that is provided with above-described embodiment between convering system 200.Lyophilized formulations manufacturing line of the present invention, owing to being provided with the on line freeze-drying system based on many freeze dryers of the present invention, therefore also possesses corresponding technique effect.
Below be only the preferred embodiment of the present invention, protection scope of the present invention is also not only confined to above-described embodiment, and all technical schemes belonging under thinking of the present invention all belong to protection scope of the present invention.It should be pointed out that for those skilled in the art, some improvements and modifications without departing from the principles of the present invention, should be considered as protection scope of the present invention.
Claims (14)
1. the online freeze-drying system based on many freeze dryers, comprise many freeze dryers (1), it is characterized in that: described freeze dryer (1) bottle inlet mouth, bottle outlet are positioned at the same side and upper and lower layered arrangement, described bottle inlet mouth is equipped with bottle inlet push rod (11), described bottle outlet is equipped with bottle outlet push rod (12), described each bottle inlet mouth is connected to same bottle inlet load-transfer device (3) by bottle inlet bridge plate mechanism (2), and described each bottle outlet is connected to same bottle outlet load-transfer device (5) by bottle outlet bridge plate mechanism (4).
2. the on line freeze-drying system based on many freeze dryers according to claim 1, is characterized in that: described bottle inlet load-transfer device (3) and bottle outlet load-transfer device (5) top are covered with shared laminar flow hood (6).
3. the on line freeze-drying system based on many freeze dryers according to claim 1, it is characterized in that: described freeze dryer (1) comprises freeze drying box (13) and cold-trap (14), bottle inlet mouth, the bottle outlet of described freeze dryer (1) is located at the side of freeze drying box (13) near bottle inlet load-transfer device (3) and bottle outlet load-transfer device (5), and described cold-trap (14) is located at the side of freeze drying box (13) away from bottle inlet load-transfer device (3) and bottle outlet load-transfer device (5).
4. the on line freeze-drying system based on many freeze dryers according to claim 1, is characterized in that: described bottle inlet load-transfer device (3) and bottle inlet bridge plate mechanism (2) are positioned at upper strata, and described bottle outlet load-transfer device (5) and bottle outlet bridge plate mechanism (4) are positioned at lower floor.
5. the on line freeze-drying system based on many freeze dryers according to claim 1, is characterized in that: described many freeze dryers (1) are linearly arranged, described freeze dryer (1) bottle inlet mouth, bottle outlet are towards a side.
6. according to the on line freeze-drying system based on many freeze dryers described in any one in claim 1 to 5, it is characterized in that: described bottle inlet bridge plate mechanism (2) comprises the bottle inlet transition apparatus (22) of bottle inlet bridge plate (21) and control bottle inlet bridge plate (21) and bottle inlet load-transfer device (3) clutch, and described bottle inlet transition apparatus (22) is located between bottle inlet bridge plate (21) and bottle inlet load-transfer device (3).
7. the on line freeze-drying system based on many freeze dryers according to claim 6, is characterized in that: the below of described bottle inlet bridge plate (21) is provided with the bottle inlet bridge plate guide rail (211) for the flexible slippage of bottle inlet bridge plate (21).
8. the on line freeze-drying system based on many freeze dryers according to claim 7, it is characterized in that: described bottle inlet transition apparatus (22) comprises bottle inlet stationary platen (221), bottle inlet movable mold (222) and bottle inlet movable mold actuator (223), described bottle inlet stationary platen (221) one sides are connected with bottle inlet load-transfer device (3), described bottle inlet movable mold (222) is located between bottle inlet stationary platen (221) opposite side and bottle inlet bridge plate (21), described freeze dryer (1) is under bottle inlet state, bottle inlet movable mold actuator (223) drives bottle inlet movable mold (222) to connect bottle inlet stationary platen (221) and bottle inlet bridge plate (21), described freeze dryer (1) is under non-bottle inlet state, described bottle inlet movable mold actuator (223) drives bottle inlet movable mold (222) to depart from bottle inlet bridge plate (21).
9. the on line freeze-drying system based on many freeze dryers according to claim 8, it is characterized in that: described bottle inlet stationary platen (221) two ends are provided with the first guide plate (224), on described the first guide plate (224), offer bottle inlet movable mold chute (225) and bottle inlet movable mold actuator chute (226), described bottle inlet movable mold (222) two ends are provided with the orienting lug being slidedly arranged in bottle inlet movable mold chute (225), described bottle inlet movable mold actuator (223) is provided with two and be telescopic drive part, two bottle inlet movable mold actuators (223) are divided into bottle inlet movable mold (222) two ends, each bottle inlet movable mold actuator (223) one end and frame are hinged, the end of the other end and bottle inlet movable mold (222) is hinged and be slidedly arranged in bottle inlet movable mold actuator chute (226).
10. according to the on line freeze-drying system based on many freeze dryers described in any one in claim 1 to 5, it is characterized in that: described bottle outlet bridge plate mechanism (4) comprises the bottle outlet transition apparatus (42) of bottle outlet bridge plate (41) and control bottle outlet bridge plate (41) and bottle outlet load-transfer device (5) clutch, and described bottle outlet transition apparatus (42) is located between bottle outlet bridge plate (41) and bottle outlet load-transfer device (5).
11. the on line freeze-drying system based on many freeze dryers according to claim 10, is characterized in that: the below of described bottle outlet bridge plate (41) is provided with the bottle outlet bridge plate guide rail (411) for the flexible slippage of bottle outlet bridge plate (41).
The 12. on line freeze-drying systems based on many freeze dryers according to claim 11, it is characterized in that: described bottle outlet transition apparatus (42) comprises bottle outlet stationary platen (421), bottle outlet movable mold (422) and bottle outlet movable mold actuator (423), described bottle outlet stationary platen (421) one sides are connected with bottle outlet load-transfer device (5), described bottle outlet movable mold (422) is located between bottle outlet stationary platen (421) opposite side and bottle outlet bridge plate (41), described freeze dryer (1) is under bottle outlet state, bottle outlet movable mold actuator (423) drives bottle outlet movable mold (422) to connect bottle outlet stationary platen (421) and bottle outlet bridge plate (41), described freeze dryer (1) is under non-bottle outlet state, described bottle outlet movable mold actuator (423) drives bottle outlet movable mold (422) to depart from bottle outlet bridge plate (41).
The 13. on line freeze-drying systems based on many freeze dryers according to claim 12, it is characterized in that: described bottle outlet stationary platen (421) two ends are provided with the second guide plate (424), on described the second guide plate (424), offer bottle outlet movable mold chute (425) and bottle outlet movable mold actuator chute (426), described bottle outlet movable mold (422) two ends are provided with the orienting lug being slidedly arranged in bottle outlet movable mold chute (425), described bottle outlet movable mold actuator (423) is provided with two and be telescopic drive part, two bottle outlet movable mold actuators (423) are divided into bottle outlet movable mold (422) two ends, each bottle outlet movable mold actuator (423) one end and frame are hinged, the end of the other end and bottle outlet movable mold (422) is hinged and be slidedly arranged in bottle outlet movable mold actuator chute (426).
14. 1 kinds of lyophilized formulations manufacturing lines, comprise filling and stopper-adding system (100) and roll convering system (200), it is characterized in that: described filling and stopper-adding system (100) and roll and be provided with the on line freeze-drying system based on many freeze dryers as described in any one in claim 1 to 13 between convering system (200).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410357934.0A CN104176690B (en) | 2014-07-25 | 2014-07-25 | A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line |
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| CN201410357934.0A CN104176690B (en) | 2014-07-25 | 2014-07-25 | A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations production line |
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| CN104176690B CN104176690B (en) | 2016-06-08 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104590857A (en) * | 2014-12-30 | 2015-05-06 | 楚天科技股份有限公司 | Bottle-feeding pushing rod device for freeze-drying agent preparation system |
| CN105800302A (en) * | 2014-12-27 | 2016-07-27 | 楚天科技股份有限公司 | A freeze dryer feeding method |
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| JPS63235214A (en) * | 1988-03-11 | 1988-09-30 | Yamanouchi Pharmaceut Co Ltd | Freeze dryer |
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| CN102252513A (en) * | 2011-05-27 | 2011-11-23 | 楚天科技股份有限公司 | Transition device for feeding and discharging of freeze dryer |
| CN102583042A (en) * | 2012-03-12 | 2012-07-18 | 楚天科技股份有限公司 | Bottle pushing device for freeze dryer |
| CN202897990U (en) * | 2012-09-26 | 2013-04-24 | 上海东富龙科技股份有限公司 | Sectional type transition bridge device |
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| CN203624538U (en) * | 2013-10-12 | 2014-06-04 | 楚天科技股份有限公司 | Turning plate mechanism for automatic feeding and discharging of freeze dryer |
| CN103662709A (en) * | 2013-12-04 | 2014-03-26 | 楚天科技股份有限公司 | Feeding platform and freeze-drying-line mobile feeding and discharging system |
| CN204079449U (en) * | 2014-07-25 | 2015-01-07 | 楚天科技股份有限公司 | A kind of on line freeze-drying system based on multiple stage freeze dryer and lyophilized formulations manufacturing line |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105800302A (en) * | 2014-12-27 | 2016-07-27 | 楚天科技股份有限公司 | A freeze dryer feeding method |
| CN104590857A (en) * | 2014-12-30 | 2015-05-06 | 楚天科技股份有限公司 | Bottle-feeding pushing rod device for freeze-drying agent preparation system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104176690B (en) | 2016-06-08 |
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