CN104173598A - Composition for treating gastritis and peptic ulcer and preparation method thereof - Google Patents
Composition for treating gastritis and peptic ulcer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gastritis and peptic ulcer and a preparation method thereof. The traditional Chinese medicine composition is characterized by having the efficacies of regulating vital energy and regulating the middle warmer, promoting blood circulation to arrest pain, clearing heat and promoting dieresis and the like, wherein a substrate is prepared from the following traditional Chinese medicine compositions and an excipient in pharmaceutical significance: radix zanthoxyli, radix rehmanniae, citrus chirocarpus, streptocaulon griffithii hook., verbena, fructus aurantii immaturus, bighead atractylodes rhizome, poria cocos and radix glycyrrhizae. An experiment proves that the traditional Chinese medicine composition is fast in curative effect on gastritis and peptic ulcer and comparable to the Western medicine, and is free of a side effect and low in cost.
Description
[technical field]
A kind of compositions and method for making for the treatment of gastritis and peptic ulcer of this disclosure of the invention, is characterized in that having the effects such as regulating the flow of Qi and the middle Jiao, promoting blood circulation and stopping pain, clearing away heat-damp and promoting diuresis.
[background technology]
Stomachache in life is mainly that gastritis and peptic ulcer cause, in crowd, sickness rate is higher.
Gastritis is the glutinous membranous inflammation that any cause of disease causes, often, with epithelial damage and mucosa regeneration, can be divided into acute and chronic two classes.Two kinds of pure that what acute gastritis was common is and erosives.The former shows as epigastric discomfort, pain, anorexia and feels sick, vomits; The latter's digestive tract hemorrhage is main manifestations, has hematemesis and melena.Chronic gastritis is divided into again superficial gastritis, atrophic gastritis and hypertrophic gastritis conventionally.Chronic gastritis course of disease delay, non-evident sympton and sign mostly, the indigestion symptoms such as general rarely seen glutted, pantothenic acid after meal, belch, irregularities stomachache.
Peptic ulcer refers to gastric ulcer and duodenal ulcer, is due to gastric acid and pepsin, the digestion of mucosa self to be formed.The mechanism that relevant peptic ulcer occurs, still reasonable with attack factor and the unbalance theory of defense factor at present.Attack factor mainly refers to gastric acid, pepsin, helicobacter pylori and NSAID (non-steroidal anti-inflammatory drug); Defense factor mainly comprises secretion, cell membrane integrity, cell regeneration and prostaglandin generation, the intestinal hormone etc. of Gastric Mucosa Blood Flow amount, bicarbonate and mucus.In normal physiological situation, gastroduodenal mucosa often contact have the gastric acid of vigorous erosion power and under sour environment, be activated, pepsin that can aminosal, in addition, also often taken the photograph the invasion and attack of people's various harmful substances, but can resist the infringement of these invasion and attack factors, maintain the integrity of mucosa, this is because gastroduodenal mucosa has series of defence and repair mechanism.This mechanism relates generally to 3 aspects: the 1. mucus before epithelium and bicarbonate: the slime layer of most surface be together with physical barriers to pepsin disperse, be the cushion that keeps high pH gradient between gastric juice and neutral mucosa in the bicarbonate between slime layer and epithelial cell; 2. epithelial cell: epithelial cells mucus and bicarbonate maintain the 26S Proteasome Structure and Function before epithelium; Epithelial cell end face film plays barrier action to sour back diffusion; Epithelial cell reproduction speed is very fast, substitutes in time impaired and dead cell, repairs damaged part; 3. after epithelium: the blood flow in the abundant capillary network of gastric mucosa is for the vigorous secretion of epithelial cell and self constantly update energy matter is provided, and the positive monovalence hydrion that back diffusion enters mucosa is taken away.In addition, prostaglandin E has cytoprotective, promotes mucosa blood flow to increase the functions such as mucus and bicarbonate secretion; The effect of epidermal growth factor (EGF) tool cytoprotective and promotion epithelium regeneration.Think at present, this of gastroduodenal mucosa improves and effectively defends and repair mechanism, be enough to resist gastric acid/pepsic erosion, generally speaking, only have and damaged this mechanism when some factor and gastric acid/pepsin just may occur corrode mucosa and cause ulcer.In recent years research is clear and definite, thus the most commonly encountered diseases that helicobacter pylori and NSAID (non-steroidal anti-inflammatory drug) are infringement gastroduodenal Mucosa Barriers causes peptic ulcer because of.Smoking, heredity, Stomach duodenum dyskinesia, also relevant with infringement Grastiodudenal mucosa barrier.Rare special circumstances, when excessive gastric acid secretion also may cause peptic ulcer to occur considerably beyond the defense reaction of mucosa.In general, peptic ulcer is a kind of multi-factor disease, wherein helicobacter pylori infections is known Etiological with taking NSAID (non-steroidal anti-inflammatory drug), and ulcer is the result of mucosa invasion and attack factor and defending factors loss of equilibrium, and gastric acid plays a crucial role in ulcer.The symptom main manifestations of peptic ulcer is stomachache, often with inappetence, and fullness and oppression in the stomach distension, nausea and vomiting, acid regurgitation and epigastric upset, the symptom that the gastric qis such as belch are become estranged, also have many patients taking the various complication of ulcer if perforation, hemorrhage, pyloric obstruction are as onset symptoms.
The medicine of western medical treatment gastritis and peptic ulcer is identical: (1) gastric mucosal protection medicine (as colloidal bismuth subcitrate, sucralfate, Marzulene-S, gel aluminum hydroxide, hydrotalcite, gastric Mucin, prostaglandin etc.); (2) adjust gastrointestinal motility function medicament (as: domperidone, motilium); (3) medicine that antacid is conventional is taking gastric acid secretion inhibiting as main proton pump inhibitor (PPI) (as: omeprazole, pantoprazole, lansoprazole, esomeprazole, rabeprazole), H2-receptor antagonist (as: cimetidine, ranitidine, famotidine), in and gastric acid be main alkaline matter (as sodium bicarbonate, calcium carbonate, magnesium hydroxide, gel aluminum hydroxide, magnesium trisilicate); (4) find helicobacter pylori (HP) positive if checked, should take antibiotic, as clarithromycin, amoxicillin, metronidazole, amoxicillin, furazolidone, levofloxacin, tetracycline etc., there is the effect of removing Hp, generally can select two kinds of antibiotic, normal and gastric mucosa protective agent and antacid use in conjunction; (5) analgesic Upper abdominal pain is compared with good to eat atropine, probanthine, Semen daturae tablet or the 654-2 of taking of severe one, to reduce gastric acid secretion and to alleviate colic symptoms; (6) other symptomatic treatment medicines can be used digestant, as pancreatin, yeast tablet, lactasinum, simethicone sheet etc., prevent that bile reflux from can take cholestyramine with absorption gallbladder juice; Have the hematemesis person of having blood in stool, cimetidine is oral.
The diseases such as acute gastritis in western medicine, chronic gastritis, peptic ulcer, stomach spasm, gastroptosis, prolapse of gastric mucosa, stomach neurosis, when it is during taking epigastrium gastralgia as main clinical manifestation, the traditional Chinese medical science is classified as the categories such as " gastric abscess " " noisy ".Traditional Chinese medical science demonstration is upper, shows as excess syndrome, is divided into the syndromes such as cold-evil visitor stomach, retention of food and drink, hyperactive liver-QI attacking the stomach, syndrome of liver-stomach heat, damp-heat in the spleen and stomach, blood stasis stagnation; Show as deficiency syndrome, be divided into the syndromes such as stomach-Yin virtual loss, Deficiency and coldness of spleen and stomach; Disease causes void because of real for a long time, or excess caused by deficiency, and many factors influences each other, the complicated syndrome that can form cold and heat and asthenia and sthenia and see.Chinese traditional treatment primary disease not only has good short term effect, and improving gastral cavilty and General Symptoms, have no side effect, relapse rate is low etc., and aspect still has suitable superiority.
[summary of the invention]
A kind of compositions and method for making for the treatment of gastritis and peptic ulcer of this disclosure of the invention, is characterized in that having the effects such as regulating the flow of Qi and the middle Jiao, promoting blood circulation and stopping pain, clearing away heat-damp and promoting diuresis, treatment gastritis and peptic ulcer curative effect soon, have no side effect, cost economy.
This invents a kind of compositions and method for making for the treatment of gastritis and peptic ulcer, it is characterized in that having the effects such as regulating the flow of Qi and the middle Jiao, promoting blood circulation and stopping pain, clearing away heat-damp and promoting diuresis, and substrate is prepared from by excipient in following Chinese medicine composition and pharmacy meaning:
Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae.
The pharmacology of this invention compositions is:
Radix Zanthoxyli: bitter in the mouth, pungent, property is flat, slightly poisonous, returns liver, stomach warp.Function cures mainly: promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral.The traumatic injury, rheumatic arthralgia, stomachache, the toothache that cause for qi depression to blood stasis, venom; The burning hot wound of external treatment soup.The Stomach duodenum ulcer that is used for the treatment of among the people.
Radix Rehmanniae: sweet-bitter flavor, cool in nature, enter the heart, liver, spleen, lung four warps.Effect: clearing away heat and promoting production of body fluid YIN nourishing, nourishes blood.Cure mainly fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon is hindered constipation, hepatic and renal YIN deficiency.Modern pharmacology shows helicobacter pylori (HP) sensitivity.
Fructus Citri Sarcodactylis: acrid in the mouth, hardship, warm in nature.Return Liver Channel, stomach warp, spleen channel, lung meridian.Function cures mainly: liver-smoothing, qi-regulating; Stomach function regulating reduces phlegm.Hypochondriac pain, breast for depression of liver-QI are vexed; The abdominal distention of incoordination between the liver and stomach, stagnation of QI in spleen and stomach, belch, nauseating; Chronic cough abundant expectoration.
Radix Streptocauli Griffithii: bitter in the mouth, micro-sweet, cool in nature.Function cures mainly: heat-clearing and toxic substances removing, scattered silt pain relieving.For cat fever, enteritis, dysentery, stomachache, gastric ulcer, treating swelling and pain by traumatic injury, venom.
Herba Verbenae: bitter in the mouth, cool in nature, return liver, spleen channel.Function cures mainly: promoting blood circulation to remove blood stasis, removing toxic substances, suppressing the hyperactive liver pathogenic fire purging, inducing diuresis to remove edema.For acute gastroenteritis, jaundice due to damp-heat, gastralgia etc.
Fructus Aurantii Immaturus: bitter in the mouth, pungent; Cold in nature.Return spleen, stomach, liver, heart channel.Effect: dispelling the stagnated QI removing food stagnancy, reduces phlegm except painful abdominal mass.In stagnant, stop; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature, return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis is antiabortive.Cure mainly insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Poria: slightly sweet flavor, property is flat, GUIXIN, lung, spleen, kidney channel.Effect: eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.For dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.
Radix Glycyrrhizae: sweet in the mouth, property is flat, enters spleen, stomach, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Modern pharmacology proves, glycyrrhiza preparation can promote stomach mucus to form and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; To HP sensitivity.
Each medical material composition weight ratio of the present composition is:
Radix Zanthoxyli: Radix Rehmanniae: Fructus Citri Sarcodactylis: Radix Streptocauli Griffithii: Herba Verbenae: Fructus Aurantii Immaturus: the Rhizoma Atractylodis Macrocephalae: Poria: Radix Glycyrrhizae=(2-4): (1-3): (2-4): (2-4): (2-4): (1-3): (1-3): (1-3): (2-4).
The manufacture method of the present composition and step:
Method for making one: by raw material rinsing airings such as Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizaes, vacuum drying, is crushed and screened into fine powder, mixes with appropriate auxiliary material, makes various shape agent in pharmacy meaning.
Method for making two: by raw material rinsing airings such as Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizaes, part material is ground into fine powder, remaining medical material adopts water to decoct or with alcohol reflux, by extracting liquid filtering purification, after concentrated, mix with fine powder and appropriate auxiliary material, make various shape agent in pharmacy meaning.
Method for making three: adopt the method for water distillation to extract after volatile oil Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, with Radix Zanthoxyli, Radix Rehmanniae, Radix Streptocauli Griffithii, Herba Verbenae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae etc., adopt water to decoct or with alcohol reflux, by extracting liquid filtering purification, after concentrated, mix with appropriate auxiliary material, add volatile oil, make various shape agent in pharmacy meaning.
Method for making four: first adopt water to decoct the medical materials such as Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, collect volatile oil simultaneously, then filter, by ethanol or water reflux, extract, for eight taste medical materials, by extracting liquid filtering purification, after concentrating, mix with appropriate auxiliary material, add volatile oil, make various shape agent in pharmacy meaning.
Method for making five: the part pulverizing medicinal materials in Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, licorice medicinal materials is become to fine powder, remaining Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus adopts the method for water distillation to extract after volatile oil, adopt water to decoct with the medical material such as remaining Radix Zanthoxyli, Radix Rehmanniae, Radix Streptocauli Griffithii, Herba Verbenae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae or with alcohol reflux, by extracting liquid filtering purification, after concentrated, mix with fine powder and appropriate auxiliary material, add volatile oil, make various shape agent in pharmacy meaning.
Method for making six: by ethanol or the water reflux, extract, for medical material such as Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, by extracting liquid filtering purification, after concentrated, mix with appropriate auxiliary material, make various shape agent in pharmacy meaning.
In above-mentioned preparation method, extract medical material effective ingredient, water or ethanol make solvent separately, also can water and ethanol alternately make solvent, also can adopt the water of different proportion and ethanol to extract respectively; Ingredients can united extraction, also can extract respectively, finally merges.Filtering purification can be filter screen, can be also eluting after absorption with macroporous adsorbent resin.If water decocts, add the water of 4～10 times of weight, decoct 0.5 hour～3 hours, decoct 1～4 time, preferably add the water of 8 times of amounts, decoct 1 hour, decoct 3 times; If with alcohol reflux, add the ethanol of 4～12 times of amounts, reflux, extract, 0.5～3 hour, extracts 1～4 time, preferably adds the ethanol (concentration 50%) of 8 times of amounts to extract 1 hour, extracts 3 times; If water decocts or alcohol reflux extracts respectively, be " add the water of 8 times of amounts; decoct 1～2 hour, decoct 2 times ", and " adding the ethanol (concentration 50%～70%) of 8 times of amounts to extract 1～2 hour; to extract 2 times " extract respectively, preferably add the water of 8 times of amounts, decoct 1 hour, decoct 2 times, then add the ethanol (concentration 50%～70%) of 8 times of amounts to extract 2 times, each 1 hour.Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus adopt the method for water extraction volatile oil to be: medical material is placed in to the container of sealing, adds the water of 4～10 times of weight, connect reflux, decoct or distill 1～4 hour, collect volatile oil simultaneously.Also the volatile oil of collecting can be carried out to beta-cyclodextrin inclusion compound, make it more stable, be convenient to join in powder or granule.The part medical material of pulverizing can be all or part of of single medical material, can be also part or all of a few taste medicines.
In above-mentioned preparation method, the various dosage forms that described medicine is made up of effective ingredient and the medically acceptable adjuvant of described medical material.Preferred dosage form is oral liquid, granule, tablet, capsule.
The prevention effect of the present composition is confirmed by following experiment.
One, the preventive effect to the Stomach duodenum damage due to ethanol:
Only get rat 150g/, be divided at random model group, experimental group, positive control (bismuth potassium citrate) group, 9 every group.Administration test liquid is all pure water preparations, and model group gives isopyknic pure water, and gavage is all with long 5-10cm, and the sebific duct of external diameter 0.2-0.3cm inserts stomach from esophagus, ensures that dosage is accurate.Experimental group gives following " embodiment 2 " prepared effective ingredient, dosage is 6.7g/kg/d by crude drug, and bismuth potassium citrate group dosage is 62mg/kg/d.Below respectively organize every day spice and feed 2 times, for three days on end, the 3rd day gastric infusion, fasting be can't help water 24 hours, after administration in the 4th day 2 hours, respectively organizes equal gavage 95% concentration ethanol 0.01ml/g, after 2 hours, de-neck is put to death rat, cuts abdominal part open, complete taking-up Mus stomach and duodenum, cut off gastric wall in rats, duodenum along greater gastric curvature, rinse coat of the stomach, duodenum with clear water, filter paper blots, and flattens, observe and record Gastroduodenal mucosal lesions degree of injury, calculate damaged area.
From prevention interpretation, substantially all there is congested, hemorrhage, edema, erosion and ulcer in various degree in finding rat stomach; There is hyperemia in various degree, hemorrhage, edema in duodenum, consistent with stomach degree of injury height.The model group stomach damage gross area is 117mm
2; The experimental group stomach damage gross area is 31.5m m
2; The bismuth potassium citrate group stomach damage gross area is 33m m
2.Present composition preventive effect is remarkable, suitable with Western medicine bismuth potassium citrate.
[0034] two, the therapeutical effect to the Stomach duodenum damage due to ethanol:
Only get rat 150g/, be divided at random model group, experimental group, positive control (bismuth potassium citrate) group, 9 every group.Administration test liquid is all pure water preparations, and model group gives isopyknic pure water, and gavage is all with long 5-10cm, and the sebific duct of external diameter 0.2-0.3cm inserts stomach from esophagus, ensures that dosage is accurate.Experimental group gives following " embodiment 3 " prepared effective ingredient, its dosage is 13.4g/kg/d by crude drug, and bismuth potassium citrate group dosage is 124mg/kg/d.The fasting of each group be can't help water 24 hours, and then fasting is prohibited water 2 hours, the then ethanol 0.01ml/g of gavage 95% concentration.Latter 4 hours of modeling success, the equal gavage 1.5ml pure water of each group, after 8 hours, experimental group gives following " embodiment 2 " prepared effective ingredient, its dosage is 3.35g/kg/ time by crude drug, bismuth potassium citrate group dosage is 31mg/kg/ time, and model group gives isopyknic pure water.Every 6 hours gavages 1 time, one day totally 4 times, for three days on end.After administration in the 3rd day 2 hours, de-neck is put to death rat, cut abdominal part open, complete taking-up Mus stomach and duodenum, cut off gastric wall in rats, duodenum along greater gastric curvature, rinses coat of the stomach, duodenum with clear water, filter paper blots, flatten, observe and record Grastiodudenal mucosa degree of injury, calculate damaged area.
From treatment interpretation, the model group stomach damage gross area is 148.5m m
2; Experimental group recovery from illness; The recovery from illness of bismuth potassium citrate group.The duodenal situation of model group and stomach damage high-positive correlation, but situation is lighter than stomach situation, only slight red and swollen, there is no ulcer phenomenon; The duodenum of experimental group, bismuth potassium citrate group is all normal.Present composition therapeutic effect is remarkable, suitable with Western medicine bismuth potassium citrate, on alleviation General Symptoms, is better than Western medicine bismuth potassium citrate.
Three, the preventive and therapeutic effect to " exhausting property of power swimming exercise acute gastric mucosal injury animal model experiment ":
Adopt the drum of high 60cm, bottom surface diameter 55cm as rats'swimming groove, depth of water 50cm, 28 DEG C of water temperatures.Exhausting property of power swimming exercise adopts without swimming with a load attached to the body.
Only get rat 150g/, be divided at random model group, experimental group, positive control (ranitidine) group, 9 every group.Administration test liquid is all pure water preparations, and model group gives isopyknic pure water, and gavage is all with long 5-10cm, and the sebific duct of external diameter 0.2-0.3cm inserts stomach from esophagus, ensures that dosage is accurate.The fasting of each group be can't help water 24 hours, then experimental group gives following " embodiment 5 " prepared effective ingredient, its dosage is 3.35g/kg/ time by crude drug, ranitidine group dosage is 31mg/kg/ time, model group gives isopyknic pure water, after gavage, put into water went swimming.After 5 hours, respectively organize again gavage once.Swim after 10 hours, de-neck is put to death rat, cuts abdominal part open, complete taking-up Mus stomach and duodenum, cut off gastric wall in rats, duodenum along greater gastric curvature, rinse coat of the stomach, duodenum with clear water, filter paper blots, flatten, observe and record Gastroduodenal mucosal lesions degree of injury, calculate damaged area.
Preventive and therapeutic effect analysis from " exhausting property of power swimming acute gastric ulcer animal model experiment ": the visible point-like of model group stomach or streak petechia, fester, the mucosal lesion gross area is: 121.5m m
2; The petechia of the visible point-like of positive control (ranitidine) group stomach, fester, the mucosal lesion gross area is: 18m m
2; Experimental group stomach is normal, there is no petechia and festers.The present composition is better than Western medicine ranitidine.
Four, the experiment of toxic and side effects:
Get 100 ± 5g/ rat only, sub-model matched group, experimental group, 10 every group.Experimental group gives pharmaceutical quantities and is 13.4g/kg/d by crude drug, and spice is fed, and every day 2 times, paired observation has no any untoward reaction for 1 month.
The plus-minus of the present composition changes: for differential diagnosis in tcm " deficiency of both QI and YIN " " weakness of the spleen and stomach ", can add Radix Codonopsis, Radix Ginseng, Rhizoma Zingiberis Recens etc., in fill temperature; If check and find helicobacter pylori (HP) positive; generally can select one or both antibiotic (as clarithromycin, amoxicillin, metronidazole, amoxicillin, furazolidone, levofloxacin, tetracycline etc.), with gastric mucosa protective agent and antacid use in conjunction.
[detailed description of the invention]
Following specific embodiment is detailed description of the invention, should not be understood as limitation of the present invention.
Embodiment 1:
Radix Zanthoxyli 100g, Radix Rehmanniae 200g, Fructus Citri Sarcodactylis 200g, Radix Streptocauli Griffithii 200g, Herba Verbenae 150g, Fructus Aurantii Immaturus 100g, Rhizoma Atractylodis Macrocephalae 200g, Poria 100g, Radix Glycyrrhizae 200g, by above-mentioned raw materials rinsing airing, vacuum drying, pulverize and sieve, become fine powder, mix, every 100g powder adds refined honey 120-150g and makes honeyed pill, every ball 10g.
Embodiment 2:
Radix Zanthoxyli 200g, Radix Rehmanniae 150g, Fructus Citri Sarcodactylis 200g, Radix Streptocauli Griffithii 300g, Herba Verbenae 300g, Fructus Aurantii Immaturus 100g, Rhizoma Atractylodis Macrocephalae 200g, Poria 150g, Radix Glycyrrhizae 200g, be ground into fine powder by Radix Zanthoxyli 30g, Radix Streptocauli Griffithii 30g, and remaining medical material adds 17L water to decoct, decoct 3 times, each 1 hour, by extracting liquid filtering purification, be condensed into after fluid extract, mix with fine powder, sieve, dry at 60 DEG C, granulate sieves, incapsulate, to obtain final product.
Embodiment 3:
Radix Zanthoxyli 200g, Radix Rehmanniae 200g, Fructus Citri Sarcodactylis 200g, Radix Streptocauli Griffithii 200g, Herba Verbenae 200g, Fructus Aurantii Immaturus 100g, Rhizoma Atractylodis Macrocephalae 200g, Poria 100g, Radix Glycyrrhizae 200g, by Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus adopts the method for water distillation to extract after volatile oil, with Radix Zanthoxyli, Radix Rehmanniae, Radix Streptocauli Griffithii, Herba Verbenae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae etc., add 15L ethanol (concentration 50%) reflux, extract, extract 2 times, each 1 hour, after use 15L water extraction 1 hour, extracting solution is merged and filters purification, reclaim ethanol, be condensed into after fluid extract, mix with appropriate Icing Sugar, granulate, dry, spray into volatile oil, seal 12 hours, make drug particles.
Embodiment 4:
Radix Zanthoxyli 200g, Radix Rehmanniae 100g, Fructus Citri Sarcodactylis 200g, Radix Streptocauli Griffithii 200g, Herba Verbenae 200g, Fructus Aurantii Immaturus 150g, Rhizoma Atractylodis Macrocephalae 150g, Poria 100g, Radix Glycyrrhizae 100g, above-mentioned medical material first adopts 11L water to carry out vacuum and decocts 2 hours, collect volatile oil simultaneously, then filter, eight taste medical materials are used to 10L ethanol (concentration 60%) reflux, extract, 1 hour, extract 2 times, by extracting liquid filtering purification, reclaim ethanol, be condensed into after fluid extract, add starch to mix, dry at 60 DEG C, be screened into granule, add the volatile oil of beta-cyclodextrin inclusion compound, be mixed, compacting in flakes, coating, .
Embodiment 5:
Radix Zanthoxyli 200g, Radix Rehmanniae 100g, Fructus Citri Sarcodactylis 200g, Radix Streptocauli Griffithii 200g, Herba Verbenae 200g, Fructus Aurantii Immaturus 100g, Rhizoma Atractylodis Macrocephalae 100g, Poria 100g, Radix Glycyrrhizae 100g, above-mentioned medical material adds 10L ethanol (concentration 50%) reflux, extract, 1 hour, extracts 3 times, by extracting liquid filtering purification, reclaim ethanol, concentrating under reduced pressure is dried to fine powder, mixes with appropriate Icing Sugar, dextrin, with 80% ethanol soft material processed, the granulation of sieving, dry at 60 DEG C, the granulation of sieving, subpackage, to obtain final product.
Design under the prerequisite of spirit not departing from the present invention, various change row and improvement that this area ordinary person carries out technical solution of the present invention, all should fall in the definite protection domain of claim of the present invention.
Claims (9)
1. treat compositions and the method for making of gastritis and peptic ulcer for one kind, it is characterized in that thering is regulating the flow of Qi and the middle Jiao, promoting blood circulation and stopping pain, the effects such as clearing away heat-damp and promoting diuresis, substrate is prepared from by excipient in following Chinese medicine composition and pharmacy meaning: Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae.
2. according to claim 1, the method for making of Chinese medicine composition of the present invention is:
(1) method for making one: by raw material rinsing airings such as Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizaes, vacuum drying, be crushed and screened into fine powder, mix with appropriate auxiliary material, make various shape agent in pharmacy meaning;
(2) method for making two: by raw material rinsing airings such as Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizaes, part material is ground into fine powder, remaining medical material adopts water to decoct or with alcohol reflux, by extracting liquid filtering purification, after concentrated, mix with fine powder and appropriate auxiliary material, make various shape agent in pharmacy meaning;
(3) method for making three: adopt the method for water distillation to extract after volatile oil Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, with Radix Zanthoxyli, Radix Rehmanniae, Radix Streptocauli Griffithii, Herba Verbenae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae etc., adopt water to decoct or with alcohol reflux, by extracting liquid filtering purification, after concentrated, mix with appropriate auxiliary material, add volatile oil, make various shape agent in pharmacy meaning;
(4) method for making four: first adopt water to decoct the medical materials such as Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, collect volatile oil simultaneously, then filter, by ethanol or water reflux, extract, for eight taste medical materials, by extracting liquid filtering purification, after concentrating, mix with appropriate auxiliary material, add volatile oil, make various shape agent in pharmacy meaning;
(5) method for making five: the part pulverizing medicinal materials in Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, licorice medicinal materials is become to fine powder, remaining Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus adopts the method for water distillation to extract after volatile oil, adopt water to decoct with the medical material such as remaining Radix Zanthoxyli, Radix Rehmanniae, Radix Streptocauli Griffithii, Herba Verbenae, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae or with alcohol reflux, by extracting liquid filtering purification, after concentrated, mix with fine powder and appropriate auxiliary material, add volatile oil, make various shape agent in pharmacy meaning;
(6) method for making six: by ethanol or the water reflux, extract, for medical material such as Radix Zanthoxyli, Radix Rehmanniae, Fructus Citri Sarcodactylis, Radix Streptocauli Griffithii, Herba Verbenae, Fructus Aurantii Immaturus, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, by extracting liquid filtering purification, after concentrated, mix with appropriate auxiliary material, make various shape agent in pharmacy meaning.
3. according to claim 1, each medical material composition weight ratio of Chinese medicine composition of the present invention is:
Radix Zanthoxyli: Radix Rehmanniae: Fructus Citri Sarcodactylis: Radix Streptocauli Griffithii: Herba Verbenae: Fructus Aurantii Immaturus: the Rhizoma Atractylodis Macrocephalae: Poria: Radix Glycyrrhizae=(2-4): (1-3): (2-4): (2-4): (2-4): (1-3): (1-3): (1-3): (2-4).
4. according to described in claim 1, the various dosage forms that Chinese medicine composition of the present invention is made up of effective ingredient and the medically acceptable adjuvant of described medical material or medical material.
5. according to described in claim 2, extract medical material effective ingredient in present composition preparation method, water or ethanol make solvent separately, also can water and ethanol alternately make solvent, also can adopt the water of different proportion and ethanol to extract respectively; Ingredients can united extraction, also can extract respectively, finally merges; Filtering purification can be filter screen, can be also eluting after absorption with macroporous adsorbent resin.
6. according to described in claim 2, in present composition preparation method, extract medical material effective ingredient: water decocts, and is the water that adds 4～10 times of weight, decocts 0.5 hour～3 hours, decocts 1～4 time; With alcohol reflux, be the ethanol that adds 4～12 times of amounts, reflux, extract, 0.5～3 hour, extracts 1～4 time; Water decocts or alcohol reflux extracts respectively, is to extract respectively " add the water of 8 times of amounts, decoct 1～2 hour, decoct 2 times " and " add the ethanol (concentration 50%～70%) of 8 times of amounts to extract 1～2 hour, extract 2 times "; Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus adopt the method for water extraction volatile oil to be: medical material is placed in to the container of sealing, adds the water of 4～10 times of weight, connect reflux, decoct or distill 1～4 hour, collect volatile oil simultaneously.
7. according to described in claim 2, in present composition preparation method, extract medical material effective ingredient: with water extraction, be the water that adds 8 times of amounts, decoct 1 hour, decoct 3 times; With ethanol extraction, be that the ethanol (concentration 50%) that adds 8 times of amounts extracts 1 hour, extract 3 times; Water decocts or alcohol reflux extracts respectively, is the water that adds 8 times of amounts, decocts 1 hour, decocts 2 times, then adds the ethanol (concentration 50%～70%) of 8 times of amounts to extract 2 times, each 1 hour.
8. according to claim 1; the present composition can add Radix Codonopsis, Radix Ginseng, Rhizoma Zingiberis Recens etc.; can with one or both antibiotic (as clarithromycin, amoxicillin, metronidazole, amoxicillin, furazolidone, levofloxacin, tetracycline etc.), with gastric mucosa protective agent and antacid use in conjunction.
9. according to described in claim 2, in present composition preparation method, the part medical material of pulverizing can be all or part of of single medical material, can be also part or all of a few taste medicines.
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