CN109045242A - The drug for treating atrophic gastritis - Google Patents

The drug for treating atrophic gastritis Download PDF

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Publication number
CN109045242A
CN109045242A CN201811122917.3A CN201811122917A CN109045242A CN 109045242 A CN109045242 A CN 109045242A CN 201811122917 A CN201811122917 A CN 201811122917A CN 109045242 A CN109045242 A CN 109045242A
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parts
semen coicis
atrophic gastritis
stomach
spleen
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陈丽妹
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Beijing Three Medical Wisdom Technology Co Ltd
Beijing Sany Intelligent Technology Co Ltd
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Beijing Three Medical Wisdom Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/748Oldenlandia or Hedyotis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994Coix (Job's tears)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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Abstract

The present invention provides a kind of drugs for treating atrophic gastritis: including being prepared from the following traditional Chinese medicines in parts by weight: 10-30 parts of oldenlandia diffusa, 10-40 parts of radix pseudostellariae, 10-50 parts of Semen Coicis Semen Coicis, 5-20 parts of stir-baked RADIX BUPLEURI with vinegar, 5-20 parts of caulis perllae, 10-30 parts of curcuma zedoary.According to the technical solution of the present invention, play the role of that Qinghua is damp and hot, replenishes qi to invigorate the spleen, for treating gastral cavilty ruffian plug caused by atrophic gastritis is damp heat in the spleen and the stomach and syndrome of qi deficiency, belch, limb out of strength is tired, and loose watery stool is indigestion and loss of appetite, dark tongue quality, and tongue fur is greasy or yellow greasy, slippery are thin or heavy.

Description

The drug for treating atrophic gastritis
Technical field
The present invention relates to technical field of pharmaceuticals, in particular to a kind of drug for treating atrophic gastritis.
Background technique
It is referred to as (CAG) a kind of common disease, with gastric epithelial and gland that atrophic gastritis, which is also referred to as atrophic gastritis, Body atrophy, number are reduced, and stomach lining is thinning, and mucous membrane base thickens, or with gland metaplasia and intestinal gland metaplasia, or the increasing that is not true to type The raw chronic digestive system disease being characterized.Often show as upper abdomen secret anguish, turgor, belch, loss of appetite, or thin, anaemia Deng no specificity.A kind of more pathogenic factor diseases and precancerous lesion, 1978 the World Health Organization (WHO) CAG is arranged For the precancerous condition of gastric cancer, it is classified as Gastric precancerous condition, especially with intestinal metaplasia or atypical hyperplasia person, canceration can Energy property is bigger.It is fallen ill slowly, and patient's condition is touching, and delay is refractory, treats intractable.
Modern medicine thinks that the cause of disease of atrophic gastritis has: 1. helicobacter pyloris (Hp) infection;2. eating habit, Smoking, drinks, food stimulus damages the drug etc. of stomach lining;3. immune factor, in atrophic gastritis, especially body of stomach gastritis The blood of patient, gastric juice or in the thick liquid cell of atrophy mucous membrane, can often find parietal cell antibody or intrinsic factor antibody, thus think from Body immune response is the related cause of disease of atrophic gastritis;4. bile or Duodenal reflux;5. physical factors, clinical statistics knot Fruit shows that the occurrence of this disease and age are positively correlated in significant;6. inherent cause, the status in the morbidity of A type atrophic gastritis is It is proved, PCA, IFA positive rate are high in pernicious anaemia kinsfolk, and atrophic gastritis is common;7. metal contacts, Lead exposed work Author's Mechanism of Gastric Ulcer rate is high, and stomach lining biopsy discovery atrophic gastritis disease incidence also increases.Many huge sum of moneys in addition to lead Belonging to such as mercury, copper and zinc has certain damaging action to stomach lining.
Atrophic gastritis is separately divided into three-level according to the degree of atrophy:
Slight: antrum portion shallow-layer body of gland is in focal atrophy, is reduced, and the curved body of gland of size is normal.
Moderate: antrum portion and small curved body of gland have atrophy, reduce, and it is relatively slight extensive to cut range.
Severe: the major part atrophy of antrum portion is reduced, only a small number of original bodies of gland of residual, large and small curved and curved body of gland atrophy;Or Mucous membrane is significant thinning, the complete atrophy of original body of gland, disappearance, and instead metaplasia body of gland.
Treatment mostly uses following types of drug:
1. protection the common drug of gastric mucosa medicine have colloidal bismuth citrate (CBS), ulcerlmin, dioctahedral smectite, Marzulene-S, Gel aluminum hydroxide, gastric mucin and gavirin tablet etc..
2. adjusting gastrointestinal motility function drug Abdeminal pain metoclopramide or domperidone etc..Hiccup, abdominal distension are backflowed Phenomenon is main person, medicine for stomach dynamic can be used, such as metoclopramide, dompendone or Cisapride (prepulsid).
If antibiotic, clarithromycin, oxyammonia should be taken 3. antibiotic gastrocopy discovery helicobacter pylori experiment is positive Parasiticin, gentamicin, furazolidone, streptomysin, kanamycins, tetracycline, scholar's mycin etc. play the role of removing HP, It is general to can be selected two kinds, often with gastric mucosa protectant and antiacid use in conjunction.
4. the common drug of antiacid has Cimetidine, ranitidine, famotidine, sodium bicarbonate (sodium bicarbonate), hydrogen-oxygen Change magnesium, gastropine, gel aluminum hydroxide, gavirin tablet etc..
5. Upper abdominal pain is compared with the orally available atropine of severe one, pro-banthine, Semen daturae tablet, to reduce gastric acid secretion and alleviate abdominal pain Symptom.
But these treatments only improve symptom to a certain extent, eradicate to CAG, Western medicine still lacks specific medicament at present.
Summary of the invention
The present invention is directed to solve at least one of the technical problems existing in the prior art or related technologies.
For this purpose, it is an object of the invention to provide a kind of drugs for treating atrophic gastritis.
In view of this, technical solution of the present invention provides a kind of drug for treating atrophic gastritis: including by with The Chinese medicine of lower parts by weight is made: 10-30 parts of oldenlandia diffusa, 10-40 parts of radix pseudostellariae, and 10-50 parts of Semen Coicis Semen Coicis, stir-baked RADIX BUPLEURI with vinegar 5-20 Part, 5-20 parts of caulis perllae, 10-30 parts of curcuma zedoary.
Preferably, oldenlandia diffusa 10-20 parts, 15-30 parts of radix pseudostellariae, 20-40 parts of Semen Coicis Semen Coicis, 6-12 parts of stir-baked RADIX BUPLEURI with vinegar, 6-12 parts of caulis perllae, 10-20 parts of curcuma zedoary.
Preferably, 15 parts of oldenlandia diffusa, 20 parts of radix pseudostellariae, 30 parts of Semen Coicis Semen Coicis, 10 parts of stir-baked RADIX BUPLEURI with vinegar, 10 parts of caulis perllae, cowherb 15 parts of art.
One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:
Play the role of that Qinghua is damp and hot, replenishes qi to invigorate the spleen, atrophic gastritis is damp heat in the spleen and the stomach and syndrome of qi deficiency institute for treating The gastral cavilty ruffian plug of cause, belch, limb out of strength is tired, and loose watery stool is indigestion and loss of appetite, dark tongue quality, and tongue fur is greasy or yellow greasy, slippery are thin or heavy.Its prescription Side's solution is the mechanism of action are as follows:
Oldenlandia diffusa mildly bitter flavor is sweet, cold in nature in side, function clearing heat, detoxicating, dispelling dampness, for main pathogenesis syndrome of dampness-heat of spleen and stomach If therefore being monarch drug in a prescription.Modern pharmacology research shows that oldenlandia diffusa has suppressing and killing helicobacter pylori effect.Radix pseudostellariae sweet-bitter flavor, property It is flat, returns spleen lung channel, not only enriching spleen-QI, but also nourishing stomach-YIN, for the product of clear benefit;Semen Coicis Semen Coicis invigorating spleen to remove dampness, the two are directed to accompanying symptoms syndrome of qi deficiency And set, it is altogether ministerial drug.First wood gram second soil, the prosperous then horizontal criminal's stomach of irritability lead to liver-stomach disharmony, therefore share stir-baked RADIX BUPLEURI with vinegar soothing liver-qi stagnation, item Up to irritability;Caulis perllae regulating qi-flowing for harmonizing stomach;Curcuma zedoary blood-breaking promoting the circulation of qi, three are adjuvant altogether.Modern pharmacology research shows oldenlandia Grass and curcuma zedoary still have antitumor action, it can block and reverse precancerous lesions of chronic atrophic gastritis.Said components mutually cooperate with, altogether It is damp and hot with Qinghua is played, the effect of replenishing qi to invigorate the spleen.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description Obviously, or practice through the invention is recognized.
Specific embodiment
In order to be more clearly understood that aforementioned aspect of the present invention, feature and advantage, With reference to embodiment The present invention is further described in detail.It should be noted that in the absence of conflict, embodiments herein and reality The feature applied in example can be combined with each other.
In the following description, numerous specific details are set forth in order to facilitate a full understanding of the present invention, still, the present invention may be used also To be implemented using other than the one described here other modes, therefore, protection scope of the present invention is not by described below Specific embodiment limitation.
Atrophic gastritis different TCM syndrome types have damp heat in the spleen and the stomach, weakness of the spleen and the stomach, deficiency of stomach-Yin, the deficiency of Yin folder stasis of blood and liver stomach not With.It is directed to main card type spleen and stomach damp-heat type, the prescription through science, and the clinical verification through many years, obtain reality of the invention Apply a kind of Chinese medicinal formulae for treating atrophic gastritis described in example.The prescription is not only curative for effect, and refining formula is pacified Entirely, being very suitable to exploitation is Chinese patent drug.
The drug of the treatment atrophic gastritis of embodiment according to the present invention, including the Chinese medicine system by following parts by weight At: 10-30 parts of oldenlandia diffusa, 10-40 parts of radix pseudostellariae, 10-50 parts of Semen Coicis Semen Coicis, 5-20 parts of stir-baked RADIX BUPLEURI with vinegar, 5-20 parts of caulis perllae, 10-30 parts of curcuma zedoary.
Preferably, oldenlandia diffusa 10-20 parts, 15-30 parts of radix pseudostellariae, 20-40 parts of Semen Coicis Semen Coicis, 6-12 parts of stir-baked RADIX BUPLEURI with vinegar, 6-12 parts of caulis perllae, 10-20 parts of curcuma zedoary.
Preferably, 15 parts of oldenlandia diffusa, 20 parts of radix pseudostellariae, 30 parts of Semen Coicis Semen Coicis, 10 parts of stir-baked RADIX BUPLEURI with vinegar, 10 parts of caulis perllae, cowherb 15 parts of art.
The major function of the drug of the present embodiment are as follows: Qinghua is damp and hot, replenishes qi to invigorate the spleen, wet for atrophic gastritis taste Gastral cavilty ruffian plug caused by hot and syndrome of qi deficiency, belch, limb out of strength is tired, and loose watery stool is indigestion and loss of appetite.Dark tongue quality, tongue fur is greasy or yellow greasy, slippery are thin Or it is heavy.Its prescription side solution is the mechanism of action are as follows:
Oldenlandia diffusa mildly bitter flavor is sweet, cold in nature in side, function clearing heat, detoxicating, dispelling dampness, for main pathogenesis syndrome of dampness-heat of spleen and stomach If therefore being monarch drug in a prescription.Modern pharmacology research shows that oldenlandia diffusa has suppressing and killing helicobacter pylori effect.Radix pseudostellariae sweet-bitter flavor, property It is flat, returns spleen lung channel, not only enriching spleen-QI, but also nourishing stomach-YIN, for the product of clear benefit;Semen Coicis Semen Coicis invigorating spleen to remove dampness, the two are directed to accompanying symptoms syndrome of qi deficiency And set, it is altogether ministerial drug.First wood gram second soil, the prosperous then horizontal criminal's stomach of irritability lead to liver-stomach disharmony, therefore share stir-baked RADIX BUPLEURI with vinegar soothing liver-qi stagnation, item Up to irritability;Caulis perllae regulating qi-flowing for harmonizing stomach;Curcuma zedoary blood-breaking promoting the circulation of qi, three are adjuvant altogether.Modern pharmacology research shows oldenlandia Grass and curcuma zedoary still have antitumor action, it can block and reverse precancerous lesions of chronic atrophic gastritis.All medicines are harmonious, and play Qinghua altogether Function that is damp and hot, replenishing qi to invigorate the spleen.
The pharmacological action of each compatibility Chinese medicine is described below in prescription:
Oldenlandia diffusa: this product is the drying herb of madder wort oldenlandia diffusa.Mildly bitter flavor, it is cold in nature, stomach, large intestine, Small intestinl channel.With clearing heat and detoxicating, the effect of diuresis of blood circulation promoting.It is clinically used for tonsillitis, sphagitis, urinary tract infections, hepatitis, tumour Deng.Modern pharmacology confirms that it can enhance immunity of organisms, inhibits growth of tumour cell, reinforces phagocytosis.
Radix pseudostellariae: this product is the dried root of pinkwort caryophyllaceous ginseng.Sweet, slight bitter is put down.Returns spleen, lung channel.QI invigorating is strong Spleen, it is promoting production of body fluid and nourishing the lung.Tired, the loss of appetite for spleen deficiency body, eak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration and thirst, dryness of the lung dry cough.
Radix bupleuri: for the root or herb of Umbelliferae herbaceos perennial radix bupleuri (Bupleurum Chinese) and radix bupleuri scorzoneraefolii (RADIX BUPLEURI SCORZONERAEFOLII). Acrid flavour, hardship, cold nature return liver, gallbladder, lung channel.In inducing diaphoresis, soothing liver-qi stagnation, yang invigorating, preventing malaria of bringing down a fever.Clinic is chiefly used in feeling Fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, uterine prolapse, rectal prolapse etc. are emitted, and the pharmacology with liver protection is used.Radix bupleuri vinegar The property of liter hair can be lowered after system, in order to avoid rise hair too.Modern medicine confirms that radix bupleuri Central nervous system has apparent calm, town Bitterly, antipyretic, cooling effect;There is liver protection to digestive system, cholagogue, inhibit gastric secretion and spasmolysis;In addition also have anti- The effects of inflammation, antipathogen.
Semen coicis: for the mature seed kernel of grass family herbaceos perennial semen coicis.It is sweet in flavor, light, cool in nature, returns spleen, stomach, lung Through.Advantageous water penetration is wet, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, the effect of detoxicating and resolving a mass.It is clinically used for oedema, tinea pedis, difficult urination, Splenasthenic diarrhea, arthritis with fixed pain caused by dampness muscular constricture, pulmonary abscess, acute appendicitis;Wart, cancerous swelling.Clinic is mostly raw use, is fried with the power for enhancing its invigorating the spleen.Modern medicine Reason confirms that it has the effects that calmness, eases pain, is antipyretic and antitumor.
Caulis perllae: this product is the drying stem of Lamiaceae plant purple perilla.It is acrid in flavour and warm in nature.Return lung, the spleen channel.Regulating the flow of QI to ease the stomach, analgesic, miscarriage prevention. Bored, the gastral cavity pain for chest diaphragm ruffian, belch vomiting, threatened abortion.Modern medical studies have confirmed that there is promotion digestive juice secretion, promote The effect of gastrointestinal peristalsis can be reduced bronchial secretion, alleviate bronchial spasm and bacteriostasis.
Curcuma zedoary: this product is zingiberaceous plant zedoary, Guangxi zedoary or the dry rhizome of Radix Curcumae.It is pungent, bitter, temperature.Return liver, spleen Through.Promoting the circulation of qi blood-breaking, clearing stagnation and killing pain.Yong Yu abdominal mass and lump, blood stasis closed, chest impediment and cardialgia, dyspepsia distending pain.Modern pharmacological research confirms With antibacterial, antitumor, immune, Robust speaker feature and excited gastrointestinal tract effect.
Using with the prescription of the present embodiment is that atrophic gastritis is treated by basic side, after treatment in 1 course for the treatment of (90 days), It is respectively 96.7%, 66.7% in conjunction with clinical and gastroscopy pathology total effective rate, treatment group of the present invention, western medicine group is respectively 63.3%, 36.7%, through statistical analysis, difference is statistically significant (P < 0.05).
Below with reference to embodiment, the present invention is further explained:
Embodiment 1:
Weigh 15 parts of oldenlandia diffusa, 20 parts of radix pseudostellariae, 30 parts of Semen Coicis Semen Coicis, 10 parts of stir-baked RADIX BUPLEURI with vinegar, 10 parts of caulis perllae, curcuma zedoary 15 Part.
Preparation step:
By the weighed each taste Chinese medicine of institute, decoction is decocted by traditional handicraft or during Chinese patent medicine preparation technique routinely is processed into The clinical main Chinese patent medicine preparation such as tablet defined in state's pharmacopeia, pill, capsule, granule, powder or oral solution.
Embodiment 2:
Weigh 10 parts of oldenlandia diffusa, 10 parts of radix pseudostellariae, 10 parts of Semen Coicis Semen Coicis, 5 parts of stir-baked RADIX BUPLEURI with vinegar, 5 parts of caulis perllae, curcuma zedoary 10 Part.
Preparation step is as described in Example 1.
Embodiment 3:
Weigh 30 parts of oldenlandia diffusa, 40 parts of radix pseudostellariae, 50 parts of Semen Coicis Semen Coicis, 20 parts of stir-baked RADIX BUPLEURI with vinegar, 20 parts of caulis perllae, curcuma zedoary 30 Part.
Preparation step is as described in Example 1.
Embodiment 4:
Weigh 20 parts of oldenlandia diffusa, 30 parts of radix pseudostellariae, 40 parts of Semen Coicis Semen Coicis, 12 parts of stir-baked RADIX BUPLEURI with vinegar, 12 parts of caulis perllae, curcuma zedoary 20 Part.
Preparation step is as described in Example 1.
Embodiment 5:
Weigh 12 parts of oldenlandia diffusa, 25 parts of radix pseudostellariae, 25 parts of Semen Coicis Semen Coicis, 6 parts of stir-baked RADIX BUPLEURI with vinegar, 9 parts of caulis perllae, curcuma zedoary 12 Part.
Preparation step is as described in Example 1.
Embodiment 6:
Weigh 18 parts of oldenlandia diffusa, 15 parts of radix pseudostellariae, 15 parts of Semen Coicis Semen Coicis, 9 parts of stir-baked RADIX BUPLEURI with vinegar, 6 parts of caulis perllae, curcuma zedoary 18 Part.
Preparation step is as described in Example 1.
Embodiment 7:
Weigh 25 parts of oldenlandia diffusa, 18 parts of radix pseudostellariae, 30 parts of Semen Coicis Semen Coicis, 15 parts of stir-baked RADIX BUPLEURI with vinegar, 15 parts of caulis perllae, curcuma zedoary 25 Part.
Preparation step is as described in Example 1.
Embodiment 8:
Weigh 15 parts of oldenlandia diffusa, 30 parts of radix pseudostellariae, 45 parts of Semen Coicis Semen Coicis, 18 parts of stir-baked RADIX BUPLEURI with vinegar, 10 parts of caulis perllae, curcuma zedoary 15 Part.
Preparation step is as described in Example 1.
Clinical application example
Case 1:
Certain is shut out, female, 30 years old, first visit in November, 2014.
Electronic gastroscope: chronic superficial gastritis is with rotten to the corn;
Pathology shows: (antrum) severe chronic gastritis (active stage), partially in atrophic gastritis with moderate intestines, part Glandular hyperplasia.(antrum M) severe chronic gastritis (active stage), local mucous membrane are rotten to the corn, in atrophic gastritis with slight intestines, Slight atypical hyperplasia, HP (+), it is proposed that follow-up.(stomach angle) severe chronic gastritis (active stage), the local slight atrophy of body of gland is with light Spend intestines, slight atypical hyperplasia, it is proposed that follow-up;
(body of stomach) light-moderate chronic superficial gastritis (active stage);
Symptom: gastral cavilty portion ruffian plug or postprandial turgor, for dry without bitter taste, limb out of strength is tired, no nausea, defecates viscous.Arteries and veins is thin Sliding, tongue is dark red, yellow,greasy and thin fur;
Diagnosis: Chinese medicine: stomach ruffian (liver-stomach disharmony, damp and hot interior knot, have the deficiency of vital energy concurrently);
Doctor trained in Western medicine: atrophic gastritis is with intestines, dysplasia;
Therapeutic scheme is that prescription of the present invention is basic side's treatment.
Treat January after in December, 2014 pathological examination are as follows:
(antrum) moderate chronic atrophic gastritis, with slight intestinal metaplasia, gentle activity, part body of gland has slight Atypia.(at gastric antrum erosion) mucous membrane moderate chronic is scorching, with slight intestinal metaplasia, gentle activity, focal individual body of gland tools There is light-moderate atypia.HP (+) (stomach angle) mucous membrane severe chronic is scorching, and with slight intestinal metaplasia, individual bodies of gland have slight different Type.Chronic superficial gastritis that (body of stomach) is slight.
Clinical symptoms are obviously improved.It can be seen that from pathological examination, each portion's pathologic condition of patient's stomach has clear improvement, by severe Switch to light moderate.
Case 2:
Liu, female, 51 years old, first visit one day in March, 2015.
Gastroscope shows: atrophic gastritis is with rotten to the corn;
Pathology shows: antrum severe intestines, slight atypical hyperplasia;The moderate atrophy of stomach angle, slight intestinesization companion are not true to type slightly Hyperplasia;
Symptom: bitter taste, ozostomia, gastral cavilty turgor, belch frequency are made, no pantothenic acid, insomnia, anxiety.Stool is normal.Small and wiry pulse Sliding, tongue is dark red, moss thin yellow
Therapeutic scheme is that present invention side is that basic side's plus-minus is decocted in water for oral dose.
After treatment 3 months, clinical symptoms disappear substantially, one day in June, 2015
Gastroscope shows: atrophic gastritis
Pathology shows: (stomach angle) light-moderate chronic atrophic gastritis, and slight intestines
(antrum) moderate chronic is scorching, slight intestines
It can be seen that from pathological examination, conditions of patients is obviously controlled.
Case 3:
Shao, male, 52 years old, first visit in 06 month in 2015.
Gastroscope shows: atrophic gastritis (atrophy is with intestines) HP (+++);
Pathology shows: (antrum) severe intestines, severe atrophy;(antrum antetheca, stomach angle) moderate chronic is scorching;
Symptom: ozostomia, without nauseous sour regurgitation, heartburn, stool is normal, and chilly is out of strength, and bitter taste, arteries and veins is fine and smooth and heavy, and tongue is dark It is red, yellow,greasy and thin fur;
Diagnosis: Chinese medicine: stomach ruffian (liver-stomach disharmony, damp and hot interior knot, have the deficiency of vital energy concurrently);
Doctor trained in Western medicine: atrophic gastritis is with intestines, dysplasia;
Therapeutic scheme is that present invention side is that basic side is decocted in water for oral dose with disease plus-minus.
It takes medicine after March, all diseases disappear substantially, in September, 2015 one day,
Gastroscope shows: atrophic gastritis is negative with erosion HP
Pathology shows: atrophic gastritis that (antrum) is slight, local surfaces epithelium missing;Chronic gastritis that (stomach angle) is slight, Part is in slight atrophic gastritis, part Glandular Dilatation.
It can be seen that from gastroscope and pathological examination, patient's state of an illness after present invention side is treated is clearly better.
Case 4:
Sun, female, first visit in 2 months in 2015 in 63 years old.
Gastroscope shows: atrophic gastritis is with bile regurgitation, oesophagus isolatism phlebangioma;
Pathology shows: (stomach angle) mucous membrane moderate chronic is scorching, and part body of gland is reduced, body of gland is slight intestines;(antrum) mucous membrane moderate Chronic inflammation, part show moderate chronic atrophic gastritis accompanied body of gland moderate intestines.
Symptom: gastral cavilty portion makees when scorching hot, turgor, and dry mouth with bitter taste is out of strength, no nausea, and stool is normal.Arteries and veins is fine and smooth, pink tongue, Whitish tongue is greasy;
Diagnosis: Chinese medicine: stomach ruffian (syndrome of liver-stomach heat has the deficiency of vital energy concurrently);
Doctor trained in Western medicine: atrophic gastritis is with intestines, bile regurgitation;
Therapeutic scheme is that present invention side is that basic side is decocted in water for oral dose with disease plus-minus.
It takes medicine after March, all diseases disappear substantially, one day in May, 2015,
Gastrocopy: atrophic gastritis;
Pathology shows: chronic gastritis that (stomach angle) is slight, local interstitial edema, body of gland are sparse.
It can be seen that from gastroscope and pathological examination, patient's state of an illness after present invention side is treated is clearly better.
Prescription of the present invention is effective to the treatment safety of atrophic gastritis in summary, can effectively improve chronic wither The clinical symptoms and pathologic condition of contracting gastritis sufferer.And reasonable recipe refines, and is very suitable to exploitation at Chinese materia medica preparation (patent medicine).
In the description of this specification, the description of term " one embodiment ", " some embodiments ", " specific embodiment " etc. Mean that particular features, structures, materials, or characteristics described in conjunction with this embodiment or example are contained at least one reality of the invention It applies in example or example.In the present specification, schematic expression of the above terms are not necessarily referring to identical embodiment or reality Example.Moreover, description particular features, structures, materials, or characteristics can in any one or more of the embodiments or examples with Suitable mode combines.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.

Claims (3)

1. a kind of drug for treating atrophic gastritis, which is characterized in that including being prepared from the following traditional Chinese medicines in parts by weight:
10-30 parts of oldenlandia diffusa, 10-40 parts of radix pseudostellariae, 10-50 parts of Semen Coicis Semen Coicis, 5-20 parts of stir-baked RADIX BUPLEURI with vinegar, 5-20 parts of caulis perllae, 10-30 parts of curcuma zedoary.
2. the drug for the treatment of atrophic gastritis according to claim 1, it is characterised in that:
10-20 parts of oldenlandia diffusa, 15-30 parts of radix pseudostellariae, 20-40 parts of Semen Coicis Semen Coicis, 6-12 parts of stir-baked RADIX BUPLEURI with vinegar, 6-12 parts of caulis perllae, 10-20 parts of curcuma zedoary.
3. the drug for the treatment of atrophic gastritis according to claim 2, it is characterised in that:
15 parts of oldenlandia diffusa, 20 parts of radix pseudostellariae, 30 parts of Semen Coicis Semen Coicis, 10 parts of stir-baked RADIX BUPLEURI with vinegar, 10 parts of caulis perllae, 15 parts of curcuma zedoary.
CN201811122917.3A 2018-09-26 2018-09-26 The drug for treating atrophic gastritis Pending CN109045242A (en)

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