CN1410099A - Renshujianwei granules stomachia and its preparation method - Google Patents
Renshujianwei granules stomachia and its preparation method Download PDFInfo
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- CN1410099A CN1410099A CN 02138103 CN02138103A CN1410099A CN 1410099 A CN1410099 A CN 1410099A CN 02138103 CN02138103 CN 02138103 CN 02138103 A CN02138103 A CN 02138103A CN 1410099 A CN1410099 A CN 1410099A
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- rhizoma curcumae
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Abstract
A Chinese medicine in the form of granules for treating chronic atrophic gastritis and lesion before stomach cancer is prepared from 8 Chinese medicinal materials including astragalus root, white atractylodes rhizome, coix seed, scutellaria root, etc. through pretreating, extracting effective components, concentrating, pulverizing, coating, mixing, granulating and packaging. Its advantages are high curative effect and no toxic by-effect.
Description
Technical field:
The present invention relates to a kind of Chinese medicine granules product and preparation method thereof, the particularly a kind of stomach strengthening granules agent product that can treat chronic atrophic gastritis and gastric precancerous lesion and preparation method thereof belongs to the medicinal preparation field.
Background technology:
Gastric cancer is one of modal malignant tumor of China, and its sickness rate occupies the prostatitis of various malignant tumor and in rising trend, shows that after deliberation the gastric epithelial cell canceration is not to be to become cancerous cell owing to normal cell one jumps, but a progressive process.Before developing into malignant tumor, often experience the preceding variation of the cancer that continues for many years, as if energy and these pathological changes of early treatment, will be the important effective way of preventing and treating gastric cancer.Aspect the research of gastric mucosa precancerous lesion, it is emphasis of studying at present that two kinds of pathological changes are arranged, and promptly chronic atrophic gastritis is important precancerous lesion with intestinal metaplasia in gastric mucosa (being called for short intestinalization) and dysplasia.Can the someone uses the growth of R8923 or Western medicine anticancer such as sodium butyrate or selenium compound at present, but these Western medicine all have certain toxic and side effects, use safely and also need further research.Also the someone uses the Chinese herbal treatment precancerous lesion, but because being every doctor, prescription leaves according to experience separately, the prescription that the shortage science is unified, and mostly be traditional decocting method during preparation again, drug effect can not well be brought into play, further reduce the therapeutic effect of Chinese medicine again.
Summary of the invention:
Purpose of the present invention mainly is in order to overcome the weak point that Western medicine has strong toxic and side effects, on the basis of a large amount of Chinese medicines of research prescription, provide a kind of and have no side effect, the effective Renshujianwei granules stomachia of treatment gastric mucosa precancerous lesion that can suitability for industrialized production.
Another object of the present invention is in order to ensure fully containing various active ingredients in the Renshujianwei granules stomachia, a kind of scientific and reasonable preparation method being provided.
Renshujianwei granules stomachia of the present invention, mainly be that the extraction active ingredient is formulated from Chinese medicine astragalus, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix Scutellariae, Herba Agrimoniae, Rhizoma Curcumae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, its preparation parts by weight are: Radix Astragali 10-30 part, Rhizoma Atractylodis Macrocephalae 5-20 part, Semen Coicis 5-20 part, Radix Scutellariae 5-20 part, Herba Agrimoniae 5-20 part, Rhizoma Curcumae 5-20 part, Herba Lobeliae Chinensis 5-20 part, Herba Hedyotidis Diffusae 5-20 part.The preparation method of above-mentioned granule is: (one), pretreatment: Herba Agrimoniae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae are cleaned cutting; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae section big gun are processed; Rhizoma Curcumae is thinly sliced.(2), extract: the Rhizoma Curcumae of thinly slicing is added the water heating keep little boiling a few hours, vapor distillation extracts Rhizoma Curcumae volatile oil, and Rhizoma Curcumae volatile oil, medicinal residues I and Rhizoma Curcumae aqueous solution is standby; The Radix Astragali, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae three flavors are placed Multifunction tank, add an amount of alcohol reflux secondary, extracted twice liquid is merged, filter, decompression recycling ethanol, being concentrated into relative density is the clear paste I of 1.10-1.15, and clear paste I and medicinal residues II is standby; Rhizoma Curcumae aqueous solution, medicinal residues I and medicinal residues II and Radix Scutellariae, Herba Agrimoniae two flavor medical materials are placed multi-function extractor, add the several times water gaging, decoct secondary, merge twice aqueous solution, leave standstill, filter, cream I and clear paste II merge, and the clear paste III that is evaporated to relative density and is 1.30-1.35 is standby.(4), pulverize: the Rhizoma Atractylodis Macrocephalae and Semen Coicis are sprayed an amount of ethanol respectively, and moistening volatilizes more than half an hour naturally, and crushed after being dried becomes particle diameter standby less than 10 microns micropowder.(5), the enclose of Oleum Curcumae: take by weighing an amount of beta-schardinger dextrin-, add and add the Rhizoma Curcumae volatile oil stirring after water is made saturated aqueous solution, leave standstill, filter after enclose is finished, it is that the Oleum Curcumae clathrate is standby that gained clathrate crushed after being dried becomes fine powder.(6), mixing granulation: with clear paste III, Semen Coicis micropowder, Rhizoma Atractylodis Macrocephalae micropowder, Oleum Curcumae clathrate, add an amount of dextrin and sweeting agent again and be mixed and made into soft material, granulate, drying is made granule.(7), granulate: dried granules is crossed 10 orders and 50 mesh sieves.(8), packing: the gained granule is distributed into bag promptly.
Renshujianwei granules stomachia of the present invention is a natural product, have no side effect, have advantages such as benefiting QI for activating blood circulation and heat-clearing and toxic substances removing be effective, be mainly used in treatment chronic atrophic gastritis and gastric precancerous lesion, make chronic atrophic gastritis and take a turn for the better with gastropathy such as intestinal metaplasia in gastric mucosa and dysplasias, also have the nourishing the stomach effect that is good for the stomach, prevent the generation of above-mentioned disease.With the Renshujianwei granules stomachia that preparation method provided by the invention makes, can fully extract the fat-soluble and water miscible effective ingredient in the Chinese crude drug; And use the cyclodextrin inclusion compound Oleum Curcumae, improved the utilization rate and the stability of volatility Oleum Curcumae; Particularly that content of starch is high or contain the still indefinite Chinese crude drug of volatile oil or active ingredient and effective site and be processed into the active ingredient that method that micropowder directly is used as medicine more can keep medical material comprehensively, reasonably prescription adds rational preparation method, make Renshujianwei granules stomachia of the present invention become can industrialized great production treatment chronic atrophic gastritis and the effective oral granular formulation that has no side effect of gastric precancerous lesion.
The specific embodiment:
Embodiment 1: a kind of Renshujianwei granules stomachia, it is formulated as follows to get 10 parts of the Radixs Astragali, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Semen Coiciss, 5 parts of Radix Scutellariaes, 5 parts of Herba Agrimoniaes, 5 parts of Rhizoma Curcumae, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Hedyotidis Diffusaes by weight.
2: the 2 kinds of Renshujianwei granules stomachias of embodiment, it is formulated as follows to get 20 parts of the Radixs Astragali, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Semen Coiciss, 10 parts of Radix Scutellariaes, 10 parts of Herba Agrimoniaes, 10 parts of Rhizoma Curcumae, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Hedyotidis Diffusaes by weight.
3: the 3 kinds of Renshujianwei granules stomachias of embodiment, it is formulated as follows to get 20 parts of the Radixs Astragali, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Semen Coiciss, 10 parts of Radix Scutellariaes, 10 parts of Herba Agrimoniaes, 10 parts of Rhizoma Curcumae, 5 parts of Herba Lobeliae Chinensis, 5 parts of Herba Hedyotidis Diffusaes by weight.
4: the 4 kinds of Renshujianwei granules stomachias of embodiment, it is formulated as follows to get 30 parts of the Radixs Astragali, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Semen Coiciss, 20 parts of Radix Scutellariaes, 20 parts of Herba Agrimoniaes, 20 parts of Rhizoma Curcumae, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Hedyotidis Diffusaes by weight.
5: the 5 kinds of Renshujianwei granules stomachias of embodiment, it is formulated as follows to get 16 parts of the Radixs Astragali, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Semen Coiciss, 12 parts of Radix Scutellariaes, 13 parts of Herba Agrimoniaes, 14 parts of Rhizoma Curcumae, 12 parts of Herba Lobeliae Chinensis, 12 parts of Herba Hedyotidis Diffusaes by weight.
After taking by weighing relevant Chinese medicine respectively by above-mentioned parts by weight, more promptly by following step and method preparation, (one), pretreatment: with Herba Agrimoniae, Herba Lobeliae Chinensis, the clean cutting of Herba Hedyotidis Diffusae; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae section big gun are processed; Rhizoma Curcumae is thinly sliced.(2), extract: the Rhizoma Curcumae of thinly slicing is added the water heating keep little boiling a few hours, vapor distillation extracts Rhizoma Curcumae volatile oil, and Rhizoma Curcumae volatile oil, medicinal residues I and Rhizoma Curcumae aqueous solution is standby; The Radix Astragali, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae three flavors are placed Multifunction tank, add an amount of alcohol reflux secondary, extracted twice liquid is merged, filter, decompression recycling ethanol, being concentrated into relative density is the clear paste I of 1.10-1.15, and clear paste I and medicinal residues II is standby; Rhizoma Curcumae aqueous solution, medicinal residues I and medicinal residues II and Radix Scutellariae, Herba Agrimoniae two flavor medical materials are placed multi-function extractor, add the several times water gaging, decoct secondary, merge twice aqueous solution, leave standstill, filter, the clear paste II that is evaporated to relative density and is 1.10-1.15 is standby.(3), concentrate: clear paste I and clear paste II are merged, and the clear paste III that is evaporated to relative density and is 1.30-1.35 is standby.(4), pulverize: the Rhizoma Atractylodis Macrocephalae and Semen Coicis are sprayed an amount of ethanol respectively, and moistening volatilizes more than half an hour naturally, and crushed after being dried becomes particle diameter standby less than 10 microns micropowder.(5), the enclose of Oleum Curcumae: take by weighing an amount of beta-schardinger dextrin-, add and add the Rhizoma Curcumae volatile oil stirring after water is made saturated aqueous solution, leave standstill, filter after enclose is finished, it is that the Oleum Curcumae clathrate is standby that gained clathrate crushed after being dried becomes fine powder.(6), mixing granulation: with clear paste III, Semen Coicis micropowder, Rhizoma Atractylodis Macrocephalae micropowder, Oleum Curcumae clathrate, add an amount of dextrin and sweeting agent again and be mixed and made into soft material, granulate, drying is made granule.(7), granulate: dried granules is crossed 10 orders and 50 mesh sieves.(8), packing: the gained granule is distributed into bag promptly.
With the Renshujianwei granules stomachia that preparation method provided by the invention makes, can fully extract the fat-soluble and water miscible effective ingredient in the Chinese crude drug; And use the cyclodextrin inclusion compound Oleum Curcumae, improved the utilization rate and the stability of volatility Oleum Curcumae; Particularly that content of starch is high or contain the still indefinite Chinese crude drug of volatile oil or active ingredient and effective site, being processed into micropowder as Semen Coicis and the Rhizoma Atractylodis Macrocephalae two flavor Chinese medicines directly is used as medicine, comfortable taste, more can keep the active ingredient of medical material comprehensively, increase operation rate, saved supplementary product consumption again and reduced dose.The method of directly being used as medicine with micropowder is also applicable to other Chinese medicine preparation.Compatibility of the present invention is precise and appropriate, the property of medicine is straight and even sensible, deficiency and excess is taken into account, has replenishing QI to invigorate the spleen, promoting blood circulation to remove obstruction in the collateral, the effect of clearing away heat and eliminating dampness adds rational preparation, make Renshujianwei granules stomachia of the present invention become can industrialized great production product, be treatment chronic atrophic gastritis and gastric mucosa precancerous lesion obvious results oral granular formulation.During use, take one time one bag 12 grams, one day three times or follow the doctor's advice after mixing it with hot water.
The Pharmacodynamic test of active extract result relevant with function master smelting that Renshujianwei granules stomachia of the present invention carries out through institute of Materia Medica,Chinese Academy of Medical Sciences shows: Renshujianwei granules stomachia is all having drug action preferably aspect protection cell anti-oxidative damage, anti-mutation, anti-promoting, anti-chemocarcinogenesis and the attenuating tumor cell grade of malignancy.Through Nanjing University of Traditional Chinese Medicine's new drug and marine drug research center acute toxicity test and the long term toxicity test result that animal carries out shown again: Renshujianwei granules stomachia is taken safely, is had no side effect.
Claims (3)
1, a kind of Renshujianwei granules stomachia, it is formulated to it is characterized in that extracting from comprise Chinese medicine astragalus, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Radix Scutellariae, Herba Agrimoniae, Rhizoma Curcumae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae active ingredient, and its preparation parts by weight are: Radix Astragali 10-30 part, Rhizoma Atractylodis Macrocephalae 5-20 part, Semen Coicis 5-20 part, Radix Scutellariae 5-20 part, Herba Agrimoniae 5-20 part, Rhizoma Curcumae 5-20 part, Herba Lobeliae Chinensis 5-20 part, Herba Hedyotidis Diffusae 5-20 part.
2, the preparation method of the Renshujianwei granules stomachia of claim 1 is characterized in that it being to follow these steps to carry out: (one), pretreatment: Herba Agrimoniae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae are cleaned cutting; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae section big gun are processed; Rhizoma Curcumae is thinly sliced.(2), extract: the Rhizoma Curcumae of thinly slicing is added the water heating keep little boiling a few hours, vapor distillation extracts Rhizoma Curcumae volatile oil, and Rhizoma Curcumae volatile oil, medicinal residues I and Rhizoma Curcumae aqueous solution is standby; The Radix Astragali, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae three flavors are placed Multifunction tank, add an amount of alcohol reflux secondary, extracted twice liquid is merged, filter, decompression recycling ethanol, being concentrated into relative density is the clear paste I of 1.10-1.15, and clear paste I and medicinal residues II is standby; Rhizoma Curcumae aqueous solution, medicinal residues I and medicinal residues II and Radix Scutellariae, Herba Agrimoniae two flavor medical materials are placed multi-function extractor, add the several times water gaging, decoct secondary, merge twice aqueous solution, leave standstill, filter, the clear paste II that is evaporated to relative density and is 1.10-1.15 is standby.(3), concentrate: clear paste I and clear paste II are merged, and the clear paste III that is evaporated to relative density and is 1.30-1.35 is standby.(4), pulverize: the Rhizoma Atractylodis Macrocephalae and Semen Coicis are sprayed an amount of ethanol respectively, and moistening volatilizes more than half an hour naturally, and crushed after being dried becomes particle diameter standby less than 10 microns micropowder.(5), the enclose of Oleum Curcumae: take by weighing an amount of beta-schardinger dextrin-, add and add the volatile oil stirring that Rhizoma Curcumae extracts after water is made saturated aqueous solution, leave standstill, filter after enclose is finished, it is that the Oleum Curcumae clathrate is standby that gained clathrate crushed after being dried becomes fine powder.(6), mixing granulation: with clear paste III, Semen Coicis micropowder, Rhizoma Atractylodis Macrocephalae micropowder, Oleum Curcumae clathrate, add an amount of dextrin and sweeting agent again and be mixed and made into soft material, granulate, drying is made granule.(7), granulate: dried granules is crossed 10 orders and 50 mesh sieves.(8), packing: the gained granule is distributed into bag promptly.
3, preparation method as claimed in claim 2 is characterized in that being applicable to that content of starch is high or containing the Chinese medicine preparation that the still indefinite Chinese crude drug of volatile oil or active ingredient and effective site is prepared with the method that micropowder directly is used as medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02138103 CN1231241C (en) | 2002-08-13 | 2002-08-13 | Renshujianwei granules stomachia and its preparation method |
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| CN 02138103 CN1231241C (en) | 2002-08-13 | 2002-08-13 | Renshujianwei granules stomachia and its preparation method |
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| CN1410099A true CN1410099A (en) | 2003-04-16 |
| CN1231241C CN1231241C (en) | 2005-12-14 |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1321672C (en) * | 2004-10-14 | 2007-06-20 | 上海市普陀区中心医院 | Chinese traditional medicine compound preparation for treating chronic gastritis accompanied with Helicobacter pylori infection |
| CN104888118A (en) * | 2015-06-01 | 2015-09-09 | 潘华峰 | Traditional Chinese medicinal composition for treating chronic atrophic gastritis as well as preparation method and application thereof |
| CN105663600A (en) * | 2016-04-11 | 2016-06-15 | 烟台市蓝洋之草医药生物科技有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating stomach cancer |
| CN105687644A (en) * | 2016-04-11 | 2016-06-22 | 烟台市蓝洋之草医药生物科技有限公司 | Traditional Chinese medicine composition for treating gastric cancer |
| CN109045242A (en) * | 2018-09-26 | 2018-12-21 | 北京三医智慧科技有限公司 | The drug for treating atrophic gastritis |
| CN110664960A (en) * | 2018-12-29 | 2020-01-10 | 南京中山制药有限公司 | Traditional Chinese medicine composition for gastric mucosa precancerous lesion and preparation method and application thereof |
| CN110721289A (en) * | 2018-12-29 | 2020-01-24 | 南京中山制药有限公司 | Preparation method of Renzhu stomach-invigorating granules |
| CN111948330A (en) * | 2020-07-03 | 2020-11-17 | 江苏弘典中药产业研究院有限公司 | Detection method of finger-print of Renzhu stomach-invigorating granules |
| CN113995808A (en) * | 2020-07-27 | 2022-02-01 | 潘小安 | Medicament for treating cancer |
| CN114470116A (en) * | 2022-03-24 | 2022-05-13 | 南京市溧水区中医院 | Traditional Chinese medicine composition for influencing expression level of gastric mucosa oncogene |
-
2002
- 2002-08-13 CN CN 02138103 patent/CN1231241C/en not_active Expired - Lifetime
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1321672C (en) * | 2004-10-14 | 2007-06-20 | 上海市普陀区中心医院 | Chinese traditional medicine compound preparation for treating chronic gastritis accompanied with Helicobacter pylori infection |
| CN104888118A (en) * | 2015-06-01 | 2015-09-09 | 潘华峰 | Traditional Chinese medicinal composition for treating chronic atrophic gastritis as well as preparation method and application thereof |
| CN104888118B (en) * | 2015-06-01 | 2018-07-20 | 广州中医药大学(广州中医药研究院) | Treat the Chinese medicine composition and its preparation method and application of atrophic gastritis |
| CN105663600A (en) * | 2016-04-11 | 2016-06-15 | 烟台市蓝洋之草医药生物科技有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating stomach cancer |
| CN105687644A (en) * | 2016-04-11 | 2016-06-22 | 烟台市蓝洋之草医药生物科技有限公司 | Traditional Chinese medicine composition for treating gastric cancer |
| CN109045242A (en) * | 2018-09-26 | 2018-12-21 | 北京三医智慧科技有限公司 | The drug for treating atrophic gastritis |
| CN110664960A (en) * | 2018-12-29 | 2020-01-10 | 南京中山制药有限公司 | Traditional Chinese medicine composition for gastric mucosa precancerous lesion and preparation method and application thereof |
| CN110721289A (en) * | 2018-12-29 | 2020-01-24 | 南京中山制药有限公司 | Preparation method of Renzhu stomach-invigorating granules |
| CN111948330A (en) * | 2020-07-03 | 2020-11-17 | 江苏弘典中药产业研究院有限公司 | Detection method of finger-print of Renzhu stomach-invigorating granules |
| CN111948330B (en) * | 2020-07-03 | 2022-06-17 | 江苏弘典中药产业研究院有限公司 | Detection method of finger-print of Renzhu stomach-invigorating granules |
| CN113995808A (en) * | 2020-07-27 | 2022-02-01 | 潘小安 | Medicament for treating cancer |
| CN114470116A (en) * | 2022-03-24 | 2022-05-13 | 南京市溧水区中医院 | Traditional Chinese medicine composition for influencing expression level of gastric mucosa oncogene |
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| CN1231241C (en) | 2005-12-14 |
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