CN104173222A - Use of flos mume extract product as sunscreen effective component - Google Patents
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- CN104173222A CN104173222A CN201310194934.9A CN201310194934A CN104173222A CN 104173222 A CN104173222 A CN 104173222A CN 201310194934 A CN201310194934 A CN 201310194934A CN 104173222 A CN104173222 A CN 104173222A
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- 241000628997 Flos Species 0.000 title claims abstract description 63
- 239000000284 extract Substances 0.000 title claims abstract description 55
- 230000000475 sunscreen effect Effects 0.000 title abstract description 3
- 239000000516 sunscreening agent Substances 0.000 title abstract description 3
- 239000002537 cosmetic Substances 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 239000004615 ingredient Substances 0.000 claims description 20
- 238000000605 extraction Methods 0.000 claims description 18
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- 238000012360 testing method Methods 0.000 abstract description 6
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- 238000010828 elution Methods 0.000 description 13
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- 230000001476 alcoholic effect Effects 0.000 description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 235000011158 Prunus mume Nutrition 0.000 description 2
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- 230000003266 anti-allergic effect Effects 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
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Abstract
A use of a flos mume extract product as a sunscreen effective component is provided. Ultraviolet resistance tests show that: the flos mume extract product is excellent in ultraviolet resistance, can be mixed with other cosmetic auxiliary materials and additives and prepared into various skin-care cosmetic compositions and various preparation types, and the extract product has practical application value.
Description
Technical field
The present invention relates to the new purposes of plant extract, relate in particular to the new purposes of FLOS MUME extract as sun-proof effective ingredient.
Background technology
Sunlight can cause skin to cross presenility and other change of skin as erythema, tanned even skin carcinoma.The damage great majority that sunlight causes are that the ultraviolet radiation that is 200 to 400nm by wavelength causes.The UVC that its medium wavelength is less than 290nm is absorbed by ozone layer substantially, cannot arrive ground; Wave-length coverage is that 290 to 320nm UVB can cause burning and cutaneous pigmentation; Wave-length coverage is that 320 to 400nm UVA can cause slightly burning and tanned.Conventionally the sun-prevention component using in cosmetics, as nano titanium oxide, zinc oxide, benzophenone etc., owing to existing such as skin irritation, stopping up the problems such as pore, heliosensitivity, has strict consumption restriction.The sunscreen in natural plants source, because of its wide spectrum, safe sun-proof result, enjoys consumer's favor.
FLOS MUME is the plant Flos Mume (Prunus mume sieb.Et Zucc.) of Rosaceae Li Yake Prunus prunus mume (sieb.) sieb.et zucc. subgenus, originates in China, at existing more than 3000 cultivation history of China.Known FLOS MUME flower aspect the traditional Chinese medical science for " dispersing the stagnated live-QI to relieve the stagnation of QI, appetizing is promoted the production of body fluid, and reduces phlegm.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, uncomfortable in chest, globus hystericus, summer-heat excessive thirst, inappetence, vomiting during pregnancy, scrofula tuberculosis, varioliform exanthema." (" Chinese medicine voluminous dictionary " Shanghai science tech publishing house is write by Nanjing University of Traditional Chinese Medicine).The extract that discloses recently Flos Mume has effect (the Matsuda H that removes free radical, Chem Pharm Bull.2003,51 (4): 440～443), have antiallergic effect (CN102552076A), have treatment and prevention dermatitis effect (CN101461905A), have tyrosine-kinase enzyme inhibition activity check melanin generate effect (CN1335881A; KR914963-B1).But, and the unexposed FLOS MUME extract of crossing has sun-proof effect.
Summary of the invention
The object of the invention is the defect for prior art, the purposes of FLOS MUME extract as sun-proof effective ingredient is provided.
First the present invention discloses the purposes of FLOS MUME extract as sun-proof effective ingredient.
Further, described sun-proof effective ingredient is specially uvioresistant effective ingredient.
Described FLOS MUME is for being derived from the alabastrum part of Rosaceae Prunus prunus mume (sieb.) sieb.et zucc. Subgenus FLOS MUME (Prunus mume sieb.Et Zucc.).
Described FLOS MUME extract is the extract that described FLOS MUME makes through extracting solvent extraction.Described extraction solvent, only otherwise damage effect of the present invention, has no particular limits, and can be water; The monohydric alcohol such as methanol, ethanol; The polyhydric alcohol such as 1,3 butylene glycol, propylene glycol; The lower alkyl esters such as ethyl acetate; Ether, acetone etc.In the present invention, also above-mentioned solvent can be used in combination.Preferred extraction solvent is water, methanol, ethanol, 1,3 butylene glycol or its combination.Especially preferred extraction solvent is water, ethanol or its combination (being ethanol water).
More specifically, FLOS MUME extract of the present invention adopts following method to make: taking FLOS MUME alabastrum as raw material, crushed after being dried becomes coarse powder to sieve, get dried powder, with ethanol and/or deionized water, as extracting solvent extraction, filtrate merges, and after concentrating, obtains FLOS MUME extract.
Described concentrated method includes but not limited to: atmospheric evaporation, reduction vaporization, thin film evaporation, multiple-effect evaporation.
Preferably, time prepared by described FLOS MUME extract, meet any one in following condition or multinomial:
1) ethanol water that described extraction solvent is 50-95v% preferably, is the ethanol water of 50-90v%;
2) described FLOS MUME alabastrum is 1g:10ml-1g:50ml with the solid-liquid ratio that extracts solvent;
3) extraction time is 0.5-2 hour;
4) extract at room temperature;
In the time adopting 50% ethanol water to extract 1 hour with 50 times of solid-liquid ratios, can obtain higher extraction ratio.
Described FLOS MUME extract can directly be used as uvioresistant effective ingredient, or can further be used as uvioresistant effective ingredient through conventional step purification and/or after being dried.Wherein the method for purification includes but not limited to: the purification of saltouing, macroporous resin adsorption purification, ethanol deposition and purification, ion-exchange resin purification, flocculation sediment purification, membrane separation purification, polycaprolactam purification, silica gel adsorption chromatography purification etc., dry method includes but not limited to: oven drying method, drum-type seasoning, belt drying method, hygroscopic desiccation method, fluid-bed drying, spray drying method, hypobaric drying method, freeze-drying, infrared drying, micro-wave drying method etc.
Concrete, the purification process of described FLOS MUME extract can be: by FLOS MUME extract with after deionized water dissolving, be loaded to the absorption of macroporous adsorbent resin packed column, use successively the ethanol water eluting of deionized water, variable concentrations, collect stream part, evaporate to dryness, obtains the alcohol elution of FLOS MUME water elution position and variable concentrations.
The ethanol water concentration range of described variable concentrations is: 20-80v% ethanol water.
Further, described purposes is specially: using FLOS MUME extract as skin uvioresistant effective ingredient.
Described uvioresistant comprises anti-UVA and anti-UVB.
Further, described purposes is: be used for the preparation of cosmetics using described FLOS MUME extract as uvioresistant effective ingredient.
Based on such use, the invention also discloses a kind of uvioresistant cosmetic composition, described cosmetic composition contains FLOS MUME extract.
Described uvioresistant cosmetic composition is taking FLOS MUME extract as its uvioresistant effective ingredient.
Describedly refer to taking FLOS MUME extract as its uvioresistant effective ingredient: in described cosmetic composition, can FLOS MUME extract be its unique uvioresistant effective ingredient, or also FLOS MUME extract can be contained as one of its uvioresistant effective ingredient composition with uvioresistant effect same with other simultaneously.
Each optimum condition of the present invention all can combination in any.
Uvioresistant test shows, FLOS MUME extract has good uvioresistant effect, adjuvant used for cosmetic to it and other and additive can be mixed and made into cosmetic composition and the various dosage form of various skin nursings.FLOS MUME extract does not have toxic and side effects to human body, and it is remarkable to anti-ultraviolet effect, has actual application value.
Detailed description of the invention
Below, by specific instantiation explanation embodiments of the present invention, those skilled in the art can understand other advantages of the present invention and effect easily by the disclosed content of this description.The present invention can also be implemented or be applied by other different detailed description of the invention, and the every details in this description also can be based on different viewpoints and application, carries out various modifications or change not deviating under spirit of the present invention.
Embodiment 1 FLOS MUME extraction conditions preferably
Get FLOS MUME 10g, adopt L9 (3
3) orthogonal test (drug research common mathematical method and computer program, Guizhou science and technology publishing house, 1997) carry out the optimization of extraction process, taking solid-liquid ratio (A), alcoholic solution concentration (B), extraction time (C) as experimental factor.Carry out positive quadraturing design test taking extraction ratio as index, Optimized Extraction Process condition.Factor level designs in table 1, wherein considers from production cost, and extraction time is generally no more than 2 hours.The results are shown in Table 1-3.
Extracting method: by pulverizing after FLOS MUME alabastrum cleaning-drying, mix with ethanol water, at normal temperatures, extract certain hour, isolate extracting solution, after pressure reducing and steaming solvent, obtain FLOS MUME crude extract.Calculate extraction ratio according to extraction ratio=crude extract weight/raw material weight * 100%.
Table 1 orthogonal test factor level
Table 2L9 (3
3) orthogonal experiment plan takes into account result table
Table 3 orthogonal test intuitive analysis table
Intuitive analysis can obtain, and A3B2C1 is 50 times of solid-liquid ratios, 1 hour extraction time, 50% concentration of alcohol, is the optimum extraction condition of FLOS MUME extract.
Embodiment 2
By pulverizing after commercially available 100g FLOS MUME alabastrum cleaning-drying, mix with 2L70% alcoholic solution, at normal temperatures, extract 2 hours, isolate extracting solution, steam after alcoholic solution through decompression, obtain FLOS MUME extract 13g.
Embodiment 3
By pulverizing after commercially available 50g FLOS MUME alabastrum cleaning-drying, mix with 2.5L50% alcoholic solution, at normal temperatures, extract 1 hour, isolate extracting solution, steam after deionized water through decompression, obtain FLOS MUME extract 16g.
Embodiment 4
By pulverizing after commercially available 100g FLOS MUME alabastrum cleaning-drying, mix with 2L95% alcoholic solution, at normal temperatures, extract 2 hours, isolate extracting solution, steam after alcoholic solution through decompression, obtain FLOS MUME extract 11g.
Embodiment 5
Get the FLOS MUME extract 10g in embodiment 2, with after deionized water dissolving, be loaded to AB-8 resin filling post, use successively deionized water, 20% ethanol, 40% ethanol, 60% ethanol and 80% ethanol elution, collect respectively eluent, decompression steams second alcohol and water, obtains respectively water elution position, 20% alcohol elution, 40% alcohol elution, 60% alcohol elution and 80% alcohol elution.
Embodiment 6
The FLOS MUME extract preparing according to embodiment 2-embodiment 5, evaluates the sun-proof result of FLOS MUME extract in accordance with the following methods.Concrete steps are: FLOS MUME extract, with after deionized water dissolving, is used 0.45um filtering with microporous membrane, is diluted to the solution of 0.2mg/mL, with general general T6 ultraviolet-visual spectrometer, the ultraviolet absorptivity T λ of mensuration solution under 280nm to 400nm wavelength of analysing.
The in-vitro evaluation method in UVB district is the method based on spectroscopy, the ultraviolet light transmittance of working sample under specific wavelength, and obtain corresponding spf value by solar spectral intensity normal data.The given SPF accounting equation of SPF vitro detection mathematical model obtaining with probability function form according to Diffey and Robson,
spf value is greater than 15, shows that FLOS MUME extract has good protection effect to UVB.
The star categorizing system that the evaluation in UVA district adopts Boot to propose, is followed successively by without star, a star to four-star, and star is higher, and UVA protection effect is better.Record FLOS MUME extract according to Boots star categorizing system and UVA defence is up to four-star, show that FLOS MUME extract also has good protection effect to UVA.
Result is as follows:
| FLOS MUME extract | SPF | UVA defends grade |
| Embodiment 2 | 56.8 | Four-star |
| Embodiment 3 | 47.1 | Four-star |
| Embodiment 4 | 33.6 | Three-star |
| Embodiment 5 water elution positions | 10.2 | One star |
| Embodiment 520% alcohol elution | 15.9 | Two stars |
| Embodiment 540% alcohol elution | 51.7 | Four-star |
| Embodiment 560% alcohol elution | 30.3 | Three-star |
| Embodiment 580% alcohol elution | 22.4 | Two stars |
The above; it is only preferred embodiment of the present invention; not to any formal and substantial restriction of the present invention; should be understood that; for those skilled in the art; do not departing under the prerequisite of the inventive method, also can make some improvement and supplement, these improvement and the supplementary protection scope of the present invention that also should be considered as.All those skilled in the art, without departing from the spirit and scope of the present invention, a little change of making when utilizing disclosed above technology contents, the equivalent variations of modifying and developing, be equivalent embodiment of the present invention; Meanwhile, the change of any equivalent variations that all foundations essence technology of the present invention is done above-described embodiment, modification and differentiation, all still belong in the scope of technical scheme of the present invention.
Claims (7)
1. FLOS MUME extract is as the purposes of sun-proof effective ingredient.
2. purposes as claimed in claim 1, is characterized in that, described sun-proof effective ingredient is specially uvioresistant effective ingredient.
3. purposes as claimed in claim 1, is characterized in that, described FLOS MUME extract is the extract that FLOS MUME is made through extracting solvent extraction.
4. purposes as claimed in claim 1, it is characterized in that, described FLOS MUME extract adopts following method to make: taking FLOS MUME alabastrum as raw material, crushed after being dried becomes coarse powder to sieve, get dried powder, with ethanol and/or deionized water, as extracting solvent extraction, filtrate merges, and after concentrating, obtains FLOS MUME extract.
5. purposes as claimed in claim 4, is characterized in that, time prepared by described FLOS MUME extract, also meets any one in following condition or multinomial:
1) ethanol water that described extraction solvent is 50-95v%;
2) described FLOS MUME alabastrum is 1g:10ml-1g:50ml with the solid-liquid ratio that extracts solvent;
3) extraction time is 0.5-2 hour;
4) extract at room temperature.
6. purposes as claimed in claim 4, is characterized in that, described FLOS MUME extract is directly used as sun-proof effective ingredient, or is further used as sun-proof effective ingredient through conventional step purification and/or after being dried.
7. the purposes as described in claim as arbitrary in claim 1-6, is characterized in that, described purposes is: using FLOS MUME extract as sun-proof effective ingredient for the preparation of cosmetics.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512732A (en) * | 2017-11-24 | 2019-03-26 | 北京东方淼森生物科技有限公司 | Have effects that repair exterior-applied plant extract, cosmetics of skin barrier and preparation method thereof |
| CN112451449A (en) * | 2020-12-26 | 2021-03-09 | 浙江英树生物科技有限公司 | Use of Prunus mume extract for preventing and/or repairing skin photodamage |
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|---|---|---|---|---|
| CN1335881A (en) * | 1998-12-25 | 2002-02-13 | 株式会社东农园 | UME extract having medicinal effects and compositions containing the same |
| CN101190281A (en) * | 2006-11-27 | 2008-06-04 | 杭州尤美特科技有限公司 | Prune tree extract and preparation method and application thereof |
| CN102552076A (en) * | 2010-12-13 | 2012-07-11 | 烟台新时代健康产业日化有限公司 | Anti-allergy preparation and preparation method and application thereof |
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2013
- 2013-05-23 CN CN201310194934.9A patent/CN104173222B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1335881A (en) * | 1998-12-25 | 2002-02-13 | 株式会社东农园 | UME extract having medicinal effects and compositions containing the same |
| CN101190281A (en) * | 2006-11-27 | 2008-06-04 | 杭州尤美特科技有限公司 | Prune tree extract and preparation method and application thereof |
| CN102552076A (en) * | 2010-12-13 | 2012-07-11 | 烟台新时代健康产业日化有限公司 | Anti-allergy preparation and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512732A (en) * | 2017-11-24 | 2019-03-26 | 北京东方淼森生物科技有限公司 | Have effects that repair exterior-applied plant extract, cosmetics of skin barrier and preparation method thereof |
| CN112451449A (en) * | 2020-12-26 | 2021-03-09 | 浙江英树生物科技有限公司 | Use of Prunus mume extract for preventing and/or repairing skin photodamage |
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| CN104173222B (en) | 2017-04-19 |
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Address after: 201403 Shanghai City, Fengxian District Lifenglu No. 12 Patentee after: Shanghai Natural Hall Group Co.,Ltd. Address before: No. 12 Lifeng Road, Modern Agriculture Park, Fengxian District, Shanghai, March 2014 Patentee before: JALA Group Co. |
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