CN104173222B - Use of flos mume extract product as sunscreen effective component - Google Patents
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- CN104173222B CN104173222B CN201310194934.9A CN201310194934A CN104173222B CN 104173222 B CN104173222 B CN 104173222B CN 201310194934 A CN201310194934 A CN 201310194934A CN 104173222 B CN104173222 B CN 104173222B
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- 241000628997 Flos Species 0.000 title claims abstract description 58
- 239000000284 extract Substances 0.000 title claims abstract description 48
- 230000000475 sunscreen effect Effects 0.000 title abstract description 3
- 239000000516 sunscreening agent Substances 0.000 title abstract description 3
- 239000002537 cosmetic Substances 0.000 claims abstract description 10
- 238000000605 extraction Methods 0.000 claims description 19
- 239000004615 ingredient Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 11
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 244000018795 Prunus mume Species 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 235000011158 Prunus mume Nutrition 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 241001164374 Calyx Species 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 12
- 238000012360 testing method Methods 0.000 abstract description 6
- 239000000654 additive Substances 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 230000006750 UV protection Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- 238000010828 elution Methods 0.000 description 13
- 238000000746 purification Methods 0.000 description 9
- 238000001035 drying Methods 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 7
- 229910021641 deionized water Inorganic materials 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000006837 decompression Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000287 crude extract Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000018779 Globus Sensation Diseases 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 235000004789 Rosa xanthina Nutrition 0.000 description 1
- 241000220222 Rosaceae Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 238000005377 adsorption chromatography Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
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- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
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- 239000011148 porous material Substances 0.000 description 1
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- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A use of a flos mume extract product as a sunscreen effective component is provided. Ultraviolet resistance tests show that: the flos mume extract product is excellent in ultraviolet resistance, can be mixed with other cosmetic auxiliary materials and additives and prepared into various skin-care cosmetic compositions and various preparation types, and the extract product has practical application value.
Description
Technical field
The present invention relates to the new application of plant extract, more particularly to FLOS MUME extract is used as the new of sun-proof effective ingredient
Purposes.
Background technology
Sunlight can cause skin to cross presenility and other change of skin such as erythema, tanned or even skin carcinoma.Sunlight
The great majority that damage for causing are caused by the ultraviolet irradiation that wavelength is 200 to 400nm.UVC of its medium wavelength less than 290nm
Substantially absorbed by ozone layer, it is impossible to reach ground；Wave-length coverage is that the UVB of 290 to 320nm can cause to burn and skin pigment
It is calm；Wave-length coverage be the UVA of 320 to 400nm can cause slightly to burn with it is tanned.Sun-prevention component generally used in cosmetics
Such as nano titanium oxide, Zinc Oxide, benzophenone etc., due to there are problems that such as skin irritation, blocking pore,
There is strict consumption to limit.The sunscreen of natural botanical source enjoys consumers because of its wide spectrum, safe sun-proof result.
FLOS MUME is the plant Flos Mume of Rosaceae Lee's subfamily Prunus prunus mume (sieb.) sieb.et zucc. subgenus（Prunus mume sieb.Et Zucc.）,
Original China, in existing more than 3000 cultivation history of China.Known FLOS MUME flower in terms of the traditional Chinese medical science be used for " dispersing the stagnated live-QI to relieve the stagnation of QI,
Appetizing is promoted the production of body fluid, resolving sputum.Stomachache due to hyperactive liver-QI attacking the stomach is cured mainly, uncomfortable in chest, globus hystericuss, summer-heat excessive thirst, inappetence, vomiting during pregnancy, scrofula tuberculosis, pox
Rash.”（Nanjing University of Traditional Chinese Medicine writes《Chinese medicine voluminous dictionary》Shanghai science tech publishing house）.Recently disclose the extraction of Flos Mume
Thing has functions that to remove free radical（Matsuda H,Chem Pharm Bull.2003,51(4)：440～443）, with anti-
Quick effect（CN102552076A）, have functions that treat and prevent dermatitises（CN101461905A）, with tyrosine-kinase
Enzyme inhibition activity suppresses effect that melanin is generated（CN1335881A；KR914963-B1）.But, it is not disclosed FLOS MUME
Extract has sun-proof effect.
The content of the invention
The purpose of the present invention is the defect for prior art, there is provided FLOS MUME extract is used as the use of sun-proof effective ingredient
On the way.
The present invention discloses FLOS MUME extract first as the purposes of sun-proof effective ingredient.
Further, the sun-proof effective ingredient is specially uvioresistant effective ingredient.
Described FLOS MUME is from Rosaceae Prunus prunus mume (sieb.) sieb.et zucc. Subgenus FLOS MUME（Prunus mume sieb.Et
Zucc.）Alabastrum part.
Described FLOS MUME extract is extract obtained in the extracted solvent extraction of the FLOS MUME.It is described to extract molten
Agent, as long as not damaging the effect of the present invention, then has no particular limits, can be water；The monohydric alcohols such as methanol, ethanol；1,3- fourths
The polyhydric alcohol such as glycol, Propylene Glycol；The lower alkyl esters such as ethyl acetate；Ether, acetone etc..In the present invention, it is also possible to will be above-mentioned
Solvent combination is used.Preferred Extraction solvent is water, methanol, ethanol, 1,3 butylene glycol or its combination.It is especially preferred to extract molten
Agent is water, ethanol or its combination（That is ethanol water）.
More specifically, FLOS MUME extract of the invention is obtained using following method：With FLOS MUME alabastrum as raw material, do
It is ground into coarse powder to sieve after dry, takes dried powder, extracted as Extraction solvent with ethanol and/or deionized water, filtrate merges, Jing
FLOS MUME extract is obtained after concentration.
The method of the concentration is included but is not limited to：Atmospheric evaporation, reduction vaporization, thin film evaporation, multiple-effect evaporation.
Preferably, when prepared by the FLOS MUME extract, meeting any one of following condition or multinomial：
1）Ethanol water of the Extraction solvent for 50-95v%, preferably, for the ethanol water of 50-90v%；
2）The FLOS MUME alabastrum is 1g with the solid-liquid ratio of Extraction solvent：10ml-1g：50ml；
3）Extraction time is 0.5-2 hours；
4）Extract at room temperature；
When adopting 50% ethanol water and extracting 1 hour with 50 times of solid-liquid ratios, higher extraction ratio can be obtained.
The FLOS MUME extract can be directly used as uvioresistant effective ingredient, or step that can be further Jing conventional is pure
Change and/or be used as uvioresistant effective ingredient after being dried.The method of wherein purification is included but is not limited to：Saltout purification, macropore tree
Fat adsorption and purification, ethanol precipitation purification, ion-exchange resin purification, flocculation sediment purification, membrane separation purification, polycaprolactam are pure
Change, silica gel adsorption chromatography purification etc., dry method is included but is not limited to：Oven drying method, drum-type seasoning, belt drying method, suction
Wet seasoning, fluid-bed drying, spray drying method, hypobaric drying method, freeze-drying, infrared drying, micro-wave drying method
Deng.
Specifically, the purification process of the FLOS MUME extract can be：After FLOS MUME extract deionized water is dissolved,
The absorption of macroporous adsorbent resin packed column is loaded to, successively the ethanol water eluting of deionized water, variable concentrations, collects stream
Part, it is evaporated, obtains the alcohol elution of FLOS MUME water elution position and variable concentrations.
The ethanol water concentration range of the variable concentrations is：20-80v% ethanol waters.
Further, the purposes is specially：Using FLOS MUME extract as skin uvioresistant effective ingredient.
The uvioresistant includes uva-resistant with anti-UVB.
Further, the purposes is：It is used for cosmetics using the FLOS MUME extract as uvioresistant effective ingredient
Preparation.
Based on such use, the invention also discloses a kind of uvioresistant cosmetic composition, the cosmetic composition
Containing FLOS MUME extract.
The uvioresistant cosmetic composition is with FLOS MUME extract as its uvioresistant effective ingredient.
It is described to refer to by its uvioresistant effective ingredient of FLOS MUME extract：In the cosmetic composition, can be with green
Calyx prunus mume extract is its unique uvioresistant effective ingredient, or can also be effective as its uvioresistant using FLOS MUME extract
One of composition is contained simultaneously with other same compositions with uvioresistant effect.
Each optimum condition of the present invention can combination in any.
Uvioresistant test shows that FLOS MUME extract has excellent uvioresistant effect, and it can be made up with other
Product adjuvant is mixed and made into the cosmetic composition and various dosage forms of various skin nursings with additive.FLOS MUME extract is to people
Body does not have toxic and side effects, and which is notable to anti-ultraviolet effect, with actual application value.
Specific embodiment
Embodiments of the present invention are illustrated below by way of specific instantiation, those skilled in the art can be by this specification
Disclosed content understands other advantages and effect of the present invention easily.The present invention can also pass through concrete realities different in addition
The mode of applying is carried out or applies, the every details in this specification can also based on different viewpoints with application, without departing from
Various modifications and changes are carried out under the spirit of the present invention.
1 FLOS MUME extraction conditions of embodiment it is preferred
FLOS MUME 10g is taken, using L9 (33) orthogonal test (drug research common mathematical method and computer program, Guizhou
Science Press, 1997) carries out the optimization of extraction process, with solid-liquid ratio (A), ethanol solution concentration (B), extraction time (C) is
Experimental factor.Positive quadraturing design test, Optimized Extraction Process condition are carried out by index of extraction ratio.Factor level design is shown in Table 1, its
In consider that extraction time is usually no more than 2 hours from production cost.The results are shown in Table 1-3.
Extracting method：To crush after FLOS MUME alabastrum cleaning-drying, mix with ethanol water, at normal temperatures, extract one
Fix time, isolate extracting solution, Jing after decompression boils off solvent, that is, obtain FLOS MUME crude extract.According to extraction ratio=crude extract weight
Amount/raw material weight * 100% calculates extraction ratio.
1 orthogonal test factor level of table
Table 2L9 (33) Orthogonal Experiment and Design and result table
3 orthogonal test of table analytical table directly perceived
Analysis directly perceived can be obtained, and A3B2C1 is 50 times of solid-liquid ratios, 1 hour extraction time, 50% concentration of alcohol, is that FLOS MUME is carried
Take the optimum extraction condition of thing.
Embodiment 2
To crush after commercially available 100g FLOS MUME alabastrum cleaning-drying, mix with 2L70% ethanol solution, at normal temperatures, extract 2
Hour, extracting solution is isolated, Jing after decompression steams ethanol solution, that is, FLOS MUME extract 13g is obtained.
Embodiment 3
To crush after commercially available 50g FLOS MUME alabastrum cleaning-drying, mix with 2.5L50% ethanol solution, at normal temperatures, extract
1 hour, extracting solution is isolated, Jing after decompression steams deionized water, that is, obtain FLOS MUME extract 16g.
Embodiment 4
To crush after commercially available 100g FLOS MUME alabastrum cleaning-drying, mix with 2L95% ethanol solution, at normal temperatures, extract 2
Hour, extracting solution is isolated, Jing after decompression steams ethanol solution, that is, FLOS MUME extract 11g is obtained.
Embodiment 5
FLOS MUME extract 10g in Example 2, after deionized water dissolving, is loaded to AB-8 resin packed columns, according to
Secondary deionized water, 20% ethanol, 40% ethanol, 60% ethanol and 80% ethanol elution, collect eluent respectively, and decompression steams ethanol
And water, respectively obtain water elution position, 20% alcohol elution, 40% alcohol elution, 60% alcohol elution and 80%
Alcohol elution.
Embodiment 6
The FLOS MUME extract prepared according to embodiment 2- embodiment 5, evaluates FLOS MUME in accordance with the following methods and extracts
The sun-proof result of thing.Concretely comprise the following steps：After the dissolving of FLOS MUME extract deionized water, 0.45um filtering with microporous membranes are used, it is dilute
The solution of 0.2mg/mL is interpreted into, with the general T6 ultraviolet-visual spectrometers of general analysis, measure solution is under 280nm to 400nm wavelength
Ultraviolet absorptivity T λ.
The in-vitro evaluation method in UVB areas is the method based on spectroscopy, determination sample UV transmittance at a particular wavelength,
And by solar spectral intensity normal data obtaining corresponding spf value.According to Diffey and Robson with probability function form
The SPF accounting equations given by SPF vitro detection mathematical modeies for obtaining,
Spf value is more than 15, shows that FLOS MUME extract has good protection effect to UVB.
The star categorizing system that the evaluation in UVA areas is proposed using Boot, is followed successively by without star, a star to four-star, star
Level is higher, and UVA protection effects are better.FLOS MUME extract is measured according to Boots star categorizing systems to be up to UVA defence
It is four-star, show that FLOS MUME extract also has good protection effect to UVA.
As a result it is as follows：
| FLOS MUME extract | SPF | UVA defends grade |
| Embodiment 2 | 56.8 | It is four-star |
| Embodiment 3 | 47.1 | It is four-star |
| Embodiment 4 | 33.6 | It is three-star |
| 5 water elution position of embodiment | 10.2 | One star |
| 520% alcohol elution of embodiment | 15.9 | Two stars |
| 540% alcohol elution of embodiment | 51.7 | It is four-star |
| 560% alcohol elution of embodiment | 30.3 | It is three-star |
| 580% alcohol elution of embodiment | 22.4 | Two stars |
The above, only presently preferred embodiments of the present invention, not any formal and substantial to present invention restriction,
It should be pointed out that for those skilled in the art, on the premise of without departing from the inventive method, can also make
Some improvement and supplement, these improve and supplement also should be regarded as protection scope of the present invention.All those skilled in the art,
Without departing from the spirit and scope of the present invention, when make using disclosed above technology contents it is a little more
Dynamic, modification and the equivalent variations for developing, are the Equivalent embodiments of the present invention；Meanwhile, all substantial technologicals pair according to the present invention
Change, modification and the differentiation of any equivalent variations that above-described embodiment is made, still falls within the scope of technical scheme
It is interior.
Claims (1)
1. FLOS MUME extract is used for preparing the purposes of cosmetics as sun-proof effective ingredient；The sun-proof effective ingredient is specially
Uvioresistant effective ingredient；The FLOS MUME extract is by extract obtained in FLOS MUME extracted solvent extraction；It is described green
Calyx prunus mume extract is obtained using following method：With FLOS MUME alabastrum as raw material, crushed after being dried is sieved into coarse powder, takes xeraphium
End, is extracted as Extraction solvent with the ethanol water of 50-95v%, and the FLOS MUME alabastrum with the solid-liquid ratio of Extraction solvent is
1g：10ml-1g：50ml, at normal temperatures extract 0.5-2 hours, filtrate merge, it is concentrated after obtain FLOS MUME extract.
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| CN201310194934.9A CN104173222B (en) | 2013-05-23 | 2013-05-23 | Use of flos mume extract product as sunscreen effective component |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109512732B (en) * | 2017-11-24 | 2021-03-30 | 北京东方淼森生物科技有限公司 | External plant extract and cosmetic with skin barrier repairing effect and preparation method thereof |
| CN112451449A (en) * | 2020-12-26 | 2021-03-09 | 浙江英树生物科技有限公司 | Use of Prunus mume extract for preventing and/or repairing skin photodamage |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1335881A (en) * | 1998-12-25 | 2002-02-13 | 株式会社东农园 | UME extract having medicinal effects and compositions containing the same |
| CN101190281A (en) * | 2006-11-27 | 2008-06-04 | 杭州尤美特科技有限公司 | Prune tree extract and preparation method and application thereof |
| CN102552076A (en) * | 2010-12-13 | 2012-07-11 | 烟台新时代健康产业日化有限公司 | Anti-allergy preparation and preparation method and application thereof |
-
2013
- 2013-05-23 CN CN201310194934.9A patent/CN104173222B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1335881A (en) * | 1998-12-25 | 2002-02-13 | 株式会社东农园 | UME extract having medicinal effects and compositions containing the same |
| CN101190281A (en) * | 2006-11-27 | 2008-06-04 | 杭州尤美特科技有限公司 | Prune tree extract and preparation method and application thereof |
| CN102552076A (en) * | 2010-12-13 | 2012-07-11 | 烟台新时代健康产业日化有限公司 | Anti-allergy preparation and preparation method and application thereof |
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