CN104172418B - 一种治疗泌尿性结石的醋饮及其制备方法 - Google Patents
一种治疗泌尿性结石的醋饮及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成：白芥子9-15份，玉米6-12份，甘草10-15份，枳壳5-10份，乌药6-12份，白茅根15-60份，川芎5-15份，鱼脑石4.5-9份，荸荠5-15份，川木通2-5份，八仙草5-15份，醋60-100份。本发明具有利尿通淋、利水渗湿之功效，对由泌尿性结石引起的疼痛、尿赤、排尿困难有很好的治疗作用，能够极有效且较为快速的治疗泌尿性结石，是一种治疗泌尿性结石较为理想安全的药物。
Description
技术领域
本发明属中医中药领域，尤其是涉及一种治疗泌尿性结石的醋饮及其制备方法。
背景技术
泌尿性结石又称尿路结石、尿石症，是泌尿系的常见病。是指在泌尿系统内因尿液浓缩沉淀形成颗粒或成块样聚集物，为泌尿系统常见病，好发于青壮年，近年来随着环境污染的不断扩大，人们生活习惯的改变，泌尿系结石的病人在不断地增加。泌尿性结石是肾、输尿管、膀胱、尿道结石的总称，结石可见于肾、膀胱、输尿管和尿道的任何部位。按尿路结石所在的部位基本分为上尿路结石和下尿路结石。上尿路结石是指肾和输尿管结石；下尿路结石包括膀胱结石和尿道结石。当尿中形成结石晶体的盐类呈饱和状态、抑制晶体形成物质不足和核基质的存在就会形成结石，结石成分有草酸钙、磷酸钙和磷酸镁铵等。泌尿性结石的致病原因较为为复杂，中医认为泌尿系结石的病因病机为《诸病源候论》载：“诸淋者，由肾虚而膀胱热故也”的影响，认为其病因病机主要是肾虚膀胱气化无力失司，湿热蕴结，煎熬津液．日久月累，聚而成石。泌尿性结石以突然发生的剧烈腰痛、牵引少腹，尿频、尿急、尿痛、尿色混浊，甚至尿中有血或砂石为主要临床表现。泌尿系结石可引起尿路损伤、梗阻，并发感染，致使肾功能受损，所以一旦检查发现患泌尿性结石应及时治疗。对于泌尿性结石，西医的治疗方法是小结石(直径在0.5厘米以下)采用多饮水，依靠身体自身机能等待排石，此方法使患者十分被动，在等待排石的过程中，患者依然要忍受病痛的折磨；大结石采用手术治疗，即通过内腔镜(如肾盂镜、输尿管镜)下取石术、体外震波碎石术及膀胱结石的爆破疗法等，效果虽好，但手术费用较高，且碎石排出过程中，可能引起肾绞痛，给患者造成额外的身体负担。
在已有中医中药领域治疗泌尿性结石的技术中，授权公告号 CN 102125605 B（申请号 201010019338.3）的专利文件公开了一种具有治疗泌尿系结石，同时又有补肾作用的中药颗粒制剂，其特征在于该中药制剂的组分以及重量分数为：枸杞30 份、冬葵子15 份、滑石30 份、木通12 份、鹿角胶15 份、鸡内金12 份、鸡内金12 份、白芥子15 份、甘草6 份、黄芪30 份、大黄15 份，同时，在本配方中加入蜂蜜2-8 份。中国发明专利申请CN02153898.0于2003年5月28日公开了一种名称为“一种治疗泌尿系结石的中药制剂及其制备方法”，它是以中药胡桃仁为原料，经压榨出油、醇提醇沉、喷雾干燥等工艺得到胡桃仁油和胡桃仁提取物干粉，两者再按一定比例量混合均匀，以混合物的药物活性成分制成适合服用的剂型，此发明配方简单，只有核桃仁一味原料，无法做到对不同部位的泌尿性结石进行辨证治疗的目的，且加工提炼工序麻烦，成本较高。
发明内容
针对现有的治疗现状，本发明的目的之一在于提供一种治疗泌尿性结石的醋饮，具有易操作、疗效显著、病患承受痛苦小的特点，并且它采用地方上较为常见的中药材作为原料，成本低廉。
本发明的另一目的就是提供上述治疗泌尿性结石醋饮的制备方法。
本发明的上述目的是通过以下技术方案来实现的：
一种治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成：白芥子9-15份，玉米6-12份，甘草10-15份，枳壳5-10份，乌药6-12份，白茅根15-60份，川芎5-15份，鱼脑石4.5-9份，荸荠5-15份，川木通2-5份，八仙草5-15份，醋60-100份。
上述治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成：白芥子10-12份，玉米7-10份，甘草11-14份，枳壳6-9份，乌药9-11份，白茅根25-40份，川芎8-11份，鱼脑石5-8份，荸荠7-12份，川木通3-4份，八仙草7-12份，醋70-90份。
上述治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成：白芥子10份，玉米8份，甘草12份，枳壳8份，乌药10份，白茅根30份，川芎10份，鱼脑石6.5份，荸荠10份，川木通3.5份，八仙草10份，醋80份。
一种治疗泌尿性结石的醋饮的制备方法，具体有以下步骤制备而成：
①取新鲜的玉米，切成块，置于砂锅内，加水微火慢煮1-3小时，过滤，滤液备用；
②将鱼脑石置于小火上，烧至外部焦黑为度，使药物表面部分炭化，然后研磨成细末，过80-120目筛；
③将醋加入到步骤①所得滤液中，一边用大铁勺搅拌一边熬煮，待滤液煮开后加入白芥子，甘草，枳壳，乌药，白茅根，川芎、荸荠、川木通、八仙草和步骤②所得鱼脑石，武火煎开，转文火煎煮20-40分钟，密封静置10-15小时，取上清液待用；
④将步骤③所得上清液，于80-100℃干热灭菌，密封于塑料瓶中，即得醋饮。
上述醋饮的制备方法，制备步骤①水的用量是玉米重量的8-12倍（优选的，水的用量是玉米重量的9-11倍，更佳优选的，水的用量是玉米重量的10倍）。
上述醋饮的制备方法，制备步骤①加水微火慢煮1.5-2.5小时（优选的加水微火慢煮2小时）。
上述醋饮的制备方法，制备步骤②细末过90-110目筛（优选过100目筛）。
上述醋饮的制备方法，制备步骤③武火煎开，转文火煎煮25-35分钟（优选武火煎开，转文火煎煮30分钟）。
上述醋饮的制备方法，制备步骤③密封静置11-14小时（优选的密封静置12小时）。
上述醋饮的制备方法，制备步骤④于80-100℃干热灭菌3-9分钟（优选的，于85-95℃干热灭菌5-7分钟，更佳优选的，于90℃干热灭菌6分钟）。
上述醋饮的制备方法，优选的，以米醋为最佳的制备醋饮原料。
使用方法：一日3-6次，每次取本发明醋饮40-50ml，可根据个人口味添加糖或者蜂蜜，10天为一个疗程。
该醋饮对泌尿性结石效果显著，有止痛、利尿的功效。方中的玉米经过加工后变成玉米水，玉米水有甘甜的味道，加入米醋和中药熬煮后得到酸甜口味的醋饮，方中白芥子、甘草和川芎均有止痛的功效，能在服药初期快速缓解患者的疼痛症状，使患者有坚持治疗的信心；枳壳、白茅根、鱼脑石、荸荠、川木通和八仙草均有利尿的作用，可以促使结石顺畅快速的排出，减轻患者的身体痛苦与负担。
各原料药的药理功效分别为：
白芥子：白芥子，别名辣菜子，一年或二年生植物白芥的干燥成熟种子。十字花科，呈球形，表面灰白色至淡黄色，种皮薄而脆，有油性。无臭，味辛辣。可入药。温肺豁痰利气，散结通络止痛，化痰逐饮；散结消肿。主咳喘痰多；胸满胁痛；肢体麻木；关节肿痛；湿痰流注；阴疽肿毒。治乳痈、乳癌、乳腺疼痛、结核、痰饮咳喘，胸胁胀满疼痛，反胃呕吐，中风不语，肢体痹痛麻木，脚气，阴疽，肿毒，跌打肿痛。
玉米：玉米亦称玉蜀黍、包谷、苞米、棒子；粤语称为粟米，闽南语称作番麦，是一年生禾本科草本植物，具有利尿、降压、利胆、降血糖的功效。
甘草：甘，平，归心、肺、脾、胃经。功效: 补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。主治： 用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
枳壳：性味: 苦、辛、酸，温。归经: 归脾、胃经。功效: 理气宽中，行滞消胀。主治: 用于胸胁气滞．胀满疼痛，食积不化，痰饮内停；胃下垂，脱肛，子宫脱垂。乌药：味甘，性平。有利水渗湿的功效，主要用于小便不利。
乌药：1 挥发油的兴奋作用：内服时，有兴奋大脑皮质的作用，并有促进呼吸，兴奋心肌，加速血循环，升高血压及发汗的作用。局部外用使局部血管扩张，血循环加速，缓和肌肉痉挛性疼痛。2、抑菌作用：对金黄色葡萄球菌，甲型溶血性链球菌，伤寒杆菌，变形杆菌，绿脓杆菌，大肠杆菌均有抑制作用。3、对消化道的影响：有报导乌药对胃肠平滑肌有双重作用，此外，乌药能增加消化液的分泌。4、止血作用：体外实验证明，乌药干粉能明显缩短家兔血浆再钙化时间，促进血凝及良好的止血作用。5、其它作用：用乌药长期喂大鼠，可使体重增加，并对小鼠肉瘤-180有抑制作用，其龙脑可发汗、兴奋、镇痉、驱虫等。
白茅根：性味: 甘，寒。归经: 归肺、胃、膀胱经。功效: 凉血止血，清热利尿。主治: 用于血热吐血．衄血，尿血，热病烦渴，黄疸，水肿，热淋涩痛；急性肾炎水肿。
川芎：性味: 辛，温。归经: 归肝、胆、心包经。功效: 活血行气，祛风止痛。 主治: 用于月经不调．经闭痛经，癥瘕腹痛，胸胁刺痛，跌扑肿痛，头痛。风湿痹痛。
鱼脑石：基原：为石首鱼科黄鱼属动物大黄鱼和小黄鱼的头骨中的耳石。药性：甘、咸，平。功用主治：化石，通淋，解毒。主治石淋，小便淋沥不畅，鼻渊，聤耳出脓。
荸荠：荸荠:别名马蹄、乌芋、地栗。性味功效:甘、寒。功能清热、化痰、消积、化疣。适用于温病消渴、黄疸、热淋、痞积、目赤、咽喉肿痛、赘疣等。预防急性传染病、清热泻火、凉血解毒、利尿通便祛痰、消食除胀，调理痔疮或痢疾便血、妇女崩漏、阴虚肺燥、痰热咳嗽、咽喉不利、痞块积聚、目赤障翳、辅助退烧等功效。此外，荸荠含有一种抗病毒物质可抑制流脑，流感病毒，能用于预防流脑及流感的传播。
川木通：川木通：基原：为毛莨科铁线莲属植物小木通、绣球藤等的藤茎。成分：1.小木通 含黄铜苷类成分：威灵仙苷。2.绣球藤 含有以常春藤皂苷元为苷元的六糖皂苷及三糖皂苷。药性：淡、微苦，寒。功用主治：清热利尿，通经下乳。主治湿热癃闭，水肿，淋证，口舌生疮，湿热痹痛，关节不利，妇人闭经，乳汁不通。宜忌：气弱津伤，精滑遗尿，小便过多及孕妇慎服。
八仙草：又名锯子草、拉拉藤、飞扬藤，味茜草科拉拉藤属植物猪殃殃或粗叶拉拉藤的全草。药性：全草纤细，易破碎，表面灰绿或绿褐色，气微，味辛、味苦，性微寒。成分：猪殃殃地上部分含生物碱，果实含大麦芽胺，加利果酸等；粗叶拉拉藤地上部分含车叶草苷，维生素C。根据现代药理研究发现，该药具有抑菌、抗癌、清热解毒、利尿通淋、消肿止痛的功效，用于痈疽肿毒，阑尾炎，感冒发热，尿血等。
米醋：米醋是众多种类醋中营养价值较高的一种，含有丰富的碱性氨基酸、糖类物质、有机酸、维生素B1、维生素B2、维生素C、无机盐、矿物质等，具有祛脂降压,降低胆固醇,解毒,解酒,消食,减肥,安神除烦,有益心血管。
本发明醋饮基于中医中药辩症治疗的原理。选用的药材有用于表症止痛、利尿的，也有用于里症除热调肾的，属于内外兼顾且安全有效的药物，对泌尿性结石有极好的治疗作用。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案，但保护范围不被此限制。
实施例 1一种治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成（每份取10g）：白芥子9份，玉米6份，甘草10份，枳壳5份，乌药6份，白茅根15份，川芎5份，鱼脑石4.5份，荸荠5份，川木通2份，八仙草5份，醋60份。
上述治疗泌尿性结石的醋饮的制备方法，步骤如下：
①取新鲜的玉米，切成块，置于砂锅内，加水微火慢煮1小时，水的用量是玉米重量的8倍，过滤，滤液备用；
②将鱼脑石置于小火上，烧至外部焦黑为度，使药物表面部分炭化，然后研磨成细末，过80目筛；
③将醋加入到步骤①所得滤液中，一边用大铁勺搅拌一边熬煮，待滤液煮开后加入白芥子，甘草，枳壳，乌药，白茅根，川芎、荸荠、川木通、八仙草和步骤②所得鱼脑石，武火煎开，转文火煎煮20分钟，密封静置10小时，取上清液待用；
④将步骤③所得上清液，于80℃干热灭菌3分钟，密封于塑料瓶中，即得醋饮。
典型病例一朱XX，男，52岁，山东省德州人士，某高校的教师，不明原因的右侧腰痛，发作时大汗淋漓，疼痛向同侧腹股沟放射，半个月前曾出现尿频、尿痛的症状，仔细观察发现有血尿症状，医院诊断为肾窦近中部有0.3*0.4cm强回声光斑，确诊为泌尿性结石，由于患者想继续给学生上课，又坚持保守治疗，医生就建议饮用本发明醋饮。
饮用实施例1所得的醋饮，饮用1天，小便顺畅了很多，疼痛有所减轻，继续饮用4天，疼痛基本消失，小便顺畅，继续服用10周，去医院检查，结石已完全排出，停药至今未复发。
实施例 2一种治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成（每份取10g）：白芥子15份，玉米12份，甘草15份，枳壳10份，乌药12份，白茅根60份，川芎15份，鱼脑石9份，荸荠15份，川木通5份，八仙草15份，醋100份。
上述治疗泌尿性结石的醋饮的制备方法，步骤如下：
①取新鲜的玉米，切成块，置于砂锅内，加水微火慢煮3小时，水的用量是玉米重量的12倍，过滤，滤液备用；
②将鱼脑石置于小火上，烧至外部焦黑为度，使药物表面部分炭化，然后研磨成细末，过120目筛；
③将醋加入到步骤①所得滤液中，一边用大铁勺搅拌一边熬煮，待滤液煮开后加入白芥子，甘草，枳壳，乌药，白茅根，川芎、荸荠、川木通、八仙草和步骤②所得鱼脑石，武火煎开，转文火煎煮40分钟，密封静置15小时，取上清液待用；
④将步骤③所得上清液，于80-100℃干热灭菌9分钟，密封于塑料瓶中，即得醋饮。
实施例 3一种治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成（每份取10g）：白芥子10份，玉米7份，甘草11份，枳壳6份，乌药9份，白茅根25份，川芎8份，鱼脑石5份，荸荠7份，川木通3份，八仙草7份，醋70份。
上述治疗泌尿性结石的醋饮的制备方法，步骤如下：
①取新鲜的玉米，切成块，置于砂锅内，加水微火慢煮1.5小时，水的用量是玉米重量的9倍，过滤，滤液备用；
②将鱼脑石置于小火上，烧至外部焦黑为度，使药物表面部分炭化，然后研磨成细末，过90目筛；
③将醋加入到步骤①所得滤液中，一边用大铁勺搅拌一边熬煮，待滤液煮开后加入白芥子，甘草，枳壳，乌药，白茅根，川芎、荸荠、川木通、八仙草和步骤②所得鱼脑石，武火煎开，转文火煎煮25分钟，密封静置11小时，取上清液待用；
④将步骤③所得上清液，于85℃干热灭菌5分钟，密封于塑料瓶中，即得醋饮。
实施例 4一种治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成（每份取10g）：白芥子12份，玉米10份，甘草14份，枳壳9份，乌药11份，白茅根40份，川芎11份，鱼脑石8份，荸荠12份，川木通4份，八仙草12份，醋90份。
上述治疗泌尿性结石的醋饮的制备方法，步骤如下：
①取新鲜的玉米，切成块，置于砂锅内，加水微火慢煮2.5小时，水的用量是玉米重量的11倍，过滤，滤液备用；
②将鱼脑石置于小火上，烧至外部焦黑为度，使药物表面部分炭化，然后研磨成细末，过110目筛；
③将醋加入到步骤①所得滤液中，一边用大铁勺搅拌一边熬煮，待滤液煮开后加入白芥子，甘草，枳壳，乌药，白茅根，川芎、荸荠、川木通、八仙草和步骤②所得鱼脑石，武火煎开，转文火煎煮35分钟，密封静置14小时，取上清液待用；
④将步骤③所得上清液，于95℃干热灭菌7分钟，密封于塑料瓶中，即得醋饮。
典型病例二：俎XX，女，60岁，山东济南人士。2年前有过泌尿性结石，在医院进行碎石治疗痊愈出院，出院后半年复发，但最近反复出现排尿困难，尿不尽，下腹胀痛，去医院经B超、X线检查，膀胱镜检查，发现有结石0.7*0.6cm，诊断为泌尿性结石，由于碎石法对俎女士不太实用，所以医生建议其饮用本发明所得醋饮。
饮用实施例4所得的醋饮，服用5天，排尿困难症状好转，疼痛减轻；饮用20天，期间有小块结石随尿液排出，小便基本正常；继续饮用1个月，去医院检查结石已完全排出；减少药量服用继续巩固10天，停药至今未复发。
实施例 5一种治疗泌尿性结石的醋饮，取下述重量配比的主要原料制备而成（每份取10g）：白芥子10份，玉米8份，甘草12份，枳壳8份，乌药10份，白茅根30份，川芎10份，鱼脑石6.5份，荸荠10份，川木通3.5份，八仙草10份，醋80份。
上述治疗泌尿性结石的醋饮的制备方法，步骤如下：
①取新鲜的玉米，切成块，置于砂锅内，加水微火慢煮2小时，水的用量是玉米重量的10倍，过滤，滤液备用；
②将鱼脑石置于小火上，烧至外部焦黑为度，使药物表面部分炭化，然后研磨成细末，过100目筛；
③将醋加入到步骤①所得滤液中，一边用大铁勺搅拌一边熬煮，待滤液煮开后加入白芥子，甘草，枳壳，乌药，白茅根，川芎、荸荠、川木通、八仙草和步骤②所得鱼脑石，武火煎开，转文火煎煮30分钟，密封静置12小时，取上清液待用；
④将步骤③所得上清液，于90℃干热灭菌6分钟，密封于塑料瓶中，即得醋饮。
试验例：实施例5所得治疗泌尿性结石的醋饮的临床应用：2008年6月-2011年12月，在4所医院筛选200例患者，其中女性100例，男性100例，年龄最大的72岁，最小年龄28岁，平均年龄50岁。试验之前1周，对该人群进行连续观察，记录症状及变化，随机分为两组，实验组及对照组，实验组服用实施例5所得产品，对照组服用其它药品（例如苧麻二金汤、化瘀排石汤等常规治疗泌尿性结石的药物）。使用方法为: 一日3-6次，每次取本发明醋饮40-50ml，可根据个人口味添加糖或者蜂蜜，10天为一个疗程，在饮用本发明的同时配合多喝水。疗效情况判定标准:治愈:饮用本品后，不适症状消失，结石完全排出；有效：饮用本品后，不适症状减轻或部分消失，结石基本排出；无效：饮用本品一个疗程，不适症状无变化。结果如表1所示。
表1:服用实施例5产品28-72岁泌尿性结石患者治疗结果
治疗效果：治愈85例（85%）， 有效10例（10%），无效5例（5%），总有效率95%。效果明显优于对照组。
经临床试验证明，对于直径0.5cm以下的结石，饮用本品5天即可有部分结石排出，严重者，饮用本品10天也会有好转，且治疗过程中无副作用，费用低廉，复发率极低，是治疗泌尿性结石安全且有效的药物。
Claims (16)
1.一种治疗泌尿性结石的醋饮，其特征在于：取下述重量配比的主要原料制备而成：白芥子9-15份，玉米6-12份，甘草10-15份，枳壳5-10份，乌药6-12份，白茅根15-60份，川芎5-15份，鱼脑石4.5-9份，荸荠5-15份，川木通2-5份，八仙草5-15份，醋60-100份。
2.根据权利要求1所述的治疗泌尿性结石的醋饮，其特征在于：取下述重量配比的主要原料制备而成：白芥子10-12份，玉米7-10份，甘草11-14份，枳壳6-9份，乌药9-11份，白茅根25-40份，川芎8-11份，鱼脑石5-8份，荸荠7-12份，川木通3-4份，八仙草7-12份，醋70-90份。
3.根据权利要求1所述的治疗泌尿性结石的醋饮，其特征在于：取下述重量配比的主要原料制备而成：白芥子10份，玉米8份，甘草12份，枳壳8份，乌药10份，白茅根30份，川芎10份，鱼脑石6.5份，荸荠10份，川木通3.5份，八仙草10份，醋80份。
4.根据权利要求1-3任一项所述的治疗泌尿性结石的醋饮的制备方法，其特征在于：步骤如下：
①取新鲜的玉米，切成块，置于砂锅内，加水微火慢煮1-3小时，水的用量是玉米重量的8-12倍，过滤，滤液备用；
②将鱼脑石置于小火上，烧至外部焦黑为度，使药物表面部分炭化，然后研磨成细末，过80-120目筛；
③将醋加入到步骤①所得滤液中，一边用大铁勺搅拌一边熬煮，待滤液煮开后加入白芥子，甘草，枳壳，乌药，白茅根，川芎、荸荠、川木通、八仙草和步骤②所得鱼脑石，武火煎开，转文火煎煮20-40分钟，密封静置10-15小时，取上清液待用；
④将步骤③所得上清液，于80-100℃干热灭菌3-9分钟，密封于塑料瓶中，即得醋饮。
5.根据权利要求4所述的醋饮的制备方法，其特征在于：制备步骤①水的用量是玉米重量的9-11倍。
6.根据权利要求5所述的醋饮的制备方法，其特征在于：制备步骤①水的用量是玉米重量的10倍。
7.根据权利要求4所述的醋饮的制备方法，其特征在于：制备步骤①加水微火慢煮1.5-2.5小时。
8.根据权利要求7所述的醋饮的制备方法，其特征在于：制备步骤①加水微火慢煮2小时。
9.根据权利要求4所述的醋饮的制备方法，其特征在于：制备步骤②细末过90-110目筛。
10.根据权利要求9所述的醋饮的制备方法，其特征在于：制备步骤②细末过100目筛。
11.根据权利要求4所述的醋饮的制备方法，其特征在于：制备步骤③武火煎开，转文火煎煮25-35分钟。
12.根据权利要求11所述的醋饮的制备方法，其特征在于：制备步骤③武火煎开，转文火煎煮30分钟。
13.根据权利要求4所述的醋饮的制备方法，其特征在于：制备步骤③密封静置11-14小时。
14.根据权利要求13所述的醋饮的制备方法，其特征在于：制备步骤③密封静置12小时。
15.根据权利要求4所述的醋饮的制备方法，其特征在于：制备步骤④于85-95℃干热灭菌5-7分钟。
16.根据权利要求15所述的醋饮的制备方法，其特征在于：制备步骤④于90℃干热灭菌6分钟。
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| CN100479854C (zh) * | 2006-10-18 | 2009-04-22 | 龚崇明 | 一种适于治疗多器官结石症的药物及其制备方法 |
| CN101732621A (zh) * | 2009-12-25 | 2010-06-16 | 黄毅 | 治疗肾结石的中药 |
| CN102266501B (zh) * | 2011-07-25 | 2012-12-05 | 王疆宏 | 一种结石通茶组合物及其制备方法 |
| CN103385954A (zh) * | 2012-05-08 | 2013-11-13 | 陈�田 | 一种用于治疗肾结石的中药组合物 |
| CN102895597B (zh) * | 2012-10-17 | 2014-03-05 | 于大鹏 | 一种治疗泌尿系结石的药剂 |
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