CN104169282B - Ip受体激动剂的盐 - Google Patents

Ip受体激动剂的盐 Download PDF

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Publication number
CN104169282B
CN104169282B CN201380013971.3A CN201380013971A CN104169282B CN 104169282 B CN104169282 B CN 104169282B CN 201380013971 A CN201380013971 A CN 201380013971A CN 104169282 B CN104169282 B CN 104169282B
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CN
China
Prior art keywords
pah
receptor
receptor agonists
tolyl
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201380013971.3A
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English (en)
Chinese (zh)
Other versions
CN104169282A (zh
Inventor
C·勒布朗
S·C·麦基翁
A·佩尔伯格
N·图菲利
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380013971.3A 2012-01-13 2013-01-11 Ip受体激动剂的盐 Expired - Fee Related CN104169282B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261586324P 2012-01-13 2012-01-13
US61/586,324 2012-01-13
PCT/IB2013/050283 WO2013105066A1 (en) 2012-01-13 2013-01-11 Salts of an ip receptor agonist

Publications (2)

Publication Number Publication Date
CN104169282A CN104169282A (zh) 2014-11-26
CN104169282B true CN104169282B (zh) 2016-04-20

Family

ID=47757663

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380013971.3A Expired - Fee Related CN104169282B (zh) 2012-01-13 2013-01-11 Ip受体激动剂的盐

Country Status (6)

Country Link
US (1) US9174985B2 (OSRAM)
EP (1) EP2802584B1 (OSRAM)
JP (1) JP6058698B2 (OSRAM)
CN (1) CN104169282B (OSRAM)
ES (1) ES2561353T3 (OSRAM)
WO (1) WO2013105066A1 (OSRAM)

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CN105801578A (zh) * 2016-04-28 2016-07-27 华南理工大学 一种半饱和吡嗪衍生物的合成方法及应用

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US10744223B2 (en) 2011-03-25 2020-08-18 Szent Co. Scented material compositions and articles for use with food and beverage
US9801969B2 (en) 2011-03-25 2017-10-31 Szent Bev Co. Scented attachment for containers
US9174985B2 (en) 2012-01-13 2015-11-03 Novartis Ag Salts of 7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid as IP receptor agonists
AR089698A1 (es) 2012-01-13 2014-09-10 Novartis Ag Compuestos heterociclicos antagonistas del receptor ip
EP2802585A1 (en) 2012-01-13 2014-11-19 Novartis AG Fused piperidines as ip receptor agonists for the treatment of pah and related disorders
CN105189500A (zh) 2013-02-13 2015-12-23 诺华股份有限公司 Ip受体激动剂杂环化合物
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
WO2015089137A1 (en) 2013-12-11 2015-06-18 Karos Pharmaceuticals, Inc. Acylguanidines as tryptophan hydroxylase inhibitors
WO2016109501A1 (en) 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Amide compounds as tryptophan hydroxylase inhibitors
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
USD826047S1 (en) 2017-03-29 2018-08-21 Szent Co. Bottle ring
CN110877768B (zh) * 2017-05-05 2022-05-06 圣特公司 一种用于制作香味传递系统的方法
USD950384S1 (en) 2018-05-16 2022-05-03 Szent Co. Bottle
US11097877B2 (en) 2018-05-31 2021-08-24 Szent Co. Scent delivery and preservation systems and methods for beverage containers
EP3880680A1 (en) 2018-11-14 2021-09-22 Altavant Sciences GmbH A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (tph1) for treating diseases or disorders associated with peripheral serotonin
US11018362B2 (en) 2019-05-30 2021-05-25 Lih-Ren Shiue System for generating electricity using oxygen from water
US11312528B2 (en) 2019-10-07 2022-04-26 Szent Co. Scented attachments for beverage cartons

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WO2010008864A2 (en) * 2008-06-24 2010-01-21 Amira Pharmaceuticals, Inc. Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors
US20100280041A1 (en) * 2009-04-30 2010-11-04 Kaohsiung Medical University Rhokinase-dependent inhibition activity on pulmonary artery endothelium dysfunction, medial wall thickness and vascular obstruction of pulmodil and pulmodil-1

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AR089698A1 (es) 2012-01-13 2014-09-10 Novartis Ag Compuestos heterociclicos antagonistas del receptor ip
US9174985B2 (en) 2012-01-13 2015-11-03 Novartis Ag Salts of 7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid as IP receptor agonists
EP2802585A1 (en) 2012-01-13 2014-11-19 Novartis AG Fused piperidines as ip receptor agonists for the treatment of pah and related disorders
EP2802582A1 (en) 2012-01-13 2014-11-19 Novartis AG Fused dihydropyrido [2,3 -b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
CN105189500A (zh) 2013-02-13 2015-12-23 诺华股份有限公司 Ip受体激动剂杂环化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007017096A1 (en) * 2005-07-29 2007-02-15 Laboratorios Almirall, S.A. Pyrazine derivatives useful as adenosine receptor antagonists
WO2010008864A2 (en) * 2008-06-24 2010-01-21 Amira Pharmaceuticals, Inc. Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors
US20100280041A1 (en) * 2009-04-30 2010-11-04 Kaohsiung Medical University Rhokinase-dependent inhibition activity on pulmonary artery endothelium dysfunction, medial wall thickness and vascular obstruction of pulmodil and pulmodil-1

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105801578A (zh) * 2016-04-28 2016-07-27 华南理工大学 一种半饱和吡嗪衍生物的合成方法及应用

Also Published As

Publication number Publication date
WO2013105066A1 (en) 2013-07-18
US20150011555A1 (en) 2015-01-08
JP2015503610A (ja) 2015-02-02
ES2561353T3 (es) 2016-02-25
EP2802584B1 (en) 2015-11-18
CN104169282A (zh) 2014-11-26
US9174985B2 (en) 2015-11-03
JP6058698B2 (ja) 2017-01-11
EP2802584A1 (en) 2014-11-19

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