CN104161832A - 草药组合物phy906及其在化学治疗中的应用 - Google Patents

草药组合物phy906及其在化学治疗中的应用 Download PDF

Info

Publication number
CN104161832A
CN104161832A CN201410401772.6A CN201410401772A CN104161832A CN 104161832 A CN104161832 A CN 104161832A CN 201410401772 A CN201410401772 A CN 201410401772A CN 104161832 A CN104161832 A CN 104161832A
Authority
CN
China
Prior art keywords
phy906
cpt
mice
cancer
chemotherapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410401772.6A
Other languages
English (en)
Chinese (zh)
Inventor
Y-C·程
S-H·刘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of CN104161832A publication Critical patent/CN104161832A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201410401772.6A 2004-11-09 2005-11-09 草药组合物phy906及其在化学治疗中的应用 Pending CN104161832A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62594304P 2004-11-09 2004-11-09
US60/625,943 2004-11-09
US11/100,433 US7534455B2 (en) 2000-03-09 2005-04-07 Herbal composition PHY906 and its use in chemotherapy
US11/100,433 2005-04-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800461878A Division CN101098705A (zh) 2004-11-09 2005-11-09 草药组合物phy906及其在化学治疗中的应用

Publications (1)

Publication Number Publication Date
CN104161832A true CN104161832A (zh) 2014-11-26

Family

ID=36337179

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410401772.6A Pending CN104161832A (zh) 2004-11-09 2005-11-09 草药组合物phy906及其在化学治疗中的应用
CNA2005800461878A Pending CN101098705A (zh) 2004-11-09 2005-11-09 草药组合物phy906及其在化学治疗中的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005800461878A Pending CN101098705A (zh) 2004-11-09 2005-11-09 草药组合物phy906及其在化学治疗中的应用

Country Status (8)

Country Link
US (1) US7534455B2 (https=)
EP (1) EP1812028A4 (https=)
JP (1) JP5057987B2 (https=)
CN (2) CN104161832A (https=)
AU (1) AU2005304493B2 (https=)
CA (1) CA2583761C (https=)
TW (1) TW200630105A (https=)
WO (1) WO2006053049A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109414422A (zh) * 2016-05-23 2019-03-01 耶鲁大学 使用包含phy906提取物、黄芩提取物或来自这些提取物的化合物的联合疗法改善抗免疫检查点抑制剂的治疗指数

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871279B2 (en) 2000-03-09 2014-10-28 Yale University Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen
US8309141B2 (en) * 2000-03-09 2012-11-13 Yale University Herbal composition PHY906 and its use in chemotherapy
US8394365B2 (en) * 2003-09-17 2013-03-12 Nektar Therapeutics Multi-arm polymer prodrugs
TWI361075B (en) * 2007-03-16 2012-04-01 Brion Res Inst Of Taiwan Pharmaceutical composition for inhibiting the syndrome of snore
US20110111070A1 (en) * 2007-10-25 2011-05-12 Yung-Chi Cheng Use of phy906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome
US20130136811A1 (en) * 2010-05-26 2013-05-30 President And Fellows Of Harvard College Compositions and Methods for Pain Reduction
US8597695B1 (en) 2010-11-13 2013-12-03 Sirbal Ltd. Herbal combinations for treatment of a skin condition
US8541382B2 (en) 2010-11-13 2013-09-24 Sirbal Ltd. Cardiac glycoside analogs in combination with emodin for cancer therapy
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US20170049687A1 (en) 2015-07-29 2017-02-23 Sirbal Ltd. Herbal Combinations For Treating Scalp Conditions
EP3076984B1 (en) 2013-12-02 2018-11-14 Sirbal Ltd. Herbal combinations for treatment of a skin condition
SG11201901540UA (en) 2016-06-22 2019-04-29 Univ Yale Mechanism based quality control for botanical medicine
US10086026B2 (en) * 2016-06-27 2018-10-02 Uwais M. Syed Combined herbal and pharmaceutical composition and method
CN107970299A (zh) * 2017-11-16 2018-05-01 饶本强 一种清热解毒抗肿瘤复方制剂
CN112040965B (zh) * 2018-02-28 2023-04-14 中央大学校产学协力团 用于预防、减轻或治疗恶病质和肌肉损失的组合物
CN110105149B (zh) * 2019-04-23 2022-02-01 来宾市农业科学院 一种蚕沙防治甘蔗螟虫的方法
CN109991341B (zh) * 2019-05-17 2022-04-01 无限极(中国)有限公司 一种制首乌的质量检测方法
EP4087585A4 (en) * 2019-12-09 2023-12-06 Yale University COMPOSITIONS AND METHODS FOR PREVENTING CANCER RECURRENCE
JP2023545880A (ja) * 2020-03-30 2023-11-01 イエール ユニバーシティ 炎症性および線維性疾患および障害の処置法
US12011284B2 (en) * 2020-05-19 2024-06-18 Peachy Corp. Systems and methods for preventing and treating wrinkles
TW202337484A (zh) * 2022-03-01 2023-10-01 耶魯大學 用於調節t細胞之活化t細胞核因子(nfat)活性的組成物及方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211180A1 (en) * 2000-03-09 2003-11-13 Yung-Chi Cheng Herbal composition phy906 and its use in chemotheraphy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936621A (ja) * 1982-08-25 1984-02-28 Tsumura Juntendo Inc 脂肪分解促進作用阻害剤
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5665393A (en) * 1996-09-03 1997-09-09 International Medical Research, Inc. Herbal composition for treating prostate carcinoma
US6048847A (en) * 1997-09-30 2000-04-11 Dabur Research Foundation Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this
US6630176B2 (en) * 2000-03-07 2003-10-07 Mount Sinai School Of Medicine Of New York University Herbal remedies for treating allergies and asthma
US20030180395A1 (en) * 2000-07-26 2003-09-25 Bernd Bueter Plant extract

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211180A1 (en) * 2000-03-09 2003-11-13 Yung-Chi Cheng Herbal composition phy906 and its use in chemotheraphy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
纪春祥等: "《肿瘤学》", 31 January 2004, 科学技术出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109414422A (zh) * 2016-05-23 2019-03-01 耶鲁大学 使用包含phy906提取物、黄芩提取物或来自这些提取物的化合物的联合疗法改善抗免疫检查点抑制剂的治疗指数

Also Published As

Publication number Publication date
WO2006053049A3 (en) 2007-03-22
JP2008519767A (ja) 2008-06-12
JP5057987B2 (ja) 2012-10-24
US7534455B2 (en) 2009-05-19
US20050196473A1 (en) 2005-09-08
TW200630105A (en) 2006-09-01
CA2583761C (en) 2015-04-21
AU2005304493B2 (en) 2012-05-10
WO2006053049A2 (en) 2006-05-18
CA2583761A1 (en) 2006-05-18
EP1812028A2 (en) 2007-08-01
CN101098705A (zh) 2008-01-02
AU2005304493A1 (en) 2006-05-18
EP1812028A4 (en) 2010-01-20

Similar Documents

Publication Publication Date Title
CN100490845C (zh) 一种草药组合物及其在化疗中的应用
AU2005304493B2 (en) Herbal composition PHY906 and its use in chemotherapy
MXPA03003446A (es) Nueva composicion herbacea medicinal para tratar enfermedades del higado y vih.
US10849951B2 (en) Use of PHY906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome
US20130101688A1 (en) Herbal composition phy906 and its use in chemotherapy
US20120009282A1 (en) Use of the combination of phy906 and a tyrosine kinase inhibitor as a cancer treatment regimen
KR100950164B1 (ko) 뇌졸중과 치매를 포함하는 퇴행성뇌질환의 예방과 치료용 건강기능성식품 및 약제학적 조성물
CN111603501B (zh) 一种用于原发性肝癌的中药组合物及其应用
HK1111910A (en) Herbal composition phy906 and its use in chemotherapy
CN100512828C (zh) 复方板蓝根泡腾片及其制备方法
AU2001245508B2 (en) Compositions consisting of PHY906 and chemotherapeutic agents
CN118806832B (zh) 一种用于晚期原发性肝癌的中药组合物及其应用
CN105106574A (zh) 一种中药组合物在治疗不孕不育中的应用
CN111298061A (zh) 一种清热解毒、祛瘀散结的中药组合物及其制备方法
CN110585203B (zh) 小檗碱联合芒柄花黄素在制备抗肿瘤药物中的应用
CN119185487A (zh) 一种治疗多发性骨髓瘤的药物组合物及其应用
CN119074858A (zh) 一种治疗白血病的组合物及其制备方法、应用
TW202237152A (zh) 中草藥組合物及其製備抗癌藥物之用途
CN106668601A (zh) 一种治疗脑血管病痰热证的中药组合物及其制备方法与应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20141126